doi: 10.1016/s0092-8674(00)81965-0.
The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene
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- PMID:10458611
- DOI: 10.1016/s0092-8674(00)81965-0
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The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene
L Lin et al. Cell..
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Abstract
Narcolepsy is a disabling sleep disorder affecting humans and animals. It is characterized by daytime sleepiness, cataplexy, and striking transitions from wakefulness into rapid eye movement (REM) sleep. In this study, we used positional cloning to identify an autosomal recessive mutation responsible for this sleep disorder in a well-established canine model. We have determined that canine narcolepsy is caused by disruption of the hypocretin (orexin) receptor 2 gene (Hcrtr2). This result identifies hypocretins as major sleep-modulating neurotransmitters and opens novel potential therapeutic approaches for narcoleptic patients.
Comment in
- Narcolepsy: a key role for hypocretins (orexins).Siegel JM.Siegel JM.Cell. 1999 Aug 20;98(4):409-12. doi: 10.1016/s0092-8674(00)81969-8.Cell. 1999.PMID:10481905Free PMC article.Review.No abstract available.
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