beta-catenin signaling and cancer
- PMID:10580987
- DOI: 10.1002/(SICI)1521-1878(199912)22:1<1021::AID-BIES6>3.0.CO;2-P
beta-catenin signaling and cancer
Abstract
Since its discovery as a protein associated with the cytoplasmic region of E-cadherin, beta-catenin has been shown to perform two apparently unrelated functions: it has a crucial role in cell-cell adhesion in addition to a signaling role as a component of the Wnt/wg pathway. Wnt/wg signaling results in beta-catenin accumulation and transcriptional activation of specific target genes during development. It is now apparent that deregulation of beta-catenin signaling is an important event in the genesis of a number of malignancies, such as colon cancer, melanoma, hepatocellular carcinoma, ovarian cancer, endometrial cancer, medulloblastoma pilomatricomas, and prostate cancer. beta-catenin mutations appear to be a crucial step in the progression of a subset of these cancers, suggesting an important role in the control of cellular proliferation or cell death. The APC/beta-catenin pathway is highly regulated and includes players such as GSK3-beta, CBP, Groucho, Axin, Conductin, and TCF. c-MYC and cyclin D1 were recently identified as a key transcriptional targets of this pathway and additional targets are likely to emerge. Published 1999 John Wiley & Sons, Inc.
Similar articles
- Overexpression of Icat induces G(2) arrest and cell death in tumor cell mutants for adenomatous polyposis coli, beta-catenin, or Axin.Sekiya T, Nakamura T, Kazuki Y, Oshimura M, Kohu K, Tago K, Ohwada S, Akiyama T.Sekiya T, et al.Cancer Res. 2002 Jun 1;62(11):3322-6.Cancer Res. 2002.PMID:12036951
- Activation of Wnt/beta-catenin/Tcf signaling in mouse skin carcinogenesis.Bhatia N, Spiegelman VS.Bhatia N, et al.Mol Carcinog. 2005 Apr;42(4):213-21. doi: 10.1002/mc.20077.Mol Carcinog. 2005.PMID:15765534
- Cross-talk between Rac1 GTPase and dysregulated Wnt signaling pathway leads to cellular redistribution of beta-catenin and TCF/LEF-mediated transcriptional activation.Esufali S, Bapat B.Esufali S, et al.Oncogene. 2004 Oct 28;23(50):8260-71. doi: 10.1038/sj.onc.1208007.Oncogene. 2004.PMID:15377999
- Cadherin and catenin alterations in human cancer.Hajra KM, Fearon ER.Hajra KM, et al.Genes Chromosomes Cancer. 2002 Jul;34(3):255-68. doi: 10.1002/gcc.10083.Genes Chromosomes Cancer. 2002.PMID:12007186Review.
- The Yin-Yang of TCF/beta-catenin signaling.Barker N, Morin PJ, Clevers H.Barker N, et al.Adv Cancer Res. 2000;77:1-24. doi: 10.1016/s0065-230x(08)60783-6.Adv Cancer Res. 2000.PMID:10549354Review.
Cited by
- Circulatory shear flow alters the viability and proliferation of circulating colon cancer cells.Fan R, Emery T, Zhang Y, Xia Y, Sun J, Wan J.Fan R, et al.Sci Rep. 2016 Jun 3;6:27073. doi: 10.1038/srep27073.Sci Rep. 2016.PMID:27255403Free PMC article.
- Molecular targets of curcumin for cancer therapy: an updated review.Kasi PD, Tamilselvam R, Skalicka-Woźniak K, Nabavi SF, Daglia M, Bishayee A, Pazoki-Toroudi H, Nabavi SM.Kasi PD, et al.Tumour Biol. 2016 Oct;37(10):13017-13028. doi: 10.1007/s13277-016-5183-y. Epub 2016 Jul 28.Tumour Biol. 2016.PMID:27468716Review.
- A positive feedback loop between tryptophan hydroxylase 1 and β-Catenin/ZBP-89 signaling promotes prostate cancer progression.Ge C, Yan J, Yuan X, Xu G.Ge C, et al.Front Oncol. 2022 Sep 12;12:923307. doi: 10.3389/fonc.2022.923307. eCollection 2022.Front Oncol. 2022.PMID:36172162Free PMC article.
- Association of PYGO2 and EGFR in esophageal squamous cell carcinoma.Moghbeli M, Abbaszadegan MR, Farshchian M, Montazer M, Raeisossadati R, Abdollahi A, Forghanifard MM.Moghbeli M, et al.Med Oncol. 2013 Jun;30(2):516. doi: 10.1007/s12032-013-0516-9. Epub 2013 Mar 3.Med Oncol. 2013.PMID:23456637
- Adenomatous polyposis coli (APC) regulates multiple signaling pathways by enhancing glycogen synthase kinase-3 (GSK-3) activity.Valvezan AJ, Zhang F, Diehl JA, Klein PS.Valvezan AJ, et al.J Biol Chem. 2012 Feb 3;287(6):3823-32. doi: 10.1074/jbc.M111.323337. Epub 2011 Dec 19.J Biol Chem. 2012.PMID:22184111Free PMC article.
Publication types
MeSH terms
Substances
Related information
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials
Miscellaneous