Alcohol-induced euphoria: exclusion of serotonin
- PMID:11139411
- DOI: 10.1093/alcalc/36.1.22
Alcohol-induced euphoria: exclusion of serotonin
Abstract
During the first 30 min after acute ethanol consumption by three fasting normal male volunteers, no increase in circulating tryptophan availability to the brain occurred. On the contrary, a small decrease was observed, which became stronger subsequently. We conclude from this preliminary study that brain serotonin levels are not increased after alcohol intake by normal subjects and that, consequently, this indolylamine is unlikely to mediate the euphoric effects of alcohol.
Similar articles
- Decrease in circulating tryptophan availability to the brain after acute ethanol consumption by normal volunteers: implications for alcohol-induced aggressive behaviour and depression.Badawy AA, Morgan CJ, Lovett JW, Bradley DM, Thomas R.Badawy AA, et al.Pharmacopsychiatry. 1995 Oct;28 Suppl 2:93-7. doi: 10.1055/s-2007-979626.Pharmacopsychiatry. 1995.PMID:8614707Clinical Trial.
- Enhanced sensitivity to the euphoric effects of alcohol in schizophrenia.D'Souza DC, Gil RB, Madonick S, Perry EB, Forselius-Bielen K, Braley G, Donahue L, Tellioglu T, Zimolo Z, Gueorguieva R, Krystal JH.D'Souza DC, et al.Neuropsychopharmacology. 2006 Dec;31(12):2767-75. doi: 10.1038/sj.npp.1301207. Epub 2006 Sep 20.Neuropsychopharmacology. 2006.PMID:16985503Clinical Trial.
- Single-dose ritanserin and alcohol in healthy volunteers: a placebo-controlled trial.Estevez F, Parrillo S, Giusti M, Monti JM.Estevez F, et al.Alcohol. 1995 Nov-Dec;12(6):541-5. doi: 10.1016/0741-8329(95)00041-0.Alcohol. 1995.PMID:8590616Clinical Trial.
- Alcohol, aggression and serotonin: metabolic aspects.Badawy AA.Badawy AA.Alcohol Alcohol. 1998 Jan-Feb;33(1):66-72. doi: 10.1093/oxfordjournals.alcalc.a008350.Alcohol Alcohol. 1998.PMID:9539179Review.
- Interactions between 3,4-methylenedioxymethamphetamine and ethanol in humans and rodents.Mohamed WM, Hamida SB, de Vasconcelos AP, Cassel JC, Jones BC.Mohamed WM, et al.Neuropsychobiology. 2009;60(3-4):188-94. doi: 10.1159/000253554. Epub 2009 Nov 5.Neuropsychobiology. 2009.PMID:19893335Review.
Cited by
- Positive Emotion Regulation and Psychopathology: A Transdiagnostic Cultural Neuroscience Approach.Hechtman LA, Raila H, Chiao JY, Gruber J.Hechtman LA, et al.J Exp Psychopathol. 2013 May 13;4(5):502-528. doi: 10.5127/jep.030412.J Exp Psychopathol. 2013.PMID:24812583Free PMC article.
- Serotonin induced hepatic steatosis is associated with modulation of autophagy and notch signaling pathway.Niture S, Gyamfi MA, Kedir H, Arthur E, Ressom H, Deep G, Kumar D.Niture S, et al.Cell Commun Signal. 2018 Nov 8;16(1):78. doi: 10.1186/s12964-018-0282-6.Cell Commun Signal. 2018.PMID:30409162Free PMC article.
- Cannabinoid Ligands and Alcohol Addiction: A Promising Therapeutic Tool or a Humbug?Kleczkowska P, Smaga I, Filip M, Bujalska-Zadrozny M.Kleczkowska P, et al.Neurotox Res. 2016 Jan;29(1):173-96. doi: 10.1007/s12640-015-9555-7. Epub 2015 Sep 9.Neurotox Res. 2016.PMID:26353844Free PMC article.Review.
- Intravenous ethanol infusion decreases human cortical γ-aminobutyric acid and N-acetylaspartate as measured with proton magnetic resonance spectroscopy at 4 tesla.Gomez R, Behar KL, Watzl J, Weinzimer SA, Gulanski B, Sanacora G, Koretski J, Guidone E, Jiang L, Petrakis IL, Pittman B, Krystal JH, Mason GF.Gomez R, et al.Biol Psychiatry. 2012 Feb 1;71(3):239-46. doi: 10.1016/j.biopsych.2011.06.026. Epub 2011 Aug 19.Biol Psychiatry. 2012.PMID:21855054Free PMC article.Clinical Trial.
- Effects of tryptophan depletion and a simulated alcohol binge on impulsivity.Dougherty DM, Mullen J, Hill-Kapturczak N, Liang Y, Karns TE, Lake SL, Mathias CW, Roache JD.Dougherty DM, et al.Exp Clin Psychopharmacol. 2015 Apr;23(2):109-21. doi: 10.1037/a0038943. Epub 2015 Mar 2.Exp Clin Psychopharmacol. 2015.PMID:25730415Free PMC article.Clinical Trial.
MeSH terms
Substances
Related information
LinkOut - more resources
Full Text Sources
Other Literature Sources