The Y chromosome as a target for acquired and amplified genetic material in evolution.Vladimir A. Gvozdev,Galina L. Kogan &Lev A. Usakin -2005 -Bioessays 27 (12):1256-1262.detailsThe special properties of the Y chromosome stem form the fact that it is a non‐recombining degenerate derivative of the X chromosome. The absence of homologous recombination between the X and the Y chromosome leads to gradual degeneration of various Y chromosome genes on an evolutionary timescale. The absence of recombination, however, also favors the accumulation of transposable elements on the Y chromosome during its evolution, as seen with both Drosophila and mammalian Y chromosomes. Alongside these processes, the acquisition and (...) amplification of autosomal male benefit genes occur. This review will focus on recent studies that reveal the autosome‐acquired genes on the Y chromosome of both Drosophila and humans. The evolution of the acquired and amplified genes on the Y chromosome is also discussed. Molecular and comparative analyses of Y‐linked repeats in the Drosophila melanogaster genome demonstrate that there was a period of their degeneration followed by a period of their integration into RNAi silencing, which was beneficial for male fertility. Finally, the function of non‐coding RNA produced by amplified Y chromosome genetic elements will be discussed. BioEssays 27:1256–1262, 2005. © 2005 Wiley Periodicals, Inc. (shrink)
On sharing a pie: Modeling costly prosocial behavior.Vladimir A. Lefebvre -2004 -Behavioral and Brain Sciences 27 (4):565-566.detailsIn this comment, I describe how the processes of free giving can be simulated with the help of the Reflexive Intentional Model of the Subject (RIMS). This simulation demonstrates that there are two essential factors affecting the size of a share given to others: limits accepted by the society as “normal,” and the individual's subjective estimation of a mean share donated by other members of the society.
Oncogenic microRNAs (OncomiRs) as a new class of cancer biomarkers.Vladimir A. Krutovskikh &Zdenko Herceg -2010 -Bioessays 32 (10):894-904.detailsSmall non‐coding RNAs (microRNAs or miRs) represent one of the most fertile areas of cancer research and recent advances in the field have prompted us to reconsider the traditional concept of cancer. Some miRs exert negative control over the expression of numerous oncoproteins in normal cells and consequently their deregulation is believed to be an important mechanism underlying cancer development and progression. Owing to their distinct patterns of expression associated with cancer type, remarkable stability and presence in blood and other (...) body fluids, miRs are considered to be highly promising cancer biomarkers. The identification of “miR signatures” associating cancer cell phenotypes with disease outcome and specific risk factor exposures will undoubtedly open new avenues for early diagnosis and therapy of cancer, as well as for the development of novel strategies for cancer prevention. (shrink)
Strict embedding of the elementary ontology into the monadic second-order calculus of predicates admitting the empty individual domain.Vladimir A. Smirnov -1987 -Studia Logica 46 (1):1 - 15.detailsThere is given the proof of strict embedding of Leniewski's elementary ontology into monadic second-order calculus of predicates providing a formalization of the class of all formulas valid in all domains (including the empty one). The elementary ontology with the axiom S (S S) is strictly embeddable into monadic second-order calculus of predicates which provides a formalization of the classes of all formulas valid in all non-empty domains.
Cosmic intelligence and Black holes.Vladimir A. Lefebvre &Yuri N. Efremov -2008 -World Futures 64 (8):563 – 576.detailsWe propose that black holes may serve as a physical substratum for intelligent beings, based on(1) The descriptions of brain and psyche are complementary to each other, as internal and external observers of a black hole in the Susskind-t'Hooft's schema.(2) There is an aspect of the inner structure of a black hole that is isomorphic to the structure of the human subjective domain in the psychological model of reflexion.(3) Both black holes and the brain-psyche system have a facet that can (...) be represented using thermodynamic concepts.(4) Both lend themselves to a holographic description. (shrink)
Voluntary and Involuntary Attention in Bistable Visual Perception: A MEG Study.Parth Chholak,Vladimir A. Maksimenko,Alexander E. Hramov &Alexander N. Pisarchik -2020 -Frontiers in Human Neuroscience 14.detailsIn this study, voluntary and involuntary visual attention focused on different interpretations of a bistable image, were investigated using magnetoencephalography. A Necker cube with sinusoidally modulated pixels' intensity in the front and rear faces with frequencies 6.67 Hz and 8.57 Hz, respectively, was presented to 12 healthy volunteers, who interpreted the cube as either left- or right-oriented. The tags of these frequencies and their second harmonics were identified in the average Fourier spectra of the MEG data recorded from the visual (...) cortex. In the first part of the experiment, the subjects were asked to voluntarily control their attention by interpreting the cube orientation as either being on the left or right. Accordingly, we observed the dominance of the corresponding spectral component, and voluntary attention performance was measured. In the second part of the experiment, the subjects were asked to focus their gaze on a red marker at the center of the cube image without putting forth effort in its interpretation. The alternation of the dominant spectral energies at the second harmonics of the stimulation frequencies was treated as changes in the cube orientation. Based on the results of the first experimental stage and using a wavelet analysis, we developed a method which allowed us to identify the currently perceived cube orientation. Finally, we characterized involuntary attention using the distribution of dominance times when focusing attention on one of the cube orientations, which was related to voluntary attention performance and brain noise. In particular, we confirmed our hypothesis that higher attention performance is associated with stronger brain noise. (shrink)
Andrey Smirnov: The Logic of Sense as a Logic of Culture.Vladimir A. Konev -2021 -Russian Studies in Philosophy 58 (6):439-456.detailsThis article analyzes the philosophical views of the Russian philosopher Andrey V. Smirnov. Smirnov has advanced and substantiated the idea that there exist at least two distinct ways of linking th...
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Dynamic Approximation of Self-Referential Sentences.Vladimir A. Stepanov -2022 -Studia Humana 11 (3-4):25-29.detailsNon-classical logic via approximation of self-referential sentences by dynamical systems are consistently presented. The new 6-valued truth values (here A=Liar, V=TruthTeller) are presented as a function of the classical truth values xi ∈ {0,1}, which resulted in a philosophical standpoint known as Suszko’s Thesis. Three-valued truth tables were created corresponding to Priest’s tables of the same name. In the process of constructing 4-valued truth tables, two more new truth values (va, av) were revealed that do not coincide with the four (...) original ones. Therefore, the closed tables turned out to be 6-valued. Prof Dunn’s 4-valued truth tables are compared with our 4-valued truth tables. De Morgan’s laws are confirmed by six-valued truth tables. Constructed 3-, 4- and 6-valued lattices obeying De Morgan’s laws. (shrink)
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The Problematic Area of Philosophical Discourses on the Application of Artificial Intelligence Systems in Society.Vladimir A. Tsvyk,Irina V. Tsvyk &Tatiana P. Pavlova -2023 -RUDN Journal of Philosophy 27 (4):928-939.detailsThe study relevance lies in understanding strategic objectives' content concerning intelligent technologies’ application. The development and application of artificial intelligence in various branches of human activity carry the potential for global changes in society, which, in methodological terms, increases the relevance of considering these problems. The study of ethical problems of artificial intelligence in the concept of sustainable development of society is connected with the dynamic development of innovative artificial intelligence (AI) technologies, which are considered a process of becoming a (...) new technosubject in the context of neuroscience development. The article emphasizes that the development of artificial intelligence acts as an innovative form of technology development when a new kind of human-machine technosubject is formed. The authors identify social problems of artificial intelligence application as the digitalization of life becomes a global anthropological challenge. Innovations of artificial intelligence are directly related to a number of ethical problems, as they contribute not only to the sustainable development of society but also cause dehumanization of relations between people and society. Based on the analysis of qualitative changes in scientific and technological research, using human-machine devices is becoming inevitable. Humankind must develop ethical guidelines for the application of AI systems. (shrink)
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Эвристический Потенциал Метафизики.Vladimir A. Yakovlev -2008 -Proceedings of the Xxii World Congress of Philosophy 15:337-342.detailsThe new world outlook paradigm of creativity correlates with the fundamental principles of metaphysics and modern natural science. The essential programs of development of science have been formed in Antiquity as the metaphysical principles. For example – principle of continuity VS principle of discreteness of matter;movement as God’s first impulse VS movement as natural attribute of matter. In the field of metaphysics were elaborated the very impotent concepts of modern science – matter, movement, force, atom, corpuscle, energy and others (M. (...) Wartofsky, J. Agassi). Nowadays philosophers and scientists discuss such metaphysical principles as so called antropic principle (S. Hawking, B. Carter); the deep expediency and harmony of physical laws (I. Rosental, Y. Linnick); the principle of synergy and self – organization of nature (I. Prigojin, H. Haken). All these principles may be united in the new metaphysical idea of informational matrix of Universe. (shrink)
Sacredness in an experimental chamber.Vladimir A. Lefebvre -2006 -Behavioral and Brain Sciences 29 (2):189-190.detailsI focus on the problem of whether a specific biologic basis exists for reinforcing the power of money. I argue in favor of its existence based on a new interpretation of data obtained in experiments with pigeons and rats in an experimental chamber. The experiments demonstrated that in the animals' behavior we can observe some features that had been considered pertinent to human beings only, such as making certain sources of utility “sacred.” (Published Online April 5 2006).
Characteristics of structurally finite classes of order-preserving three-valued logic maps.Anton A.Esin -forthcoming -Logic Journal of the IGPL.detailsThis paper investigates structural properties of monotone function classes within the framework of three-valued logic (3VL), aiming to characterize dependencies and constraints that ensure structural finiteness and order-preserving properties. This research delves into characteristics of structurally finite classes of order-preserving 3VL map. Monotonicity plays a critical role in understanding functional behaviour, which is essential for structuring closed logical operations within $ P_{k} $. We define $ F $ as a closed class in $ P_{k} $, consisting only of mappings that (...) comply with specified operations and are strictly confined to $ P_{k} $. The notation $ F(n) $ represents the subset of mappings in $ F $ dependent on $ n $ variables, highlighting the limited scope of inputs and their respective outputs. Further analysis through $ CR(F) $ facilitates the identification of precursor subclasses within $ F $, which have not yet achieved closure under all necessary operations—a pivotal step in constructing intermediate mapping classes. Within the framework of 3VL, the study examines order-preserving maps $ f_{D}, f_{K}, f_{M^{(2)}}, f_{DM^{(2)}}, f_{KM^{(2)}} $, deliberately excluding the sets $ D, K, M^{(2)} $, where $ DM^{(2)} $ is defined as $ D \cap M^{(2)} $ and $ KM^{(2)} $ as $ K \cap M^{(2)} $. The lattice framework in $ P_{k}(1) $ for $ k = 3 $ systematically organizes these mapping classes based on their completeness properties, with particular emphasis on classes such as $ M $, which is characterized as a comprehensive set governed by the operations of maximum and minimum. Our theorems establish structural finiteness for classes of unary order-preserving maps, emphasizing their two-variable dependency in class construction. This study extends existing findings on single-variable monotonic functions within 3VL by integrating criteria of linear order. Key results include the classification of mapping classes $ F \subseteq M $ containing $ M^{(1)}_{3} $, categorized into distinct groups: $ M^{(1)}_{3}, KM^{(2)}, DM^{(2)}, M^{(2)}, K, D, M $. Inclusion relations are visualized diagrammatically, showing the hierarchical structure of these monotone classes, ultimately validating the structural finiteness of classes incorporating all unary order-preserving maps within the broader context of 3VL. (shrink)
The Natural Histroy of Religion & Dialoguies Concerning Natural Religion.A. Wayne Colver &JohnVladimir Price (eds.) -1976 - Oxford University Press.detailsA scholarly edition of the writings of David Hume. The edition presents an authoritative text, together with an introduction, commentary notes, and scholarly apparatus.
Kronos Philosophical Journal, vol.V/2016.Vladimir Varava,Natalia Rostova,Piotr Nowak,Janusz Dobieszewski,Fedor Girenok,Marina Savel'eva,Anastasia Gacheva,Irena Księżopolska,Carl A. P. Ruck,John Uebersax,Peter Warnek,Edward P. Butler,Apostolos L. Pierris,Jeff Love,Svetozar Minkov,Ivan Dimitrijević,Wawrzyniec Rymkiewicz,Grzegorz Czemiel &David Kretz -unknowndetailsThe annual Kronos Philosophical Journal was established in Warsaw in 2012. The papers presented in the annual might be of interest to the readers from outside Poland, allowing them to familiarize themselves with the dynamic thought of contemporary Polish authors, as well as entirely new topics, rarely discussed by English speaking authors. Volume V/2016 comprises articles problematizing Russian phlosophy and literature as well as Ancient Greek philosophy and culture.
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Paneth cells: Maintaining dynamic microbiome‐host homeostasis, protecting against inflammation and cancer.Vladimir N. Nikolenko,Marine V. Oganesyan,Maria V. Sankova,Kirill V. Bulygin,Andzhela D. Vovkogon,Negoriya A. Rizaeva &Mikhail Y. Sinelnikov -2021 -Bioessays 43 (3):2000180.detailsThe human intestines are constantly under the influence of numerous pathological factors: enteropathogenic microorganisms, food antigens, physico‐chemical stress associated with digestion and bacterial metabolism, therefore it must be provided with a system of protection against adverse impact. Recent studies have shown that Paneth cells play a crucial role in maintaining homeostasis of the small intestines. Paneth cells perform many vital functions aimed at maintaining a homeostatic balance between normal microbiota, infectious pathogens and the human body, regulate the qualitative composition and (...) number of intestinal microorganisms, prevent the introduction of potentially pathogenic species, and protect stem cells from damage. Paneth cells take part in adaptive and protective‐inflammatory reactions. Paneth cells maintain dynamic balance between microbial populations, and the macroorganism, preventing the development of intestinal infections and cancer. They play a crucial role in gastrointestinal homeostasis and may be key factors in the etiopathological progression of intestinal diseases. (shrink)