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Invitro fertilization and the risk of birth and developmental defects - facts and fictions Poland is being swept by a wave of discussions on various aspects of IVF application. Scientists of various disciplines are getting involved in these discussions as opponents to this form of procreation. Referring to research carried out all over the world, they demonstrate that children born thanks to the invitro procedure are significantly more susceptible to all sorts of disease. The author, surveying (...) available research data, shows that, in reality, the worse health of invitro-conceived children deals with a narrow number of well-identified disorders and in most cases is of correlative, not causative nature. The main reason for the weaker health of these children is often connected with the advanced age of the parents who choose IVF and their health condition, as compared to those who become parents in a natural way. (shrink)

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This paper explores whether egg donation could still be ethically justified if invitro gametogenesis (IVG) became reliable and safe. In order to do this, issues and concerns that might inform a patient’s reasoning in choosing to use donor eggs instead of IVG are explored and assessed. It is concluded that egg donation would only be ethically justified in a narrow range of special cases given the (hypothetical) availability of IVG treatment and, further, that egg donation could itself be (...) replaced by donation through IVG techniques. Two possible criticisms of this position are then considered: Ones based on respect for patient wishes, and on loss of donor benefit. It is concluded that whilst neither argument constitutes a strong enough reason to continue with programmes of egg donation, egg‐sharing programmes could still be permitted come the advent of IVG; these could then provide a morally acceptable source of “natural” donor eggs. (shrink)

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This study examines recent French bioethics laws governing the uses of new reproductive and genetic technologies (NRGTs)—including in-vitro fertilization, surrogate motherhood, prenatal diagnostics, sex selection, and cloning—in light of feminist claims to women’s rights, especially a woman’s right to reproductive freedom. To this end, the study explores two interrelated questions: First, to what extent have French feminists supported NRGT development and treatment? Second, to what extent do French national bioethics debates, laws, and policies reflect feminist reactions to NRGTs? The (...) investigation of these questions is informed by recent theories of state feminism that show how national policy debates are gendered by particular sets of feminist ideas, and how policy choices resulting from these debates turn some of these ideas into law (McBride Stetson and Mazur 1995). Some of the most pressing feminist concerns in this area include women’s loss of control over their bodies and fertility, women’s exploitation and commercialization of their bodies, and women’s health risks from NRGTs. The analysis of pronouncements by French feminist writers, researchers, and policy-makers reveals a multiplicity of feminist stances on NRGTs, showing keenly how feminists contest what constitutes effective feminist public policies to illuminate the fact that these policies are subject to shifting political contestations, rather than the reflection of a fixed set of feminist ideas. While contemporary French feminists grapple with the potential merits and dangers of NRGTS, the study shows that feminists generally seem to support NRGTs, as long as French law protects women’s reproductive autonomy. Seen in this light, France’s strong sense of the right to procreate through facilitation of access to NRGTs is not a contradiction of France’s strong social and legal support for women’s reproductive freedom, but rather enables French lawmakers to regulate NRGTs more effectively. (shrink)

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Invitro gametogenesis (IVG) is believed to be the next big breakthrough in reproductive medicine. The prima facie acceptance of this possible future technology is notable when compared to the general prohibition on human reproductive cloning. After all, if safety is the main reason for not allowing reproductive cloning, one might expect a similar conclusion for the reproductive application of IVG, since both technologies hold considerable and comparable risks. However, safety concerns may be overcome, and are presumably not the (...) sole reason why cloning is being condemned. We therefore assess the non‐safety arguments against reproductive cloning, yet most of these can also be held against IVG. The few arguments that cannot be used against IVG are defective. We conclude from this that it will be hard to defend a ban on reproductive cloning while accepting the reproductive use of IVG. (shrink)

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Current guidance from the American Society for Reproductive Medicine (ASRM) and the American College of Obstetricians and Gynecologists (ACOG) indicates that body mass index (BMI) ought not be used alone for invitro fertilization (IVF) exclusionary policies, but the reasons for using BMI alongside other criteria are less clear. This article aims to fill a gap in the literature on this point and follow the findings to a logical conclusion regarding the role of BMI in IVF policies of the (...) future. The article discusses why BMI might be useful in IVF policies, explores evidence that other metrics may be sufficient to estimate population-level risk, and addresses whether policies ought to continue to use BMI. Because BMI has a morally problematic history, results in disproportionate outcomes along racialized lines, and has the potential to reinforce negative stereotypes, the article suggests that providers ought to replace BMI with other metrics. (shrink)

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The volume presents 20 essays on the ontological, moral, and legal status of the invitro embryo.

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Fertility treatments raise a range of social and ethical issues regarding self-identity for family, sexual intimacy, and the interests and welfare of potential children. Eggs and sperm are combined to produce fertilized eggs. These eggs are then implanted as embryos and grow into viable fetuses, which are carried by the original mother or a surrogate mother. This artificial form of conception can challenge religious values and family structures. In-vitro fertilization (IVF) can be considered either as a medical miracle or (...) playing with divinity. What obligation do medical professionals have to infertile women and to what extent? The bioethical dilemma of IVF use encompasses different moral issues for all involved in the process. Ethical issues address respect for personal autonomy, access and care, and the duty of the health care provider to be compassionate to persons whose actions and moral values may be different from their own. Health care providers need to impart empathy, understanding and sensitivity towards this unique type of patient population. The conflict for those treating patients who are trying to conceive by IVF includes respect for personal autonomy, nonmaleficence, justice, utility and the ethics of care. As a registered nurse in a postpartum hospital unit, I have seen antepartum and postpartum women involved with this new technology. I have worked with mothers and their partners as they experience different levels of anxiety and hope for the future. There is an underlying psychosocial connection with patients who undergo IVF treatments. The purpose of this article is to explore the ethical use of IVF on older women. Is this type of biotechnolgy being applied for the right reasons and for the best patient population? (shrink)

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Invitro fertilisation is now an established technique for treating some forms of infertility, yet it remains ethically controversial. New developments, such as embryo donation and embryo freezing, have led to further discussion. We briefly discuss the ethical aspects of IVF, focusing on the issues of resource allocation, the 'unnaturalness' of the procedure, the moral status of the embryo, surrogate motherhood, and restrictions on access to IVF. We argue that, on the whole, IVF is an ethically justifiable method of (...) assisting infertile couples. (shrink)

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Invitro gametogenesis (IVG) might offer numerous research and clinical benefits. Some potential clinical applications of IVG, such as allowing opposite‐sex couples experiencing infertility to have genetically related children, have attracted support. Others, such as enabling same‐sex reproduction and solo reproduction, have attracted significantly more criticism. In this paper, we examine how different ethical principles might help us to draw lines and distinguish between ethically desirable and undesirable uses of IVG. We discuss the alleged distinction between therapeutic and non‐therapeutic (...) uses of assisted reproduction in the context of IVG, and show how it is both problematic to apply in practice and theoretically dubious. We then discuss how the ethical principles of reproductive justice and beneficence apply to IVG for opposite‐sex reproduction, same‐sex reproduction, and solo reproduction. We suggest that these principles generate strong reasons for the use of IVG for opposite‐sex and same‐sex reproduction, but not for solo reproduction. (shrink)

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Reproductive biotechnologies, also known as assisted reproductive technologies (ART), have undergone significant development over time, reaching a remarkable level of evolution in the 20th century. Currently, several biotechnologies stand out, among which Artificial Insemination (AI), widely spread globally, Embryo Production (EP) both in vivo and invitro for embryo transfer, Intracytoplasmic Sperm Injection (ICSI), sexing, among other innovations. InVitro Production (IVP) of embryos has emerged as the biotechnology that has experienced the greatest development and evolution in recent (...) decades, covering various fields such as research in assisted human reproduction, obtaining transgenic animals for biomedicine, preservation of endangered species and conservation of animals of high genetic value. This research aims to analyze the relevance of IVP, as well as the fundamental elements that make up this complex process. IVP of embryos involves several stages, from oocyte procurement, oocyte selection and invitro maturation, sperm preparation, invitro fertilization, to the culture of the resulting zygotes to blastocysts. These blastocysts, once transferable to recipients, culminate in the birth of a new being. However, this process has both advantages and disadvantages, which motivates continuous innovation in the field. (shrink)

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Invitro embryology not only makes possible the growing of human tissue to remedy infertility but also for many other experimental purposes. This paper examines the ethical issues involved in such work and outlines the circumstances in which such work is morally permissible and those in which it is not.

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A series of recent scientific results suggest that, in the not-too-distant future, it will be possible to create viable human gametes from human stem cells. This paper discusses the potential of this technology to make possible what I call ‘invitro eugenics’: the deliberate breeding of human beings invitro by fusing sperm and egg derived from different stem-cell lines to create an embryo and then deriving new gametes from stem cells derived from that embryo. Repeated iterations of (...) this process would allow scientists to proceed through multiple human generations in the laboratory. Invitro eugenics might be used to study the heredity of genetic disorders and to produce cell lines of a desired character for medical applications. More controversially, it might also function as a powerful technology of ‘human enhancement’ by allowing researchers to use all the techniques of selective breeding to produce individuals with a desired genotype. (shrink)

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ABSTRACT This article deals with a cluster of moral problems raised by the new techniques of human fertilisation. It is concerned primarily with the putative rights of embryos brought into being as a by‐product of the practice of invitro fertilisation. In this connection it investigates the basis for the ascription of rights to entities and asserts the view that consciousness is a pre‐requisite for the possession of rights. It draws attention to the speciesism implicit in attitudes of some (...) of those who have contributed to the debate. It also examines other issues briefly, raising, for example, the question whether children by AID (or by invitro fertilisation by donor) must be denied access to information about their genetic fathers; and looking at objections to the new techniques based on the so‐called unnaturalness of the procedures involved. (shrink)

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The prospect of consumable meat produced in a laboratory setting without the need to raise and slaughter animals is both realistic and exciting. Not only could such invitro meat become popular due to potential cost savings, but it also avoids many of the ethical and environmental problems with traditional meat productions. However, as with any new technology, invitro meat is likely to face some detractors. We examine in detail three potential objections: 1) invitro meat (...) is disrespectful, either to nature or to animals; 2) it will reduce the number of happy animals in the world; and 3) it will open the door to cannibalism. While each objection has some attraction, we ultimately find that all can be overcome. The upshot is that invitro meat production is generally permissible and, especially for ethical vegetarians, worth promoting. (shrink)

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Steroid hormone receptors are ligand‐inducible transcription factors that exhibit potent effects on gene expression in living cells. Precise dissection of their mode of action at the molecular level can best be carried out in functional cell‐free systems. This article will describe the benefits of such systems and review their development up to the recent establishment of steroid receptor‐dependent invitro transcription. Subsequent advances in our knowledge of receptor function arising from the exploitation of this powerful experimental tool will be (...) described. Particular emphasis will be placed upon two key problems: the role of steroid hormone in receptor action and the mechanisms by which steroid receptors activate gene transcription. (shrink)

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The Mycobacterium Tuberculosis complex is a group of species of Mycobacteria involved in a serious bacterial disease which infects the respiratory system and organs. Multi-drug resistant (MDR) strains have been produced as a result of the fast emergence of resistance against first-line anti-tuberculosis medicines in recent years worldwide. The objective of this study is to determine alternatives to anti-mycobacterial antibiotics, such as Manuka honey and Indian costus. MTB isolates (???? = 15) were evaluated for their susceptibility to Manuka honey graded (...) as +15 and Indian costus by using different concentrations. Among the TB isolates (???? = 15) tested, four (27%) isolates were resistant at 15% v/v honey, while, at 18% v/v of Manuka honey, two (13%) isolates were found to be resistant. Resistance was not seen at honey concentrations of 20% v/v. On the other hand, Indian costus had a slight effectiveness at concentrations of 20% and 25%, affecting only two and five isolates of Mycobacteria, respectively; however, all isolates were inhibited at a concentration of 33% v/v of Indian costus. The present study clearly demonstrates that supposed alternatives (Manuka honey graded as +15 and Indian costus) possess significant anti-mycobacterial activity invitro; however, further clinical trials should be performed to corroborate our initial findings. (shrink)

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After the typical theological and bioethical questions about invitro fertilization (IVF) are vetted, there remains a three-dimensional understanding of responsibility that is not typically considered in Christian bioethics. This paper will explore responsibility to the spouses’ loving union, their bodies, and society in order to ascertain the morality of IVF. In a marriage partnership, the spouses’ primary responsibility is to each other. Although in matrimony physical union is essential to marriage, children are not. The second dimension of responsibility (...) focuses on the body—“the temple of God”—and on our responsibility to care for it. This concerns the woman, her husband, and even the newborn. Finally, the third understanding of responsibility leads us to address social concerns, with an emphasis on social dynamics, especially the cost of IVF procedures and how they siphon medical resources away from more urgent human needs in health care and within society. (shrink)

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Technological advances in genetic testing have enabled prospective parents to learn about their risk of passing a genetic condition to their future children. One option for those who want to ensure that their biological children do not inherit a genetic condition is to create embryos through invitro fertilisation and use a technique called preimplantation genetic testing to screen embryos for genetic abnormalities before implantation. Unfortunately, due to its high cost, IVF-with-PGT is out of reach for the vast majority (...) of Americans. This article addresses an issue that has been underexplored in the medical ethics literature: the lack of insurance coverage for IVF-with-PGT.Within the US system, a key concept in insurance is that of medically necessary care, which broadly consists of diagnostic services and treatment services. In this article, I argue that IVF-with-PGT could be classified as either a diagnostic service or as a treatment service. To make this case, I show that IVF-with-PGT is similar to other types of services that are often covered by US insurance providers. In light of these similarities, I argue that the current system is inconsistent with respect to what is—and is not—covered by insurance. To promote consistency and fairness in coverage, like cases should be treated alike—starting with greater coverage for IVF-with-PGT. (shrink)

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In-vitro fertilization is becoming a pressing issue in contemporary societies. The article considers it starting form the Polish debate but takes up its broader anthropological an ethical aspects. Dealing with the latter, it also employs some acute remarks from Dignitas Personae. Finally it considers an approach to invitro against the background of European Convention on Bioethics. In its conclusion the paper offers a balanced pro-life stance, albeit critical of invitro.

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Invitro meat is presented by innovators as the most realistic and sustainable solution to the problems of current meat production and consumption. The innovators argue that invitro meat could be more environmentally friendly, animal friendly, healthier, and safer than conventional meat. The paper elaborates different reactions of experts and stakeholders from science, civil society, economy, and politics to the innovators’ reasoning. The semi-structured interviews were conducted for the project “Visions of invitro meat. Analysis of (...) technical and societal aspects and visions of invitro meat” funded by the German Ministry of Education and Research. In this paper we will show how our interview partners positioned themselves in relation to the innovators’ vision on IVM and which other visions they brought into the discussion about IVM and the future of meat. The project was based on a concept of visions as socio-epistemic practices that are increasingly recognised as important elements in innovation and transformation processes. The analysis of these visions conducted in interviews with experts and stakeholders provided new knowledge for the conceptualisation and appraisal of invitro meat beyond the innovators’ rhetoric. (shrink)

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Global In-vitro Diagnostics Market Size research report offers in-depth assessment of revenue growth, market definition, segmentation, industry potential, influential trends for understanding the future outlook and current prospects for the market. -/- Get a Sample Copy of the Report at – -/- Invitro Diagnostics (IVD) are medical devices used to perform diagnostic tests on biological samples such as blood, urine, and tissues. The IVD tests help detect and monitor infectious diseases, autoimmune diseases, and several medical conditions that (...) are being used to analyze drug therapies. Furthermore, according to the British In-vitro Diagnostic Association, invitro diagnostics tests influence approximately 70% of clinical decisions. However, less than 1% of the NHS's budget is spent developing innovative IVD product portfolios each year. -/- Drivers & Restraints -/- The global in-vitro diagnostics market size stood at USD 97.12 Billion in 2023 and is projected to reach USD 157.02 Billion by 2030, exhibiting at a CAGR of 7.1% in the forecast period -/- This study provides information about the sales and revenue during the historic and forecasted period of (2024 to 2030). Understanding the segments helps in identifying the importance of different factors that aid market growth. Estimations about the CAGR value for specific forecast period, market drivers, market restraints, and competitive strategies are assessed in this In-vitro Diagnostics Market report. -/- This report focuses on In-vitro Diagnostics Market volume and value at the global level, regional level and company level. From a global perspective, this report represents overall In-vitro Diagnostics Market market size by analysing historical data and future prospect. Regionally, this report focuses on several key regions: North America, Europe, Asia-Pacific, Latin America and Middle East and Africa. -/- Competitive Strategic Window: -/- The Competitive Strategic Window analyses the competitive landscape in terms of markets, applications, and geographies to help the vendor define an alignment or fit between their capabilities and opportunities for future growth prospects. It describes the optimal or favorable fit for the vendors to adopt successive merger and acquisition strategies, geography expansion, research & development, and new product introduction strategies to execute further business expansion and growth during a forecast period. -/- An Overview of the Impact of COVID-19 on this Market: -/- The advancement of COVID-19 has conveyed the world to a stop. We fathom that this prosperity crisis amazingly influences associations across ventures. Nevertheless, everything fortunate or unfortunate should reach a conclusion. There are a couple of organizations that are fighting and some are thriving. By and large, essentially every region is relied upon to be impacted by the pandemic. -/- We are advancing incessant endeavors to help your business support and create during COVID-19 pandemics. Considering our experience and expertise, we will offer you an impact examination of Covid episode across ventures to help you with preparing for what's to come. -/- Key players covered in the global In-vitro Diagnostics Market research report: -/- F. Hoffmann-La Roche Ltd (Switzerland) Abbott Laboratories (U.S.) Thermo Fisher Scientific Inc. (U.S.) Sysmex Corporation (Japan) Siemens Healthineers AG (Germany) BD (Becton, Dickinson, and Company) (U.S.) Seegene Inc. (Republic of Korea) DiaSorin S.p.A. (Italy) Quest Diagnostics Incorporated (U.S.) Bio-Rad Laboratories, Inc. (U.S.). (shrink)

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Production of oocytes from pluripotent cell cultures in a dish represents a new paradigm in stem cell and developmental biology and has implications for how we think about life. The spark of life for the next generation occurs at fertilization when sperm and oocyte fuse. In animals, gametes are the only cells that transmit their genomes to the next generation. Oocytes contain in addition a large cytoplasm with factors that direct embryonic development. Reconstitution of mouse oocyte and embryonic development in (...) culture provides experimental opportunities and facilitates an unprecedented understanding of molecular mechanisms. However, the application of invitro gametogenesis to reproductive medicine or infertility treatment remains challenging. One significant concern is the quality of invitro‐derived oocytes. Here, we review the current understanding and identify limitations in generating oocytes invitro. From this basis, we explore opportunities for future improvements of the invitro approach to generating high‐quality oocytes. (shrink)

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Abstract:Research into the development of stem cell-derived (SCD) gametes in humans, otherwise known asin vitrogametogenesis (IVG), is largely motivated by reproductive aims. Especially, the goal of establishing genetic parenthood by means of SCD-gametes is considered an important aim. However, like other applications in the field of assisted reproduction, this technology evokes worries about the possibility of creating so-called ‘designer babies.’ In this paper, we investigate various ways in which SCD-gametes could be used to create such preference-matched offspring, and what this (...) would mean for the acceptability of IVG, if it is premised that it is morally problematic to ‘design’ offspring. We argue that IVG might facilitate the creation of preference-matched offspring, but conclude that this should not undermine the moral acceptability of IVG altogether—even if one concedes the premise that creating ‘designer babies’ is morally problematic. In the light of this, we also point at a possible inconsistency for a position that condemns the creation of ‘designer offspring,’ while accepting the various endeavors to have genetically related offspring. (shrink)

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This chapter focuses on a novel class of models used in frontier research in the bioengineering sciences – invitro simulation models – that provide the basis for biological experimentation. These bioengineered models are hybrid constructions, composed of living tissues or cells and engineered materials. Specifically, it discusses the processes through which invitro models were built, experimented with, and justified in a tissue engineering lab. It examines processes of design, construction, experimentation, evaluation, and redesign of in (...) class='Hi'>vitro simulation models, in general, as instances of building the source analogy (as distinguished from retrieving an analogy), which figures prominently in creative frontier scientific research. Building the analogical source is a bootstrapping process, which furthers the articulation, as well as the solution of the problem. -/- . (shrink)

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Genetic recombination involves the exchange of genetic material between chromosomes to produce new assortments of alleles. As such, it affects one of the most fundamental and important components of heredity – the genome itself. To understand the molecular basis of recombination, efforts have been directed to try to determine how simple organisms recombine their DNA. One approach involves the development of invitro systems in which recombination reactions can be studied using purified enzymes. Detailed studies of these systems, using (...) enzymes isolated from bacteria and bacterial viruses, indicate the formation of unique protein‐DNA complexes. The structure of the DNA within these complexes has important consequences for the subsequent formation of recombinant products. (shrink)

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The Principle of Procreative Beneficence (PB) holds that when a couple plans to have a child, they have significant moral reason to select, of the possible children they could have, the child who is most likely to experience the greatest wellbeing – that is, the most advantaged child, the child with the best chance at the best life.1 PB captures the common sense intuitions of many about reproductive decisions. PB does not posit an absolute moral obligation – it does not (...) dictate what people must do. Instead it holds that there is a significant moral reason to select the best child, but one that must be weighed against other reasons.Recent research suggests that it may become possible to derive gametes (eggs and sperm) from human stem cells invitro, a process which we will term invitro gametogenesis (IVG). The ability to create large numbers of eggs or sperm through IVG greatly increases our capacity to select the best child possible. (shrink)

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Human beings have always used technology to navigate the world around them. Some of it has had devastating consequences for the environment. In particular, technology that made industrial animal agriculture possible has led to climate change, deforestation, loss of biodiversity, pollution of water, and soil desertification among other environmental impacts. Cell cultured or invitro meat has the potential to satisfy the same demand while reducing impacts on the environment. Many of the moral arguments offered in favor of in (...)vitro meat have been consequentialist in nature. Some of the main arguments against it have been motivated by virtue theory. This paper will defend invitro meat on virtue theoretic grounds. The first section of the paper addresses arguments that have been offered and those that might potentially be offered against invitro meat on the basis of virtues such as reverence for life, temperance, respect for nature, and simplicity. The second section provides an argument for curiosity as an environmental virtue and emphasizes the importance of using the Indian concept of ahimsa to guide our thinking about how to be curious virtuously. I argue that developing invitro meat is an example of this kind of curiosity. (shrink)

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While invitro animal meat is not yet commercially available, the public has already begun to form opinions of IVM as a result of news stories and events drawing attention to its development. As such, we can discern public perceptions of the ethics of IVM before its commercial release. This affords advocates of environmentally sustainable, healthy, and just diets with a unique opportunity to reflect on the social desirability of the development of IVM. This work draws upon an analysis (...) of ethical perceptions of IVM in 814 US news blog comments related to the August 2013 tasting of the world’s first IVM hamburger. Specifically, I address three primary questions: How does the public perceive the ethics of IVM development? How acceptable is IVM to the public relative to alternative approaches to reducing animal meat consumption? and What should all of this mean for the ongoing development and promotion of IVM? Ultimately, it is argued that there is a strong need for facilitation of public dialogue around IVM, as well as further research comparing the acceptability of IVM to other alternatives. (shrink)

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The production, manipulation and exploitation of future visions are increasingly important elements in practices of visioneering socio-technical processes of innovation and transformation. This becomes obvious in new and emerging science and technologies and large-scale transformations of established socio-technical systems. A variety of science and technology studies provide evidence on correlations between expectations and anticipatory practices with the dynamics of such processes of change. Technology assessment responded to the challenges posed by the influence of visions on the processes by elaborating methodologies (...) for a “vision assessment” as a contribution to what is now increasingly known as “hermeneutical TA”. But until now, the practical functions of visions in the processes have not been explained in a way that satisfies the empirical needs of TA’s vision assessment—that is to provide future-oriented knowledge based on the analysis of ongoing changes in the present without knowing the future outcomes. Our leading hypothesis is that we can only understand the practical roles of visions in current processes if we analyse them as socio-epistemic practices which simultaneously produce new knowledge and enable new social arrangements. We elaborate this by means of two cases: the visions of InVitro meat and of the smart grid. Here, we interpret visioneering more in its collective dimension as a contingent and open-ended process, emerging from heterogeneous socio-epistemic practices. This paper aims at improving TA’s vision assessments and related STS research on visionary practices for real-time analysis and assessments. (shrink)

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