Biomaterials and bone mechanotransduction
- PMID:11519777
- DOI: 10.1016/s0142-9612(01)00002-3
Biomaterials and bone mechanotransduction
Abstract
Bone is an extremely complex tissue that provides many essential functions in the body. Bone tissue engineering holds great promise in providing strategies that will result in complete regeneration of bone and restoration of its function. Currently, such strategies include the transplantation of highly porous scaffolds seeded with cells. Prior to transplantation the seeded cells are cultured in vitro in order for the cells to proliferate, differentiate and generate extracellular matrix. Factors that can affect cellular function include the cell-biomaterial interaction, as well as the biochemical and the mechanical environment. To optimize culture conditions, good understanding of these parameters is necessary. The new developments in bone biology, bone cell mechanotransduction, and cell-surface interactions are reviewed here to demonstrate that bone mechanotransduction is strongly influenced by the biomaterial properties.
Similar articles
- Building bone tissue: matrices and scaffolds in physiology and biotechnology.Riminucci M, Bianco P.Riminucci M, et al.Braz J Med Biol Res. 2003 Aug;36(8):1027-36. doi: 10.1590/s0100-879x2003000800008. Epub 2003 Jul 23.Braz J Med Biol Res. 2003.PMID:12886456
- Bone modeling adaptation as a method for promoting development of bone tissue engineered construct in vitro.Chunqiu Z, Xizheng Z, Xin D, Weimin Z.Chunqiu Z, et al.Med Hypotheses. 2007;69(1):178-81. doi: 10.1016/j.mehy.2006.09.072. Epub 2007 Jan 22.Med Hypotheses. 2007.PMID:17236725
- Cellular and molecular mechanisms for the bone response to mechanical loading.Bloomfield SA.Bloomfield SA.Int J Sport Nutr Exerc Metab. 2001 Dec;11 Suppl:S128-36. doi: 10.1123/ijsnem.11.s1.s128.Int J Sport Nutr Exerc Metab. 2001.PMID:11915911Review.
- Fractionated human adipose tissue as a native biomaterial for the generation of a bone organ by endochondral ossification.Guerrero J, Pigeot S, Müller J, Schaefer DJ, Martin I, Scherberich A.Guerrero J, et al.Acta Biomater. 2018 Sep 1;77:142-154. doi: 10.1016/j.actbio.2018.07.004. Epub 2018 Jul 4.Acta Biomater. 2018.PMID:30126590
- Bone tissue remodeling and development: focus on matrix metalloproteinase functions.Paiva KB, Granjeiro JM.Paiva KB, et al.Arch Biochem Biophys. 2014 Nov 1;561:74-87. doi: 10.1016/j.abb.2014.07.034. Epub 2014 Aug 23.Arch Biochem Biophys. 2014.PMID:25157440Review.
Cited by
- Umbilical cord mesenchymal stem cells from gestational diabetes show impaired ability to up-regulate paracellular permeability from sub-endothelial niche.Salem S, Leach L.Salem S, et al.Clin Sci (Lond). 2024 Jan 24;138(2):87-102. doi: 10.1042/CS20230657.Clin Sci (Lond). 2024.PMID:38168704Free PMC article.
- Cell interactions in bone tissue engineering.Pirraco RP, Marques AP, Reis RL.Pirraco RP, et al.J Cell Mol Med. 2010 Jan;14(1-2):93-102. doi: 10.1111/j.1582-4934.2009.01005.x. Epub 2009 Dec 27.J Cell Mol Med. 2010.PMID:20050963Free PMC article.Review.
- The impact of the parameters of the constitutive model on the distribution of strain in the femoral head.Wronski S, Wit A, Tarasiuk J, Lipinski P.Wronski S, et al.Biomech Model Mechanobiol. 2023 Apr;22(2):739-759. doi: 10.1007/s10237-022-01678-y. Epub 2022 Dec 21.Biomech Model Mechanobiol. 2023.PMID:36539625Free PMC article.
- Electrospun Biomimetic Nanofibrous Scaffolds: A Promising Prospect for Bone Tissue Engineering and Regenerative Medicine.Anjum S, Rahman F, Pandey P, Arya DK, Alam M, Rajinikanth PS, Ao Q.Anjum S, et al.Int J Mol Sci. 2022 Aug 16;23(16):9206. doi: 10.3390/ijms23169206.Int J Mol Sci. 2022.PMID:36012473Free PMC article.Review.
- Novel Kraft Softwood Lignin-Derived Carbon Quantum Dots: Synthesis, Characterization, and In Vitro Cytocompatibility.Christoph E, Yu L, Newby SD, Rivera Orsini MA, Scroggins J, Keffer DJ, Harper DP, Dhar M.Christoph E, et al.Nanomaterials (Basel). 2024 Jun 13;14(12):1029. doi: 10.3390/nano14121029.Nanomaterials (Basel). 2024.PMID:38921905Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources