Pharmacological profile of apigenin, a flavonoid isolated from Matricaria chamomilla
- PMID:10751547
- DOI: 10.1016/s0006-2952(00)00264-1
Pharmacological profile of apigenin, a flavonoid isolated from Matricaria chamomilla
Abstract
Dried flowers of Matricaria chamomilla L. are largely used to provide sedative as well as spasmolytic effects. In the present study, we examined in particular the pharmacological property of a fraction isolated from a methanolic extract of M. chamomilla, which was identified by HPLC-MS-MS analysis as apigenin. By radioreceptor binding assays, we demonstrated the ability of the flavone to displace a specific radioligand, [(3)H]Ro 15-1788, from the central benzodiazepine binding site. Electrophysiological studies performed on cultured cerebellar granule cells showed that apigenin reduced GABA (gamma-aminobutyric acid)-activated Cl(-) currents in a dose-dependent fashion. The effect was blocked by co-application of Ro 15-1788, a specific benzodiazepine receptor antagonist. Accordingly, apigenin reduced the latency in the onset of picrotoxin-induced convulsions. Moreover, apigenin injected i.p. in rats reduced locomotor activity, but did not demonstrate anxiolytic, myorelaxant, or anticonvulsant activities. The present results seem to suggest that the inhibitory activity of apigenin on locomotor behaviour in rats cannot be ascribed to an interaction with GABA(A)-benzodiazepine receptor but to other neurotransmission systems, since it is not blocked by Ro 15-1788.
Similar articles
- Behavioral characterisation of the flavonoids apigenin and chrysin.Zanoli P, Avallone R, Baraldi M.Zanoli P, et al.Fitoterapia. 2000 Aug;71 Suppl 1:S117-23. doi: 10.1016/s0367-326x(00)00186-6.Fitoterapia. 2000.PMID:10930722
- Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects.Viola H, Wasowski C, Levi de Stein M, Wolfman C, Silveira R, Dajas F, Medina JH, Paladini AC.Viola H, et al.Planta Med. 1995 Jun;61(3):213-6. doi: 10.1055/s-2006-958058.Planta Med. 1995.PMID:7617761
- Anxiolytic effect of wogonin, a benzodiazepine receptor ligand isolated from Scutellaria baicalensis Georgi.Hui KM, Huen MS, Wang HY, Zheng H, Sigel E, Baur R, Ren H, Li ZW, Wong JT, Xue H.Hui KM, et al.Biochem Pharmacol. 2002 Nov 1;64(9):1415-24. doi: 10.1016/s0006-2952(02)01347-3.Biochem Pharmacol. 2002.PMID:12392823
- [Evaluation of the activity on the mouse CNS of several plant extracts and a combination of them].Della Loggia R, Tubaro A, Redaelli C.Della Loggia R, et al.Riv Neurol. 1981 Sep-Oct;51(5):297-310.Riv Neurol. 1981.PMID:6118937Review.Italian.
- A review of the bioactivity and potential health benefits of chamomile tea (Matricaria recutita L.).McKay DL, Blumberg JB.McKay DL, et al.Phytother Res. 2006 Jul;20(7):519-30. doi: 10.1002/ptr.1900.Phytother Res. 2006.PMID:16628544Review.
Cited by
- Perspective: Therapeutic Potential of Flavonoids as Alternative Medicines in Epilepsy.Kwon JY, Jeon MT, Jung UJ, Kim DW, Moon GJ, Kim SR.Kwon JY, et al.Adv Nutr. 2019 Sep 1;10(5):778-790. doi: 10.1093/advances/nmz047.Adv Nutr. 2019.PMID:31111873Free PMC article.
- Flavonoid modulation of GABA(A) receptors.Hanrahan JR, Chebib M, Johnston GA.Hanrahan JR, et al.Br J Pharmacol. 2011 May;163(2):234-45. doi: 10.1111/j.1476-5381.2011.01228.x.Br J Pharmacol. 2011.PMID:21244373Free PMC article.Review.
- Flavonoids and the CNS.Jäger AK, Saaby L.Jäger AK, et al.Molecules. 2011 Feb 10;16(2):1471-85. doi: 10.3390/molecules16021471.Molecules. 2011.PMID:21311414Free PMC article.Review.
- Perioperative Risks of Dietary and Herbal Supplements.Levy I, Attias S, Ben-Arye E, Goldstein L, Matter I, Somri M, Schiff E.Levy I, et al.World J Surg. 2017 Apr;41(4):927-934. doi: 10.1007/s00268-016-3825-2.World J Surg. 2017.PMID:27878352
- Measurement of melatonin in alcoholic and hot water extracts of Tanacetum parthenium, Tripleurospermum disciforme and Viola odorata.Ansari M, Rafiee Kh, Yasa N, Vardasbi S, Naimi SM, Nowrouzi A.Ansari M, et al.Daru. 2010;18(3):173-8.Daru. 2010.PMID:22615614Free PMC article.
MeSH terms
Substances
Related information
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials