. 2020 Feb 11;21(1):13. doi:10.1186/s10194-020-01087-5
© The Author(s) 2020
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Table 2.
Meta-analyses results of genetic variants with statistically significance (P-value< 5*10−8) from GWAS
| Author, year | Gene/variant | Comparison | OR (95%CI) | P-Value | Ethnicity | No. of cases/controls | FPRP Values at Prior probability | BFDP 0.001 | BFDP 0.000001 | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR 1.2 | OR 1.5 | |||||||||||
| 0.001 | 0.000001 | 0.001 | 0.000001 | |||||||||
| Chang X, 2018 [45] | NMUR2/rs1946225 | G vs. T | 2.29 (1.73–3.05) | 9.55E-09 | Overall 3 (European 1, African 2) | 1212/13494 | 0.717 | 1.000 | 0.006 | 0.851 | 0.027 | 0.965 |
| Chang X, 2018 [45] | NMUR2/rs72793414 | A vs. G | 2.44 (1.85–3.23) | 3.81E-10 | Overall 3 (European 1, African 2) | 1212/13494 | 0.545 | 0.999 | 0.001 | 0.541 | 0.003 | 0.743 |
| Gormley P, 2016 [40] | LRP1/rs11172113 | C vs. T | 0.90 (0.89–0.91) | 5.6E-49 | Overall (Caucasian 22) | 59,674/316078 | – | – | – | – | 6.004E-72 | 6.011E-69 |
| Gormley P, 2016 [40] | PRDM16/rs10218452 | G vs. A | 1.11 (1.10–1.13) | 5.3E-38 | Overall (Caucasian 22) | 59,674/316078 | – | – | – | – | 8.348E-25 | 8.356E-22 |
| Gormley P, 2016 [40] | FHL5/rs67338227 | T vs. A | 1.09 (1.08–1.11) | 2.0E-27 | Overall (Caucasian 22) | 59,674/316078 | – | – | – | – | 4.430E-15 | 4.435E-12 |
| Gormley P, 2016 [40] | TSPAN2/rs2078371 | C vs. T | 1.11 (1.09–1.13) | 4.1E-24 | Overall (Caucasian 22) | 59,674/316078 | – | – | – | – | 8.348E-25 | 8.356E-22 |
| Gormley P, 2016 [40] | TRPM8/rs10166942 | C vs. T | 0.94 (0.89–0.99) | 1.0E-23 | Overall (Caucasian 22) | 59,674/316078 | 0.951 | 1.000 | 0.951 | 1.000 | 0.998 | 1.000 |
| Gormley P, 2016 [40] | PHACTR1/rs9349379 | G vs. A | 0.93 (0.92–0.95) | 5.8E-22 | Overall (Caucasian 22) | 59,674/316078 | 2.308E-08 | 2.310E-05 | 2.308E-08 | 2.310E-05 | 4.007E-06 | 3.995E-03 |
| Gormley P, 2016 [40] | MEF2D/rs1925950 | A vs. G | 1.07 (1.06–1.09) | 9.1E-22 | Overall (Caucasian 22) | 59,674/316078 | 8.014E-10 | 8.022E-07 | 8.014E-10 | 8.022E-07 | 1.694E-07 | 1.695E-04 |
| Gormley P, 2016 [40] | SLC24A3/rs4814864 | C vs. G | 1.07 (1.06–1.09) | 2.2E-19 | Overall (Caucasian 22) | 59,674/316078 | 8.014E-10 | 8.022E-07 | 8.014E-10 | 8.022E-07 | 1.694E-07 | 1.695E-04 |
| Gormley P, 2016 [40] | FGF6/rs1024905 | A vs. G | 1.06 (1.04–1.08) | 2.1E-17 | Overall (Caucasian 22) | 59,674/316078 | 9.959E-07 | 9.959E-04 | 9.959E-07 | 9.959E-04 | 1.767E-04 | 0.150 |
| Gormley P, 2016 [40] | C7orf10/rs186166891 | T vs. A | 1.09 (1.07–1.12) | 9.7E-16 | Overall (Caucasian 22) | 59,674/316078 | 4.993E-07 | 4.935E-04 | 4.993E-07 | 4.935E-04 | 6.430E-05 | 6.048E-02 |
| Gormley P, 2016 [40] | PLCE1/rs10786156 | G vs. C | 0.95 (0.94–0.96) | 2.0E-14 | Overall (Caucasian 22) | 59,674/316078 | – | – | – | – | 3.842E-16 | 3.846E-13 |
| Gormley P, 2016 [40] | KCNK5/rs10456100 | T vs. C | 1.06 (1.04–1.07) | 6.9E-13 | Overall (Caucasian 22) | 59,674/316078 | – | – | – | – | 3.372E-28 | 3.376E-25 |
| Gormley P, 2016 [40] | ASTN2/rs6478241 | T vs. A | 1.05 (1.04–1.07) | 1.2E-12 | Overall (Caucasian 22) | 59,674/316078 | 4.011E-04 | 0.287 | 4.011E-04 | 0.287 | 0.055 | 0.983 |
| Gormley P, 2016 [40] | MRVI1/rs4910165 | G vs. C | 0.94 (0.91–0.98) | 2.9E-11 | Overall (Caucasian 22) | 59,674/316078 | 0.783 | 1.000 | 0.783 | 1.000 | 0.993 | 1.000 |
| Gormley P, 2016 [40] | HPSE2/rs12260159 | A vs. G | 0.92 (0.89–0.94) | 3.2E-10 | Overall (Caucasian 22) | 59,674/316078 | 2.979E-11 | 2.982E-08 | 2.979E-11 | 2.982E-08 | 5.906E-09 | 5.912E-06 |
| Gormley P, 2016 [40] | CFDP1/rs77505915 | A vs. T | 1.05 (1.03–1.06) | 3.3E-10 | Overall (Caucasian 22) | 59,674/316078 | – | – | – | – | 3.476E-18 | 3.479E-15 |
| Gormley P, 2016 [40] | RNF213/rs17857135 | C vs. T | 1.06 (1.04–1.08) | 5.2E-10 | Overall (Caucasian 22) | 59,674/316078 | 9.959E-07 | 9.959E-04 | 9.959E-07 | 9.959E-04 | 1.767E-04 | 0.150 |
| Gormley P, 2016 [40] | NRP1/rs2506142 | G vs. A | 1.06 (1.04–1.07) | 1.5E-09 | Overall (Caucasian 22) | 59,674/316078 | – | – | – | – | 3.372E-28 | 3.376E-25 |
| Gormley P, 2016 [40] | GPR149/rs13078967 | C vs. A | 0.87 (0.83–0.91) | 1.8E-09 | Overall (Caucasian 22) | 59,674/316078 | 1.300E-06 | 1.299E-03 | 1.260E-06 | 1.260E-03 | 1.117E-04 | 0.101 |
| Gormley P, 2016 [40] | JAG1/rs111404218 | G vs. C | 1.05 (1.03–1.07) | 2.0E-09 | Overall (Caucasian 22) | 59,674/316078 | 4.011E-04 | 0.287 | 4.011E-04 | 0.287 | 0.055 | 0.983 |
| Gormley P, 2016 [40] | SPINK2/rs7684253 | T vs. C | 0.96 (0.94–0.97) | 2.5E-09 | Overall (Caucasian 22) | 59,674/316078 | 1.153E-11 | 1.154E-08 | 1.153E-11 | 1.154E-08 | 4.525E-09 | 4.530E-06 |
| Gormley P, 2016 [40] | ZCCHC14/rs4081947 | G vs. A | 1.03 (1.00–1.06) | 2.5E-09 | Overall (Caucasian 22) | 59,674/316078 | 0.978 | 1.000 | 0.978 | 1.000 | 1.000 | 1.000 |
| Gormley P, 2016 [40] | HEY2/rs1268083 | C vs. T | 0.96 (0.95–0.97) | 5.3E-09 | Overall (Caucasian 22) | 59,674/316078 | 1.153E-11 | 1.154E-08 | 1.153E-11 | 1.154E-08 | 4.525E-09 | 4.530E-06 |
| Gormley P, 2016 [40] | WSCD1/rs75213074 | T vs. C | 0.89 (0.86–0.93) | 7.1E-09 | Overall (Caucasian 22) | 59,674/316078 | 2.044E-04 | 0.170 | 2.040E-04 | 0.170 | 0.015 | 0.937 |
| Gormley P, 2016 [40] | GJA1/rs28455731 | T vs. G | 1.06 (1.04–1.08) | 7.3E-09 | Overall (Caucasian 22) | 59,674/316078 | 9.959E-07 | 9.959E-04 | 9.959E-07 | 9.959E-04 | 1.767E-04 | 0.150 |
| Gormley P, 2016 [40] | TGFBR2/rs6791480 | T vs. C | 1.04 (1.03–1.06) | 7.8E-09 | Overall (Caucasian 22) | 59,674/316078 | 0.052 | 0.982 | 0.052 | 0.982 | 0.863 | 1.000 |
| Gormley P, 2016 [40] | ITPK1/rs11624776 | C vs. A | 0.96 (0.94–0.97) | 7.9E-09 | Overall (Caucasian 22) | 59,674/316078 | 1.153E-11 | 1.154E-08 | 1.153E-11 | 1.154E-08 | 4.525E-09 | 4.530E-06 |
| Gormley P, 2016 [40] | ADAMTSL4/rs6693567 | T vs. C | 1.05 (1.03–1.06) | 1.2E-08 | Overall (Caucasian 22) | 59,674/316078 | – | – | – | – | 3.476E-18 | 3.479E-15 |
| Gormley P, 2016 [40] | CCM2L/rs144017103 | T vs. C | 0.85 (0.76–0.96) | 1.2E-08 | Overall (Caucasian 22) | 59,674/316078 | 0.934 | 1.000 | 0.899 | 1.000 | 0.993 | 1.000 |
| Gormley P, 2016 [40] | YAP1/rs10895275 | A vs. T | 1.04 (1.03–1.06) | 1.6E-08 | Overall (Caucasian 22) | 59,674/316078 | 0.052 | 0.982 | 0.052 | 0.982 | 0.863 | 1.000 |
| Gormley P, 2016 [40] | MED14/rs12845494 | G vs. C | 0.96 (0.95–0.97) | 1.7E-08 | Overall (Caucasian 22) | 59,674/316078 | 1.153E-11 | 1.154E-08 | 1.153E-11 | 1.154E-08 | 4.525E-09 | 4.530E-06 |
| Gormley P, 2016 [40] | DOCK4/rs10155855 | T vs. A | 1.08 (1.05–1.12) | 2.1E-08 | Overall (Caucasian 22) | 59,674/316078 | 0.032 | 0.971 | 0.032 | 0.971 | 0.688 | 1.000 |
| Gormley P, 2016 [40] | LRRIQ3/rs1572668 | G vs. A | 1.04 (1.02–1.05) | 2.1E-08 | Overall (Caucasian 22) | 59,674/316078 | 8.873E-13 | 8.882E-10 | 8.873E-13 | 8.882E-10 | 4.186E-10 | 4.190E-07 |
| Gormley P, 2016 [40] | CARF/rs138556413 | G vs. A | 0.88 (0.84–0.92) | 2.3E-08 | Overall (Caucasian 22) | 59,674/316078 | 1.748E-05 | 0.017 | 1.733E-05 | 0.017 | 1.395E-03 | 0.583 |
| Gormley P, 2016 [40] | ARMS2/rs2223089 | C vs. G | 0.93 (0.91–0.95) | 3.0E-08 | Overall (Caucasian 22) | 59,674/316078 | 2.308E-08 | 2.310E-05 | 2.308E-08 | 2.310E-05 | 4.007E-06 | 3.995E-03 |
| Gormley P, 2016 [40] | IGSF9B/rs561561 | T vs. A | 0.94 (0.92–0.96) | 3.4E-08 | Overall (Caucasian 22) | 59,674/316078 | 8.384E-06 | 0.008 | 8.384E-06 | 0.008 | 1.254E-03 | 0.557 |
| Gormley P, 2016 [40] | MPPED2/rs11031122 | C vs. T | 1.04 (1.03–1.06) | 3.5E-08 | Overall (Caucasian 22) | 59,674/316078 | 0.052 | 0.982 | 0.052 | 0.982 | 0.863 | 1.000 |
| Gormley P, 2016 [40] | NOTCH4/rs140002913 | A vs. G | 0.91 (0.88–0.94) | 3.8E-08 | Overall (Caucasian 22) | 59,674/316078 | 1.204E-05 | 0.012 | 1.204E-05 | 0.012 | 1.229E-03 | 0.552 |
| Anttila V, 2013 [29] | PRDM16/rs2651899 | C vs. T | 1.09 (1.07–1.12) | 3.28E-14 | Overall (Caucasian 19) | 23,285/95425 | 4.933E-07 | 4.935E-04 | 4.933E-07 | 4.935E-04 | 6.430E-05 | 0.0605 |
| Anttila V, 2013 [29] | TSPAN2/rs12134493 | A vs. C | 1.14 (1.10–1.18) | 6.71E-14 | Overall (Caucasian 19) | 23,285/95425 | 9.555E-11 | 9.565E-08 | 9.538E-11 | 9.548E-08 | 1.305E-08 | 1.307E-05 |
| Anttila V, 2013 [29] | MEF2D/rs2274316 | C vs. A | 1.07 (1.04–1.09) | 3.14E-08 | Overall (Caucasian 19) | 23,285/95425 | 8.014E-10 | 8.022E-07 | 8.014E-10 | 8.022E-07 | 1.694E-07 | 1.695E-04 |
| Anttila V, 2013 [29] | TRPM8/rs7577262 | A vs. G | 0.87 (0.84–0.90) | 3.27E-13 | Overall (Caucasian 19) | 23,285/95425 | 8.231E-13 | 8.239E-10 | 8.180E-13 | 8.188E-10 | 1.259E-10 | 1.260E-07 |
| Anttila V, 2013 [29] | FHL5/rs13208321 | A vs. T | 1.18 (1.13–1.24) | 2.15E-12 | Overall (Caucasian 19) | 23,285/95425 | 8.181E-08 | 8.189E-05 | 6.109E-08 | 6.115E-05 | 5.781E-06 | 5.753E-03 |
| Anttila V, 2013 [29] | c7orf10/rs4379368 | T vs. C | 1.11 (1.08–1.15) | 1.46E-09 | Overall (Caucasian 19) | 23,285/95425 | 7.560E-06 | 7.511E-03 | 7.560E-06 | 7.511E-03 | 7.339E-04 | 0.424 |
| Anttila V, 2010 [16] | MTDH/rs1835740 | C vs. T | 1.18 (1.13–1.24) | 1.60E-11 | Overall (Caucasian 7) | 5950/50809 | 1.109E-06 | 1.109E-03 | 8.138E-07 | 8.139E-04 | 6.811E-05 | 0.064 |
GWAS genome-wide association studies,OR odds radio,CI confidence interval,FPRP false-positive rate probability,BFDP Bayesian false discovery probability