Review
doi: 10.1038/35105024.T-cell regulation by CD28 and CTLA-4
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- DOI: 10.1038/35105024
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Review
T-cell regulation by CD28 and CTLA-4
M L Alegre et al. Nat Rev Immunol.2001 Dec.
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Abstract
Activation of T lymphocytes is thought to require at least two signals, one delivered by the T-cell receptor complex after antigen recognition, and one provided on engagement of co-stimulatory receptors, such as CD28. Recent studies are providing clues as to the specific signalling roles of co-stimulatory receptors. Furthermore, superimposition of inhibitory signals, such as those delivered by cytotoxic T-lymphocyte antigen 4 (CTLA-4), leads to a complex network of positive and negative co-stimulatory signals, the integration of which modulates immune responses.
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