PET imaging of dopamine D2 receptors with [18F]fluoroclebopride in monkeys: effects of isoflurane- and ketamine-induced anesthesia
- PMID:10481842
- DOI: 10.1016/S0893-133X(98)00101-8
PET imaging of dopamine D2 receptors with [18F]fluoroclebopride in monkeys: effects of isoflurane- and ketamine-induced anesthesia
Abstract
The purpose of the present study was to determine whether positron emission tomography (PET) studies in monkeys with the dopamine (DA) D2 receptor ligand [18F]fluoroclebopride (FCP) would be significantly influenced by anesthetic induction with isoflurane (approximately 5.0%) compared to induction with 10 mg/kg ketamine. Five experimentally-naive adult male cynomolgus monkeys (Macaca fascicularis) were trained to sit calmly in a primate restraint chair. Before the first PET scan, each monkey was anesthetized, by mask, with isoflurane. After complete sedation, the monkey was intubated and anesthesia was maintained throughout the PET study by isoflurane (approximately 1.5%). At least 1 month later, a second PET study was conducted in which anesthesia was induced with ketamine and maintained by isoflurane (approximately 1.5%). Irrespective of induction anesthetic, there was a high uptake of [18F]FCP and a linear rate of washout from the basal ganglia for all monkeys. There were also no differences in time to peak uptake (approximately 25 min), in clearance half-life (t1/2 = 140-164 min) or in D2 binding (distribution volume ratios of 2.48 vs. 2.50). These results indicate that induction anesthetic did not differentially affect D2 binding of [18F]FCP in monkeys. Furthermore, the low variability between studies indicates that [18F]FCP is an excellent ligand for longitudinal studies of D2 receptors in nonhuman primates.
Similar articles
- Comparison of two fluorine-18 labeled benzamide derivatives that bind reversibly to dopamine D2 receptors: in vitro binding studies and positron emission tomography.Mach RH, Nader MA, Ehrenkaufer RL, Line SW, Smith CR, Luedtke RR, Kung MP, Kung HF, Lyons D, Morton TE.Mach RH, et al.Synapse. 1996 Dec;24(4):322-33. doi: 10.1002/(SICI)1098-2396(199612)24:4<322::AID-SYN2>3.0.CO;2-F.Synapse. 1996.PMID:10638823
- PET imaging of striatal dopamine D2 receptors in nonhuman primates: increases in availability produced by chronic raclopride treatment.Czoty PW, Gage HD, Nader MA.Czoty PW, et al.Synapse. 2005 Dec 15;58(4):215-9. doi: 10.1002/syn.20200.Synapse. 2005.PMID:16206180
- Difference in response of D2 receptor binding between 11C-N-methylspiperone and 11C-raclopride against anesthetics in rhesus monkey brain.Kobayashi K, Inoue O, Watanabe Y, Onoe H, Långström B.Kobayashi K, et al.J Neural Transm Gen Sect. 1995;100(2):147-51. doi: 10.1007/BF01271537.J Neural Transm Gen Sect. 1995.PMID:8962684
- Impact of isoflurane anesthesia on D2 receptor occupancy by [18F]fallypride measured by microPET with a modified Logan plot.Tantawy MN, Peterson TE, Jones CK, Johnson K, Rook JM, Conn PJ, Baldwin RM, Ansari MS, Kessler RM.Tantawy MN, et al.Synapse. 2011 Nov;65(11):1173-80. doi: 10.1002/syn.20955. Epub 2011 Jun 17.Synapse. 2011.PMID:21584868Free PMC article.
- Effects of Anesthesia on Cerebral Blood Flow and Functional Connectivity of Nonhuman Primates.Zhang X.Zhang X.Vet Sci. 2022 Sep 22;9(10):516. doi: 10.3390/vetsci9100516.Vet Sci. 2022.PMID:36288129Free PMC article.Review.
Cited by
- Neurochemical modulators of sleep and anesthetic states.Van Dort CJ, Baghdoyan HA, Lydic R.Van Dort CJ, et al.Int Anesthesiol Clin. 2008 Summer;46(3):75-104. doi: 10.1097/AIA.0b013e318181a8ca.Int Anesthesiol Clin. 2008.PMID:18617819Free PMC article.Review.No abstract available.
- Characterization of dopamine D1 and D2 receptor function in socially housed cynomolgus monkeys self-administering cocaine.Czoty PW, Morgan D, Shannon EE, Gage HD, Nader MA.Czoty PW, et al.Psychopharmacology (Berl). 2004 Jul;174(3):381-8. doi: 10.1007/s00213-003-1752-z. Epub 2004 Feb 7.Psychopharmacology (Berl). 2004.PMID:14767632
- Characterization of the dopamine receptor system in adult rhesus monkeys exposed to cocaine throughout gestation.Hamilton LR, Czoty PW, Gage HD, Nader MA.Hamilton LR, et al.Psychopharmacology (Berl). 2010 Jul;210(4):481-8. doi: 10.1007/s00213-010-1847-2. Epub 2010 Apr 20.Psychopharmacology (Berl). 2010.PMID:20401746Free PMC article.
- In vivo quantification of localized neuronal activation and inhibition in the rat brain using a dedicated high temporal-resolution beta +-sensitive microprobe.Pain F, Besret L, Vaufrey F, Grégoire MC, Pinot L, Gervais P, Ploux L, Bloch G, Mastrippolito R, Lanièce P, Hantraye P.Pain F, et al.Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10807-12. doi: 10.1073/pnas.162368899. Epub 2002 Jul 22.Proc Natl Acad Sci U S A. 2002.PMID:12136134Free PMC article.
- Effects of social reorganization on dopamine D2/D3 receptor availability and cocaine self-administration in male cynomolgus monkeys.Czoty PW, Gould RW, Gage HD, Nader MA.Czoty PW, et al.Psychopharmacology (Berl). 2017 Sep;234(18):2673-2682. doi: 10.1007/s00213-017-4658-x. Epub 2017 Jun 12.Psychopharmacology (Berl). 2017.PMID:28608008Free PMC article.
Publication types
MeSH terms
Substances
Related information
Grants and funding
LinkOut - more resources
Full Text Sources