doi: 10.1016/s0014-5793(01)02499-1.
Binding and regulation of HIF-1alpha by a subunit of the proteasome complex, PSMA7
Affiliations
- PMID:11389899
- DOI: 10.1016/s0014-5793(01)02499-1
Item in Clipboard
Binding and regulation of HIF-1alpha by a subunit of the proteasome complex, PSMA7
S Cho et al. FEBS Lett..
Free article Display options
Format
Display options
Format
Abstract
The hypoxia-inducible factor-1alpha (HIF-1alpha) is an important transcription factor for cellular responses to oxygen tension. It is rapidly degraded under normoxic conditions by the ubiquitin-dependent proteasome pathway. Here we report a critical role of the 20S proteasome subunit PSMA7 in HIF-1alpha regulation. PSMA7 was found to interact specifically with two subdomains of HIF-1alpha. PSMA7 inhibited the transactivation function of HIF-1alpha under both normoxic and hypoxia-mimicking conditions. In addition, we show that the PSMA7-mediated regulation of HIF-1alpha activity is associated with the proteasome pathway.
Similar articles
- Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes.Salceda S, Caro J.Salceda S, et al.J Biol Chem. 1997 Sep 5;272(36):22642-7. doi: 10.1074/jbc.272.36.22642.J Biol Chem. 1997.PMID:9278421
- Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein.Tanimoto K, Makino Y, Pereira T, Poellinger L.Tanimoto K, et al.EMBO J. 2000 Aug 15;19(16):4298-309. doi: 10.1093/emboj/19.16.4298.EMBO J. 2000.PMID:10944113Free PMC article.
- Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway.Huang LE, Gu J, Schau M, Bunn HF.Huang LE, et al.Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):7987-92. doi: 10.1073/pnas.95.14.7987.Proc Natl Acad Sci U S A. 1998.PMID:9653127Free PMC article.
- Regulation of HIF by the von Hippel-Lindau tumour suppressor: implications for cellular oxygen sensing.Mole DR, Maxwell PH, Pugh CW, Ratcliffe PJ.Mole DR, et al.IUBMB Life. 2001 Jul;52(1-2):43-7. doi: 10.1080/15216540252774757.IUBMB Life. 2001.PMID:11795592Review.
- Hypoxia-inducible factor 1: regulation by hypoxic and non-hypoxic activators.Déry MA, Michaud MD, Richard DE.Déry MA, et al.Int J Biochem Cell Biol. 2005 Mar;37(3):535-40. doi: 10.1016/j.biocel.2004.08.012.Int J Biochem Cell Biol. 2005.PMID:15618010Review.
Cited by
- Atypical protein kinase C regulates dual pathways for degradation of the oncogenic coactivator SRC-3/AIB1.Yi P, Feng Q, Amazit L, Lonard DM, Tsai SY, Tsai MJ, O'Malley BW.Yi P, et al.Mol Cell. 2008 Feb 29;29(4):465-76. doi: 10.1016/j.molcel.2007.12.030.Mol Cell. 2008.PMID:18313384Free PMC article.
- SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors.Montagner M, Enzo E, Forcato M, Zanconato F, Parenti A, Rampazzo E, Basso G, Leo G, Rosato A, Bicciato S, Cordenonsi M, Piccolo S.Montagner M, et al.Nature. 2012 Jul 19;487(7407):380-4. doi: 10.1038/nature11207.Nature. 2012.PMID:22801492
- Evolution and regulation of the downstream gene of hypoxia-inducible factor-1alpha in naked carp (Gymnocypris przewalskii) from Lake Qinghai, China.Cao YB, Chen XQ, Wang S, Wang YX, Du JZ.Cao YB, et al.J Mol Evol. 2008 Nov;67(5):570-80. doi: 10.1007/s00239-008-9175-4. Epub 2008 Oct 22.J Mol Evol. 2008.PMID:18941827
- Proteasome-dependent regulation of signal transduction in retinal pigment epithelial cells.Fernandes AF, Guo W, Zhang X, Gallagher M, Ivan M, Taylor A, Pereira P, Shang F.Fernandes AF, et al.Exp Eye Res. 2006 Dec;83(6):1472-81. doi: 10.1016/j.exer.2006.07.024. Epub 2006 Oct 5.Exp Eye Res. 2006.PMID:17027001Free PMC article.
- Interleukin-1β promotes hypoxia-induced apoptosis of glioblastoma cells by inhibiting hypoxia-inducible factor-1 mediated adrenomedullin production.Sun W, Depping R, Jelkmann W.Sun W, et al.Cell Death Dis. 2014 Jan 23;5(1):e1020. doi: 10.1038/cddis.2013.562.Cell Death Dis. 2014.PMID:24457964Free PMC article.
Publication types
MeSH terms
Substances
Related information
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Miscellaneous