Review
doi: 10.1016/s0070-2153(03)53002-2.Developmental roles and clinical significance of hedgehog signaling
Affiliations
- PMID:12509125
- DOI: 10.1016/s0070-2153(03)53002-2
Item in Clipboard
Review
Developmental roles and clinical significance of hedgehog signaling
Andrew P McMahon et al. Curr Top Dev Biol.2003.
Display options
Format
Display options
Format
Abstract
Cell signaling plays a key role in the development of all multicellular organisms. Numerous studies have established the importance of Hedgehog signaling in a wide variety of regulatory functions during the development of vertebrate and invertebrate organisms. Several reviews have discussed the signaling components in this pathway, their various interactions, and some of the general principles that govern Hedgehog signaling mechanisms. This review focuses on the developing systems themselves, providing a comprehensive survey of the role of Hedgehog signaling in each of these. We also discuss the increasing significance of Hedgehog signaling in the clinical setting.
Similar articles
- Decoding the Hedgehog signal in animal development.Jia J, Jiang J.Jia J, et al.Cell Mol Life Sci. 2006 Jun;63(11):1249-65. doi: 10.1007/s00018-005-5519-z.Cell Mol Life Sci. 2006.PMID:16596340Free PMC article.Review.
- The world according to hedgehog.Hammerschmidt M, Brook A, McMahon AP.Hammerschmidt M, et al.Trends Genet. 1997 Jan;13(1):14-21. doi: 10.1016/s0168-9525(96)10051-2.Trends Genet. 1997.PMID:9009843Review.
- Hedgehog signaling in gastrointestinal development and disease.Harmon EB, Ko AH, Kim SK.Harmon EB, et al.Curr Mol Med. 2002 Feb;2(1):67-82. doi: 10.2174/1566524023363130.Curr Mol Med. 2002.PMID:11898849Review.
- Yorkie and Scalloped signaling regulates Notch-dependent lineage specification during Drosophila hematopoiesis.Ferguson GB, Martinez-Agosto JA.Ferguson GB, et al.Curr Biol. 2014 Nov 17;24(22):2665-72. doi: 10.1016/j.cub.2014.09.081. Epub 2014 Oct 30.Curr Biol. 2014.PMID:25454586Free PMC article.
- Similarities between the Hedgehog and Wnt signaling pathways.Kalderon D.Kalderon D.Trends Cell Biol. 2002 Nov;12(11):523-31. doi: 10.1016/s0962-8924(02)02388-7.Trends Cell Biol. 2002.PMID:12446114Review.
Cited by
- An increase in reactive oxygen species underlies neonatal cerebellum repair.Pakula A, El Nagar S, Bayin NS, Christensen JB, Stephen DN, Reid AJ, Koche R, Joyner AL.Pakula A, et al.bioRxiv [Preprint]. 2025 Feb 18:2024.10.14.618368. doi: 10.1101/2024.10.14.618368.bioRxiv. 2025.PMID:39464104Free PMC article.Preprint.
- Uncovering the secreted signals and transcription factors regulating the development of mammalian middle ear ossicles.Ankamreddy H, Bok J, Groves AK.Ankamreddy H, et al.Dev Dyn. 2020 Dec;249(12):1410-1424. doi: 10.1002/dvdy.260. Epub 2020 Oct 28.Dev Dyn. 2020.PMID:33058336Free PMC article.Review.
- IFT25 links the signal-dependent movement of Hedgehog components to intraflagellar transport.Keady BT, Samtani R, Tobita K, Tsuchya M, San Agustin JT, Follit JA, Jonassen JA, Subramanian R, Lo CW, Pazour GJ.Keady BT, et al.Dev Cell. 2012 May 15;22(5):940-51. doi: 10.1016/j.devcel.2012.04.009.Dev Cell. 2012.PMID:22595669Free PMC article.
- Cytoneme-mediated delivery of hedgehog regulates the expression of bone morphogenetic proteins to maintain germline stem cells in Drosophila.Rojas-Ríos P, Guerrero I, González-Reyes A.Rojas-Ríos P, et al.PLoS Biol. 2012;10(4):e1001298. doi: 10.1371/journal.pbio.1001298. Epub 2012 Apr 3.PLoS Biol. 2012.PMID:22509132Free PMC article.
- Cdon mutation and fetal alcohol converge on Nodal signaling in a mouse model of holoprosencephaly.Hong M, Christ A, Christa A, Willnow TE, Krauss RS.Hong M, et al.Elife. 2020 Sep 2;9:e60351. doi: 10.7554/eLife.60351.Elife. 2020.PMID:32876567Free PMC article.
Publication types
MeSH terms
Substances
Related information
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources