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Review
.2000 Oct;50(4):285-95.
doi: 10.1046/j.1365-2125.2000.00261.x.

Macrolide - induced clinically relevant drug interactions with cytochrome P-450A (CYP) 3A4: an update focused on clarithromycin, azithromycin and dirithromycin

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Review

Macrolide - induced clinically relevant drug interactions with cytochrome P-450A (CYP) 3A4: an update focused on clarithromycin, azithromycin and dirithromycin

J F Westphal. Br J Clin Pharmacol.2000 Oct.
No abstract available

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Figure 1
Figure 1
Metabolism of macrolides.
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References

    1. Watkins PB. Drug metabolism by cytochrome P-450 in the liver and small bowel. Gastroenterol Clin N Am. 1992;21:511–526. - PubMed
    1. Slaughter RL, Edwards DJ. Recent advances: the cytochrome P – 450 enzymes. Ann Pharmacother. 1995;29:619–624. - PubMed
    1. Pessayre D, Larrey D, Funck-Brentano C, et al. Drug interactions and hepatitis produced by some macrolide antibiotics. J Antimicrob Chemother. 1985;16(Suppl H):181–194. - PubMed
    1. Periti P, Mazzei T, Mini E, Novelli A. Pharmacokinetic drug interactions of macrolides. Clin Pharmacokin. 1992;23:106–131. - PubMed
    1. Gascon PM, Dayer P. Comparative effects of macrolide antibiotics on liver mono-oxygenases. Clin Pharmacol Ther. 1991;49:158. Abstract.

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