Review
doi: 10.1016/s0197-0186(99)00050-9.Regulation of neuronal voltage-gated calcium channels by ethanol
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- PMID:10405992
- DOI: 10.1016/s0197-0186(99)00050-9
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Review
Regulation of neuronal voltage-gated calcium channels by ethanol
H J Walter et al. Neurochem Int.1999 Aug.
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Abstract
Voltage-gated calcium channels are key regulators of neuronal excitability. Several studies indicate that intoxicating concentrations of ethanol inhibit L-type, N-type and possibly T-type channels. The effects of ethanol on other channel subtypes are not yet clear. Chronic exposure to ethanol is associated with increases in functional L-type channels and this may contribute to signs of ethanol withdrawal. Preclinical studies in animals suggest that L-type calcium channel antagonists decrease ethanol consumption and signs of alcohol withdrawal. Although L-type channel antagonists do not appear to alter the performance impairing or psychological effects of acute ethanol administration, clinical trials will be needed to determine if L-type channel antagonists reduce ethanol consumption in humans.
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