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Aim: To determine the current state of knowledge on nursing and ethics and to assess the knowledge and experience based on the evidence in this regard. Background: Although ethics is at the center of the nursing profession and the ethical issues affecting nurses are given much importance, few studies have focused on professional ethics in nursing. In this respect, ethics has become a concept that contains controversial and ambiguous situations. Design: The Preferred Reporting Items for Systematic Reviews and Meta-analyses guide, (...) a basic search algorithm, was taken. Data sources: Cochrane, PubMed, CINAHL Complete, PsycINFO, and ULAKBIM from 2012 to 2016. Review methods: Following a systematic search strategy, all papers were assessed in relation to inclusion criteria and type of study. When sufficient information was not available in the title and summary of the works, the necessary data were evaluated in full texts. Results: This review was completed with 27 articles meeting the research criteria. The evaluation identified six themes: (1) ethics and nursing, (2) ethical difficulties/ethical dilemmas and nursing, (3) ethical competence and nursing, (4) professional ethics and nursing, (5) ethics, education, and nursing, and (6) ethics in health research. Conclusion: As a result of the review, a synthesis of high evidence-level research relating to nursing ethics was obtained. The emphasis was on the importance of further research and education so that the ethical aspects of nursing can be better understood throughout the studies. Nursing researchers’ level of evidence on ethics and their orientation to high research design will shed light on uncertain and controversial aspects of the subject. Ethical consideration: Since this was a systematic review, no ethical approval was required. There is no conflict of interest in this literature review. (shrink)

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Medical paternalism has long been a common medical practice. However, patient autonomy in healthcare has been recently adopted by doctors and patients alike. This study explored whether doctors and patients in a tertiary care hospital in Saudi Arabia preferred autonomy or paternalism in shared decision‐making. A total of 118 participants (51 patients requiring total knee replacement, owing to stages 3–4 of osteoarthritis, and 67 doctors) from the Eastern province, Saudi Arabia. responded to a 17‐question category‐based questionnaire involving four scales of (...) autonomy. Descriptive statistics and chi‐square test results revealed that in this hospital, patients preferred a paternalistic approach toward their medical care along with a full disclosure of the risks related to surgical procedures. We recommend health education regarding the specific autonomy subscales (doctor knows best, patient should decide, right to non‐participation, and obligatory risk information), and the implementation of protocols that protect patients' rights and enhance personal autonomy. (shrink)

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Chapman and colleagues make a compelling case for reforming the Common Rule to better protect group interests in genomics and data-centric research (Chapman et al. 2025). Drawing on insights from p...

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Two thought experiments are discussed which suggest, first, a geometric interpretation of the concept of a (say, vector) potential (i.e., as a kinematic quantity associated with a transformation between moving frames of reference suitably related to the problem) and, second, that, in a quantum treatment one should extend the notion of the equivalence principle to include not only the equivalence of inertial forces with suitable “real” forces, but also the equivalence of potentials of such inertial forces and the potentials of (...) suitable real forces. The two types of cancellation are physically independent of each other, because of the Aharonov-Bohm effect. Finally, we show that the latter effect itself can be understood “geometrically” as a kinematic effect arising upon the transformation between the two reference frames. (shrink)

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Explaining how stereotypes and norms influence role-identities during reflected appraisal processes, we develop a theory about diverse groups of minority men—the “minority masculinity stress theory”—and apply it to Asian American men. We conceptually integrate hegemonic masculinity, stereotypes, and mental health to examine how Asian American men experience masculinity and how their experiences are uniquely stressful. We analyze elicited text from an open-ended questionnaire to explain two experiences of masculinity-related stress: trying to live up to the masculine ideal and enacting work-related (...) role-identities. Regarding the former, we discuss four illustrations—toughness, body image, restrictive emotionality, and heterosexuality—and two involving the latter—achiever and provider. We found that Asian American men receive stereotypical reflected appraisals that contradict potentially positive self-concepts and emphasize achievement beyond typical standards of hegemonic masculinity. Moreover, Asian American men’s role-identities contradict hegemonic masculinity, resulting in reflected appraisals that predispose them toward stress. (shrink)

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Volume 25, Issue 3, March 2025, Page 7-9.

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Heritable monogenic maladies, the byproduct of single gene mutations, comprise a broad range of over 10,000 inborn afflictions (OMIM® 2023). Some of the more common monogenic disorders in question...

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This article isolates ten prepositions, which constitute the undercurrent paradigm of contemporary discourse of health disease and medicine. Discussion of the interrelationship between those prepositions leads to a systematic refutation of this paradigm. An alternative set is being forwarded. The key notions of the existing paradigm are that health is the natural condition of humankind and that disease is a deviance from that nature. Natural things are harmonious and healthy while human made artifacts are coercive interference with natural balance. It (...) is suggested that the current paradigm is influenced by the world of finances and by instrumental reason. The alternative model suggests that human nature cannot be delineated. Humans fashion their own selves and nature by artificial means, medicine among them. The article discusses the implications of the paradigm adapted in various scholarly and popular debates such as the use of sex hormones for contraception, the care of the elderly, holistic medicine and distributive justice in health care. Medicine is not an isolated or a privileged realm. There is no unique entitlement to health care. It is always part of a broader agenda of social values and institutions. A open view of human societies, values and practices as they are situated within concrete material conditions is the platform required for an integrative and creative discourse of health care. (shrink)

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This essay conceptualizes the intersections between contemporary catastrophes and political life by exploring how narratives of catastrophe mediate discursive and objective processes of catastrophization. It argues for the need to counteract catastrophization, a discursive and objective political phenomenon, by not only re-cognizing how catastrophes impinge on political life but by offering a more critical understanding of this intersection. The essay thus calls for the politicization of catastrophe as a response to the “catastrophization of political life.” Apropos of these concerns, it (...) engages with Habermas in order to explore how his political theory and interventions illustrate important aspects of the intersections between narratives of catastrophe and contemporary political life, say, how discursive catastrophization leads to the misrecognition of objective modalities of catastrophe. Overall, this essay offers an account of how to conceptualize catastrophe and catastrophization in order to articulate the broad contours of a political theory of catastrophe. (shrink)

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The purpose of this article is to analyze the variability of the "Self-made-man" idea in the context of the Christian Middle Ages in its primarily historical and philosophical presentation. Research is based on the historical and philosophical analysis of the medieval philosophy presented foremost by the works of Aurelius Augustine, P. Abelard, Thomas Aquinas, and also by the modern researches of this epoch. Theoretical basis. Historical, comparative, and hermeneutic methods became fundamental for this research. Originality. The conducted analysis allowed to (...) draw a conclusion that, despite the still existing view of the Middle Ages as a kind of an ideological gap in the formation of the self-determination idea, the Christian philosophy of this period not only does not reject but also gives essentially the universal character of the ancient intention to recognize the individual’s right to self-determination and self-government, makes it not only religiously acceptable but also obligatory. Conclusions. Despite to general theocentrism, providentialism and fatalism of Christian medieval philosophy and culture in general, at its epicenter there is a man of a special type, focused on preserving spiritual autonomy and identity in the social dimensions of their existence, and at the same time, on personal responsibility for their own destiny. Such focus became a logical and somewhat unexpected result of the complex interaction of numerous factors of medieval culture, as well as the ideas and intentions inherited from Antiquity. In particular, the idea that a person who does not act freely cannot be morally responsible for what he does, as well as the intentions of the ancient sage to autonomy, autarky, and apoliticism. In the Middle Ages, this intention became essentially universal, as it became a right, even an obligation of every Christian to be free, at least from the worldly, in determining and realizing his own destiny. The gradual compromise recognition that personal salvation is possible only as a result of synergy, i.e. the co-participation of God’s grace and human freedom, legitimizes and strengthens its focus on active personal efforts and personal responsibility for one’s own salvation, in fact for one’s own destiny. All this in historical perspective was found in its radicalized and purified from all sorts of mystical and religious layers of expression in the idea of "Self-made-man". (shrink)

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Special issue: Pre ́cis and Commentaries on Veit’s ‘Animal Consciousness’ Abstract: Facing stress and producing stress responses are crucial aspects of an organism’s life and the evolution of both its species and of the other species in its environment, which are co-evolving with it. Philosophers and biologists emphasize the importance of environmental complexity and how organisms deal with it in evolution of cognitive processes. This article adds to these discussions by highlighting the importance of stress physiology in processes connected to (...) plant cognition. While this article supports the thesis that life means cognizing (i.e., sensing the environment, arranging internal processes according to that perception, and affecting the environment with its actions), it also emphasizes that there are various kinds of organisms. In this regard, plant cognition is not animal cognition. However, given both the variety and continuity in evolutionary processes and the similarities even between the distantly related organisms in the tree of life, I argue that it is usually useful to consider and compare physiological and molecular mechanisms in plants and animals as well as the concepts and research processes in animal and plant science. Although the “pathological complexity” thesis that Veit (2023) presents is fruitful in considering the evolution of consciousness and cognition, I argue that, when thinking of biological processes in relation to cognition, stress can be a helpful concept (maybe even as suitable as pathological complexity) in thinking of organisms’ responses to environmental complexity and their adaptation and acclimation processes. (shrink)

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Frankfurt Okulu felsefe ve sosyolojinin arasında yer alan bir düşünce hareketini oluşturur. Hareketin en tanınmış üyeleri Theodor W. Adorno, Max Horkheimer ve Herbert Marcus’tur. Adorno gibi diğerlerinin de düşünceleri Aydınlanma eleştirisi, estetik, kültür teorisi ve genel olarak çağdaş toplumun değerlendirilmesi gibi oldukça geniş bir alana yayılmaktadır. Karl Marx ve Sigmund Freud Frankfurt Okulu düşünürlerinin düşüncelerinin şekillenmesindeki en önemli iki figürü oluşturmaktadır. Adorno ve Teoloji adlı bu eser, Adorno’nun eserlerinden hareketle teoloji, metafizik ve genel olarak din konusuna taalluk eden konuları ele (...) alıp incelemektedir. (shrink)

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Discussion of a short text on ethics, originally Greek, translated into Arabic and Hebrew, and adopted by some Christians, Muslims and Jews for guiding their lives.

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In many Western European countries, gender equality and sexual tolerance have increasingly become markers of national cultures and European values that face an insistent threat from Muslims. Gender equality and sexual tolerance are increasingly framed in cultural terms and they play an important role in the construction of a social imaginary based on a cultural antagonism between ‘us’ and ‘them’. This article argues that a new ‘culturalized’ social imaginary has been established by turning ‘immigrant workers’ into ‘Muslim immigrants’ over the (...) last three decades. The unending moral panics around Muslim immigrants’ cultural practices such as honor killings, forced marriages, headscarves, female circumcision and homophobia create a sense of imminent threat and force progressive movements to forge unlikely alliances with right-wing groups against the insidious threat. These alliances are not, however, ephemeral mobilizations in defense of ‘common achievements’; the notion of common achievements creates a sense of cultural sameness vis-a-vis Muslims. Thus, what we see is the displacement of the internal frontiers and the creation of a new ‘hegemonic bloc’ around ‘common cultural values’. And this hegemonic displacement creates unresolvable tensions within feminist and queer movements. (shrink)

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INTRODUCTION[|]It can be thought that ethical problems will rise as the population gets older. Issues such as competence and autonomy of the elderly are among the rising ehtical problems. The fact people aged 65 and over are being questioned about their competence, is an ethical problem in Turkey and this issue is discussed in this work. [¤]METHODS[|]Many institutions subject people over 65 to adequacy audit in decision making stage and this is repeated for every new situation. As a result of (...) this, people over 65 have to be examined by a doctor although there isn't a medical condition. This problem has been discussed within the framework of the following questions: 'In what extent is it legitimate to question the adequacy of a person aged over 65? How does a person feel when her/his adequacy is questioned? Can she/he be the same person as she/he feels before? When does being and individual or adequacy of a person disappear? And, who can decide in this issue?' [¤]RESULTS[|]-[¤]DISCUSSION AND CONCLUSION[|]It has been thought that autonomy of people over 65 years is violated partly and being over 65 years is perceieved as an abnormal situation. [¤]. (shrink)

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Responsibility is a central juridical, moral and social concept that calls on individuals to act in ways that are necessary and morally right. It represents a fundamental normative relationship that bridges abstract philosophical ideas with empirical social realities. Despite its everyday importance, the derivation and application of responsibility are complex and often contested. This article explores the meaning and conditions under which responsibility can be justifiably demanded, as well as its practical enforceability. Responsibility is understood as a normative relationship with (...) both moral and legal dimensions, constructed through social interactions. A responsible practice requires intersubjective agreement on the reasons and motives for actions, enabling the formulation and implementation of ethical justifications. (shrink)

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The current study assessed the extent to which the use of referential prosody varies with communicative demand. Speaker–listener dyads completed a referential communication task during which speakers attempted to indicate one of two color swatches (one bright, one dark) to listeners. Speakers' bright sentences were reliably higher pitched than dark sentences for ambiguous (e.g., bright red versus dark red) but not unambiguous (e.g., bright red versus dark purple) trials, suggesting that speakers produced meaningful acoustic cues to brightness when the accompanying (...) linguistic content was underspecified (e.g., “Can you get the red one?”). Listening partners reliably chose the correct corresponding swatch for ambiguous trials when lexical information was insufficient to identify the target, suggesting that listeners recruited prosody to resolve lexical ambiguity. Prosody can thus be conceptualized as a type of vocal gesture that can be recruited to resolve referential ambiguity when there is communicative demand to do so. (shrink)

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Science can (also) be studied as responsible and rational human activity, guided and legitimated by its own normative system: a finite and ordered set of norms and values for agents in a given field of activity. Such norms of inquiry are needed for a rationality requirement of science, which also presupposes a partial agreement on (acceptance of, respect for) these norms between scientists and their social environment. The notions of scientific accountability, autonomy, and freedom of inquiry are elucidated by means (...) of an action-theoretic definition of science and by a certain use of the distinction between internal methodological) and external norms of science. (shrink)

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Recent studies revealed how the reference to Zhuangzi played a determining role in the evolution of Heidegger’s thinking. Among the sources is a work written in 1945 under the title _Country Path Conversations_. The last of these conversations presents strong similarities with another between Confucius and Yan Hui, imagined by Zhuangzi at the beginning of the fourth chapter. Analogies between these two conversations are so numerous that it is surprising that it has not been noticed until now. However, the establishment (...) of this rapprochement is crucial. It might show how deep is the echo that Heidegger acknowledged between his work and the Lao-Zhuang perspective. Moreover, it reveals that this resonance is not limited to the themes of the “path” and the “letting be,” but also concerns the essential problem of evil and the way to face it. (shrink)

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The essential nature of legislative power is to make the laws; that of executive power is to execute those law. The difference between the two is both substantial and significant; it is the difference between the rule of arbitrary power and the rule of law. This paper will seek to trace the genesis of an independent judicial power, in both theory and practice, through an examination of sections of The Constitutions of Clarendon, The Assize of Clarendon, Hobbes’ Leviathan, Locke’s Second (...) Treatise, Montesquieu’s Spirit of the Laws, as well as The Federalist Papers. Moreover, it will seek to establish its executive nature and to explain why it is so often (at least presently) misunderstood to be akin to the legislative power. (shrink)

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Articles on the philosophy of Sri Aurobindo Ghose, 1872-1950, philosopher and writer from India.

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Dinsel değişim, din psikolojisinin kurulduğu dönemden itibaren güncelliğini koruyan konular arasında yer almaktadır. Tarihsel süreçten bugüne kadar olumlu veya olumsuz biçimde neredeyse tüm insanların muhtelif boyutlarda dinsel unsurlar ile temas ediyor oluşu, dinsel değişim konusunu akademik alanda önemli ve güncel tutan hususlardandır. Bu çalışma; inançlı olduğu hâlde dine karşı ilgisiz bir hayat sürdüren Yaşar Alptekin’in neden ve nasıl dindarlaştığı sorusuna cevap aramaktadır. Nitel araştırma tekniklerinden olan durum çalışması desenine bağlı olarak yürütülen bu araştırmada veriler doküman incelemesi ile elde edilmiştir. Bu (...) doğrultuda Yaşar Alptekin’in bizzat kendisinin kaleme aldığı kitaplar ve onunla çeşitli sosyal medya platformlarında yapılan röportajlar, birinci elden kaynaklar olarak kullanılmıştır. Bu anlamda mevcut çalışma, psikobiyografik araştırma geleneği içinde değerlendirilebilir. Toplanan bilgi ve malumatlar, betimsel analiz tekniği ile çözümlenmiştir. Alptekin’in özel yaşamı, siyasi görüşü ve sanatçı yönü gibi konular, çalışmanın kapsamı dışında tutulmuştur. Ayrıca bu çalışmada yer alan bilgi ve malumatlar, araştırmanın yapılmış olduğu tarihe kadarki dokümanlar ile sınırlıdır. Araştırmanın temel sorusuna cevap ararken dinsel değişimin aşamaları, güdüleri, motifleri, çeşitleri, gerçekleşme biçimi ve sonuçları hakkında din psikolojisi literatüründe yer alan kuramsal yaklaşımlardan destek alınmıştır. Bu bağlamda psikanalitik ve varoluşçu yaklaşımlarla birlikte sosyal kimlik kuramından da faydalanılmıştır. Bu noktada öncelikle Alptekin’in çocukluk, gençlik ve yetişkinlik döneminde yaşadığı önemli olaylar ve hayatını etkileyen hadiseler, dinsel değişimi harekete geçiren nedenler kapsamında analize çalışılmıştır. Alptekin’in değişim öncesi ve sonrası kişilik ve kimlik bakımından nasıl bir değişim yaşadığı, bunun kendisiyle ve sosyal çevresi ile ilişkilere nasıl yansıdığı sorusuna odaklanılmıştır. Ulaşılan bulgulara göre Alptekin’in dinsel değişim sürecini harekete geçiren nedenler; “çocukluk dönemini mutsuz geçirmesi”, bu anlamda “sevgisiz ve ilgisiz büyümesi”, “yetişkinlik döneminde yaşadığı anlamsızlık duygusu”, “samimiyet arayışı”, “içerisinde bulunduğu gelişim döneminin etkileri”, “zihinsel tatminsizlik”, “aile içi sorunlar” ve “değişime eşlik eden dinî tecrübeler” şeklinde sıralanabilir. Meydana gelmiş olan dinsel değişim sonucunda Yaşar Alptekin’in kimlik ve dünya görüşü başta olmak üzere giyim tarzından arkadaş çevresine, ilişkilerine yön veren temel belirleyicilerden insanlara bakışına kadar bireysel ve sosyal hayatında köklü değişimler yaşandığı izlenmektedir. Ancak onun, temel kişilik yapısında fark edilebilir bir değişime rastlanmamıştır. Mevcut kişiliği, değişim sonrası kimliği ile bütünleşmiştir. (shrink)

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The recent surge in psychedelic-assisted therapy (PAT) research and anticipated Food and Drug Administration (FDA) approval of MDMA (methylenedioxymethamphetamine) and psilocybin treatments has bro...

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The necessity, method and content of childhood religious education are discussed from various perspectives in our country and around the world. The ‘Gift to the Child’ education method, which is applied in England where different religions live together, is a secular religious education approach with psychological, pedagogical and theological foundations. According to this method, which was developed with different methods from adult religious education and considering educational-scientific inferences, children can learn many information and skills based on religions and can transform (...) this into positive gains in their lives. The ‘Gift to the Child’ method processes concepts such as Allah, prophet, revelation and prayer with values such as responsibility, empathy, tolerance and love. It is distinguished from other religious education practices by aiming to highlight the child’s sense of holiness.This study examines the effect of the ‘Call to Prayer’ section, which is included in the ‘Gift to the Child’ method, one of the childhood religious education approaches, on children’s religious development in the Religious Culture and Moral Knowledge course. The applicability of the ‘Gift to the Child’ method, which aims to obtain educational-scientific inferences by comparing children with religious content, is discussed in terms of the educational process, teacher-student-material dimension and religious education.In examining the applicability of this approach, which evaluates religious development theory and development theories together and can be evaluated in terms of its achievements; After conducting a literature review from relevant sources, the data of the study were collected with the semi-structured interview technique, which is one of the qualitative research methods. The data of the study were collected through teacher interviews conducted with the cross-sectional research method. Semi-structured interviews were conducted with 10 teachers working in secondary schools of official educational institutions affiliated to the Ministry of National Education. During the course, the teachers allowed the students to express their opinions on the subject and did not intervene in their questions and answers. As a result of the findings obtained from the data, it was observed that the use of achievements and materials prepared according to the ‘Gift to the Child’ method in religious education positively affected the religious development of the students. (shrink)

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The study aimed to shed light on the impact of using the digital library in encouraging and developing scientific research from the point of view of graduate students at the College of Business at King Khalid University during the COVID-19 crisis. The descriptive analytical approach was used to achieve the objectives of the study. A questionnaire was used to collect data and information, and the SPSS program was used to analyze the data. The study reached several results, including the fact (...) that the digital library helps detect plagiarism, forgery, copying, and imitation in scientific and technological research and facilitates communication between academic researchers from faculty members and students by logging in. The digital library and the exchange of ideas and information contribute to the development of scientific research. Graduate students use the resources in the digital library to efficiently complete their assignments and scientific research. The use of the digital library contributed to saving time and effort for graduate students. It was recommended that the culture of digital awareness be spread by preparing workshops for graduate students to introduce them to digital libraries and teach them how to use and activate them in the service of scientific research. (shrink)

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While the problem of nihilism is derived from a particular historical and intellectual context in Western philosophy, i.e., the pantheism controversy in modern German philosophy and the ideas of Nietzsche, non-Western thinkers also engaged with it and developed responses to it. In this article, I am interested in analyzing Muhammad Iqbal’s (1877–1938), a leading Muslim thinker (a Sufi) from India, engagement with the problem of nihilism and his response to it from a Sufi perspective. Arguing that the existing literature on (...) Iqbal fails to understand the deeper impact of Nietzsche’s ideas on Iqbal’s philosophy and the dramatic role “the problem of nihilism” played in causing changes in Iqbal’s philosophy, or on Iqbal’s intellectual development, in this article, I analyze how Iqbal’s encounter with the ideas of Nietzsche during his study period in Europe between 1905 and 1908 has introduced him to the problem of nihilism in its Nietzschean form, how this led Iqbal to a nihilistic mood/crisis from 1909 to 1913, and then how he later developed a response to nihilism by reconstructing the Sufi cosmology and by revaluating the Sufi values of the pantheistic/Persian type of Sufism – the outcome of which is found in his philosophical poemAsrar-i-Khudî(1915). (shrink)

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Мета. Автори ставлять за мету дослідити еволюцію парадигм концепту зла в західній філософській та психологічній думці. Теоретичний базис. Дослідження ґрунтується на новітніх методологічних підходах до встановлення взаємозв’язку між філософським, психологічним і теологічним розумінням сутності зла та його проявів. Наукова новизна. Уперше в українській науці здійснено систематизацію еволюції концепту зла у філософському та психологічному розумінні. Висновки. Аналіз основних міфологічних, теологічних, філософських та психологічних концепцій зла дає можливість систематизувати їх у вигляді п’яти головних парадигм. Примордіальною парадигмою можна вважати дуалістичну, яка зберігає свій (...) вплив до нашого часу. Зло розуміється в ній як уособлення природних катастроф, хвороб, людських злочинів і силою, що протистоїть Добру. Антична філософія та християнство намагаються позбавити зло його онтологічного статусу: зло як таке не існує, а є лише відсутністю Добра. На основі такого розуміння формується привативна парадигма, яка панувала в європейській філософсько-теологічній свідомості понад тисячоліття. Вона стала підґрунтям для філософської теодицеї: виправдання всеблагого Бога перед лицем зла, що насправді існує. Але наприкінці ХVІІІ сторіччя ця парадигма поступилася місцем діалектико-романтичній, найбільш яскравими представниками якої є Шеллінг, Гегель та Ніцше. Концепт зла переосмислено й подано як необхідну складову світу, яка разом із добром належить до вищої реальності. Нове розуміння концепт зла отримує в психоаналізі Фройда, Юнга та Фрома: його джерелом визначено підсвідоме людини, а зовнішнім виявом – агресію. Подібне розуміння зла притаманне і багатьом іншим психологічним школам, деякі з них проводили навіть психологічні експерименти щодо первісно злої природи людини. Утім, подібні "експерименти" характерні для соціальних практик тоталітарних режимів, на підставі чого виникає концепція "банальності" зла. Поява ж останньої постмодерністської парадигми розуміння зла пов’язана зі спробою деяких мислителів відкинути всі попередні концепції та повернутися до найдавнішої дуалістичної парадигми. Здавалося б, падіння більшості тоталітарних режимів та очікування "кінця історії" не давали підстави для популяризації цієї парадигми, але події початку 20-х років нашого століття вказують на необхідність її актуалізації. (shrink)

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The growing demand for uterus transplantation (UTx) invites continued philosophical evaluation of the function of UTx (and what constitutes its ‘success’), as well as the recipient eligibility for UTx. Currently, UTx caters to partnered, cisgender women of childbearing age looking to get pregnant and give birth to a biogenetically related child. The medical justification for this—the treatment of uterine infertility—explains the primacy of this practice. However, this dominant conceptualization of UTx does not necessarily capture the diverse needs for which both (...) cis- and transgender women might take interest in UTx that are not strictly procreative, such as bodily integrity and gender identity reasons. In this paper, I argue that non-procreative motivations for uterus acquisition ought to be taken seriously as a matter of non-discrimination and consistency. (shrink)

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Cyclin-dependent kinase 5 has been implicated in Alzheimer's disease pathogenesis. Here, we demonstrate that overexpression of p25, an activator of cdk5, led to increased levels of BACE1 mRNA and protein in vitro and in vivo. A p25/cdk5 responsive region containing multiple sites for signal transducer and activator of transcription was identified in the BACE1 promoter. STAT3 interacts with the BACE1 promoter, and p25-overexpressing mice had elevated levels of pSTAT3 and BACE1, whereas cdk5-deficient mice had reduced levels. Furthermore, mice with a (...) targeted mutation in the STAT3 cdk5 responsive site had lower levels of BACE1. Increased BACE levels in p25 overexpressing mice correlated with enhanced amyloidogenic processing that could be reversed by a cdk5 inhibitor. These data demonstrate a pathway by which p25/cdk5 increases the amyloidogenic processing of APP through STAT3-mediated transcriptional control of BACE1 that could have implications for AD pathogenesis. (shrink)

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L. T. Hobhouse (1864–1929) is most familiar today as a leading theorist of British new liberalism. This article recovers and examines his overlooked commentary on the concept and rhetoric of race, which constituted part of his better-known project of advancing an authoritative account of liberal doctrine. His writings during and after the South African War, I argue, represent a prominent effort to cast liberalism as compatible with both imperial rule and what he called ‘the idea of racial equality’. A properly (...) liberal empire, he asserted, would dissolve the colour line. This article traces the arguments Hobhouse advanced to make this claim, and explores his motivations for doing so. I contend that Hobhouse drew on the idiom of race as a form of exclusionary rhetoric, to delegitimise rival accounts of liberal empire and to cast his own as properly cosmopolitan. This recovery, I suggest, offers payoffs for our understanding of both Hobhouse's political thought and, more broadly, the uses of ‘race’ in twentieth-century liberalism. (shrink)

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As a version of creationism—which claims that fictional charac- ters are created by authors who write characters into existence by penning their names in their works—abstract creationism claims that fictional objects are abstract entities. However, I want to modify the conception of what constitutes a fictional object. In short, I am going to give a defense of abstract creationism that offers answers to the questions, as outlined by Stuart Brock, of ontology, identity, and plenitude by developing a claim that—except for (...) rigidly referring proper names—fictional terms and nonfictional terms are all abstract objects.Working off the debates surrounding abstract creationism, and with a nod to D. M. Armstrong's... (shrink)

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David Friedell has recently discussed the relationship between intrinsic and extrinsic properties of art, specifically in music. Friedell claims that normative social rules dictate who can change the intrinsic or extrinsic properties of a piece of music. I claim that in text-based theater—as a particular art form—the dividing line between intrinsic and extrinsic properties of a play is sometimes tenuous. This tenuousness is due to a play's bifurcated existence as a dramatic text and as many theatrical performances.

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In recent decades, researchers have attempted to prospectively identify individuals at high risk of developing psychosis in the hope of delaying or preventing psychosis onset. These psychosis risk individuals are identified as being in an ‘At-Risk Mental State’ (ARMS) through a standardised psychometric interview. However, disclosure of ARMS status has attracted criticism due to concerns about the risk–benefit ratio of disclosure to patients. Only approximately one quarter of ARMS patients develop psychosis after three years, raising concerns about the unnecessary harm (...) associated with such ‘false-positive’ results. These harms are especially pertinent when identifying psychosis risk individuals due to potential stigma and discrimination in a young clinical population. A dearth of high-quality evidence supporting interventions for ARMS patients raises further doubts about the benefit accompanying an ARMS disclosure. Despite ongoing discussion in the bioethical literature, these concerns over the ethical justification of disclosure to ARMS patients are not directly addressed in clinical guidelines. In this paper, we aim to provide a unified disclosure strategy grounded in principle-based analysis for ARMS clinicians. After considering the ethical values at stake in ARMS disclosure, and their normative significance, we argue that full disclosure of the ARMS label is favoured in the vast majority of clinical situations due to the strong normative significance of enhancing patients' understanding. We then compare our framework with other approaches to ARMS disclosure and outline its limitations. (shrink)

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Kastamonulu şair ve yazar Sofuzâde Mehmet Tevfik Efendi (1874-1960) edebî anlayışını, şiire ve şairliğe dair görüşlerini farklı yönleri ile ortaya koyan şiirler kaleme almıştır. Sofuzâde’nin gazel formunda kaleme alınmış, manzum poetika niteliğindeki bu şiirlerinde, şiirin özelliklerini, şairin vasıflarını ve dini-tasavvufi söylemin temellerini ortaya koyabilme gerekçesi ile bu makale kaleme alınmıştır. Bahsi geçen poetik şiirler müstakil bir biçimde, daha evvel akademik bir çalışmaya konu olmamıştır. 20. yüzyılda klasik şiir geleneği içinde, özellikle dini-tasavvufi ve hikemi tarzın bir temsilcisi olarak Sofuzâde’de varolan fikri (...) ve edebî devamlılığın ya da kırılmanın tezahürlerinin görülebilmesine yönelik gaye konunun seçilmesindeki kuvvetli saiklerdendir. Onun bahsi geçen şiirlerinden bazıları “şiirimin, şairin, sözüm ve sühan” gibi doğrudan şiiri çağrıştıran ya da “öğrensin” gibi şairliği ilan ve ispata yönelik kelimelerle müreddeftir. Bazıları ise farklı rediflerle bezenmiş olsa da mana ve kavramlar itibariyle hep şiirin etrafında dolanır. Sofuzâde’nin şair ile ilgili tanımlamalarına kimi zaman “gerçek şair”i genel manada tasvir ettiği kimi zaman da şair geçinenler/müteşairler ve bunların özelliklerine değindiği beyitlerde rastlanır. Yer yer kendi şiirini ve şairliğini de öven Sofuzâde, böylelikle şair kimdir sorusuna ayrıntılı cevaplar sunar. Sözün ve nazmın nasıl olması gerektiğine, şiirin sadece duygunun değil aynı zamanda şuurun da bir göstergesi olduğuna vurgu yapar. Ona göre şiir, endişenin (düşünce) lafza dökülmüş halidir, zekânın nişanıdır ve şuurun neticesidir. Sofuzâde sadece beş duyu ile sınırlanmış bir şuurdan bahsetmez. Şuurun ruh ve kalple irtibatına vurgu yapar ayrıca sezgiye dayalı irfanî söyleme atıfta bulunur. Onun şiirlerinin başlıca kaynağı Kur’an-ı Kerim’dir. Fatiha suresinden feyiz aldığını dile getiren şairin gayesi hakikati duyurmaktır. Bu bağlamda şiirlerini cihat ehlinin keskin kılıcına benzetir. Cenâb-ı Hakk’ın yardımı ve kalbine doğan sünuhat ile yazdığı şiirleri, bazen düşünce dünyasında anlamın ruhu olur; bazen mazlumların sesini duyurmak için tarihi birer vesika halini alır. Sûfî çehreli bir şair olarak Sofuzâde, “küntü kenzen” rivayeti ile irtibatlı bir biçimde “aşkı” şairlik için en önemli unsur olarak kabul eder çünkü aşk-ı hakikîyi bilen kişi hayatın manasını anlayacaktır. Hayat aslında “hüsn ve aşk”ın farklı hallerinin görünümleridir. Aşk bilgiyi, sezgiyi, irfanı ve marifeti arttırır. Bu nedenle aşktan nasibi olmayan şairlerin taklitten tahkîke ulaşamamış, lafızdan öze inememiş, kafiyenin büyüsü ile söylenmiş şiirlerini eleştirir. Varoluşu şiire, aşkı da bu şiirin mazmununa benzetmesi onun şiirle ilgili düşüncelerinin tasavvufi eksende nasıl şekillendiğine dair dikkat çekici bir unsur olarak belirginleşir. (shrink)

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Journal of Religious Ethics, Volume 49, Issue 4, Page 622-637, December 2021.

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Volume 25, Issue 3, March 2025, Page 151-153.

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Assisted conception can be distinguished from assisted gestation.1 These processes have tended to be grouped together under the generic term assisted reproductive technology in the bioethical literature. According to Chloe Romanis, however, it is worth distinguishing interventions such as surrogacy, uterus transplantation, and potentially artificial placenta technology, as falling under the genus assisted gestative technologies. This is because gestation carries unique ethico-legal implications as compared with conception. The proposed genus of assisted gestative technologies is a helpful first step in the (...) endeavour to distinguish between the different ethico-legal landscapes across various ‘assisted reproductive technologies.’ I am generally in favour of adopting AGT as a term which separates various forms of gestational services from other kinds of reproductive technologies. Yet, if assisted gestative technologies can be considered a genus of assisted reproductive technologies, we might consider surrogacy, UTx, and artificial placenta technology their individual species. Between these various species of AGTs, I would argue, there remains enough ethico-legal diversity to warrant independent discussion about the descriptive and normative functions of each AGT and the relationship between gestation, genetic relatedness and legal/moral parenthood. Chloe Romanis claims that legal and social issues about attribution of parenthood and the importance that might be placed on information about gestational origins affect all forms of AGTs.1 I take it ethical ambiguities arise because the relationship between who gestates, genetic relatedness to the prospective child, and claims to legal/moral parental responsibility can be disrupted or made ambivalent with the involvement of third-party support. For many of those who do not require reproductive assistance, the gestational labour, genetic relatedness and parental responsibility would traditionally …. (shrink)

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В статті досліджуються механізми виникнення концептосфери Інтернету «розумних» речей. Представлено розуміння процесів трансферу з ментального плану людини у простір культури концептів. Дослідження вказує на важливість еволюції ментального плану людини для процесів трансформації когнітивно перетворювальної практики людини. Такий феномен техніки, як ІРР, сформував нове ментальне середовище – концептосферу «ІРР», яка має важливе значення для формування ментального плану людини. Концептосфера «ІРР» має вплив у всіх сферах діяльності людини: науці, техніці, культурі, медицині, економіці, побуті тощо. Концептосфера «ІРР», як і сама техносфера ІРР, характеризується (...) аутопоезисом та автономністю. (shrink)

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Let ≤r and ≤sbe two binary relations on 2ℕ which are meant as reducibilities. Let both relations be closed under finite variation and consider the uniform distribution on 2ℕ, which is obtained by choosing elements of 2ℕ by independent tosses of a fair coin.Then we might ask for the probability that the lower ≤r-cone of a randomly chosen set X, that is, the class of all sets A with A ≤rX, differs from the lower ≤s-cone of X. By c osure (...) under finite variation, the Kolmogorov 0-1 aw yields immediately that this probability is either 0 or 1; in case it is 1, the relations are said to be separable by random oracles.Again by closure under finite variation, for every given set A, the probability that a randomly chosen set X is in the upper ≤r-cone of A is either 0 or 1; let Almostr be the class of sets for which the upper ≤r-cone has measure 1. In the following, results about separations by random oracles and about Almost classes are obtained in the context of generalized reducibilities, that is, for binary relations on 2ℕ which can be defined by a countable set of total continuous functionals on 2ℕ in the same way as the usual resource-bounded reducibilities are defined by an enumeration of appropriate oracle Turing machines. The concept of generalized reducibility comprises a natura resource-bounded reducibilities, but is more general; in particular, it does not involve any kind of specific machine model or even effectivity. The results on generalized reducibilities yield corollaries about specific resource-bounded reducibilities, including several results which have been shown previously in the setting of time or space bounded Turing machine computations. (shrink)

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