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The powerful combination of genetic, developmental and molecular approaches possible with the fruit fly, Drosophila melanogaster, has led to a profound understanding of the genetic control of early developmental events. However, Drosophila is a highly specialized long germ insect, and the mechanisms controlling its early development may not be typical of insects or Arthropods in general. The beetle, Tribolium castaneum, offers a similar opportunity to integrate high resolution genetic analysis with the developmental/molecular approaches currently used in other organisms. Early results (...) document significant differences between insect orders in the functions of genes responsible for establishing developmental commitments. (shrink)

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The first sexual encounter between Dominique Francon and Howard Roark in The Fountainhead is known as the “rape scene.” From the time of the novel's publication, some readers have found a contradiction between Rand's views on freedom and the violence within the novel. The ambiguity arises from the way in which the scenes leading up to the event are constructed, the sadomasochistic context of the novel, and Rand's views of gender and romantic relationships. Although Rand repeatedly denied that any rape (...) occurred, this article concludes that a rape did occur and that Rand fully intended it to be so. (shrink)

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The authors of Habits of the Heart believe that American individualism ?may have grown cancerous?that it may be destroying those social integuments that Tocqueville saw as moderating its more destructive potentialities.? However, because they come to their research with an anti?individualistic bias in place, the authors fail to acknowledge the role of either recent historical events or influences other than individualistic ideas in shaping American culture. An alternative explanation for the emergence of the isolated self and the incoherence of moral (...) discourse in American life is presented. Both of these phenomena are viewed as temporary responses to a shift in American character. (shrink)

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This review is primarily concerned with two key issues in research on dystrophin: (1) how the protein interacts with the plasma membrane of skeletal muscle fibres and (2) how an absence of dystrophin gives rise to Duchenne muscular dystrophy. In relation to the first point, we suggest that the post‐translational acylation of dystrophin may contribute to its interaction with the plasma membrane. Regarding the second point, it is generally considered that an absence of dystrophin makes the plasma membrane susceptible to (...) damage by contraction/relaxation cycles. In this connection, we propose that the progressive nature of Duchenne dystrophy, and the phenotypic characteristics of mdx mice, are more consistent with dystrophin functioning as a mechanical transducer that transmits growth stimuli from the enlarging skeleton to the muscle. On the basis of this hypothesis, dystrophin‐deficient muscles would be unable to grow at the same rate as the skeleton. (shrink)

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The question of how actin filaments are attached to membranes is of central importance to an understanding of how actin gives rise to shape and movement in cells. A number of approaches to this question have been taken, but there have been few definitive answers. Some of the limitations of these approaches are discussed, as well as possible avenues for overcoming them.

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