Learning enhances adult neurogenesis in the hippocampal formation
- PMID:10195219
- DOI: 10.1038/6365
Learning enhances adult neurogenesis in the hippocampal formation
Abstract
Thousands of hippocampal neurons are born in adulthood, suggesting that new cells could be important for hippocampal function. To determine whether hippocampus-dependent learning affects adult-generated neurons, we examined the fate of new cells labeled with the thymidine analog bromodeoxyuridine following specific behavioral tasks. Here we report that the number of adult-generated neurons doubles in the rat dentate gyrus in response to training on associative learning tasks that require the hippocampus. In contrast, training on associative learning tasks that do not require the hippocampus did not alter the number of new cells. These findings indicate that adult-generated hippocampal neurons are specifically affected by, and potentially involved in, associative memory formation.
Comment in
- New neurons in old brains: learning to survive?Greenough WT, Cohen NJ, Juraska JM.Greenough WT, et al.Nat Neurosci. 1999 Mar;2(3):203-5. doi: 10.1038/6300.Nat Neurosci. 1999.PMID:10195209No abstract available.
- Outsmarting (and outrunning) nature's harsh decree.Drew MR, Denny CA.Drew MR, et al.Nat Neurosci. 2018 Sep;21(9):1141-1142. doi: 10.1038/s41593-018-0214-1.Nat Neurosci. 2018.PMID:30127426No abstract available.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources