Efficacy of tissue glue for laceration repair in an animal model
- PMID:11727686
- DOI: 10.1111/j.1553-2712.1995.tb03219.x
Efficacy of tissue glue for laceration repair in an animal model
Abstract
Objective: To compare the efficacy of butyl-2-cyanoacrylate tissue glue (TG) for the repair of skin lacerations in rats with the efficacy of standard closure with sutures.
Methods: In a prospective study, eight rats were anesthetized and an 8-cm dorsal incision was made on each side of the midline. One wound was closed with a single layer of interrupted 5-0 Prolene suture and one by application of TG. The time required to close each wound was recorded. Sutures were removed at seven days; the TG was allowed to fall off spontaneously. The animals were sacrificed after 20 days and the wounds were judged for cosmetic outcome. Four I x 3-cm strips of skin were excised from each wound; one strip for histologic analysis and three for load extension testing using a tensiometer. Specimens were loaded to wound failure while displacement (D) and energy absorption (EA) were recorded. The paired t-test was used for comparisons and reported as mean +/- SE. No significant difference between TG and suture was found in D (6.5 +/- 0.4 vs 5.2 (1.4 mm), EA (0.18 +/- 0.01 vs 0.17 +/- 0.03 kg x mm/cm2), or histologic features. The closure time was significantly less using TG (66 +/- 5 vs 401 +/- 17 sec; p < 0.0001).
Conclusions: 1) Sutures and TG in rat skin repair result in similar wound strengths (EA), amounts of stretch (D), and histologic feasures. 2) Wound closure is accomplished much more rapidly with TG.
Similar articles
- The cyanoacrylate topical skin adhesives.Singer AJ, Quinn JV, Hollander JE.Singer AJ, et al.Am J Emerg Med. 2008 May;26(4):490-6. doi: 10.1016/j.ajem.2007.05.015.Am J Emerg Med. 2008.PMID:18410821Review.
- Efficacy of octyl-2-cyanoacrylate tissue glue in blepharoplasty. A prospective controlled study of wound-healing characteristics.Greene D, Koch RJ, Goode RL.Greene D, et al.Arch Facial Plast Surg. 1999 Oct-Dec;1(4):292-6. doi: 10.1001/archfaci.1.4.292.Arch Facial Plast Surg. 1999.PMID:10937118Clinical Trial.
- Tensile strength of wound closure with cyanoacrylate glue.Shapiro AJ, Dinsmore RC, North JH Jr.Shapiro AJ, et al.Am Surg. 2001 Nov;67(11):1113-5.Am Surg. 2001.PMID:11730233
- Octylcyanoacrylate tissue adhesive versus suture wound repair in a contaminated wound model.Quinn J, Maw J, Ramotar K, Wenckebach G, Wells G.Quinn J, et al.Surgery. 1997 Jul;122(1):69-72. doi: 10.1016/s0039-6060(97)90266-x.Surgery. 1997.PMID:9225917
- Is skin closure with cyanoacrylate glue effective for the prevention of sternal wound infections?Chambers A, Scarci M.Chambers A, et al.Interact Cardiovasc Thorac Surg. 2010 May;10(5):793-6. doi: 10.1510/icvts.2009.230425. Epub 2010 Feb 11.Interact Cardiovasc Thorac Surg. 2010.PMID:20150191Review.
Cited by
- The use of cyanoacrylates for wound closure in head and neck surgery.Bozkurt MK, Saydam L.Bozkurt MK, et al.Eur Arch Otorhinolaryngol. 2008 Mar;265(3):331-5. doi: 10.1007/s00405-007-0454-2. Epub 2007 Sep 27.Eur Arch Otorhinolaryngol. 2008.PMID:17899144
- Comparison of 2-Octyl Cyanoacrylate with Prolene (4-0) Sutures in Extra Oral Wound Closure.Kumar P, Katiyar A, Tripathi A, Gupta A, Srivastav A, Uppal BS.Kumar P, et al.J Pharm Bioallied Sci. 2023 Jul;15(Suppl 2):S1321-S1324. doi: 10.4103/jpbs.jpbs_103_23. Epub 2023 Jul 11.J Pharm Bioallied Sci. 2023.PMID:37694012Free PMC article.
- Paediatric sutureless circumcision: a systematic literature review.Lane V, Vajda P, Subramaniam R.Lane V, et al.Pediatr Surg Int. 2010 Feb;26(2):141-4. doi: 10.1007/s00383-009-2475-y. Epub 2009 Aug 26.Pediatr Surg Int. 2010.PMID:19707772Review.
- Meta-analysis of skin adhesives versus sutures in closure of laparoscopic port-site wounds.Sajid MS, Siddiqui MR, Khan MA, Baig MK.Sajid MS, et al.Surg Endosc. 2009 Jun;23(6):1191-7. doi: 10.1007/s00464-009-0373-y. Epub 2009 Mar 5.Surg Endosc. 2009.PMID:19263132Review.
- To Evaluate the Efficacy and Effectiveness of N-butyl-2-cyanoacrylate glue (TRU SEAL) in Closure of Oral and Maxillofacial Laceration and Surgical Incisions.Singh PK, Degala S, Shetty S, Rai VS, Das A.Singh PK, et al.J Maxillofac Oral Surg. 2019 Mar;18(1):131-138. doi: 10.1007/s12663-018-1111-6. Epub 2018 Apr 21.J Maxillofac Oral Surg. 2019.PMID:30728704Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous