Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4.M. Hutchinson,Y.Zhang,K. Brown,B. Coats,M. Shridhar,P. Sholar,S. Patel,N. Crysdale,J. Harrison,S. Maier,K. Rice &L. Watkins -2008 -European Journal of Neuroscience 28 (1):20-29.detailsAlthough activated spinal cord glia contribute importantly to neuropathic pain, how nerve injury activates glia remains controversial. It has recently been proposed, on the basis of genetic approaches, that toll-like receptor 4 may be a key receptor for initiating microglial activation following L5 spinal nerve injury. The present studies extend this idea pharmacologically by showing that TLR4 is key for maintaining neuropathic pain following sciatic nerve chronic constriction injury. Established neuropathic pain was reversed by intrathecally delivered TLR4 receptor antagonists derived (...) from lipopolysaccharide. Additionally, -naltrexone, -naloxone, and -naloxone, which we show here to be TLR4 antagonists in vitro on both stably transfected HEK293-TLR4 and microglial cell lines, suppressed neuropathic pain with complete reversal upon chronic infusion. Immunohistochemical analyses of spinal cords following chronic infusion revealed suppression of CCI-induced microglial activation by -naloxone and -naloxone, paralleling reversal of neuropathic pain. Together, these CCI data support the conclusion that neuron-to-glia signaling through TLR4 is important not only for initiating neuropathic pain, as suggested previously, but also for maintaining established neuropathic pain. Furthermore, these studies suggest that the novel TLR4 antagonists -naloxone and -naloxone can each fully reverse established neuropathic pain upon multi-day administration. This finding with -naloxone is of potential clinical relevance. This is because -naloxone is an antagonist that is inactive at the -opioid selective receptors on neurons that produce analgesia. Thus, these data suggest that -opioid antagonists such as -naloxone may be useful clinically to suppress glial activation, yet -opioid agonists suppress pain. (shrink)
Instructed Hand Movements Affect Students’ Learning of an Abstract Concept From Video.IcyZhang,Karen B. Givvin,Jeffrey M. Sipple,Ji Y. Son &James W. Stigler -2021 -Cognitive Science 45 (2):e12940.detailsProducing content-related gestures has been found to impact students’ learning, whether such gestures are spontaneously generated by the learner in the course of problem-solving, or participants are instructed to pose based on experimenter instructions during problem-solving and word learning. Few studies, however, have investigated the effect of (a) performing instructed gestures while learning concepts or (b) producing gestures without there being an implied connection between the gestures and the concepts being learned. The two studies reported here investigate the impact of (...) instructed hand movements on students’ subsequent understanding of a concept. Students were asked to watch an instructional video—focused on the concept of statistical model—three times. Two experimental groups were given a secondary task to perform while watching the video, which involved moving their hands to mimic the placement and orientation of red rectangular bars overlaid on the video. Students were told that the focus of the study was multitasking, and that the instructed hand movements were unrelated to the material being learned. In the content-match group the placement of the hands reinforced the concept being explained, and in the content-mismatch group it did not. A control group was not asked to perform a secondary task. In both studies, findings indicate that students in the content-match group performed better on the posttest, and showed less variation in performance, than did students in the content-mismatch group, with control students falling in between. Instructed hand movement—even when presented as an unrelated, secondary task—can affect students’ learning of a complex concept. (shrink)
A new locus for dominant drusen and macular degeneration maps to chromosome 6q14.M. Kniazeva,E. I. Traboulsi,Z. Yu,S. T. Stefko,M. B. Gorin,Y. Y. Shugart, O'Connell Jr,C. J. Blaschak,G. Cutting,M. Han &K.Zhang -unknowndetailsPURPOSE:To report the localization of a gene causing drusen and macular degeneration in a previously undescribed North American family. METHODS:Genetic mapping studies were performed using linkage analysis in a single family with drusen and atrophic macular degeneration. RESULTS:The clinical manifestations in this family ranged from fine macular drusen in asymptomatic middle-aged individuals to atrophic macular lesions in two children and two elderly patients. We mapped the gene to chromosome 6q14 between markers D6S2258 and D6S1644. CONCLUSIONS:In a family with autosomal dominant (...) drusen and atrophic macular degeneration, the gene maps to a 3.2-cM region on chromosome 6q14. This locus appears to be distinct from, but adjacent to, the loci for cone-rod dystrophy 7 (CORD7) and North Carolina macular dystrophy (MCDR1). Future identification of the gene responsible for the disease in this family will provide a better understanding of macular degeneration. (shrink)
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Should Pediatric Patients Be Prioritized When Rationing Life-Saving Treatments During the COVID-19 Pandemic.Ryan M. Antiel,Farr A. Curlin,Govind Persad,Douglas B. White,CathyZhang,Aaron Glickman,Ezekiel J. Emanuel &John Lantos -2020 -Pediatrics 146 (3):e2020012542.detailsCoronavirus disease 2019 can lead to respiratory failure. Some patients require extracorporeal membrane oxygenation support. During the current pandemic, health care resources in some cities have been overwhelmed, and doctors have faced complex decisions about resource allocation. We present a case in which a pediatric hospital caring for both children and adults seeks to establish guidelines for the use of extracorporeal membrane oxygenation if there are not enough resources to treat every patient. Experts in critical care, end-of-life care, bioethics, and (...) health policy discuss if age should guide rationing decisions. (shrink)
A New Concept of Work Engagement Theory in Cognitive Engagement, Emotional Engagement, and Physical Engagement.Stanley Y. B. Huang,Chien-Hsiang Huang &Tai-Wei Chang -2022 -Frontiers in Psychology 12.detailsThe concept of work engagement has aroused the interest of many scholars. However, there has been limited academic research in examining how authentic leadership can influence WE, which consequently influences organizational citizenship behavior and task performance. In particular, this study divides WE into cognitive engagement, emotional engagement, and physical engagement to fully reflect the engagement theory. This study introduces three dimensions of WE and tests the theoretical model to validate cognitive engagement, emotional engagement, and physical engagement. Empirical testing using a (...) survey of 151 employees of retail travel agencies in Taiwan revealed that the AL can influence cognitive engagement, emotional engagement, and physical engagement, and also OCB and TP. These analysis results can assist vendors to implement OCB and TP through WE and AL. (shrink)
Arity and alternation in second-order logic.J. A. Makowsky &Y. B. Pnueli -1994 -Annals of Pure and Applied Logic 78 (1-3):189-202.detailsWe investigate the expressive power of second-order logic over finite structures, when two limitations are imposed. Let SAA ) be the set of second-order formulas such that the arity of the relation variables is bounded by k and the number of alternations of second-order quantification is bounded by n . We show that this imposes a proper hierarchy on second-order logic, i.e. for every k , n there are problems not definable in AA but definable in AA for some c (...) 1 , d 1 . The method to show this is to introduce the set AUTOSAT of formulas in F which satisfy themselves. We study the complexity of this set for various fragments of second-order loeic. For first-order logic FOL with unbounded alternation of quantifiers AUTOSAT is PSpace complete. For first-order logic FOL n with alternation of quantifiers bounded by n , AUTOSAT is definable in AA . AUTOSAT) is definable in AA for some c 1 , d 1. (shrink)
To help others or not: A moderated mediation model of emotional dissonance.Ling Hu,Stanley Y. B. Huang,Hung-Xin Li &Shih-Chin Lee -2022 -Frontiers in Human Neuroscience 16.detailsThis article proposes a moderated mediation model of emotional dissonance. In the model, emotional leadership negatively affects emotional dissonance, which, in turn, negatively affects helping behavior. Furthermore, the negative effect of emotional dissonance is assumed to be moderated by work-family conflict. Direct effects from both emotional leadership and work-family conflict to helping other behavior are also considered. Previous studies have neglected the mechanism of emotional dissonance, but this paper fills the gap with a moderated mediation model of emotional dissonance. This (...) article not only provides an incremental contribution to the emotional dissonance literature but also suggests means by which companies might enhance employe helping behaviors in order to achieve greater organizational efficiency. (shrink)
Did Augustine Abandon His Doctrine of Jewish Witness in Aduersus Iudaeos?John Y. B. Hood -2019 -Augustinian Studies 50 (2):171-195.detailsAugustine’s doctrine of Jewish witness maintains that, although Christianity has superseded Judaism as the one true religion, it is God’s will that the Jews continue to exist because they preserve and authenticate the Old Testament, divinely-inspired texts which foretold the coming of Jesus. Thus, Christian rulers are obligated to protect the religious liberties of the Jewish people, and the church should focus its missionary efforts on pagans rather than Jews. Current scholarly consensus holds that Augustine adhered consistently to this doctrine (...) from its first iteration in Contra Faustum in 398 until his death in 430. However, this essay argues that, when Augustine spoke his last words on the subject in the Tractatus Aduersus Iudaeos, the doctrine was no longer his primary guide in thinking about how Christians should interact with Jews. In marked contrast to his earlier views, here, Augustine passionately urges Jews to accept Christ and encourages his congregation to try to convert them. This reading of the Tractatus Aduersus Iudaeos calls for a re-examination of the development of Augustine’s teaching, particularly in the context of dramatic changes in imperial policy toward Jews in the 420s. (shrink)
The Essential Aquinas: Writings on Philosophy, Religion, and Society.Saint Thomas,Thomas Aquinas &John Y. B. Hood -2002 - Greenwood Publishing Group. Edited by John Y. B. Hood.detailsProvides a substantial selection and new translation of texts from the full range of Aquinas' writings.
Evaluating the Effectiveness of Digital Content Marketing Under Mixed Reality Training Platform on the Online Purchase Intention.C. H. Li,O. L. K. Chan,Y. T. Chow,XiangyingZhang,P. S. Tong,S. P. Li,H. Y. Ng &K. L. Keung -2022 -Frontiers in Psychology 13.detailsThe purpose of this research is to investigate the effectiveness of Digital Content Marketing on a Mixed Reality training platform environment with the consideration of online purchase intention through social media. E-commerce today encounters several common issues that cause customers to have reservations to purchase online. With the absence of physical contact points, customers often perceive more risks when making purchase decisions. Furthermore, online retailers often find it hard to engage customers and develop long-term relationships. In this research, a Structural (...) Equation Model is proposed to examine the efficacy of DCM from both immediate and long-term OPI. The results examine whether adopting DCM on an MR training platform environment through social media brings positive results in OPI. Empirical research was carried out through online questionnaires collected in 2021 and 2022. A total of 374 questionnaires were qualified for data analysis in this study, conducted with IBM SPSS and AMOS. The results imply that DCM is critical to stimulating both immediate and long-term OPI. The immediate OPI is positively affected by increasing perceived value through MR in DCM. Regarding the long-term OPI, increased customer engagement with DCM under MR environment can cultivate brand trust and significantly affect the long-term OPI. (shrink)
Impact of Empowering Leadership, Innovative Work, and Organizational Learning Readiness on Sustainable Economic Performance: An Empirical Study of Companies in Russia during the COVID-19 Pandemic.B. Faulks,Y. Song,M. Waiganjo,B. Obrenovic &Danijela Godinić -2021 -Sustainability 22 (13).detailsThe COVID-19 pandemic shocked the global economy, with numerous companies suffering losses and shutting down. However, some companies proved to be resilient, being able to sustain their economic performance despite the pandemic. The study aims to explain the sustainable economic performance of companies during the COVID-19 pandemic. The relationships between empowering leadership, innovative work behavior, organizational readiness to change, and sustainable economic performance were assessed. The data were collected via an online questionnaire from January 2021 to March 2021, during the (...) height of the COVID-19 pandemic in Russia. The respondents were Russian companies’ employees holding management positions, competent to objectively assess organizational circumstances during the COVID-19 pandemic. A sample of 337 was used in the analysis. Confirmatory factor analysis (CFA) with maximum likelihood estimation was conducted using SPSS AMOS. The structural model was tested with standardized parameter estimates, standard errors, and p-values calculated. The findings of the study suggest that innovative work behavior and organizational readiness to learn have a direct influence on sustainable economic performance. The findings also suggest that empowering leadership impacts innovative work behavior but not sustainable economic performance. The mediation analysis indicates that innovative work behavior is a mediator between empowering leadership and sustainable economic performance, whereas organizational readiness to learn is not a moderator. The study adds to the leadership and sustainability body of knowledge and contributes to the research on the COVID-19 pandemic in the organizational context. (shrink)
Fragments of Martin's Maximum in generic extensions.Y. Yoshinobu &B. Konig -2004 -Mathematical Logic Quarterly 50 (3):297.detailsWe show that large fragments of MM, e. g. the tree property and stationary reflection, are preserved by strongly -game-closed forcings. PFA can be destroyed by a strongly -game-closed forcing but not by an ω2-closed.
Non-representative Quantum Mechanical Weak Values.B. E. Y. Svensson -2015 -Foundations of Physics 45 (12):1645-1656.detailsThe operational definition of a weak value for a quantum mechanical system involves the limit of the weak measurement strength tending to zero. I study how this limit compares to the situation for the undisturbed system. Under certain conditions, which I investigate, this limit is discontinuous in the sense that it does not merge smoothly to the Hilbert space description of the undisturbed system. Hence, in these discontinuous cases, the weak value does not represent the undisturbed system. As a result, (...) conclusions drawn from such weak values regarding the properties of the studied system cannot be upheld. Examples are given. (shrink)
The Effect of Speech Variability on Tonal Language Speakers’ Second Language Lexical Tone Learning.KaileZhang,Gang Peng,Yonghong Li,James W. Minett &William S.-Y. Wang -2018 -Frontiers in Psychology 9.detailsSpeech variability facilitates non-tonal language speakers’ lexical tone learning. However, it remains unknown whether tonal language speakers can also benefit from speech variability while learning second language (L2) lexical tones. Researchers also reported that the effectiveness of speech variability was only shown on learning new items. Considering that the first language (L1) and L2 probably share similar tonal categories, the present study hypothesizes that speech variability only promotes the tonal language speakers’ acquisition of L2 tones that are different from the (...) tones in their L1. To test this hypothesis, the present study trained native Mandarin (a tonal language) speakers to learn Cantonese tones with either high variability (HV) or low variability (LV) speech materials, and then compared their learning performance. The results partially supported this hypothesis: only Mandarin subjects’ productions of Cantonese low level and mid level tones benefited from the speech variability. They probably relied on the mental representations in L1 to learn the Cantonese tones that had similar Mandarin counterparts. This learning strategy limited the impact of speech variability. Furthermore, the results also revealed a discrepancy between L2 perception and production. The perception improvement may not necessarily lead to an improvement in production. (shrink)
前言:COVID-19所引發的倫理議題再思考: Introduction: Another Moment for Reflection: Ethical Issues in the COVID-19 Pandemic.Ellen Y.Zhang -2022 -International Journal of Chinese and Comparative Philosophy of Medicine 20 (1):1-8.details影響全球的COVID-19已經進入第三年,在疫情時代或後疫情時代的種種爭論中,相關的倫理考量依然是學界關注的議題。本期的論文涉及具體的醫學倫理學問題,包括香港抗疫倫理焦點、ECMO的使用、疫情防控中的 道德兩難、現代科技大數據所引發的對個人隱私的焦慮、疫情處境中的善終和臨終關懷、審視傳統中醫學有關疫情控制的歷史研究、傳統墨家思想對現當下防疫管理的啟示作用。本期的論文的研究方法各有不同,包括哲學的、倫 理學的、實證的、歷史的、及比較的,其宗旨是引發人們對這些問題的反思和探討。.
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