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Problems in selection of topical anti-inflammatory corticosteroids
Wm D Stewart,J O Runikis,S C Verma,S Wallace
Wm D Stewart
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J O Runikis
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S C Verma
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S Wallace
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PMCID: PMC1941108 PMID:4682636
Abstract
Desonide, a non-fluorinated topical corticosteroid (16-alpha-hydroxyprednisolone acetonide), is compared with its fluorinated analogue, triamcinolone acetonide, as to vasoconstriction ability and epidermal penetration rate. Clinical effectiveness of desonide is further assessed by means of a double-blind paired comparison with an accepted potent fluorinated steroid, betamethasone 17-valerate. It is demonstrated that fluorination of the steroid molecule is not necessary to achieve potent topical anti-inflammatory effect. Vasoconstriction and epidermal penetration are not enhanced by fluorination in the drugs studied.
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Selected References
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