Biomaterials and bone mechanotransduction
- PMID:11519777
- DOI: 10.1016/s0142-9612(01)00002-3
Biomaterials and bone mechanotransduction
Abstract
Bone is an extremely complex tissue that provides many essential functions in the body. Bone tissue engineering holds great promise in providing strategies that will result in complete regeneration of bone and restoration of its function. Currently, such strategies include the transplantation of highly porous scaffolds seeded with cells. Prior to transplantation the seeded cells are cultured in vitro in order for the cells to proliferate, differentiate and generate extracellular matrix. Factors that can affect cellular function include the cell-biomaterial interaction, as well as the biochemical and the mechanical environment. To optimize culture conditions, good understanding of these parameters is necessary. The new developments in bone biology, bone cell mechanotransduction, and cell-surface interactions are reviewed here to demonstrate that bone mechanotransduction is strongly influenced by the biomaterial properties.
Similar articles
- Building bone tissue: matrices and scaffolds in physiology and biotechnology.Riminucci M, Bianco P.Riminucci M, et al.Braz J Med Biol Res. 2003 Aug;36(8):1027-36. doi: 10.1590/s0100-879x2003000800008. Epub 2003 Jul 23.Braz J Med Biol Res. 2003.PMID:12886456
- Bone modeling adaptation as a method for promoting development of bone tissue engineered construct in vitro.Chunqiu Z, Xizheng Z, Xin D, Weimin Z.Chunqiu Z, et al.Med Hypotheses. 2007;69(1):178-81. doi: 10.1016/j.mehy.2006.09.072. Epub 2007 Jan 22.Med Hypotheses. 2007.PMID:17236725
- Cellular and molecular mechanisms for the bone response to mechanical loading.Bloomfield SA.Bloomfield SA.Int J Sport Nutr Exerc Metab. 2001 Dec;11 Suppl:S128-36. doi: 10.1123/ijsnem.11.s1.s128.Int J Sport Nutr Exerc Metab. 2001.PMID:11915911Review.
- Fractionated human adipose tissue as a native biomaterial for the generation of a bone organ by endochondral ossification.Guerrero J, Pigeot S, Müller J, Schaefer DJ, Martin I, Scherberich A.Guerrero J, et al.Acta Biomater. 2018 Sep 1;77:142-154. doi: 10.1016/j.actbio.2018.07.004. Epub 2018 Jul 4.Acta Biomater. 2018.PMID:30126590
- Bone tissue remodeling and development: focus on matrix metalloproteinase functions.Paiva KB, Granjeiro JM.Paiva KB, et al.Arch Biochem Biophys. 2014 Nov 1;561:74-87. doi: 10.1016/j.abb.2014.07.034. Epub 2014 Aug 23.Arch Biochem Biophys. 2014.PMID:25157440Review.
Cited by
- Design, materials, and mechanobiology of biodegradable scaffolds for bone tissue engineering.Velasco MA, Narváez-Tovar CA, Garzón-Alvarado DA.Velasco MA, et al.Biomed Res Int. 2015;2015:729076. doi: 10.1155/2015/729076. Epub 2015 Mar 26.Biomed Res Int. 2015.PMID:25883972Free PMC article.Review.
- Morphometric analysis of patient-specific 3D-printed acetabular cups: a comparative study of commercially available implants from 6 manufacturers.Hothi H, Henckel J, Bergiers S, Di Laura A, Schlueter-Brust K, Hart A.Hothi H, et al.3D Print Med. 2022 Nov 7;8(1):33. doi: 10.1186/s41205-022-00160-w.3D Print Med. 2022.PMID:36342573Free PMC article.
- Vascularized bone tissue engineering: approaches for potential improvement.Nguyen LH, Annabi N, Nikkhah M, Bae H, Binan L, Park S, Kang Y, Yang Y, Khademhosseini A.Nguyen LH, et al.Tissue Eng Part B Rev. 2012 Oct;18(5):363-82. doi: 10.1089/ten.TEB.2012.0012. Epub 2012 Sep 4.Tissue Eng Part B Rev. 2012.PMID:22765012Free PMC article.Review.
- Osteoblasts responses to three-dimensional nanofibrous gelatin scaffolds.Sachar A, Strom TA, Serrano MJ, Benson MD, Opperman LA, Svoboda KK, Liu X.Sachar A, et al.J Biomed Mater Res A. 2012 Nov;100(11):3029-41. doi: 10.1002/jbm.a.34253. Epub 2012 Jun 15.J Biomed Mater Res A. 2012.PMID:22707234Free PMC article.
- Effect of multiple unconfined compression on cellular dense collagen scaffolds for bone tissue engineering.Bitar M, Salih V, Brown RA, Nazhat SN.Bitar M, et al.J Mater Sci Mater Med. 2007 Feb;18(2):237-44. doi: 10.1007/s10856-006-0685-1.J Mater Sci Mater Med. 2007.PMID:17323154
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources