Movatterモバイル変換

In an era dominated by digital media, the teaching of ideological and political education is increasingly influenced by the dynamics of media literacy, raising profound philosophical and ethical questions about truth, morality, and the role of education in shaping values. This study explores the necessity of enhancing the pedagogical competencies of ideological and political educators in the context of new media, examining both the opportunities and challenges posed by digital communication to the moral and spiritual dimensions of ideological instruction. By (...) integrating perspectives from constructivist learning theory and deep learning theory, this research critically analyses the ethical and philosophical implications of media literacy in ideological education. It identifies key deficiencies in contemporary teaching approaches, including a lack of engagement with digital pedagogies, an overemphasis on utilitarian assessment methods, insufficient reflection on moral and spiritual dimensions, and a failure to incorporate innovative teaching strategies that address deeper ethical reasoning. The study argues that ideological and political teaching must not only adapt to the digital age but also integrate philosophical and religious perspectives to ensure a more holistic approach to moral education. This research contributes to the broader discourse on religious philosophy, ethics, and education, proposing that ideological teaching should transcend mere political instruction to cultivate critical thinking, ethical reasoning, and spiritual awareness in students. By engaging with media literacy through a religious and philosophical lens, educators can foster a deeper understanding of truth, virtue, and moral responsibility in an increasingly complex information landscape. Future studies should further explore the role of faith traditions, ethical reasoning, and philosophical inquiry in media literacy education, reinforcing the connection between digital pedagogy, ideological discourse, and moral development. (shrink)

Direct download(2 more)   Export citation   Bookmark  

Block building is a popular play activity among young children and is also used by psychologists to assess their intelligence. However, little research has attempted to systematically explore the cognitive bases of block-building ability. The current study (N= 66 Chinese preschoolers, 32 boys and 34 girls; mean age = 4.7 years, SD = 0.29, range = 3.4 to 5.2 years) investigated the relationships between six measures of spatial skills (shape naming, shape recognition, shape composition, solid figure naming, cube transformation, and (...) mental rotation, with the former four representing form perception and the latter two representing visualization) and block-building complexity. Correlation results showed that three of the four measures of form perception (shape naming, shape recognition, and shape composition) were significantly and positively correlated with block-building complexity, whereas the two measures of visualization were not. Results from regression models indicated that shape recognition and shape composition, as well as shape-recognition-by-gender interaction, were unique predictors of children’s block-building complexity. These findings provide preliminary evidence for the basic spatial skills underlying children’s block-building complexity and have implications for classroom instructions aimed at improving preschoolers’ block-building complexity. (shrink)

Direct download(2 more)   Export citation   Bookmark  

In response to the big data era trend, statistics has become an indispensable part of mathematics education in junior high school. In this study, a pre-test and a post-test were developed for the six attributes of the data distribution characteristic. This research then used the cognitive diagnosis model to learn about the poorly mastered attributes and to verify whether cognitive diagnosis can be used for targeted intervention to improve students' abilities effectively. One hundred two eighth graders participated in the experiment (...) and were divided into two groups. Among them, the intervention materials read by the experimental group students only contained attributes that they could not grasp well. In contrast, the reading materials of the control group were non-targeted. The results of the study showed the following: The variance and the weighted average were poorly mastered by students in the pre-test; compared with the control group, the average test score of the experimental group was significantly improved; in terms of attributes, the experimental group students' mastery of variance and the weighted average was significantly improved than the pre-test, while the control group's mastery was not. Based on this, some teaching suggestions were put forward. (shrink)

Direct download(2 more)   Export citation   Bookmark   1 citation  

This study aimed to investigate the features of only child status related to physical health, mathematics achievement, and school feelings and expectations from a different perspective. A representative sample of 91,619 Grade 4 students with an average age of 10.4 ± 0.7, among which 28,631 were only children, were assessed. We used propensity score matching and the average treatment effects on the treatment to analyze data. The treatment was the only child of a family. The results indicated that only children (...) have better academic achievement and school feelings, while non-only children have better physical status and anaerobic fitness. In addition, gender and rural vs. urban areas differences were also explored. The adverse situation for rural only boys is emphasized for families, researchers, and governments to focus on. Some suggestions are given under the Two- and Three-Child Policy. (shrink)

Direct download(2 more)   Export citation   Bookmark  

School belonging is of great significance to students' physical and mental health development, especially academic improvement. However, the mechanism of the influence of school belonging on student academic achievement should be further explored, especially reading performance. Based on ecological systems theory and self-determination theory, the present research constructs a multilevel design to examine a moderated mediation model in which school belonging as a level-1 predictor, mastery goal orientation as a level-1 mediator and school disciplinary climate as a level-2 moderator jointly (...) impact reading literacy. Results of the study were based on the questionnaires from 11,364 15-year-olds nested in 332 schools in mainland China that participated in PISA 2018. The cross-sectional analysis indicated that: school belonging had a direct and positive effect on student reading literacy; the relationship between school belonging and reading literacy was prominently mediated by mastery goal orientation; both school disciplinary climate level and strength could negatively moderate the latter half path of “school belonging → mastery goal orientation → reading literacy.” Implications, limitations, and future research directions are discussed. (shrink)

Direct download(2 more)   Export citation   Bookmark  

Direct download(2 more)   Export citation   Bookmark  

This study explored the association between out-of-school physical activity and mathematical achievement in relation to mathematical anxiety, as well as the influence of parents’ support for their children’s physical activity on this association, to examine whether parental support for physical activity affects mental health and academic performance. Data were collected from the responses of 22,509 children in Grade 4 from six provinces across eastern, central, and western China who completed the mathematics component and the physical education and health component of (...) the national-level education quality assessment. A moderated moderated-mediation model was tested using PROCESS v3.4 and SPSS v19.0, with socioeconomic status, school location, and body mass index as controlled variables. Out-of-school physical activity had a positive effect on children’s mathematical achievement, and math anxiety partially mediated this association. The indices of conditional moderated mediation through the parental support of both girls and boys were, respectively, significant, indicating that children can benefit from physical activity, and that increased perceived parental support for physical activity can alleviate their children’s math anxiety and improve their mathematics, regardless of gender. However, gender differences were observed in the influence of parental support for physical activity on anxiety: Although girls’ math anxiety levels were significantly higher, the anxiety levels of girls with high parental support were significantly lower than those of boys with low parental support. (shrink)

Direct download(2 more)   Export citation   Bookmark  

In this paper, according to the perspective of customers and products, by using clustering analysis and association rule technology, this paper proposes a cross-marketing model based on an improved sequential pattern mining algorithm, where an improved algorithm AP is applied. The algorithm can reduce the time cost of constructing a projection database and the influence of the increase of support on the algorithm efficiency. The improved idea is that when the first partition is used to generate the projection database, the (...) number of itemsets in the projection database is sorted from small to large, and when the second partition is used, the sequence patterns are generated directly from the mined sequence patterns, so as to reduce the construction of the database. The experimental results show that this method can quickly mine the effective information in complex data sets, improve the accuracy and efficiency of data mining, and occupy less memory consumption, which has good theoretical value and application value. (shrink)

No categories

Direct download(2 more)   Export citation   Bookmark  

Editor’s: This text is the partial translation of one of the nine chapters from the self-improvement book titled The Art of Being Muddled in Social Conduct and Handling Affairs. This chapter in particular discusses “being muddled” as an efficient, harmony-oriented philosophy of life for navigating more positively through life and for obtaining inner peace of mind. The domains of life covered range from family life to business negotiations, and almost en passant, life issues as serious as suicide. All statements and (...) advice are illustrated with anecdotes, events, and quotes from mostly Chinese but also Japanese and Western philosophy, literature, and history. Sometimes comparisons with phenomena in the natural world are made. The author explains “the art of being/pretending to be muddled” as expressed in virtues such as forgiveness, moderation, deference, tolerance, inner firmness and external flexibility, and wisdom. Ultimately, feigned muddledness is presente... (shrink)

Direct download(3 more)   Export citation   Bookmark  

Previously published studies have reported that 150 min of short-term monocular deprivation temporarily changes perceptual eye dominance. However, the possible mechanisms underlying monocular deprivation-induced perceptual eye dominance plasticity remain unclear. Using a binocular phase and contrast co-measurement task and a multi-pathway contrast-gain control model, we studied the effect of 150 min of monocular pattern deprivation in normal adult subjects. The perceived phase and contrast varied significantly with the interocular contrast ratio, and after MPD, the patched eye became dominant. Most importantly, (...) we focused on the potential mechanisms of the deprivation effect. The data of an averaged subject was best fitted by a model, which assumed a monocular signal enhancement of the PE after the MPD. The present findings might have important implications for investigations of binocular vision in both normal and amblyopic populations. (shrink)

Direct download(2 more)   Export citation   Bookmark  

Background High-frequency oscillation (HFO) represents a promising biomarker of epileptogenicity. However, the significant interindividual differences among patients limit its application in clinical practice. Here, we applied and evaluated an individualized, frequency-based approach of HFO analysis in stereoelectroencephalography (SEEG) data for localizing the epileptogenic zones (EZs). Methods Clinical and SEEG data of 19 patients with drug-resistant focal epilepsy were retrospectively analyzed. The individualized spectral power of all signals recorded by electrode array, i.e., the relative strength of HFO, was computed with a (...) wavelet method for each patient. Subsequently, the clinical value of the relative strength of HFO for identifying the EZ was evaluated. Results Focal increase in the relative strength of HFO in SEEG recordings were identified in all 19 patients. HFOs identified inside the clinically identified seizure onset zone had more spectral power than those identified outside ( p p Conclusion The relative strength of HFO, especially fast ripples, is a promising effective biomarker for identifying the EZ and can lead to a favorable seizure outcome if used to guide epilepsy surgery. (shrink)

Direct download(2 more)   Export citation   Bookmark  

Direct download(2 more)   Export citation   Bookmark  

No categories

Direct download(3 more)   Export citation   Bookmark   2 citations  

The aim of this study was to improve the entrepreneurial performance and sports morality of college teacher-and-student entrepreneurs. Consequently, psychological capital is creatively combined with social and political education to explore college entrepreneurs’ EP and sports morality. First, following a theoretical model implementation, this article proposes several hypotheses. Then, a questionnaire survey was designed, and the data were analyzed. The results show that gender has little impact on EP and sports morality; PsyCap significantly affects the EP of college entrepreneurs at (...) the age of 33–38 years; in terms of educational background, average scores of PsyCap + SPE of bachelors are the highest, followed by masters or above, and finally, the college undergraduate; the average score of PsyCap + SPE of married respondents is 4.0, while that of the unmarried is 3.7; there is a significant difference between college entrepreneurs’ EP under the dimension of the basic enterprise situation; and the average score of the length of entrepreneurship is 9.87, which has the most significant impact on the EP and sports morality, and the significance of sports morality is 0.04. Among them, the most significant impact on EP and sports morality is weekly sports participation, with a score of 9.67. Therefore, PsyCap + SPE plays a positive role in the EP of college entrepreneurs. In contrast, sports morality has little impact on EP. This study provides a reference for the research on the influence of entrepreneurship and sports morality of college entrepreneurs. (shrink)

Direct download(2 more)   Export citation   Bookmark  

This study introduces visual cognition into Lithium-ion battery capacity estimation. The proposed method consists of four steps. First, the acquired charging current or discharge voltage data in each cycle are arranged to form a two-dimensional image. Second, the generated image is decomposed into multiple spatial-frequency channels with a set of orientation subbands by using non-subsampled contourlet transform. NSCT imitates the multichannel characteristic of the human visual system that provides multiresolution, localization, directionality, and shift invariance. Third, several time-domain indicators of the (...) NSCT coefficients are extracted to form an initial high-dimensional feature vector. Similarly, inspired by the HVS manifold sensing characteristic, the Laplacian eigenmap manifold learning method, which is considered to reveal the evolutionary law of battery performance degradation within a low-dimensional intrinsic manifold, is used to further obtain a low-dimensional feature vector. Finally, battery capacity degradation is estimated using the geodesic distance on the manifold between the initial and the most recent features. Verification experiments were conducted using data obtained under different operating and aging conditions. Results suggest that the proposed visual cognition approach provides a highly accurate means of estimating battery capacity and thus offers a promising method derived from the emerging field of cognitive computing. (shrink)

No categories

Direct download(3 more)   Export citation   Bookmark   1 citation  

Direct download(5 more)   Export citation   Bookmark   4 citations  

Direct download(2 more)   Export citation   Bookmark  

The power grid is an important connection between power sources and users, responsible for supplying and distributing electric energy to users. Modern power grids are widely distributed and large in scale, and their security faces new problems and challenges. Information entropy theory is an objective weighting method that compares the information order of each evaluation index to judge the weight value. With the wide application of entropy theory in various disciplines, the subject of introducing entropy into the power system has (...) been gradually concerned. This article aims to study the smart terminal security technology of the power grid perception layer based on information entropy data mining. This article analyzes its related methods and designs a smart terminal for the power grid. On this basis, a data analysis platform is built and a safety plan is designed. The result is that the average absolute error, root mean square error, average absolute percentage error, and mean square error of the platform's power load forecast are 1.58, 1.96, 8.2%, and 3.93, respectively. These error values are within the ideal range, and the data processing ability is strong. The packet loss rate of the adversary's eavesdropping was tested, and the average packet loss rates at locations a, b, c, and d were 1.05, 1.2, 1.81, and 2.2%, respectively. Data packets will be definitely lost, so the platform is highly secure. (shrink)

No categories

Direct download   Export citation   Bookmark  

Direct download(2 more)   Export citation   Bookmark  

_Objective_: Genetic variation, especially polymorphism of the dopamine D4 receptor gene (DRD4), has been linked to deficits in self-regulation and executive functions and to attention deficit hyperactivity disorder (ADHD), and is related to the structural and functional integrity of the default mode network (DMN), the executive control network (ECN) and the sensorimotor network (SMN). The aim of this study was to explore the effects of the 2-repeat allele of the DRD4 gene on brain network connectivity and behaviors in children with (...) ADHD. _Methods_: Using independent component analysis (ICA) and dimension analyses, we examined resting-state functional magnetic resonance imaging (fMRI) data obtained from 52 Asian medicine-naive children with ADHD (33 2-repeat absent and 19 2-repeat present). _Results_: We found that individuals with 2-repeat absent demonstrated increased within-network connectivity in the right precuneus of the DMN, the right middle frontal gyrus (MFG) of the SMN compared with individuals with 2-repeat present. Within the ECN, 2-repeat absent showed decreased within-network connectivity in the left inferior frontal gyrus (IFG) and the left anterior cingulate cortex. A deeper study found that connectivity strength of the left IFG was directly proportional to the Stroop reaction time in 2-repeat absent group, and as well as the right MFG in 2-repeat present group. _Conclusion_: Polymorphisms of the DRD4 gene, specifically 2-repeat allele, had effects on the ECN, the SMN and the DMN, especially in the prefrontal cortex (PFC) circles. ADHD children with DRD4 2-repeat allele have aberrant resting-state within-network connectivity patterns in the left IFG and the right MFG related to dysfunction in inattention symptom. This study provided novel insights into the neural mechanisms underlying the effects of DRD4 2-repeat allele on ADHD. (shrink)

Direct download(2 more)   Export citation   Bookmark   1 citation  

In this work, we investigated a covert communication method in wireless networks, which is realized by multiantenna full-duplex single relay. In the first stage, the source node sends covert messages to the relay, and the relay uses a single antenna to send interference signals to the adversary node to protect the covert information being transmitted. In the second stage, the relay decodes and forwards the covert information received in the first stage; at the same time, the relay uses zero-forcing beamforming (...) to send interference signals to the warden to ensure covert transmission. The detection error rate, transmission outage probability, maximum effective covert rate, and other performance indicators are derived in two stages, and the total performance of the system is derived and analyzed. Then, the performance indicators are verified and analyzed by simulation. Our analysis shows that the maximum effective covert rate of using the characteristics of multiantenna to interfere with Willie in the second stage is taken as the total covert performance of the system, and the transmission interruption probability is significantly less than that of the first stage, so the corresponding maximum effective concealment efficiency will be greater. (shrink)

Direct download(2 more)   Export citation   Bookmark  

Perceived trust is a key factor affecting the behavior to donate online. In order to further explore the factors and influencing mechanisms that affect the success of medical crowdfunding projects, this paper, combined with the Stimulus-Organism-Response theory, introduces the mediating variable of social presence and perceived differences in trust, and constructs a model of online users’ donation behavior to medical crowdfunding projects. We collected 437 valid samples through a questionnaire survey, and processed the data with SPSS and Amos software to (...) test and analyze the theoretical model. The research results showed that project description and user participation have a significant positive effect on social presence; project transparency and patient identity have a significant negative effect on perceived differences in trust; social presence has a positive effect on donation behavior, while the perceived difference in trust has a negative effect; social presence and perceived differences in trust play a mediating role respectively; there is no significant effect of patient status on social presence. This study further expands the application of social presence and perceived differences in trust in medical crowdfunding, and provides a theoretical basis for the success of medical crowdfunding projects. (shrink)

Direct download(2 more)   Export citation   Bookmark  

The network-based cooperative information spreading is a widely existing phenomenon in the real world. For instance, the spreading of disease outbreak news and disease prevention information often coexist and interact with each other on the Internet. Promoting the cooperative spreading of information in network-based systems is a subject of great importance in both theoretical and practical perspectives. However, very limited attention has been paid to this specific research area so far. In this study, we propose an effective approach for identifying (...) the influential latent edges which, if added to the original network, can promote the cooperative susceptible-infected-recovered dynamics. To be specific, we first obtain the probabilities of each nodes being in different node states by the message-passing approach. Then, based on the state probabilities of nodes obtained, we come up with an indicator, which incorporates both the information of network topology and the co-SIR dynamics, to measure the influence of each latent edge in promoting the co-SIR dynamics. Thus, the most influential latent edges can be located after ranking all the latent edges according to their quantified influence. We verify the rationality and superiority of the proposed indicator in identifying the influential latent edges of both synthetic and real-world networks by extensive numerical simulations. This study provides an effective approach to identify the influential latent edges for promoting the network-based co-SIR information spreading model and offers inspirations for further research on intervening the cooperative spreading dynamics from the perspective of performing network structural perturbations. (shrink)

Direct download(2 more)   Export citation   Bookmark  

As the prevalence of self-harm among adolescents in Chinese escalates, finding out the potential risk factors associated with self-harm behaviors has aroused much attention. This study aims to explore the association between parent-child separation and series of self-harm subtypes among Chinese adolescents. We survey a total of 4,928 middle school students aged from 12 to 18 years at school. Parent-child separation was investigated from four dimensions—occurrence of parental separation, separation status, age at first separation and duration of separation. Self-harm series (...) are deemed as five subtypes—highly lethal self-harm, less lethal self-harm with visible tissue damage, self-harm without visible tissue damage, self-harmful behaviors with latent damage and psychological self-harm. Multivariate logistic regression is used to explore the associations between parent-child separation and different subtypes of self-harm among adolescents. Paternal separation is associated with each type of self-harm whilst maternal separation is not correlated with highly lethal self-harm. Except for highly lethal self-harm, the other four subtypes of self-harm demonstrate a relation with both length of paternal separation and maternal separation with aOR ranging from 1.02 to 1.06. Individuals who suffer parental separation prior to the age of three were at a higher risk for four types of less-lethal self-harm. The association of parent-child separation with self-harm deserves our attention, and future research is needed to identify the underlying mechanisms. (shrink)

Direct download(2 more)   Export citation   Bookmark  

Accurate solar irradiance prediction plays an important role in ensuring the security and stability of renewable energy systems. Solar irradiance modeling is usually a time-dependent dynamic model. As a new kind of recurrent neural network, echo state network shows excellent performance in the field of time series prediction. However, the memory length of classical ESN is fixed and finite, which makes it hard to map sufficient features of solar irradiance with long-range dependency. Therefore, a novel deep echo state network with (...) variable memory pattern is proposed in this brief. VMP-DESN consists of multiple connected reservoirs in series, and there exist different types of memory modes in VMP-DESN. To remember more input history information in the states, the time delay links are added in each reservoir and between every two reservoirs. The VMP-DESN is more flexible to deal with different input signals due to its variable memory modes in the reservoir states. Additionally, the effect of different memory patterns on the VMP-DESN performance is discussed in detail, including the antidisturbance ability, memory capacity, and prediction accuracy. Finally, the effectiveness of VMP-DESN is evaluated by predicting the real solar irradiance task. (shrink)

Direct download(2 more)   Export citation   Bookmark  

Hybrid renewable energy system arises regularly in real life. By optimizing the capacity and running status of the microgrid, HRES can decrease the running cost and improve the efficiency. Such an optimization problem is generally a constrained mixed-integer programming problem, which is usually solved by linear programming method. However, as more and more devices are added into MG, the mathematical model of HRES refers to nonlinear, in which the traditional method is incapable to solve. To address this issue, we first (...) proposed the mathematical model of an HRES. Then, a coevolutionary multiobjective optimization algorithm, termed CMOEA-c, is proposed to handle the nonlinear part and the constraints. By considering the constraints and the objective values simultaneously, CMOEA-c can easily jump out of the local optimal solution and obtain satisfactory results. Experimental results show that, compared to other state-of-the-art methods, the proposed algorithm is competitive in solving HRES problems. (shrink)

Direct download(2 more)   Export citation   Bookmark  

The recent advances in assisted reproductive technology, such as hormonal stimulation, IVF, and intracytoplasmic sperm injection (ICSI), have made it possible to circumvent many causes of male and female factor infertility. However, uterine infertility is still considered an ‘‘unconditionally infertile’’ condition. Owing to the continued advances in organ transplantation, microvascular anastomosis techniques, and immunosuppressive medicine, the transplantation of organs is no longer restricted to the ones necessary for continued life. Quality-of-life enhancing types of transplantation, such as uterine transplantation, in recent (...) years, have also entered the clinical arena. This undoubtedly brings new hope to such women, but also creates ethical challenges. Selection of the donor, the impact on the recipient and offspring, as well as challenges to moral and social norms are issues that cannot be ignored. In the present review, the ethical issues of transplantation of the uterus will be discussed in light of recent progress in the procedure. (shrink)

Direct download(4 more)   Export citation   Bookmark  

Direct download(2 more)   Export citation   Bookmark   2 citations  

Direct download(2 more)   Export citation   Bookmark   3 citations  

Direct download(2 more)   Export citation   Bookmark   2 citations  

No categories

Direct download   Export citation   Bookmark  

Direct download(2 more)   Export citation   Bookmark  

Early childhood development intervention has gained considerable achievements in eliminating intergenerational transmission of poverty in rural areas. Paying further attention to rural children’s community inclusion can also promote the sustainable development of the village. However, there is a lack of systematic theoretical constructs on the village inclusion of rural children. In this study, an attempt was made to explore the problem mechanism and solution strategy of community inclusion of rural children using a grounded theory approach of in-depth interviews. Seventeen parents (...) of children in a national-level poverty-stricken county in Inner Mongolia of China were investigated, adopting the strategy of intensity sampling. The results revealed that the content of rural children’s activities demonstrates enhanced participation in the virtual environment and weakened participation in the real community environment. That is, the activities are characterized by more virtualization and individualization. Rural parents and community peers are two major channels for children’s community inclusion, while both the community peer environment and parental community participation show a weakening trend. This may be an important reason for the virtualization and individualization of the children’s psychological development environment. Developmental intervention programs for rural children in poverty-stricken areas should focus on the reconstruction of children’s community peer environment, encourage the community participation of parents, and fully mobilize local-based educational resources. (shrink)

Direct download(2 more)   Export citation   Bookmark  

This article reports on the evolution of breakdance. Given the inclusion of breakdancing in the 2024 Olympic Games in Paris, France, scholars have generated substantial international research related to breakdance teaching in recent years. However, few researchers have focused on the impact of formal formative assessment on breakdance teachers’ teaching and students’ learning. We wish to contribute to the quality of breakdance teaching and learning by identifying the positive impact of recent research on formative assessment on student learning and designing (...) a formal formative assessment task related to breakdance. This article lays out a framework of formal formative assessment tasks and identifies the positive impact of formative assessment on dance education. Although our work is far from perfect, it does provide a general methodological framework for assessing breakdance students’ abilities in formal educational settings. (shrink)

Direct download(2 more)   Export citation   Bookmark  

COVID-19 often manifests with different outcomes in different patients, highlighting the complexity of the host-pathogen interactions involved in manifestations of the disease at the molecular and cellular levels. In this paper, we propose a set of postulates and a framework for systematically understanding complex molecular host-pathogen interaction networks. Specifically, we first propose four host-pathogen interaction (HPI) postulates as the basis for understanding molecular and cellular host-pathogen interactions and their relations to disease outcomes. These four postulates cover the evolutionary dispositions involved (...) in HPIs, the dynamic nature of HPI outcomes, roles that HPI components may occupy leading to such outcomes, and HPI checkpoints that are critical for specific disease outcomes. Based on these postulates, an HPI Postulate and Ontology (HPIPO) framework is proposed to apply interoperable ontologies to systematically model and represent various granular details and knowledge within the scope of the HPI postulates, in a way that will support AI-ready data standardization, sharing, integration, and analysis. As a demonstration, the HPI postulates and the HPIPO framework were applied to study COVID-19 with the Coronavirus Infectious Disease Ontology (CIDO), leading to a novel approach to rational design of drug/vaccine cocktails aimed at interrupting processes occurring at critical host-coronavirus interaction checkpoints. Furthermore, the host-coronavirus protein-protein interactions (PPIs) relevant to COVID-19 were predicted and evaluated based on prior knowledge of curated PPIs and domain-domain interactions, and how such studies can be further explored with the HPI postulates and the HPIPO framework is discussed. (shrink)

Direct download(3 more)   Export citation   Bookmark  

Direct download(2 more)   Export citation   Bookmark   1 citation  

Direct download(2 more)   Export citation   Bookmark  

Direct download   Export citation   Bookmark  

Direct download(2 more)   Export citation   Bookmark  

Direct download(2 more)   Export citation   Bookmark   2 citations  

BackgroundMental stress and imbalance of its two neural stress systems, the autonomic nervous system and the hypothalamic–pituitary–adrenal axis, are associated with chronic prostatitis/chronic pelvic pain syndrome and erectile dysfunction. However, the comprehensive analyses of psychological stress and stress systems are under-investigated, particularly in CP/CPPS patients complicated by lower urinary tract symptoms and ED.Materials and methodsParticipants were 95 patients in CP/CPPS+ED group, 290 patients in CP/CPPS group, 124 patients in ED group and 52 healthy men in control group. The National Institutes (...) of Health Chronic Prostatitis Symptom Index, the International Index of Erectile Function-5 and the International Prostate Symptom Score were used for assessing the disease severity of CP/CPPS, LUTS and ED. Psychometric self-report questionnaires including the Beck Anxiety Inventory, Perceived Stress Scale, Type A Personality Test and Symptom Checklist 90 were completed for distress from physical symptoms. Twenty-five subjects per group were randomly selected for further investigating the changes of the HPA axis and ANS. Saliva samples were taken on 3 consecutive days at 8 specific times with strict reference to time of morning awakening for evaluation of free cortisol. Heart rate variability as marker of the ANS was measured using 24 h electrocardiography, and time-and frequency-domain variables were analyzed.ResultsThe BAI and SCL-90 scores were significantly higher in the CP/CPPS+ED, CP/CPPS and ED groups compared with the control group. The PSS scores of both groups with ED were significantly higher than the control group. Compared with the CP/CPPS group, the differences of PSS, SCL-90 and TAPT scores were statistically significant in CP/CPPS+ED patients. The IPSS scores were shown to have significantly positive correlations with BAI, PSS and SCL-90 in the CP/CPPS patients. However, in all subjects, the IIEF-5 scores were shown to have significantly negative correlations with BAI, PSS, SCL-90 and quality of life score in NIH-CPSI. Cortisol awakening response parameters and diurnal cortisol levels did not significantly vary between the four groups. Time-dependent parameters of HRV also did not differ significantly across groups. In the frequency domain analysis, low frequency was significantly lower in ED patients when compared with CP/CPPS+ED patients and healthy controls, high frequency power was significantly higher in healthy controls compared to patients with ED, CP/CPPS and CP/CPPS+ED, and the CP/CPPS+ED group had significantly higher LF/HF ratio than the control group.ConclusionCP/CPPS and ED patients score exceedingly high on most psychosocial variables. The symptom scores of LUTS and ED positively correlate with the severity of psychological stress. Our findings also suggest that the ANS sympathovagal imbalance is associated with ED and LUTS in CP/CPPS, whereas HPA axis activity is not. (shrink)

Direct download(2 more)   Export citation   Bookmark  

Direct download(4 more)   Export citation   Bookmark   2 citations  

No categories

Direct download(2 more)   Export citation   Bookmark   1 citation  

No categories

Direct download(2 more)   Export citation   Bookmark  

In ancient China, a revered Taoist sage named Zhuangzi told many parables. In Existential Psychology and the Way of the Tao, a selection of these parables will be featured. Following each parable, an eminent existential psychologist will share a personal and scholarly reflection on the meaning and relevance of the parable for psychotherapy and contemporary life. The major tenets of Zhuangzi's philosophy are featured. Taoist concepts of emptiness, stillness, Wu Wei (i.e. intentional non-intentionality), epistemology, dreams and the nature of reality, (...) character building in the midst of pain, meaning and the centrality of relationships, authenticity, self-care, the freedom that can come from one's willingness to confront death, spiritual freedom, and gradations of therapeutic care are topics highlighted in this book. (shrink)

Direct download   Export citation   Bookmark  

Direct download(3 more)   Export citation   Bookmark   1 citation  

No categories

Direct download(2 more)   Export citation   Bookmark  

Direct download   Export citation   Bookmark  

Direct download(3 more)   Export citation   Bookmark  

Direct download(2 more)   Export citation   Bookmark