Requirement of Math1 for secretory cell lineage commitment in the mouse intestine
- PMID:11739954
- DOI: 10.1126/science.1065718
Requirement of Math1 for secretory cell lineage commitment in the mouse intestine
Abstract
The mouse small intestinal epithelium consists of four principal cell types deriving from one multipotent stem cell: enterocytes, goblet, enteroendocrine, and Paneth cells. Previous studies showed that Math1, a basic helix-loop-helix (bHLH) transcription factor, is expressed in the gut. We find that loss of Math1 leads to depletion of goblet, enteroendocrine, and Paneth cells without affecting enterocytes. Colocalization of Math1 with Ki-67 in some proliferating cells suggests that secretory cells (goblet, enteroendocrine, and Paneth cells) arise from a common progenitor that expresses Math1, whereas absorptive cells (enterocytes) arise from a progenitor that is Math1-independent. The continuous rapid renewal of these cells makes the intestinal epithelium a model system for the study of stem cell regeneration and lineage commitment.
Comment in
- Development. Epithelial cell differentiation--a Mather of choice.van Den Brink GR, de Santa Barbara P, Roberts DJ.van Den Brink GR, et al.Science. 2001 Dec 7;294(5549):2115-6. doi: 10.1126/science.1067751.Science. 2001.PMID:11739944No abstract available.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Molecular Biology Databases