Review
doi: 10.1136/bmj.323.7303.42.Systematic reviews in health care: Assessing the quality of controlled clinical trials
Affiliations
- PMID:11440947
- PMCID: PMC1120670
- DOI: 10.1136/bmj.323.7303.42
Item in Clipboard
Review
Systematic reviews in health care: Assessing the quality of controlled clinical trials
P Jüni et al. BMJ..
Display options
Format
Display options
Format
No abstract available
Figures

Meta-analysis of four empirical studies relating key aspects of methodological quality of controlled trials to their effect estimates. Meta-analysis was by random effects model. Size of squares is proportional to inverse of variance of estimate

Systematic Reviews in Health Care: Meta-analysis in Context can be purchased through the BMJ Bookshop (www.bmjbookshop.com ); further information and updates for the book are available onwww.systematicreviews.uom
Similar articles
- Introduction to cumulative meta-analysis in dentistry: lessons learned from undertaking a cumulative meta-analysis in periodontology.Moles DR, Needleman IG, Niederman R, Lau J.Moles DR, et al.J Dent Res. 2005 Apr;84(4):345-9. doi: 10.1177/154405910508400410.J Dent Res. 2005.PMID:15790741
- Clinical research on acupuncture. Part 2. Controlled clinical trials, an overview of their methods.Birch S.Birch S.J Altern Complement Med. 2004 Jun;10(3):481-98. doi: 10.1089/1075553041323911.J Altern Complement Med. 2004.PMID:15253852Review.
- Investigating clinical heterogeneity in systematic reviews: a methodologic review of guidance in the literature.Gagnier JJ, Moher D, Boon H, Beyene J, Bombardier C.Gagnier JJ, et al.BMC Med Res Methodol. 2012 Jul 30;12:111. doi: 10.1186/1471-2288-12-111.BMC Med Res Methodol. 2012.PMID:22846171Free PMC article.Review.
- The powerful placebo: doubting the doubters.Greene PJ, Wayne PM, Kerr CE, Weiger WA, Jacobson E, Goldman P, Kaptchuk TJ.Greene PJ, et al.Adv Mind Body Med. 2001 Fall;17(4):298-307; discussion 312-8.Adv Mind Body Med. 2001.PMID:11931055Review.No abstract available.
- Searching for unpublished trials in Cochrane reviews may not be worth the effort.van Driel ML, De Sutter A, De Maeseneer J, Christiaens T.van Driel ML, et al.J Clin Epidemiol. 2009 Aug;62(8):838-844.e3. doi: 10.1016/j.jclinepi.2008.09.010. Epub 2009 Jan 6.J Clin Epidemiol. 2009.PMID:19128939
Cited by
- Molecular regulation of skeletal muscle mitochondrial biogenesis following blood flow-restricted aerobic exercise: a call to action.Preobrazenski N, Islam H, Gurd BJ.Preobrazenski N, et al.Eur J Appl Physiol. 2021 Jul;121(7):1835-1847. doi: 10.1007/s00421-021-04669-6. Epub 2021 Apr 8.Eur J Appl Physiol. 2021.PMID:33830325Review.
- Letter to the Editor on "Systematic Review of Diets Enriched in Oleic Acid and Obesity".Raeisi-Dehkordi H, Dianatinasab M, Amiri M.Raeisi-Dehkordi H, et al.Adv Nutr. 2021 Mar 31;12(2):575-576. doi: 10.1093/advances/nmab005.Adv Nutr. 2021.PMID:33786596Free PMC article.No abstract available.
- Fluid resuscitation with 6 % hydroxyethyl starch (130/0.4 and 130/0.42) in acutely ill patients: systematic review of effects on mortality and treatment with renal replacement therapy.Gattas DJ, Dan A, Myburgh J, Billot L, Lo S, Finfer S; CHEST Management Committee.Gattas DJ, et al.Intensive Care Med. 2013 Apr;39(4):558-68. doi: 10.1007/s00134-013-2840-0. Epub 2013 Feb 14.Intensive Care Med. 2013.PMID:23407978Review.
- Reporting guidelines for clinical trial reports for interventions involving artificial intelligence: the CONSORT-AI extension.Liu X, Cruz Rivera S, Moher D, Calvert MJ, Denniston AK; SPIRIT-AI and CONSORT-AI Working Group.Liu X, et al.Nat Med. 2020 Sep;26(9):1364-1374. doi: 10.1038/s41591-020-1034-x. Epub 2020 Sep 9.Nat Med. 2020.PMID:32908283Free PMC article.Review.
- Chinese herbal medicine for subfertile women with polycystic ovarian syndrome.Zhou K, Zhang J, Xu L, Wu T, Lim CE.Zhou K, et al.Cochrane Database Syst Rev. 2016 Oct 12;10(10):CD007535. doi: 10.1002/14651858.CD007535.pub3.Cochrane Database Syst Rev. 2016.Update in:Cochrane Database Syst Rev. 2021 Jun 4;6:CD007535. doi: 10.1002/14651858.CD007535.pub4.PMID:27731904Free PMC article.Updated.Review.
References
- Clarke M, Oxman AD, eds. Cochrane reviewers' handbook 4.0. In: Cochrane Collaboration. Cochrane Library. Oxford: Update Software, 1999.
- Cook DJ, Sackett DL, Spitzer WO. Methodologic guidelines for systematic reviews of randomized control trials in health care from the Potsdam consultation on meta-analysis. J Clin Epidemiol. 1995;48:167–171. - PubMed
- Detsky AS, Naylor CD, O'Rourke K, McGeer AJ, L'Abbé KA. Incorporating variations in the quality of individual randomized trials into meta-analysis. J Clin Epidemiol. 1992;45:255–265. - PubMed
- Moher D, Jadad AR, Nichol G, Penman M, Tugwell P, Walsh S. Assessing the quality of randomized controlled trials: an annotated bibliography of scales and checklists. Controlled Clin Trials. 1995;16:62–73. - PubMed
- Jüni P, Witschi A, Bloch R, Egger M. The hazards of scoring the quality of clinical trial for meta-analysis. JAMA. 1999;282:1054–1060. - PubMed
Publication types
MeSH terms
Related information
LinkOut - more resources
Full Text Sources