Hip hop heresies: queer aesthetics in New York City.ShantéParadigm Smalls -2022 - New York: New York University Press.detailsThis is the first book-length project to examine the relationship between blackness, queerness, and hip hop. Using aesthetics as its organizing lens, Hip Hop Heresies attends to the ways that hip hop cultural production in New York City from the 1970s through the first fifteen years of the 21st century produced hip hop cultural products (film, visual art, and music) that offer "queer articulations" of race, gender, and sexuality that are contrary to hegemonic ideas and representations of those categories in (...) hip hop production, as well as in writing about hip hop culture. (shrink)
What Is Wrong with the No-ReportParadigm and How to Fix It.Ned Block -2019 -Trends in Cognitive Sciences 23 (12):1003-1013.detailsIs consciousness based in prefrontal circuits involved in cognitive processes like thought, reasoning, and memory or, alternatively, is it based in sensory areas in the back of the neocortex? The no-reportparadigm has been crucial to this debate because it aims to separate the neural basis of the cognitive processes underlying post-perceptual decision and report from the neural basis of conscious perception itself. However, the no-reportparadigm is problematic because, even in the absence of report, subjects might engage (...) in post-perceptual cognitive processing. Therefore, to isolate the neural basis of consciousness, a no-cognitionparadigm is needed. Here, I describe a no-cognition approach to binocular rivalry and outline how this approach can help resolve debates about the neural basis of consciousness. (shrink)
The AtrocityParadigm: A Theory of Evil.Claudia Card -2002 - New York, US: Oxford University Press USA.detailsWhat distinguishes evils from ordinary wrongs? Are some evils unforgivable? How should we respond to evils? Card offers a secular theory of evil--representing a compromise between classic utilitarian and stoic approaches--that responds to these and other questions.
Cognition and Eros: a critique of the Kantianparadigm.Robin May Schott -1988 - University Park, Pa.: Pennsylvania State University Press.detailsIn the dissertation I examine the split between cognition and eros in Kant's notion of objectivity, which has become paradigmatic for modern theories about knowledge. I argue that the split between cognition, on the one hand, and feelings and desires, on the other, does not capture the necessary conditions of knowledge, as Kant claims, but involves a suppression of erotic factors of existence. ;The split between pure knowledge and sensual existence in Kant's thought reflects an ascetic tradition inherited from both (...) Greek and Christian sources, which views the body, sexuality, and in particular women's sexuality as a source of pollution. According to this tradition, since thought must be divested of the pollution of sensuous existence, women's sexuality precludes them from rational activity. Consequently, the philosophical commitment to purity has justified the exclusion of women from the practice of knowledge. ;The particular form of asceticism which is evident in Kant's treatment of sensibility of objective knowledge, of morality, and of aesthetic judgement, reflects the reified nature of relations in an emerging capitalist economy. The suppression of the immediate, sensual qualities in both the subject and object of knowledge, in Kant's system, corresponds to the suppression of the immediate, qualitative features of the subject and object in the process of commodity production. Both persons and things become reduced to a formal abstract equivalence. Kant's notion of objectivity makes normative this objectification of relations between persons and things. ;Thus, theparadigm of objective knowledge is not only damaging to the thinker, who must detach himself from the emotional and sensual facets of existence. It serves as an ideology which has justified the exclusion of women from the pursuit of knowledge, and which more generally legitimates the distorted human relations generated by the world of commodity production. ;By considering Kant's commitment to pure knowledge in the context of the genealogy of the concept of purity, the themes of asceticism and fetishism emerged as mutually illuminating. Implicit in the ascetic denial of sensuality is a dialectic which leads to an objectification of persons and things. Moreover, the fetishism of commodities involves a detachment of erotic interests from persons which results in an obsessive interest in objects. (shrink)
Challenging the EgoisticParadigm.Norman E. Bowie -1991 -Business Ethics Quarterly 1 (1):1-21.detailsMost economists are committed to some version of egoism. After distinguishing among the various sorts of egoistic claims, l cite the empirical literature against psychological egoism and show that attempts to account for this data make these economists' previous empirical claims tautological. Moreover, the assumption of egoism has undesirable consequences, especially for students; if people believe that others behave egoistically, they are more likely to behave egoistically themselves. As an alternative to egoism I recommend the commitment model of Robert Frank. (...) The equivalent of egoism at the organizational level is that business firms seek (should seek) to maximize profits. I present arguments to show that a conscious attempt by managers to maximize profits is likely to fail. A committed altruism is more likely to raise profits. I suggest that a firm should take as its primary purpose providing meaningful work for employees. (shrink)
Making Sense of Heidegger: AParadigm Shift.Thomas Sheehan -2014 - New York: Rowman & Littlefield International.detailsThis important book opens a new path in Heidegger research that will stimulate dialogue within Heidegger studies, as well as with philosophers outside the phenomenological tradition and scholars in theology, literary criticism, and existential psychiatry.
A NewParadigm for Epistemology From Reliabilism to Abilism.John Turri -2016 -Ergo: An Open Access Journal of Philosophy 3.detailsContemporary philosophers nearly unanimously endorse knowledge reliabilism, the view that knowledge must be reliably produced. Leading reliabilists have suggested that reliabilism draws support from patterns in ordinary judgments and intuitions about knowledge, luck, reliability, and counterfactuals. That is, they have suggested a proto-reliabilist hypothesis about “commonsense” or “folk” epistemology. This paper reports nine experimental studies (N = 1262) that test the proto-reliabilist hypothesis by testing four of its principal implications. The main findings are that (a) commonsense fully embraces the possibility (...) of unreliable knowledge, (b) knowledge judgments are surprisingly insensitive to information about reliability, (c) “anti-luck” intuitions about knowledge have nothing to do with reliability specifically, and (d) reliabilists have mischaracterized the intuitive counterfactual properties of knowledge and their relation to reliability. When combined with the weakness of existing arguments for reliabilism and the recent emergence of well supported alternative views that predict the widespread existence of unreliable knowledge, the present findings are the final exhibit in a conclusive case for abandoning reliabilism in epistemology. I introduce an alternative theory of knowledge, abilism, which out-performs reliabilism and well explains all the available evidence. (shrink)
Explorative Experiments: AParadigm Shift to Deal with Severe Uncertainty in Autonomous Robotics.Viola Schiaffonati -2022 -Perspectives on Science 30 (2):284-304.detailsThis paper presents a case of severe uncertainty in the development of autonomous and intelligent systems in Artificial Intelligence and autonomous robotics. After discussing how uncertainty emerges from the complexity of the systems and their interaction with unknown environments, the paper describes the novel framework of explorative experiments. This framework presents a suitable context in which many of the issues relative to uncertainty, both at the epistemological level and at the ethical one, in this field should be reframed. The case (...) of autonomous robot systems for search and rescue is used to make the discussion more concrete. (shrink)
Quasi-things: theparadigm of atmospheres.Tonino Griffero -2017 - Albany, New York: SUNY Press.detailsQuasi things come and go and we cannot wonder where they've been (starting from the wind) -- Quasi-things assault and resist us: feelings as atmospheres -- Quasi things are felt (though not localized): the isles of the felt-body -- Quasi-things are proofs of existence: pain as the genesis of the subject -- Quasi-things affect us (also indirectly): vicarious shame -- Quasi-things communicate with us: from the gaze to the portrait (and back) -- Quasi-things are the more effective the vaguer they (...) are: twilightness. (shrink)
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Ockham and Nominalism: Toward a NewParadigm.John R. White -2001 -Catholic Social Science Review 6:271-287.detailsThis article discusses what might be called the standard picture of Ockham in 20th century Catholic thought, especially as regards his theory of knowledge. First, it explains why it is that Ockham’s theory of knowledge has generally gotten bad press from Catholic philosophers. Second, it seeks to demonstrate why Ockham deserves a better reputation among Catholic thinkers.
Overcoming the NewtonianParadigm: The Unfinished Project of Theoretical Biology from a Schellingian Perspective.Arran Gare -2013 -Progress in Biophysics and Molecular Biology 113:5-24.detailsDefending Robert Rosen’s claim that in every confrontation between physics and biology it is physics that has always had to give ground, it is shown that many of the most important advances in mathematics and physics over the last two centuries have followed from Schelling’s demand for a new physics that could make the emergence of life intelligible. Consequently, while reductionism prevails in biology, many biophysicists are resolutely anti-reductionist. This history is used to identify and defend a fragmented but progressive (...) tradition of anti-reductionist biomathematics. It is shown that the mathematicoephysico echemical morphology research program, the biosemiotics movement, and the relational biology of Rosen, although they have developed independently of each other, are built on and advance this antireductionist tradition of thought. It is suggested that understanding this history and its relationship to the broader history of post-Newtonian science could provide guidance for and justify both the integration of these strands and radically new work in post-reductionist biomathematics. (shrink)
Implications of Action-OrientedParadigm Shifts in Cognitive Science.Peter F. Dominey,Tony J. Prescott,Jeannette Bohg,Andreas K. Engel,Shaun Gallagher,Tobias Heed,Matej Hoffmann,Gunther Knoblich,Wolfgang Prinz &Andrew Schwartz -2016 - In Andreas K. Engel, Karl J. Friston & Danica Kragic,The Pragmatic Turn: Toward Action-Oriented Views in Cognitive Science. MIT Press. pp. 333-356.detailsAn action-oriented perspective changes the role of an individual from a passive observer to an actively engaged agent interacting in a closed loop with the world as well as with others. Cognition exists to serve action within a landscape that contains both. This chapter surveys this landscape and addresses the status of the pragmatic turn. Its potential influence on science and the study of cognition are considered (including perception, social cognition, social interaction, sensorimotor entrainment, and language acquisition) and its impact (...) on how neuroscience is studied is also investigated (with the notion that brains do not passively build models, but instead support the guidance of action). A review of its implications in robotics and engineering includes a discussion of the application of enactive control principles to couple action and perception in robotics as well as the conceptualization of system design in a more holistic, less modular manner. Practical applications that can impact the human condition are reviewed (e.g., educational applications, treatment possibilities for developmental and psychopathological disorders, the development of neural prostheses). All of this foreshadows the potential societal implications of the pragmatic turn. The chapter concludes that an action-oriented approach emphasizes a continuum of interaction between technical aspects of cognitive systems and robotics, biology, psychology, the social sciences, and the humanities, where the individual is part of a grounded cultural system. (shrink)
The Darwinianparadigm: essays on its history, philosophy, and religious implications.Michael Ruse -1989 - New York: Routledge.detailsINTRODUCTION I first read Charles Darwin's masterpiece, On the Origin of Species , some twenty years ago. At once I fell under its spell - an emotion which ...
Constructing the Death Elephant: A SyntheticParadigm Shift for the Definition, Criteria, and Tests for Death.D. A. Shewmon -2010 -Journal of Medicine and Philosophy 35 (3):256-298.detailsIn debates about criteria for human death, several camps have emerged, the main two focusing on either loss of the "organism as a whole" (the mainstream view) or loss of consciousness or "personhood." Controversies also rage over the proper definition of "irreversible" in criteria for death. The situation is reminiscent of the proverbial blind men palpating an elephant; each describes the creature according to the part he can touch. Similarly, each camp grasps some aspect of the complex reality of death. (...) The personhood camp, in contrast to the mainstream "organism" camp, recognizes that a human organism can still be a biological living whole even without brain function. The mainstream camp, in contrast to the personhood camp, recognizes that a person can be permanently, even irreversibly unconscious, and still be a living person so long as his/her body is alive. The author proposes that hylomorphic dualism incorporates both these key insights. But to complete the picture of the entire "death elephant," a fundamentalparadigm shift is needed to make sense of other seemingly conflicting insights. The author proposes a "semantic bisection" of the concept of death, analogous to the traditional distinction at the beginning of life between "conception" and "birth." To avoid the semantic baggage associated with the term "death," the two new death-related concepts are referred to as "passing away" (or "deceased") and "deanimation," corresponding, respectively, to sociolegal ceasing-to-be (mirror image of birth) and ontological/theological ceasing-to-be of the bodily organism (mirror image of conception). Regarding criteria, the distinguishing feature is whether the cessation of function is permanent (passing away) or irreversible (deanimation). If the "dead donor rule" were renamed the "deceased donor rule" (both acronyms felicitously being "DDR"), the ethics of organ transplantation from non–heart-beating donors could, in principle, be validly governed by the DDR, even though the donors are not yet ontologically "deanimated." Thus, theparadigm shift satisfies both those who insist on maintaining the DDR and those who claim that it has all along been receiving only lip service and should be explicitly loosened to include those who are "as good as dead." Even so, a number of practical caveats remain to be worked out for non–heart-beating protocols. (shrink)
Complexity and Control: The New DesignParadigm.Scott Townsend -2014 -Design Philosophy Papers 12 (1):23-34.detailsIn this article, I outline a shift in certain design disciplines away from their particular historical identities to one of borrowing from and validating new design practices from research-based disciplines. While this move to “look outward” and engage with social contexts and disciplines is important, design practice and education often ignores the ongoing critiques of knowledge production that ultimately trace back to social “contexts” within and outside of the borrowed disciplines. Choosing a methodology based on its apparent efficacy without engaging (...) a critical framework can easily exacerbate a “micro-physics of control” (Foucault), which is further extended through the design of large technical and economic branding and information systems that many designers are increasingly involved in. The article concludes with an expansion and suggested application of a critical framing based on “situated and contingent knowledges,” reinventing the idea of subject while reconciling empirical observation as contingent with ongoing critical interrogation. (shrink)
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From Fleck's denkstil to Kuhn'sparadigm: Conceptual schemes and incommensurability.Babette E. Babich -2003 -International Studies in the Philosophy of Science 17 (1):75 – 92.detailsThis article argues that the limited influence of Ludwik Fleck's ideas on philosophy of science is due not only to their indirect dissemination by way of Thomas Kuhn, but also to an incommensurability between the standard conceptual framework of history and philosophy of science and Fleck's own more integratedly historico-social and praxis-oriented approach to understanding the evolution of scientific discovery. What Kuhn named "paradigm" offers a periphrastic rendering or oblique translation of Fleck's Denkstil/Denkkollektiv , a derivation that may also (...) account for the lability of the term "paradigm". This was due not to Kuhn's unwillingness to credit Fleck but rather to the cold war political circumstances surrounding the writing of The Structure of Scientific Revolutions . Following a discussion of Fleck's anatomical allusions, I include a brief discussion of Aristotle (on menstruation and darkened mirrors) and conclude with a reference to the productivity of error in Mach and Nietzsche. (shrink)
The Character Perspective on Complexity System and Brain-Science and TheParadigm Shift of Moral Education. 박형빈 -2017 -Journal of Ethics: The Korean Association of Ethics 1 (112):129-158.details복잡계 이론은 새로운 사회 인식의 틀로서 완전한 질서와 무질서를 보이지 않고 수많은 요소들의 상호작용으로 형성된 특징들을 통칭한다. 복잡계에서는 개별 구성요소들의 속성보다 구성요소들의 상호작용에 더 관심을 갖는다. 도덕교육에서 복잡계에 주목하는 이유는 인격의 특성과 도덕적 행동이 이루어지는 과정이 창발, 되먹임구조, 자기조직화, 비선형, 카오스, 지향성, 관계지향 등의 복잡계적 속성을 갖기 때문이다. 인간의 사고와 행동은 주체들 간의 관계와 소통이 복잡하게 어우러진 현상이다. 복잡계로서의 인격 특성에 대한 이해를 기반으로 도덕교육 패러다임의 전환 방향을 제안할 수 있다. 첫째, 도덕수업에서 학생변인 특성, 맥락 특성 등을 고려하기 위한 학생 (...) 진단의 중요성에 대한 인식으로의 변화이다. 둘째, 인격은 하나의 고정된 실체나 점으로 존재하는 것이 아닌 상황에 따라 유동적으로 변화하는 그러나 나름의 지향성을 갖는 일종의 경향성으로 존재하는 것이라는 인식의 변화이다. 셋째, 보편 처방으로서의 도덕교육뿐만 아니라 학생 개인 특성에 적합한 개별 처방으로서의 도덕교육이 동시에 필요하다는 인식으로의 변화이다. 넷째, 도덕 수업에서 거대 담론이 다루어져야 함과 마찬가지로 학생 개개인의 일상 담론이 다루어져야함에 대한 인식으로의 변화이다. 다섯째, 복잡계로서의 도덕 수업은 학생변인 간의 상호작용을 통한 창발 현상의 발생과 학생 개인 내부에서 이루어지는 창발 현상을 인식할 필요가 있다. 마지막으로 윤리학의 기반위에 교육학, 철학, 사회학, 심리학, 뇌신경과학, 정신건강의학, 인지과학 등을 종합하는 융합학문으로서의 도덕교육학으로의 변화이다. (shrink)
The Hebbianparadigm reintegrated: Local reverberations as internal representations.Daniel J. Amit -1995 -Behavioral and Brain Sciences 18 (4):617-626.detailsThe neurophysiological evidence from the Miyashita group's experiments on monkeys as well as cognitive experience common to us all suggests that local neuronal spike rate distributions might persist in the absence of their eliciting stimulus. In Hebb's cell-assembly theory, learning dynamics stabilize such self-maintaining reverberations. Quasi-quantitive modeling of the experimental data on internal representations in association-cortex modules identifies the reverberations (delay spike activity) as the internal code (representation). This leads to cognitive and neurophysiological predictions, many following directly from the language (...) used to describe the activity in the experimental delay period, others from the details of how the model captures the properties of the internal representations. (shrink)
Does the heterogeneity of autism undermine the neurodiversityparadigm?Jonathan A. Hughes -2021 -Bioethics 35 (1):47-60.detailsThe neurodiversityparadigm is presented by its proponents as providing a philosophical foundation for the activism of the neurodiversity movement. Its central claims are that autism and other neurodivergent conditions are not disorders because they are not intrinsically harmful, and that they are valuable, natural and/or normal parts of human neurocognitive variation. This paper: (a) identifies the non‐disorder claim as the most central of these, based on its prominence in the literature and connections with the practical policy claims that (...) theparadigm is supposed to support; (b) describes the heterogeneity of autism at the behavioural and causal levels, and argues that at the behavioural level this encompasses ways of being autistic that are harmful in ways that cannot be not wholly attributed to discrimination or unjust social arrangements, challenging the claim that autism is not a disorder; (c) considers and rejects responses to this challenge based on separation of high‐ and low‐functioning autism, separation of autism from co‐occurring conditions, and viewing autism as part of an individual’s identity. Two of these responses fail for reasons that are themselves connected with the behavioural and/or causal heterogeneity of autism. (shrink)
Tactile expectations and the perception of self-touch: An investigation using the rubber handparadigm.Rebekah C. White,Anne M. Aimola Davies,Terri J. Halleen &Martin Davies -2010 -Consciousness and Cognition 19 (2):505-519.detailsThe rubber handparadigm is used to create the illusion of self-touch, by having the participant administer stimulation to a prosthetic hand while the Examiner, with an identical stimulus , administers stimulation to the participant’s hand. With synchronous stimulation, participants experience the compelling illusion that they are touching their own hand. In the current study, the robustness of this illusion was assessed using incongruent stimuli. The participant used the index finger of the right hand to administer stimulation to a (...) prosthetic hand while the Examiner used a paintbrush to administer stimulation to the participant’s left hand. The results indicate that this violation of tactile expectations does not diminish the illusion of self-touch. Participants experienced the illusion despite the use of incongruent stimuli, both when vision was precluded and when visual feedback provided clear evidence of the tactile mismatch. (shrink)
Semantics and the computationalparadigm in computational psychology.Eric Dietrich -1989 -Synthese 79 (1):119-41.detailsThere is a prevalent notion among cognitive scientists and philosophers of mind that computers are merely formal symbol manipulators, performing the actions they do solely on the basis of the syntactic properties of the symbols they manipulate. This view of computers has allowed some philosophers to divorce semantics from computational explanations. Semantic content, then, becomes something one adds to computational explanations to get psychological explanations. Other philosophers, such as Stephen Stich, have taken a stronger view, advocating doing away with semantics (...) entirely. This paper argues that a correct account of computation requires us to attribute content to computational processes in order to explain which functions are being computed. This entails that computational psychology must countenance mental representations. Since anti-semantic positions are incompatible with computational psychology thus construed, they ought to be rejected. Lastly, I argue that in an important sense, computers are not formal symbol manipulators. (shrink)
Challenging the AdaptationistParadigm: Morphogenesis, Constraints, and Constructions.Marco Tamborini -2020 -Journal of the History of Biology 53 (2):269-294.detailsIn this paper, I argue that the German morphological tradition made a major contribution to twentieth-century study of form. Several scientists paved the way for this research: paleontologist Adolf Seilacher, entomologist Hermann Weber, and biologist Johann-Gerhard Helmcke together with architect Frei Otto. All of them sought to examine morphogenetic processes to illustrate their inherent structural properties, thus challenging the neo-Darwinian framework of evolutionary theory. I point out that the German theoretical challenge to adaptationist thinking was possible through an exchange and (...) transfer of practices, data, technologies, and knowledge between biologically oriented students of form and architects, designers, and engineers. This exchange of practices and knowledge was facilitated by the establishment of two collaborative research centers at the beginning of the 1970s. Hence, by showing the richness of topics, methods, and technologies discussed in German-speaking morphology between 1950 and the 1970s, this paper paves the way to a much broader comprehension of the shifts that have shaped twentieth-century evolutionary biology. (shrink)
Script-based Reappraisal Test introducing a newparadigm to investigate the effect of reappraisal inventiveness on reappraisal effectiveness.Peter Zeier,Magdalena Sandner &Michèle Wessa -2020 -Cognition and Emotion 34 (4):793-799.detailsABSTRACTThe ability to regulate emotions is essential for psychological well-being. Therefore, it is particularly important to investigate the specific dynamics of emotion regulation. In a new appr...
Geneticization: The CyprusParadigm.Henk ten Have &Rogeer Hoedemaekers -1998 -Journal of Medicine and Philosophy 23 (3):274-287.detailsGeneticization is a broad term referring to several related processes such as a spreading tendency to use a genetic model of disease explanation, a growing influence of genetics in medical practice, and the slow changing of individual and societal attitudes towards reproduction, prevention and control of disease. These processes can be demonstrated in medical literature on preventive genetic screening and counselling programs for β-thalassaemia in Cyprus, the United Kingdom and Canada. The preventive possibilities of the new genetic and diagnostic technologies (...) have been quickly understood and advocated by health professionals, and their educational strategies have created a web of social control, in marked contrast to the alleged voluntary decision-making process and free choice. Genetic diagnostic technologies have led to considerable changes in control and management of β-thalassaemia, and have generated a number of unresolved incongruities. (shrink)
Clarifying theparadigm for the ethics of donation and transplantation: Was 'dead' really so clear before organ donation?Sam D. Shemie -2007 -Philosophy, Ethics, and Humanities in Medicine 2:18-.detailsRecent commentaries by Verheijde et al, Evans and Potts suggesting that donation after cardiac death practices routinely violate the dead donor rule are based on flawed presumptions. Cell biology, cardiopulmonary resuscitation, critical care life support technologies, donation and transplantation continue to inform concepts of life and death. The impact of oxygen deprivation to cells, organs and the brain is discussed in relation to death as a biological transition. In the face of advancing organ support and replacement technologies, the reversibility of (...) cardiac arrest is now purely related to the context in which it occurs, in association to the availability and application of support systems to maintain oxygenated circulation. The 'complete and irreversible' lexicon commonly used in death discussions and legal statutes are ambiguous, indefinable and should be replaced by accurate terms. Criticism of controlled DCD on the basis of violating the dead donor rule, where autoresuscitation has not been described beyond 2 minutes, in which life support is withdrawn and CPR is not provided, is not valid. However, any post mortem intervention that re-establishes brain blood flow should be prohibited. In comparison to traditional practice, organ donation has forced the clarification of the diagnostic criteria for death and improved the rigour of the determinations. (shrink)
Atomism in crisis: An analysis of the current high energyparadigm.K. Shrader-Frechette -1977 -Philosophy of Science 44 (3):409-440.detailsSince the appearance of T. S. Kuhn's The Structure of Scientific Revolutions, scholars from various fields have sought to evaluate their disciplines in the light of Kuhnian criteria for scientific change. In this paper I argue that a newparadigm seems needed in high energy physics, and that there is no more reason to say that matter is made of elementary particles, than to say that it is not. My argument, that high energy physics is approaching a state of (...) crisis, and that a newparadigm is needed, is based on an examination of two events which, according to Kuhn, presage a conceptual revolution: (1) the "old"paradigm of normal science becomes unclear; and (2) thisparadigm fails to support normal problem solving research, and scientists begin to use it as if it were merely definitional. After examining the elementary particlesparadigm in the light of these two criteria, I conclude that high energy physics is moving from "normal science" to "extraordinary science." I argue neither that a newparadigm has been found, nor that a return to normal science is imminent; instead I attempt to briefly outline some of the conceptual problems in high energy physics to which Heisenberg, Feynman, and others have alluded, but which so far have not been spelled out in any great philosophical detail. No attempt is made to argue about what the specific consequences of these difficulties might be, but merely to begin to clarify the problems facing scientists dealing with elementary particles. (shrink)
A newparadigm in cell therapy for diabetes: Turning pancreatic α‐cells into β‐cells.Caroline B. Sangan &David Tosh -2010 -Bioessays 32 (10):881-884.detailsCell therapy means treating diseases with the body's own cells. One of the cell types most in demand for therapeutic purposes is the pancreatic β‐cell. This is because diabetes is one of the major healthcare problems in the world. Diabetes can be treated by islet transplantation but the major limitation is the shortage of organ donors. To overcome the shortfall in donors, alternative sources of pancreatic β‐cells must be found. Potential sources include embryonic or adult stem cells or, from existing (...) β‐cells. There is now a startling new addition to this list of therapies: the pancreatic α‐cell. Thorel and colleagues recently showed that under circumstances of extreme pancreatic β‐cell loss, α‐cells may serve to replenish the insulin‐producing compartment. This conversion of α‐cells to β‐cells represents an example of transdifferentiation. Understanding the molecular basis for transdifferentiation may help to enhance the generation of β‐cells for the treatment of diabetes. (shrink)
Artificial intelligence and itsparadigm.Joop Schopman -1986 -Zeitschrift Für Allgemeine Wissenschaftstheorie 17 (2):346-352.detailsBegriffsanalyse und empirische Forschung auf dem Gebiet der künstlichen Intelligenz zeigen, daß momentan derart kontroverse Ansätze entwickelt werden, daß gemeinschaftliche Momente in Perspektiven und angewandten Methodologien nur schwer auszumachen sind.
The Impact of theParadigm of Complexity On the Foundational Frameworks of Biology and Cognitive Science.Alvaro Moreno,Kepa Ruiz-Mirazo &Xabier E. Barandiaran -unknowndetailsAccording to the traditional nomological-deductive methodology of physics and chemistry [Hempel and Oppenheim, 1948], explaining a phenomenon means subsuming it under a law. Logic becomes then the glue of explanation and laws the primary explainers. Thus, the scientific study of a system would consist in the development of a logically sound model of it, once the relevant observables (state variables) are identified and the general laws governing their change (expressed as differential equations, state transition rules, maximization/minimization principles,. . . ) (...) are well determined, together with the initial or boundary conditions for each particular case. Often this also involves making a set of assumptions about the elementary components of the system (e.g., their structural and dynamic properties) and modes of local interaction. In this framework, predictability becomes the main goal and that is why research is carried out through the construction of accurate mathematical models. Thus, physics and chemistry have made most progress so far by focusing on systems that, either due to their intrinsic properties or to the conditions in which they are investigated, allow for very strong simplifying assumptions, under which, nevertheless, those highly idealized models of reality are deemed to be in good correspondence with reality itself. Despite the enormous success that this methodology has had, the study of living and cognitive phenomena had to follow a very different road, because these phenomena are produced by systems whose underlying material structure and organization do not permit such crude approximations. Seen from the perspective of physics or chemistry, biological and cognitive systems are made of an enormous number of parts or elements interacting in non-linear and selective ways, which makes very difficult their tractability through mathematical models. In addition, many of those interacting elements are hierarchically organized, in a way that the “macroscopic” (observable) parts behave according to rules that cannot be, in practice, derived from simple principles at the level of their “microscopic” dynamics.. (shrink)