Review
doi: 10.1093/emboj/20.14.3617.Small nucleolar RNA-guided post-transcriptional modification of cellular RNAs
Affiliations
- PMID:11447102
- PMCID: PMC125535
- DOI: 10.1093/emboj/20.14.3617
Item in Clipboard
Review
Small nucleolar RNA-guided post-transcriptional modification of cellular RNAs
T Kiss. EMBO J..
Display options
Format
Display options
Format
No abstract available
Figures
Fig. 1. Structure and function of (A) 2′-O-methylation and (B) pseudouridylation guide snoRNAs. The consensus sequences of boxes C, C′, D, D′, H and ACA are indicated (R is a purine and N stands for any nucleotide). Models for molecular selection of 2′-O-methylated nucleotides and pseudouridine were adopted from Kiss-László et al. (1998) and Ganot et al. (1997a), respectively.
Fig. 2. Biogenesis and function of 2′-O-methylation and pseudouridylation guide snoRNAs. In mammalian cells, all guide RNAs are synthesized within introns of pre-mRNAs in the nucleoplasm. Most intronic snoRNAs are processed from the removed and debranched host intron by exonucleolytic activities. It remains unclear whether 5′ and 3′ end processing of snoRNAs occurs already in the nucleoplasm, or later in the nucleolus. Guide snoRNAs accumulating in the nucleolus direct 2′-O-methylation and pseudouridylation of the 18S, 5.8S and 28S rRNAs, the U6 snRNA and perhaps other cellular RNAs, including tRNAs, the signal recognition particle (SRP) and telomerase RNAs. It seems that box C/D, but not box H/ACA snoRNAs, transiently appear in the Cajal body before accumulating in the nucleolus. Some guide RNAs (scaRNAs) directing modification of the pol II-transcribed spliceosomal snRNAs accumulate in the Cajal body (CB). For other details, see the text.
Similar articles
- Small nucleolar RNAs that guide modification in trypanosomatids: repertoire, targets, genome organisation, and unique functions.Uliel S, Liang XH, Unger R, Michaeli S.Uliel S, et al.Int J Parasitol. 2004 Mar 29;34(4):445-54. doi: 10.1016/j.ijpara.2003.10.014.Int J Parasitol. 2004.PMID:15013734Review.
- SnoRNAs as tools for RNA cleavage and modification.Ni J, Samarsky DA, Liu B, Ferbeyre G, Cedergren R, Fournier MJ.Ni J, et al.Nucleic Acids Symp Ser. 1997;(36):61-3.Nucleic Acids Symp Ser. 1997.PMID:9478207Review.
- Probing RNA in vivo with methylation guide small nucleolar RNAs.Liu B, Ni J, Fournier MJ.Liu B, et al.Methods. 2001 Mar;23(3):276-86. doi: 10.1006/meth.2000.1138.Methods. 2001.PMID:11243840
- Guided tours: from precursor snoRNA to functional snoRNP.Weinstein LB, Steitz JA.Weinstein LB, et al.Curr Opin Cell Biol. 1999 Jun;11(3):378-84. doi: 10.1016/S0955-0674(99)80053-2.Curr Opin Cell Biol. 1999.PMID:10395551Review.
- [Small nucleolar RNA].Pieńkowska J, Szweykowska-Kulińska Z.Pieńkowska J, et al.Postepy Biochem. 1998;44(2):102-13.Postepy Biochem. 1998.PMID:9770233Review.Polish.No abstract available.
Cited by
- Annotation of snoRNA abundance across human tissues reveals complex snoRNA-host gene relationships.Fafard-Couture É, Bergeron D, Couture S, Abou-Elela S, Scott MS.Fafard-Couture É, et al.Genome Biol. 2021 Jun 4;22(1):172. doi: 10.1186/s13059-021-02391-2.Genome Biol. 2021.PMID:34088344Free PMC article.
- Up-regulation of ribosome biogenesis by MIR196A2 genetic variation promotes endometriosis development and progression.Chang CY, Lai MT, Chen Y, Yang CW, Chang HW, Lu CC, Chen CM, Chan C, Chung C, Tseng CC, Hwang T, Sheu JJ, Tsai FJ.Chang CY, et al.Oncotarget. 2016 Nov 22;7(47):76713-76725. doi: 10.18632/oncotarget.11536.Oncotarget. 2016.PMID:27741504Free PMC article.
- Emerging landscape of non-coding RNAs in oral health and disease.Perez P, Jang SI, Alevizos I.Perez P, et al.Oral Dis. 2014 Apr;20(3):226-35. doi: 10.1111/odi.12142. Epub 2013 Jun 20.Oral Dis. 2014.PMID:23781896Free PMC article.Review.
- The emerging landscape of small nucleolar RNAs in cell biology.Dupuis-Sandoval F, Poirier M, Scott MS.Dupuis-Sandoval F, et al.Wiley Interdiscip Rev RNA. 2015 Jul-Aug;6(4):381-97. doi: 10.1002/wrna.1284. Epub 2015 Apr 16.Wiley Interdiscip Rev RNA. 2015.PMID:25879954Free PMC article.Review.
- The high diversity of snoRNAs in plants: identification and comparative study of 120 snoRNA genes from Oryza sativa.Chen CL, Liang D, Zhou H, Zhuo M, Chen YQ, Qu LH.Chen CL, et al.Nucleic Acids Res. 2003 May 15;31(10):2601-13. doi: 10.1093/nar/gkg373.Nucleic Acids Res. 2003.PMID:12736310Free PMC article.
References
- Agris P.F. (1996) The importance of being modified: roles of modified nucleosides and Mg2+ in RNA structure and function. Prog. Nucleic Acid Res. Mol. Biol., 53, 79–129. - PubMed
- Bachellerie J.-P., Michot,B., Nicoloso,M., Balakin,A., Ni,J. and Fournier, M.J. (1995) Antisense snoRNAs: a family of nucleolar RNAs with long complementarity to rRNA. Trends Biochem. Sci., 20, 261–264. - PubMed
- Balakin A.G., Smith,L. and Fournier,M.J. (1996) The RNA world of the nucleolus: two major families of small RNAs defined by different box elements with related functions. Cell, 86, 823–834. - PubMed
- Bohmann K., Ferreira,J., Santama,N., Weis,K. and Lamond,A.I. (1995) Molecular analysis of coiled body. J. Cell Sci., 19, 107–113. - PubMed
Publication types
MeSH terms
Substances
Related information
LinkOut - more resources
Full Text Sources
Other Literature Sources