. Author manuscript; available in PMC: 2011 Oct 1.

Published in final edited form as:Pharmacogenet Genomics. 2010 Oct;20(10):586–597. doi:10.1097/FPC.0b013e32833c3892

Table 1.

Description of current and published meta-analyses for selectglutathione S-transferase (GST) polymorphisms and lung cancer.

							Heterogeneity
	Number of Studies	Cases	Controls	n(minor)	f(minor)	OR (95% CI)	Q-Statistic P-Value	I² (95% CI)	Publication Bias Test P-Value
Overall

*GSTM1 (deletion)*
McWilliams, 1995 [125]	8	1254	1780	1496^c	n/a	1.34 (1.16–1.55)	n/a	n/a	n/a
Houlston, 1999 [124]	19	3305	5740	4459^c	n/a	1.14 (1.03–1.25)	0.275	15% (0%–46%)	n/a
d'Errico, 1999 [123]	21	n/a	n/a	n/a	n/a	1.34 (1.21–1.48)	Present^g	n/a	n/a
Benhamou, 2002 [121]	43	7463	10789	8998^c	n/a	1.17 (1.07–1.27)	0.007	n/a	0.4^d
Ye, 2006 [126]	119	19729	25931	22510^c	n/a	1.18 (1.14–1.23)	< 0.001	44% (30%–55%)	< 0.0001^e
Carlsten, 2008 [122]	98	19638	25266	22138^c	n/a	1.22 (1.14–1.30)	< 0.001	58% (46%–66%)	0.003^e
Present meta-analysis	85	18777	24050	21042	0.493	1.17 (1.10–1.25)	< 0.001	55% (44%–63%)	0.011^f
Present pooled analysis^h	56	11392	16165	13555	0.492	1.10 (1.04–1.16)	< 0.001	48% (31%–60%)	0.003^f
*GSTT1 (deletion)*
Raimondi, 2006 [129]	34	7629	10087	4240	0.239	1.07 (0.96–1.19)	< 0.001	n/a	0.02^e
Ye, 2006 [126]	44	9636	12322	5094^c	n/a	1.09 (1.02–1.16)	< 0.001	57% (40%–70%)	0.14^d
Present meta-analysis	45	12569	15545	6585	0.232	1.07 (0.97–1.17)	< 0.001	51% (34%–63%)	0.200^f
Present pooled analysis^h	38	8556	12287	4960	0.238	1.05 (0.97–1.14)	0.004	42% (19%–58%)	0.463^f
*GSTP1 (Ile105Val)*
Ye, 2006 [126] (per G allele)	25	6221	7602	6870^c	n/a	1.04 (0.99–1.09)	0.66	0% (0%–44%)	n/a
Cote, 2009 [130] (*G)	27	8322	5870	7053^c	n/a	1.04 (0.97–1.10)	0.27	14% (0%–42%)	0.02^e
Present meta-analysis (*G)	35	10125	10867	10458	0.497	1.03 (0.97–1.09)	0.376	5.5% (0%–31%)	0.014^f
Present meta-analysis (GG)	31	9427	9887	1870	0.161	1.05 (0.95–1.16)	0.506	0% (0%–34%)	0.400^f
Present Pooled analysis (AG)^h	20	4948	5561	5029	0.479	1.06 (0.97–1.15)	0.629	0% (0%–33%)	0.388^f
Present Pooled analysis (GG)^h	20	3096	3587	1203	0.180	0.98 (0.86–1.13)	0.372	7% (0%–37%)	0.404^f

African Descent

*GSTM1 (deletion)*
Benhamou, 2002 [121]	3	383	503	231^c	n/a	1.19 (0.88–1.62)	n/a	n/a	n/a
Present meta-analysis	4	494	615	289	0.242	1.25 (0.95–1.64)	0.292	20% (0%–61%)	0.509^f
Present pooled analysisⁱ	6	487	694	362	0.307	1.32 (1.00–1.74)	0.376	7% (0%–40%)	0.421^f

East Asian

*GSTM1 (deletion)*
McWilliams, 1995 [125]	3	475	729	565^c	n/a	1.60 (1.25–2.13)	n/a	n/a	n/a
d'Errico, 1996 [127]	3	475	729	565^c	n/a	1.60 (1.26–2.04)	n/a	n/a	n/a
Houlston, 1999 [124]	2	659	827	697^c	n/a	1.38 (1.12–1.69)	n/a	n/a	n/a
d'Errico, 1999 [123]	6	n/a	n/a	n/a	n/a	1.45 (1.23–1.70)	n/a	n/a	n/a
Benhamou, 2002 [121]	12	1841	2787	2171^c	n/a	1.33 (1.06–1.67)	0.001	n/a	0.7^e
Shi, 2008 [128] (Chinese)	20	2235	2315	2104	0.462	1.49 (1.32–1.68)	0.030	40% (6%–62%)	0.058^e
Carlsten, 2008 [122]	42	6088	7222	6242^c	n/a	1.38 (1.24–1.55)	< 0.001	56% (34%–68%)	n/a
Present meta-analysis	25	4301	5278	4333	0.452	1.21 (1.05–1.39)	< 0.001	60% (42%–72%)	0.568^f
Present pooled analysisⁱ	11	1536	1816	1434	0.428	1.25 (1.07–1.45)	0.222	22%(0%–55%)	0.661^f
*GSTT1 (deletion)*
Raimondi, 2006 [129]	8	1364	1727	1575	0.510	1.28 (1.10–1.49)	0.09	n/a	0.16^e
Present meta-analysis	9	1596	2161	1723	0.470	1.19 (0.99–1.45)	0.052	48% (1%–73%)	0.279^f
Present pooled analysisⁱ	8	1366	1749	1507	0.484	1.06 (0.88–1.27)	0.308	15% (0%–52%)	0.359^f
*GSTP1 (Ile105Val)*
Cote, 2009 [130] (*G)	8	1332	1504	944^c	n/a	1.09 (0.93–1.28)	0.51	0% (0%–61%)	n/a
Present meta-analysis (*G)	11	1959	2267	1472	0.333	1.16 (1.01–1.32)	0.641	0% (0%–42%)	0.434^f
Present meta-analysis (GG)	8	1459	1541	105	0.043	1.39 (0.92–2.10)	0.635	0% (0%–9%)	0.809^f
Present Pooled analyis (AG)ⁱ	4	604	744	457	0.339	1.31 (1.03–1.67)	0.697	0% (0%–52%)	0.620^f
Present Pooled analysis (GG)ⁱ	4	399	533	41	0.044	1.36 (0.69–2.65)	0.77	0% (0%–42%)	0.771^f

White

*GSTM1 (deletion)*
McWilliams, 1995^a [125]	6	958	1249	1077^c	n/a	1.17 (0.98–1.40)	n/a	n/a	n/a
d'Errico, 1996^b [127]	8	1032	1139	1059^c	n/a	1.32 (1.12–1.57)	n/a	n/a	n/a
Houlston, 1999 [124]	12	1850	3924	2818^c	n/a	1.08 (0.97–1.22)	n/a	n/a	n/a
d'Errico, 1999 [123]	13	n/a	n/a	n/a	n/a	1.21 (1.06–1.39)	Present^g	n/a	n/a
Benhamou, 2002 [121]	20	4039	6000	4899^c	n/a	1.10 (1.01–1.19)	0.5	n/a	0.8^e
Carlsten, 2008 [122]	36	9071	12237	10398^c	n/a	1.04 (0.97–1.11)	0.117	22% (0%–48%)	n/a
Present meta-analysis	42	11793	14868	13229	0.488	1.15 (1.06–1.26)	< 0.001	61% (48%–70%)	0.116^f
Present pooled analysisⁱ	40	9006	13080	10760	0.487	1.05 (0.98–1.12)	0.001	46% (26%–61%)	0.133^f
*GSTT1 (deletion)*
Raimondi, 2006 [129]	23	5585	7300	2380	0.185	0.99 (0.87–1.12)	0.02	n/a	0.42^e
Present meta-analysis	26	9454	11176	3837	0.184	1.01 (0.91–1.14)	0.003	49% (25%–65%)	0.965^f
Present pooled analysisⁱ	28	6747	9809	3135	0.189	1.04 (0.94–1.14)	0.034	36% (5%–56%)	0.516^f
*GSTP1 (Ile105Val)*
Cote, 2009 [130] (*G)	14	5959	5870	5560^c	n/a	1.00 (0.93–1.07)	0.23	21% (0%–53%)	n/a
Present meta-analysis (*G)	19	7186	7297	6795	0.470	1.00 (0.94–1.07)	0.221	19% (0%–49%)	0.120^f
Present meta-analysis (GG)	18	6988	7043	1460	0.178	1.02 (0.91–1.15)	0.151	26% (0%–54%)	0.799^f
Present Pooled analyis (AG)ⁱ	16	4180	4622	4336	0.493	1.02 (0.93–1.11)	0.758	0% (0%–26%)	0.722^f
Present Pooled analysis (GG)ⁱ	16	2627	2946	1107	0.199	0.96 (0.83–1.11)	0.322	12% (0%–53%)	0.430^f

Notes: n/a = information not available

includes 1 phenotype-based study

includes 3 phenotype-based studies

estimated using thef_minor from the corresponding present meta-analysis

Begg's test

Egger's test

Harbord test

Authors state that heterogeneity was present but do not report test results

Adjusted for age, gender, ancestry, smoking status and study

ⁱ

Adjusted for age, gender, smoking status and study

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Table 1.