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.2002 Oct 10;419(6907):583-6.
doi: 10.1038/nature01079.

Somatic cell nuclear transfer

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Somatic cell nuclear transfer

I Wilmut et al. Nature..

Abstract

Cloning by nuclear transfer from adult somatic cells is a remarkable demonstration of developmental plasticity. When a nucleus is placed in oocyte cytoplasm, the changes in chromatin structure that govern differentiation can be reversed, and the nucleus can be made to control development to term.

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