doi: 10.1016/s0968-0896(02)00116-5.
Hydrazinocurcumin, a novel synthetic curcumin derivative, is a potent inhibitor of endothelial cell proliferation
Affiliations
- PMID:12057633
- DOI: 10.1016/s0968-0896(02)00116-5
Item in Clipboard
Hydrazinocurcumin, a novel synthetic curcumin derivative, is a potent inhibitor of endothelial cell proliferation
Joong Sup Shim et al. Bioorg Med Chem.2002 Aug.
Display options
Format
Display options
Format
Erratum in
- Bioorg Med Chem. 2009 Oct 1;17(20):7073
Abstract
Curcumin and some of its derivatives were known as in vivo inhibitors of angiogenesis. In present study, a novel curcumin derivative, named hydrazinocurcumin (HC) was synthesized and examined for its biological activities. HC potently inhibited the proliferation of bovine aortic endothelial cells (BAECs) at a nanomolar concentration (IC(50)=520 nM) without cytotoxicity. In vivo and in vitro angiogenesis experiments showed HC as a new candidate for anti-angiogenic agent.
Copyright 2002 Elsevier Science.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources