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.1999 Feb 18;227(2):249-55.
doi: 10.1016/s0378-1119(98)00605-2.

Duet is a novel serine/threonine kinase with Dbl-Homology (DH) and Pleckstrin-Homology (PH) domains

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Duet is a novel serine/threonine kinase with Dbl-Homology (DH) and Pleckstrin-Homology (PH) domains

T Kawai et al. Gene..

Abstract

We show here the identification of Duet, a novel molecule bearing serine/threonine kinase, Dbl-Homology (DH), and Pleckstrin-Homology (PH) domains. The kinase domain of Duet shows a homology to that of DAP kinase that is involved in apoptosis, and Duet is autophosphorylated by an in-vitro kinase assay. The DH- and PH-domains are closely related to those of Trio and Kalirin. Trad mRNA is specifically expressed in skeletal muscle. Duet protein was localized to actin-associated cytoskeletal elements. These data suggest a role of Duet in the cytoskeleton-dependent cell function.

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