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Background. Research on the aryl hydrocarbon receptor (AHR) has largely focused on variations in toxic outcomes resulting from its activation by halogenated aromatic hydrocarbons. But the AHR also plays key roles in regulating pathways critical for development, and after decades of research the mechanisms underlying physiological regulation by the AHR remain poorly characterized. Previous studies identified several core genes that respond to xenobiotic AHR ligands across a broad range of species and tissues. However, only limited inferences have been made regarding (...) its role in regulating constitutive gene activity, i.e. in the absence of exogenous ligands. To address this, we profiled transcriptomic variations between AHR-active and AHR-less-active animals in the absence of an exogenous agonist across five tissues, three of which came from rats (hypothalamus, white adipose and liver) and two of which came from mice (kidney and liver). Because AHR status alone has been shown sufficient to alter transcriptomic responses, we reason that by contrasting profiles amongst AHR-variant animals, we may elucidate effects of the AHR on constitutive mRNA abundances. Results. We found significantly more overlap in constitutive mRNA abundances amongst tissues within the same species than from tissues between species and identified 13 genes (Agt, Car3, Creg1, Ctsc, E2f6, Enpp1, Gatm, Gstm4, Kcnj8, Me1, Pdk1, Slc35a3, and Sqrdl) that are affected by AHR-status in four of five tissues. One gene, Creg1, was significantly up-regulated in all AHR-less-active animals. We also find greater overlap between tissues at the pathway level than at the gene level, suggesting coherency to the AHR signalling response within these processes. Analysis of regulatory motifs suggests that the AHR mostly mediates transcriptional regulation via direct binding to response elements. Conclusions. These findings, though preliminary, present a platform for further evaluating the role of the AHR in regulation of constitutive mRNA levels and physiologic function. (shrink)

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The prevalence of ethics training in organizations rose from 50% in 2003 to 76% in 2011 (Ethics Resource Center 2012). This paper reviews the current state of ethics training in organizations and proposes a new conceptual model for designing effective ethics training programs based on Rest’s (1986) model of ethical decision-making. We argue that it is not the content of ethics training that fails to produce ethical behavior; it is the method by which ethics training is delivered. Most organizations utilize (...) training methods designed to disseminate information or facilitate ethical dilemma recognition. Few organizations utilize methods that allow for trainees to actually practice making an ethical decision. We argue that a comprehensive approach to ethics training should be used, so trainees may practice all aspects of making an ethical decision. This practice should then enhance transfer of ethics training to the job. We conclude with suggestions for how research could be conducted to empirically support these arguments and inform ethics training method choices. (shrink)

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This book examines the intricate web linking water science and society using diverse philosophical lenses. Highlighting the tensions within the threads of this web, we spotlight major conceptual tightropes that water researchers tread daily. To effectively navigate these delicate threads, a 'healthy' tension in the encompassing web is necessary. Drawing inspiration from Freud's examination of tensions in "Society and Its Discontents," we illuminate the tension-filled paradoxes inherent to water science, emphasizing the challenges in keeping these paradoxical threads taut enough to (...) ensure a navigable and sustainable bond with society. Central to our narrative is the escalating societal urge to quantify and 'manage' water—something interwoven throughout every environmental layer, including the fabric of our being. An excessive focus on management may alienate users from their water realities, jeopardizing the vital threads that sustainability tether water science and society. Consequently, this book explores compelling and inescapable tensions that resist tidy universal resolution, such as: the language of water science, including its mathematical reductions (i.e., models); the effect of water's commodification on its science; hydrology’s intersection with colonialism; and other concerns that reveal distortions in our hydrology. We aim to aid water professionals in recognizing and fine-tuning the paradoxes intrinsic to their work. To underscore the interwoven complexity of contemporary hydrology, "Hydrology and Its Discontents" guides readers into the tempestuous depths of water research, all the while urging a recalibration of perspectives and motivations. (shrink)

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The article of Finlay et al. is an excellent example of identifying constraints in the development of the brain, and their implications on brain architecture in evolution. Here we further illustrate the importance of constraints by presenting a few examples of how a small number of biophysical mechanisms or even a single life history parameter can have an enormous impact on brain evolution.

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Your perspective on life can be your power or your prison. It can serve your anxiety, your stress, and your depression, or it can support your peace, your courage, and your growth.Trent Shelton, one of the most groundbreaking and dynamic teachers of our time, wants to help you chart your path to a new perspective. Protect Your Peace offers tools to reshape your mindset and redefine the meaning you find in your life-tools that he knows can work for (...) you, because he has used them himself to transform his own life. In these pages,Trent outlines nine essential principles to help you: · Protect your energy from the things that drain it · Protect your mind from the things that distract you · Protect your soul from the things that don't fulfill you You'll learn simple strategies for setting clear boundaries, disconnecting from negativity, honing your vision and your focus, and bringing your life into alignment with your true power and purpose-withTrent as your straight-talking, profoundly inspiring guide who's with you every step of the way.Trent lets you know in no uncertain terms that there is a war on-a war for your worth. The toughest battle in it is the one you're fighting within yourself. And Protect Your Peace gives you a road map to victory. (shrink)

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In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Philosophy 39.1 (2001) 49-75 [Access article in PDF] Sensible Ends:Latent Teleology in Descartes' Account of Sensation AlisonSimmons One of Descartes' hallmark contributions to natural philosophy is his denunciation of teleology. It is puzzling, then, to find him arguing in Meditation VI that human beings have sensations in order to preserve the union of mind and body (AT VII 83). 1 This appears (...) to be just the sort of teleological explanation that he proscribes. Descartes' Anglo-American commentators have had little to say about the teleological overtones of his claims about sensation. His French commentators acknowledge these overtones, but seem largely untroubled by them. 2 It is worth pausing to be troubled, for a closer analysis reveals that Descartes' famous proscription against teleology is not as simple as it is generally thought to be. In the first half of this essay, I argue that Descartes advocates a genuinely teleological conception of the senses. My aim is not to charge Descartes with employing illicit teleology, but to argue that there is a place for teleology even in his revisionist natural philosophy. Accordingly, in the second half of this essay, I argue that Descartes' assault on teleological explanation is [End Page 49] not a sweeping assault on finality, but a more directed attack on particular uses of ends in natural philosophy. Descartes' assault leaves standing a form of teleological explanation that proves crucial to his own treatment of sensation. 1. Descartes' Rejection of Teleological Explanation at a Glance A teleological explanation is one that purports to account for something in terms of its ends or its function relative to the ends of the system of which it is a part. Aristotle's physics provides many classic examples: plants produce leaves for the protection of their fruit; spiders spin webs in order to catch food; animals grow sharp front teeth and dull back teeth in order to facilitate biting and chewing respectively; eyes are for seeing. According to Aristotle, all natural phenomena are directed toward ends and no explanation is complete without a teleological component that specifies the end for the sake of which the phenomenon occurs. Indeed ends take explanatory priorityover other causes: "Both causes [the end and the matter] must be stated by the student of nature, but especially the end; for that is the cause of the matter, not vice versa." 3 And: [T]he causes concerned in natural generation are, as we see, more than one. There is the cause for the sake of which [the end], and the cause whence the beginning of motion comes [the efficient cause]. Now we must decide which of these two causes comes first, which second. Plainly, however, that cause is the first which we call that for the sake of which. For this is the account of the thing, and the account forms the starting-point.4In other words, Aristotle argues that natural substances have the matter they do, have the parts or organs they do, are organized as they are and act as they do for the sake of their ends. To explain why things are as they are, the natural philosopher must therefore explain the ways in which they contribute to ends.Among the late scholastic Aristotelians familiar to Descartes there is considerable debate concerning the causal efficacy of ends. Genuine final causation, in which something is said to be acted on by an end, is limited to the intentional behavior of rational agents who consciously recognize their ends: only something that recognizes an end can be "moved" by one. Even here the sort of causation involved is peculiar: a rational agent is "moved" by an end insofar as the end induces a "metaphorical motion" toward (or desire for) the end in the agent's will. 5 While these scholastic Aristotelians resist attributing final causation [End Page 50] to non-rational creatures, they nevertheless persist in attributing ends to them. When Toletus, Rubio, the Coimbrans and Suarez take up the question whether nature acts propter finem, each answers it affirmatively: natural... (shrink)

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If knowing requires believing on the basis of evidence that entails what’s believed, we have hardly any knowledge at all. Hence the near-universal acceptance of fallibilism in epistemology: if it's true that "we are all fallibilists now" (Siegel 1997: 164), that's because denying that one can know on the basis of non-entailing evidence1is, it seems, not an option if we're to preserve the very strong appearance that we do know many things (Cohen 1988: 91). Hence the significance of concessive knowledge (...) attributions (CKAs) (Rysiew 2001)—i.e., sentences of the form 'S knows that p, but it's possible that q' (where q entails not-p). To many, utterances of such sentences sound very odd indeed. According to David Lewis (1996: 550), however, such sentences are merely "overt, explicit" statements of fallibilism; if so, their seeming incoherence suggests that, contrary to our everyday epistemic pretensions, "knowledge must be by definition infallible" after all (ibid.: 549). -/- Recently Jason Stanley (2005) has defended fallibilism against the Lewisian worry that overtly fallibilistic speech is incoherent. According yo Stanley, CKAs are not just odd-sounding: in most cases, they are simply false. But this doesn't impugn fallibilism. Insofar as the odd-sounding utterances Lewis cites state the fallibilist idea, the latter portion thereof ('S cannot eliminate a certain possibility in which not-p', e.g.) expresses the idea that the subject's evidence doesn't entail what's (allegedly) known (hence, the negation of any contrary propositions). According to Stanley, however, this is not the best reading of the possibility clauses CKAs contain. On the correct account of the latter, while the sentences Lewis cites are almost always self-contradictory, they don't capture the fallibilist idea after all. Here, we argue that the sentences in question do express precisely the fallibilist idea, but argue that Lewis has nonetheless failed to raise a problem for the latter. In addition, we respond to worries that the resulting view of the semantics of epistemic possibility statements has certain unacceptable consequences. (shrink)

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Human beings pose a problem for Descartes’ metaphysics. They seem to be more than a mere sum of their mental and bodily parts; human beings, Descartes insists, are unions of mind and body. But what does that union amount to? In the first, negative, part of this paper I argue that, by Descartes’ own lights, there is no way for us to answer this question if we are looking for a proper metaphysics of the union. Metaphysics is the job of (...) the intellect; it involves understanding. On Descartes’ considered view, we don’t understand the union; we feel it through the internal senses. In the second, positive, part of the paper I argue that, while Descartes does not give a properly metaphysical account of the union, he does provide a rich phenomenology of it that is of both theoretical and practical interest. Along the way, I suggest a phenomenological reading of a number of important passages that scholars have interpreted as Descartes’ attempt to provide a metaphysics of the union. (shrink)

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Presents a plethora of approaches to developing human potential in areas not conventionally addressed. Organized in two parts, this international collection of essays provides viable educational alternatives to those currently holding sway in an era of high-stakes accountability.

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While moral arguments for vegetarianism have been explored in great depth, the arguments for veganism seem less clear. Although many animals used for milk and eggs are forced to live miserable lives on factory farms, it’s possible to raise animals as food resources on farms where the animals are treated more humanely and never slaughtered. Under more humane conditions, do we harm animals to use them for food? I argue that, even under humane conditions, using animals for food typically harms (...) animals by restricting their freedom. My argument raises an important question about the extent to which animals are harmed when their freedom is restricted. On one view, it is possible to restrict animals’ freedom without harming them so long as we don’t make them suffer. This view underestimates the value of freedom for animals. Even if animals aren’t made to suffer, restricting their freedom can harm them insofar as it deprives them of freely pursuing their enjoyments in life. My argument has implications for not only the ethics of using animals as food resources but also the ethics of using animals in zoos and circuses. I examine these implications and also consider what we should do with farm animals if we cease using them for food. (shrink)

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Are embryos deserving of moral consideration in our actions? A standard view suggests that embryos are considerable only if they have interests. One argument for embryonic interests contends that embryos are harmed by death because they are deprived of valuable future lives as adult persons. Some have challenged this argument on the grounds that embryos aren’t identical to adults: either due to the potential for embryos to twin or because we do not exist until the fetus develops consciousness. These arguments (...) fail to show that embryos do not have future adult lives. There is a better reason to think that embryos cannot have interests; namely, because they are not capable of having desires. Others have held this view but have not sufficiently justified it. The justification lies in the fact that the capacity for desires is necessary to make sense of the normativity of interests. (shrink)

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Mathematics is about proofs, that is the derivation of correct statements; and calculations, that is the production of results according to well-defined sets of rules. The two notions are intimately related. Proofs can involve calculations, and the algorithm underlying a calculation should be proved correct. The aim of the author is to explore this relationship. The book itself forms an introduction to simple type theory. Starting from the familiar propositional calculus the author develops the central idea of an applied lambda-calculus. (...) This is illustrated by an account of Gödel's T, a system which codifies number-theoretic function hierarchies. Each of the book's 52 sections ends with a set of exercises, some 200 in total. These are designed to help the reader get to grips with the subject, and develop a further understanding. An appendix contains complete solutions of these exercises. (shrink)

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The standard method of generating countable ordinals from uncountable ordinals can be replaced by a use of fixed point extractors available in the term calculus of Howard’s system. This gives a notion of the intrinsic complexity of an ordinal analogous to the intrinsic complexity of a function described in Gödel’s T.

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What's the secret to happiness? How do you weather life's inevitable storms? What can you do when you're feeling anxious, depressed, or overwhelmed by life? Stoicsim was born from the wisdom of Socrates and is a school of thought that focuses on flourishing in the face of adversity. In this workbook, you'll learn how the Socratic method of questioning and self-inquiry can help you identify what you want in life, and build the resilience needed to go out and get it! (...) Combining ancient wisdom with evidence-based psychology, this practical guide will help you find fulfillment amid the chaos of modern life. You'll discover how Stoic virtues -- wisdom, justice, courage, and temperance -- can be your compass as you navigate an increasingly uncertain world. Finally, you'll learn that Stoicism isn't about being emotionless in the face of pain or suffering. It's about giving yourself space to reflect before you react, and determining for yourself how you're going to let adversity affect you. This is a key to lasting happiness. Let this workbook guide you to put this knowledge into practice, every day. (shrink)

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In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Abortion to Abolition: Reproductive Health and Justice in Canada by Martha PaynterRebeccaSimmons (bio)Abortion to Abolition: Reproductive Health and Justice in Canada by Martha Paynter Winnipeg, MB: Fernwood Publishing, 2022Martha Paynter's Abortion to Abolition: Reproductive Health and Justice in Canada is a bold, ambitious work that seeks to not only catalog Canada's meandering and often backtracking path toward reproductive justice, but to act as a manifesto for (...) Paynter's own ideas and goals for reproductive justice. The book takes the form of an anthology of stories, divided into chapters, that are grouped according to a certain right; for example, the right to bodily autonomy. This format effectively guides the reader from abortion to abolition. Paynter adroitly starts the book with white feminist favorites such as bodily autonomy and not having children. Then she logically progresses to more radical ideas such as parenting in prison and the total abolition of prisons. The stories in this book are accompanied by warm, colorful illustrations by Julia Hunt. These drawings help the reader visualize the person behind the story and the very real life that was affected by reproductive law and/or social norms. Paynter holds a PhD in nursing, and it is from this background that she writes, seeking to educate nurses and other healthcare professionals alongside a broader readership garnered through her clear, approachable writing style.Chapter 1 introduces the reader to many of the book's key themes by considering the right and need to have bodily autonomy, and the multiple ways this manifests itself in ordinary (and less-ordinary) life. Paynter considers the disparate stories of five women, all fighting in some way for bodily autonomy. The stories cover events of gender-based gun violence, sexual assault, transgender rights in prison, the legalization of sex work, police violence, and institutional racism. Each story recounted by Paynter catalogs tragedies and injustices with blunt and brutal honesty—perhaps to an unnecessary extent. Every horrific fact is laid bare for the readers as they uncover the intricacies of gender-based, imperialist, and racist violence. Paynter has chosen these stories to display the multitude of ways in which people—especially Black, Indigenous, people of color (BIPOC) and minoritized genders—can be willfully wronged by the state and [End Page 209] the criminal justice system, such that the reader must begin to confront the fact that these structures don't seem to exist to benefit or protect the most marginalized in society.Chapter 2 approaches the right not to have children through a number of stories related to contraception, abortion, and family planning. Paynter sketches some of the key points in Canada's journey toward the decriminalization of abortion, from paradoxical trailblazers, such as Dr. Emily Stowe in the 1800s, to the viral memefied content of art protestor iamkarats. While the unequivocal legality of abortion in Canada suggests incredible progressiveness and support for women's rights, Paynter paints a more complex picture through her chosen narratives. Crucially, the inequitable geographical access to abortion, in particular, throughout the huge landmass of Canada suggests that the right to not have children in Canada is not universal. Moreover, Paynter suggests that access is also bounded by financial constraints, finite public funding, and the limited availability of inclusive clinics that prioritize healthcare for LGBTQ2S+ people.Chapter 3 considers the topic of having children; in particular, the right to reproductive technologies and freedom from forced sterilization. Paynter quickly makes clear that while many white feminists might see having and not having children as diametrically opposed, they are two equally essential parts of reproductive justice. Paynter draws attention to the Sexual Sterilization Act of 1928 that was only overturned in 1972. She describes it as part of the "genocidal colonial project" (84), a collection of laws and policies aimed at fulfilling eugenicist, neoimperial ideals of increasing production of the white "race" and promoting the genocide of Indigenous peoples. Furthermore, Paynter argues that evidence of forced sterilization of Indigenous peoples, and other physical violence and neglect, persists to the present day and must be stopped and reparations made for previous harms. Paynter then considers the complex, often-debated case of commercialized surrogacy, which she defines... (shrink)

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With 13 essays, the short chapter summary approach will not work for reviewing this book.1 1 The chapters are not broken down into sections, so I can’t select representatives from sections. With not a single bad essay among them, I get no help narrowing it down that way either. I shall, then, focus on the contributions of women and more junior contributors, setting aside the chapters of the editors and others with whom I have fairly close personal connections.

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In “Knowledge and epistemic necessity,” John Hawthorne gives a defense of what he rightly calls the “standard approach” to epistemic possibility against what he calls a new “competing idea” presented by Dougherty and Rysiew which he notes has been “endorsed and elaborated upon” by Fantl and McGrath. According to the standard approach, roughly, p is epistemically possible for S if S doesn’t know that not-p. The new approach has it that p is epistemically possible if p has a non-zero epistemic (...) probability. Both approaches, he notes, would explain the oddness of CKAs, utterances of the form “p, but possibly not p.” However, he offers a number of arguments designed to show that the standard approach has other advantages. In this paper, we undermine Hawthorne’s reasons for favoring the standard approach over Dougherty and Rysiew’s alternative approach. (shrink)

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An assessment of a protocol devised to guide practitioners thinking of using covert video surveillance. Such surveillance is particularly used to help identify cases of Munchausen's syndrome by proxy. The protocol in question has been written by staff at the Academic Department of Paediatrics, North Staffordshire Hospital, Stoke-on-Trent in association with their local Area Child Protection Committee and has been commended by the Department of Health to others wishing to implement covert video surveillance.

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A comment on “Editorial 37” Content Type Journal Article Pages 93-95 DOI 10.1007/s10698-011-9110-4 Authors Brian T. Sutcliffe, Laboratoire de Chimie quantique et Photophysique, Université Libre de Bruxelles, B-1050 Bruxelles, Belgium R. Guy Woolley, School of Biomedical and Natural Sciences, NottinghamTrent University, Nottingham, NG11 8NS UK Journal Foundations of Chemistry Online ISSN 1572-8463 Print ISSN 1386-4238 Journal Volume Volume 13 Journal Issue Volume 13, Number 2.

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"This is an excellent textbook on Neoplatonism which gives the reader a very concise and lucid overview of the basic doctrines and leading thinkers of the last great philosophy to emerge before the Christianization of the Roman Empire. I’ve no doubt that my students next semester will benefit from the analyses contained in the book. The contents of the chapters are very informative and adequately place developments in their socio-cultural context." --Michael B.Simmons, Auburn University at Montgomery.

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The literature contains a disconnect between accounts of how humans learn lexical semantic representations for words. Theories generally propose that lexical semantics are learned either through perceptual experience or through exposure to regularities in language. We propose here a model to integrate these two information sources. Specifically, the model uses the global structure of memory to exploit the redundancy between language and perception in order to generate inferred perceptual representations for words with which the model has no perceptual experience. We (...) test the model on a variety of different datasets from grounded cognition experiments and demonstrate that this diverse set of results can be explained as perceptual simulation (cf. Barsalou,Simmons, Barbey, & Wilson, 2003) within a global memory model. (shrink)

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René Girard (1923-2015) est un théoricien littéraire et un anthropologue de renommée internationale. Sa carrière s'est déroulée entre la France et les États-Unis, qu'il a rejoints en 1947, après l'effondrement de son pays et la tragédie de la Seconde Guerre mondiale. Figure majeure du XXe siècle, il laisse une œuvre considérable. Mais la vie de ce penseur unique restait à écrire. Cette biographie suit le parcours personnel, mais aussi les articles et les livres d'un écrivain qui voulut révéler la vérité (...) de la littérature et la violence des institutions humaines. Mettant au jour ces deux refus d'entendre que sont le 'désir mimétique' d'un côté, le 'mécanisme du bouc émissaire' de l'autre, il a fait résonner autrement la parole qui parle dans la Bible et dans les Évangiles. Mais René Girard a aussi été le passeur injustement oublié des ténors de la pensée française qu'il a introduits aux États-Unis et avec qui il a su dialoguer en profondeur: Roland Barthes, Jacques Derrida, Michel Foucault, Lucien Goldmann, Jacques Lacan ou Jean-Pierre Vernant, sans oublier les figures essentielles que furent pour lui Claude Lévi-Strauss et Jean-Paul Sartre. Fruit d'une longue recherche, avec René Girard lui-même, sa famille et ses amis proches, éclairée de témoignages brossant le portrait d'un séducteur qui aurait pu être marchand d'art à New York, d'un existentialiste converti à trente-cinq ans sur la route de Philadelphie ou de l'introducteur malgré lui de la French Theory, cette biographie intellectuelle s'appuie sur de nombreux textes inédits et une riche correspondance. Elle se lit comme le roman d'un siècle de bruit et de fureur."--Page 4 of cover. (shrink)

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Catholic theologians afterTrent saw the Protestant teaching about the remnants of original sin in the justified as one of the ‘chief ’ errors of Protestant soteriology. Martin Luther, John Calvin, Martin Chemnitz, and many Protestant theologians believed that a view of concupiscence as sinful, strictly speaking, did away with any reliance on good works. This conviction also clarified the Christian’s dependence on the imputed righteousness of Christ. Catholic theologians condemned this position as detracting from the work of Christ (...) who takes away the sins of the world. The rejection of this teaching—and the affirmation ofTrent’s statement that original sin is taken away and that the justified at baptism is without stain or ‘immaculate’ before God—is essential for understanding Catholic opposition to Protestant soteriology. Two Spanish Dominican Thomists, Domingo de Soto and Bartolomé de Medina, rejected the Protestant teaching on imputation in part because of its connection with the view on the remnants of original sin in the justified. Adrian and Peter van Walenburch, brothers who served as auxiliary bishops of Cologne in the second half of the seventeenth century, argued that the Protestants of their time now agreed with the Catholic Church on a number of soteriological points. They also drew upon some of their post–Tridentine predecessors to offer a Catholic account of the imputation of Christ’s righteousness. Nonetheless, the issue of sin in the justified remained a point of serious controversy. (shrink)

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This short essay outlines a program for international co-operation based on an understanding of common human nature. It begins plausibly enough by a search for this common nature in terms of what constitutes ‘minimal man’; but its level of discourse and argument soon degenerate. Proceeding from the unproven claim that culture has insulated the human species to such an extent that the ‘human form’ is now stabilized, MrSimmons claims that a minimal human displays this form and exhibits ‘a (...) system of time greater than the age of its own body’. Unfortunately, this latter distinguishing characteristic of man is merely stated and neither developed nor defended. Presumably infants and mental defectives are not men according to the author’s criteria. An individual’s sense of time and timing, the author continues, can be developed, and consequently there are different levels of man. The growth from minimal to maximal man is achieved through education. This then leads the author to present a utopian scheme for achieving a world community: the world powers must allow themselves to be tamed by a world educational system centered on an autonomous World University. If MrSimmons can convince the world powers to do so, he should certainly be named Chancellor of the University. (shrink)

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Le premier volume du Corpus of Mycenaean Inscriptions from Knossos est sorti de presse en 1986 ; le second sort cette année : trente-sept raccords de fragments ont été effectués dan· le premier volume depuis la fin de 1984 et le second contient soixante-dix raccords inédits ; le· auteurs les présentent et les commentent, comme ils l'avaient déjà fait pour les quarante-troi· raccords inédits de CoMIK I (BCH 110 [1986], p. 21-39).

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A. Kenny, Frege, an introduction to the founder of modern analytic philosophy. London:Penguin, 1995. viii-h223pp. £7.99 T. Willamson, Vagueness. London:Routledge, 1994. xiii-f-325 pp. £35.00 TOM BU...

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Given that his writings span well over forty years of maturing genius and that the audiences to whom these writings were directed were as varied as the Pelagians, Donatists, and Manichees, not to mention the Sunday flock, is it any wonder that Augustine’s thought found a home in Wittenberg as well as inTrent? T. Kermit Scott, associate professor of philosophy at Purdue University, begins his survey accordingly by acknowledging that “[p]art of the task of interpreting Augustine at this (...) late date is to make plausible how able and informed students have come to such divergent views”. (shrink)

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Michel Weber, Essai sur la gnose de Harvard. Whitehead apocryphe, Louvain-la-Neuve, Les Éditions Chromatika, 2011. (978-2-930517-26-1, 292 p., 20 €) L’objet de ce livre consiste en une éludication croisée de la philosophie organique whiteheadienne et de la gnose thomasienne. Il cherche à répondre à deux questions. La philosophie de l’événement, du processus ou du procès, d’Alfred North Whitehead (1861–1947) possède-t-elle, volens nolens, un fond gnostique syrien ? L’évangile apocryphe de Thomas, le gnostique juif qui a couché par écrit l’enseignement de (...) Jésus probablement trente ans après son décès, offrant ainsi une source qui pourrait être plus ancienne que les évangiles canoniques et leur hypothétique texte-racine Q, gagne-t-il a être lu à partir de prémisses whiteheadiennes ? Michel Weber dirige le Centre de philosophie pratique « Chromatiques whiteheadiennes » à Bruxelles. Il a publié plus de cinquante ouvrages scientifiques, dont La Dialectique de l’intuition chez A. N. Whitehead (2005), Whitehead’s Pancreativism (2006 & 2011) et L’Épreuve de la philosophie (2008). (shrink)

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Qu'est-ce que les Lumières ? Comment les mêmes exigences de la raison peuvent-elles inspirer à la fois Voltaire et Robespierre ? Comment a-t-on pu si véhémentement critiquer la religion au nom de la raison, et instituer trente ans après une religion de la raison ? Comment la raison a-t-elle pu en 1763 inspirer à Voltaire son Traité de la tolérance et justifier en 1793 l'intolérance de la loi des suspects ? S'agit-il de circonstances malheureuses, de déviations ? Ou n'avons-nous pas (...) plutôt affaire à une aussi inévitable qu'insurmontable amphibolie de la raison ? Tantôt l'humble raison implore de l'erreur le droit pour la vérité de prendre place dans le cortège public des autres opinions : elle revendique la tolérance. Tantôt la raison triomphante interdit tout droit à l'injustice et à l'erreur : c'est l'intolérance de la vérité. S'il en était ainsi, on comprendrait que l'histoire n'eût fait depuis que se répéter. (shrink)

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This book presents the deterministic view of quantum mechanics developed by Nobel Laureate Gerard 't Hooft. Dissatisfied with the uncomfortable gaps in the way conventional quantum mechanics meshes with the classical world, 't Hooft has revived the old hidden variable ideas, but now in a much more systematic way than usual. In this, quantum mechanics is viewed as a tool rather than a theory. The book presents examples of models that are classical in essence, but can be analysed by the (...) use of quantum techniques, and argues that even the Standard Model, together with gravitational interactions, might be viewed as a quantum mechanical approach to analysing a system that could be classical at its core. He shows how this approach, even though it is based on hidden variables, can be plausibly reconciled with Bell's theorem, and how the usual objections voiced against the idea of 'superdeterminism' can be overcome, at least in principle. This framework elegantly explains - and automatically cures - the problems of the wave function collapse and the measurement problem. Even the existence of an "arrow of time" can perhaps be explained in a more elegant way than usual. As well as reviewing the author's earlier work in the field, the book also contains many new observations and calculations. It provides stimulating reading for all physicists working on the foundations of quantum theory. (shrink)

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Dans sa Philosophie de la nouvelle musique, Theodor W. Adorno constatait déjà que la musique "en un mouvement critique, a dissous l'idée d'oeuvre achevée et rompu avec le public". Et il ajoutait : "ni la crise sociale, ni celle de la culture - et dans le concept de crise on implique déjà la reconstruction administrante - aucune de ces crises n'a pu paralyser la vie musicale officielle". L'idée que la musique dite "contemporaine" se vive sous la forme d'une crise, et (...) que cette crise implique toutes les parties prenantes de l'acte esthétique, du compositeur au public, semble donc être installée depuis longtemps dans la pensée musicale. Plus qu'un travail historiographique, il s'agissait de mettre en évidence la nature de cette crise à travers un ensemble d'études et d'analyses impliquant des acteurs majeurs de la musique de création du vingtième siècle. En réunissant ici une série d'articles écrits depuis bientôt trente ans, l'auteur nous convie à une réflexion personnelle et sans compromis sur le bouleversement du rapport esthétique qui a traversé le champ musical et sur la manière dont il affecte notre faculté d'écouter."--Page 4 of cover. (shrink)

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In this study a combination of computer tools for coupling and virtual screening is detailed, in 108 active molecules and 3620 decoys to find stabilizers for G quadruplex. To have more precise results, combinations of coupling programs with fifteen energy scoring functions were applied. The validation and evaluation of the metrics was done with the CompScore genetic algorithm. The results showed an increase in BEDROC and EF of 50% compared to other strategies, as well as reflecting early recognition of active (...) molecules. From these results it is possible to work with the molecules that showed a good early recognition and evaluate their effect as G4 stabilizers. This ensures more efficient and accurate results in the preclinical stage for the development of anticancer drugs. Keywords: Enrichment metrics; telomere; G quadruplex ; CompScore. References [1]M. Porru, P. Zizza, M. Franceschin, C. Leonetti and A. Biroccio. «EMICORON: A multi-targeting G4 ligand with a promising preclinical profile» 2017. Biochimica et Biophysica Acta - General Subjects, 1861, 1362–1370. [Online]. Available: https://doi.org/10.1007/s00294-018-0836-6. [2]K. Tomita. «How long does telomerase extend telomeres? Regulation of telomerase release and telomere length homeostasis». Current Genetics, 64, 1177–1181. 2018. [Online]. Available: https://doi.org/10.1016/j.bbagen. 2016.11.010. [3]M. Jafri, S. Ansari, M. Alqahtani and J. Shay. «Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies. Genome Medicine., 2016. [Online]. Available: https://doi.org/10.3390/ijms19020482. [4]J. Huppert and S. Balasubramanian. «G-quadruplexes in promoters throughout the human genome». 35, 406–413. 2007. [Online]. Available: https://doi.org/10.1016/j.bbapap.2017.06.012. [5]S. Joy, Vijayakumar, S. Choi and H. Sunhye. «Role of computer-aided drug design in modern drug discovery». Archives of Pharmacal Research. 2015. [Online]. Available: https://doi.org/10.1007/s12272-015-0640-5. [6]S. Asamitsu, S. Obata, Z. Yu, T. Bando and H. Sugiyama. «Recent Progress of Targeted G-Quadruplex-Preferred Ligands Toward Cancer Therapy». Molecules, 24, 429. 2019. [En línea]. Available: https://doi.org/10.3390/molecules24030429. [7]R. Monsen and J.Trent. «Biochimie G-quadruplex virtual drug screening : A review». Biochimie, 152, 134–148. 2018. [Online]. Available: https://doi.org/10.1039/c9cc06748e. [8]J. Beauvarlet, P. Bensadoun, E. Darbo, G. Labrunie, E. Richard, I. Draskovic and M. Djavaheri-mergny. «Modulation of the ATM / autophagy pathway by a G-quadruplex ligand tips the balance between senescence and apoptosis in cancer cells». 1–18. 2019. [Online]. Available: https://doi.org/10.1093/nar/gkz095. [9].Z. Crees, J. Girard, Z. Rios, G. Botting, K. Harrington and C. Shearrow. « Oligonucleotides and G-quadruplex stabilizers: targeting telomeres and telomerase in cancer therapy».2014. [Online]. Available: https://doi.org/10.2174/1381612820666140630100702. [10].M. Meier, A. Moya-torres, N. Krahn, M. Mcdougall, L. Orriss, E. Mcrae and T. Patel. «Structure and hydrodynamics of a DNA Gquadruplex with a cytosine bulge»., 1–13. 2018. [Online]. Available: https://doi.org/10.1093/nar/gky307. (shrink)

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La mort de Michel Foucault en 1984 a coïncidé avec l'évanouissement des espoirs de transformation sociale qui avaient caractérisé l'après-guerre. Dans les décennies qui ont suivi sa mort, le néolibéralisme a triomphé et les attaques contre la sphère publique se sont amplifiées. Si Foucault n'a pas été un témoin direct de ces années, ses travaux sur le néolibéralisme n'en sont pas moins prémonitoires : la question du libéralisme occupe une place importante dans ses dernières œuvres. Depuis sa mort, l'appareil conceptuel (...) de Foucault a acquis une position centrale, voire dominante, pour une partie importante de la gauche intellectuelle mondiale. Cependant, comme le montrent les contributions à ce volume, l'attitude de Foucault à l'égard du néolibéralisme était pour le moins équivoque. Loin de mener une lutte intellectuelle contre l'orthodoxie du marché libre, Foucault a semblé y voir une opportunité pour inventer de nouvelles subjectivités. Un espace libéré du pouvoir pastoral de l'Etat social. Comment comprendre sa critique radicale de ce dernier, comprise comme un instrument du biopouvoir? Ou son soutien à l'anti-marxisme des nouveaux philosophes? Est-il possible que Foucault ait été séduit par le néolibéralisme? Cette question n'a pas qu'un intérêt biographique : elle nous oblige à nous confronter plus généralement aux mutations de la gauche depuis mai 1968, aux désillusions des années qui ont suivi et aux transformations profondes du champ intellectuel français depuis trente ans. Comprendre les années 1980 et le triomphe néolibéral, c'est explorer les recoins les plus ambigus de la gauche intellectuelle à travers l'une de ses figures les plus importantes. Ce livre est édité par Daniel Zamora et M.0 Behrent Daniel Zamora est professeur de sociologie à l'Université Libre de Bruxelles. Il travaille sur les conceptualisations de la pauvreté au XXe siècle, sur les inégalités et sur l'histoire moderne des idées. Il a écrit pour Le Monde Diplomatique, Jacobin, la Los Angeles Review of Books, Dissent, et ses textes ont été traduits dans une quinzaine de langues."--Page 4 of cover. (shrink)

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The American rock band KISS is notorious. Its notoriety derives not only from the band’s otherworldly costumes (except for of course during the unmasked period), the fact that they were inducted into the Rock and Roll Hall of Fame, their numerous hit records or the amazing stage theatrics and pyrotechnics of their live shows. It’s also related to the band’s constantly changing makeup (and I don’t mean the kind on their faces!). Of the four members, only Paul Stanley and Gene (...)Simmons were fixtures. With so many changes to the band’s composition, has KISS always remained the same band? Some see this head-scratcher as roughly similar to a conundrum in philosophical metaphysics (that’s the area of philosophy addressing problems of existence): the puzzle of Theseus’s ship. (shrink)

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In the fall of 1998Trent Lott used his power as Senate Majority Leader to prevent the confirmation of James C. Hormel, an openly gay San Francisco philanthropist who was then President Clinton’s nominee for Ambassador to Luxembourg.[2] Mr. Lott made it clear that his opposition to Hormel was based on his opposition to homosexuality in general. Asked by a television interviewer during the controversy whether homosexuality is a sin, Mr. Lott answered "Yes, it is"; he went on to (...) compare gay people to alcoholics, sex addicts, and kleptomaniacs.[3] Shortly thereafter, Dick Armey, the House Majority Leader, seconded Lott’s view, adding that “[t]he Bible is very clear on this…Both myself and Senator Lott believe very strongly in the Bible.”. (shrink)

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Deux amis se promènent. L'un est philosophe, l'autre neurologue. Ils conversent pour le plaisir, en marchant, durant quatre saisons, dans les champs et les bois. Ils dialoguent librement, sans façons, en cherchant à comprendre ce qui se passe en nous pendant que nous marchons. La marche favorise-t-elle la pensée? Si oui, pourquoi? La pensée est-elle comparable à une marche? Comment le cerveau contrôle-t-il à la fois les mouvements des jambes, l'équilibre et la posture du corps? Quels rapports entre ces trois (...) caractéristiques de l'espèce humaine : penser, parler, marcher debout? Chemin faisant, dans des termes simples et précis, ils évoquent enfin les relations entre sciences et philosophie, leur fâcheux divorce, leurs retrouvailles souhaitables. Entre divergences et convergences, leur commune volonté d'y voir clair est communicative. Et leur allégresse vite partagée. Pas à pas.Roger-Pol Droit, philosophe et écrivain, a été chercheur au C.N.R.S. et enseignant à Sciences-Po. Son oeuvre, une quarantaine de livres (recherches, pédagogie, enquêtes, fictions), est traduite en plus de trente langues. Yves Agid est professeur émérite de neurologie et de biologie cellulaire à Sorbonne Université, ancien chef de service (hôpital de la Salpêtrière), membre de l'Académie des sciences, co-fondateur de l'Institut du Cerveau. C'est un spécialiste de l'étude des mécanismes et du traitement des maladies neurodégénératives. (shrink)

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The book is mainly concerned with the problem of the logical analysis of hypothetical (conditional) statements.

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