Results for 'Stephen J. Elledge'
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- DNA damage and cell cycle regulation of ribonucleotide reductase.Stephen J.Elledge,Zheng Zhou,James B. Allen &Tony A. Navas -1993 -Bioessays 15 (5):333-339.Ribonucleotide reductase (RNR) catalyzes the rate limiting step in the production of deoxyribonucleotides needed for DNA synthesis. In addition to the well documented allosteric regulation, the synthesis of the enzyme is also tightly regulated at the level of transcription. mRNAs for both subunits are cell cycle regulated and inducible by DNA damage in all organisms examined, including E. coli, S. cerevisiae and H. sapiens. This DNA damage regulation is thought to provide a metabolic state that facilitates DNA replicational repair processes. (...) S. cerevisiae also encodes a second large subunit gene, RNR3, that is expressed only in the presence of DNA damage. Genetic analysis of the DNA damage response in S. cerevisiae has shown that RNR expression is under both positive and negative control. Among mutants constitutive for RNR expression are the general transcriptional repression genes, SSN6 and TUP1. Mutations in POL1 and POL3 also activate RNR expression, indicating that the DNA damage sensory network may respond directly to blocks in DNA synthesis. A protein kinase, Dun1, has been identified that controls inducibility of RNR1, RNR2 and RNR3 in response to DNA damage and replication blocks. This result suggests that the RNR genes in S. cerevisiae form a regulon that is coordinately regulated by protein phosphorylation in response to DNA damage. (shrink)
- Stopped for repairs.Yolanda Sanchez &Stephen J.Elledge -1995 -Bioessays 17 (6):545-548.The tumor suppressor protein p53 is intimately involved in the cellular response to DNA damage, controlling cell cycle arrest, apoptosis and the transcriptional induction of DNA damage inducible genes. A transcriptional target of p53, Gadd45, was recently found to bind to PCNA, a component of DNA replication/repair complexes, thereby implicating Gadd45 in DNA metabolism(1). Using biochemical assays, a role for Gadd45 in excision repair in vitro has been demonstrated(1). Antisense experiments have also indicated an in vivo role for the GADD45 (...) gene in UV‐irradiation survival. These discoveries establish a link between p53 and DNA repair through Gadd45. (shrink)No categories
- Value judgements and conceptual tensions: decision-making in relation to hospital discharge for people with dementia.Helen Greener,Marie Poole,Charlotte Emmett,John Bond,Stephen J. Louw &Julian C. Hughes -2012 -Clinical Ethics 7 (4):166-174.We reflect, using a vignette, on conceptual tensions and the value judgements that lie behind difficult decisions about whether or not the older person with dementia should return home or move into long-term care following hospital admission. The paper seeks, first, to expose some of the difficulties arising from the assessment of residence capacity, particularly around the nature of evaluative judgements and conceptual tensions inherent in the legal approach to capacity. Secondly, we consider the assessment of best interests around place (...) of residence, which demonstrates significant conceptual tensions. In addition, ‘best interests’ raise issues around the perception of risk and the perceptions of the family and crucially involve the notions of autonomy and trust. Finally, we not only gesture at some practical considerations based on insights from values-based medicine, but also make the suggestion that we require tighter functional assessments of residence capacity coupled with broader judgements about best interests. (shrink)
- Stephen J. Field: Craftsman of the Law.Stephen J. Field &Carl Brent Swisher -1970 -Ethics 81 (1):77-79.
- Foucault and education: disciplines and knowledge.Stephen J. Ball (ed.) -1990 - New York: Routledge.1 Introducing Monsieur FoucaultStephen J. Ball Michel Foucault is an enigma, a massively influential intellectual who steadfastly refused to align himself ...
- Regulation during challenge: A general model of learned performance under schedule constraint.Stephen J. Hanson &William Timberlake -1983 -Psychological Review 90 (3):261-282.No categories
- Peer-review practices of psychological journals: The fate of published articles, submitted again.Douglas P. Peters &Stephen J. Ceci -1982 -Behavioral and Brain Sciences 5 (2):187-255.A growing interest in and concern about the adequacy and fairness of modern peer-review practices in publication and funding are apparent across a wide range of scientific disciplines. Although questions about reliability, accountability, reviewer bias, and competence have been raised, there has been very little direct research on these variables.The present investigation was an attempt to study the peer-review process directly, in the natural setting of actual journal referee evaluations of submitted manuscripts. As test materials we selected 12 already published (...) research articles by investigators from prestigious and highly productive American psychology departments, one article from each of 12 highly regarded and widely read American psychology journals with high rejection rates (80%) and nonblind refereeing practices.With fictitious names and institutions substituted for the original ones (e.g., Tri-Valley Center for Human Potential), the altered manuscripts were formally resubmitted to the journals that had originally refereed and published them 18 to 32 months earlier. Of the sample of 38 editors and reviewers, only three (8%) detected the resubmissions. This result allowed nine of the 12 articles to continue through the review process to receive an actual evaluation: eight of the nine were rejected. Sixteen of the 18 referees (89%) recommended against publication and the editors concurred. The grounds for rejection were in many cases described as “serious methodological flaws.” A number of possible interpretations of these data are reviewed and evaluated. (shrink)
- Choice, Pathways and Transitions Post-16: New Youth, New Economies and the Global City.Stephen J. Ball,Meg Maguire &Sheila Macrae -2001 -British Journal of Educational Studies 49 (3):357-359.
- Book reviews-darwinism and the linguistic image: Language, race and natural theology in the nineteenth century.Stephen J. Alter &Uwe Hossfeld -1999 -History and Philosophy of the Life Sciences 21 (2):236-236.
- The Problem of Self-Torture: What's Being Done?Stephen J. White -2017 -Philosophy and Phenomenological Research 94 (3):584-605.We commonly face circumstances in which the cumulative negative effects of repeatedly acting in a certain way over time will be significant, although the negative effects of any one such act, taken on its own, are insubstantial. Warren Quinn's puzzle of the self-torturer presents an especially clear example of this type of predicament. This paper considers three different approaches to understanding the rational response to such situations. The first focuses on the conditions under which it is rational to revise one's (...) prior intentions. The second raises the possibility of a fundamental disconnect between the rational assessment of an extended pattern of choices and the assessment of the individual choices that make up that pattern. I show that neither adequately addresses the underlying issues. I propose a third approach, according to which the rational assessment of the “self-torturer's” choices is guided, not by any plan or intention the he has actually adopted, but by the plan or plans it would have been reasonable for him to adopt from the outset. The larger significance of this conclusion is brought out through the identification of conditions under which one's past choices can non-derivatively constrain the rational response to one's present circumstances. (shrink)
- Drones, robots and perceived autonomy: implications for living human beings.Stephen J. Cowley &Rasmus Gahrn-Andersen -2022 -AI and Society 37 (2):591-594.
- Moral and legal responsibility and the new neuroscience.Stephen J. Morse -2005 - In Judy Illes,Neuroethics: Defining the Issues in Theory, Practice, and Policy. Oxford University Press.
- Effects of Communication Modality and Speaker Identity on Metaphor Framing.Stephen J. Flusberg,Mark Lauria,Samuel Balko &Paul H. Thibodeau -2020 -Metaphor and Symbol 35 (2):136-152.People regularly encounter metaphors in a variety of different communicative settings, but most studies of metaphor framing have relied exclusively on written materials. Across three experiments (N...No categories
- Is self-respect a moral or a psychological concept?Stephen J. Massey -1982 -Ethics 93 (2):246-261.
- The consequent-entailment problem foreven if.Stephen J. Barker -1994 -Linguistics and Philosophy 17 (3):249 - 260.A comprehensive theory ofeven if needs to account for consequent ‘entailing’even ifs and in particular those of theif-focused variety. This is where the theory ofeven if ceases to be neutral between conditional theories. I have argued thatif-focusedeven ifs,especially if andonly if can only be accounted for through the suppositional theory ofif. Furthermore, a particular interpretation of this theory — the conditional assertion theory — is needed to account foronly if and a type of metalinguistic negation ofQ if P. We therefore (...) have evidence that the currently accepted approaches to conditionals are basically wrong about the semantic forms they attribute toif P, Q.11. (shrink)
- A neural network model of the structure and dynamics of human personality.Stephen J. Read,Brian M. Monroe,Aaron L. Brownstein,Yu Yang,Gurveen Chopra &Lynn C. Miller -2010 -Psychological Review 117 (1):61-92.
- Kant on self-respect.Stephen J. Massey -1983 -Journal of the History of Philosophy 21 (1):57-73.Kant on Self-respect. SJ MASSEY Journal of the History of Philosophy La Jolla, Cal. 21:11, 57-73, 1983. L'A. veut montrer que selon Kant, toute immoralitcopyright est marque de manque de respect de soi.
- Scientists’ Attitudes toward Data Sharing.Stephen J. Ceci -1988 -Science, Technology, and Human Values 13 (1-2):45-52.No categories
- Animal Behavior.Stephen J. Crowley &Colin Allen -2008 - In Michael Ruse,The Oxford handbook of philosophy of biology. New York: Oxford University Press. pp. 327--348.Few areas of scientific investigation have spawned more alternative approaches than animal behavior: comparative psychology, ethology, behavioral ecology, sociobiology, behavioral endocrinology, behavioral neuroscience, neuroethology, behavioral genetics, cognitive ethology, developmental psychobiology---the list goes on. Add in the behavioral sciences focused on the human animal, and you can continue the list with ethnography, biological anthropology, political science, sociology, psychology (cognitive, social, developmental, evolutionary, etc.), and even that dismal science, economics. Clearly, no reasonable-length chapter can do justice to such a varied collection. We (...) have opted therefore to focus on three of these subdisciplines and to provide a somewhat historical tour of them, mentioning along the way the philosophical points that are of particular interest to us, but allowing the development of these points to be limited only by the imaginations of our readers. For readers seeking a more-traditional historical survey, see Dewsbury (1984a, b) and Burghardt (1985a). Our chosen brief is to write about comparative psychology, ethology, and cognitive ethology, although other approaches, especially neuroscience, will be mentioned where appropriate. These sciences are philosophically significant because they are enmeshed in ancient philosophical questions about the nature of mind and purposeful action and about the differences between humans and other animals. These sciences are also clustered because of their attention to mechanistic explanations of individual animal behavior as opposed to attempting to capture regularities at a population level, such as the game-theoretic strategic models popular among behavioral ecologists. (shrink)
- Algebra Mal‐Rules and Cognitive Accounts of Error.Stephen J. Payne &Helen R. Squibb -1990 -Cognitive Science 14 (3):445-481.We report an empirical study of elementary algebra errors, conducted in three separate schools. The errors are diagnosed using mal‐rules, as proposed by Sleeman (1984, 1,985). Our analysis uncovers the following properties of algebra mal‐rules: The frequency of mal‐rules is severely skewed, there are many infrequent mal‐rules and few frequent ones; mal‐rules are very unstable, students typically use mal‐rules very irregularly; different mal‐rules have explanatory power in different schools (many of our most powerful mal‐rules are previously unreported); mal‐rule diagnosis Is (...) more successful with more skilled students; students' confidence ratings do not partition the total set of mal‐rules, every mal‐rule we find is associated with high confidence ratings by at least one student. The Implications of our data for cognitive theories of error generation are discussed. Contrary to commonplace assumptions, we argue that It is impossible to make a clear distinction between slips and mistakes; most errors depend on properties of the knowledge base and the cognitive architecture. Errors In a procedural skill cannot be assumed to be purely syntactic In orgin. (shrink)
- Representation and processing of lexically ambiguous words.Stephen J. Lupker -2009 - In Gareth Gaskell,Oxford Handbook of Psycholinguistics. Oxford University Press.Export citation
Bookmark - Foucault, power, and education.Stephen J. Ball -2013 - New York: Routledge.Foucault, Power, and Education invites internationally renowned scholarStephen J. Ball to reflect on the importance and influence of Foucault on his work in educational policy.
- Overview of the ethics of Thomas Aquinas.Stephen J. Pope -2002 - InThe Ethics of Aquinas. Georgetown University Press. pp. 30--52.
- Politics and Policy Making in Education.Stephen J. Ball -1991 -British Journal of Educational Studies 39 (4):450-453.
- Topologies of Power: Foucault's Analysis of Political Government beyond 'Governmentality'.Stephen J. Collier -2009 -Theory, Culture and Society 26 (6):78-108.The publication of Michel Foucault’s lectures at the Collège de France in the late 1970s has provided new insight into crucial developments in his late work, including the return to an analysis of the state and the introduction of biopolitics as a central theme. According to one dominant interpretation, these shifts did not entail a fundamental methodological break; the approach Foucault developed in his work on knowledge/power was simply applied to new objects. The present article argues that this reading — (...) which is colored by the overwhelming privilege afforded to Discipline and Punish in secondary literature — obscures an important modification in Foucault’s method and diagnostic style that occurred between the introduction of biopolitics in 1976 (in Society Must Be Defended) and the lectures of 1978 ( Security, Territory, Population) and 1979 ( Birth of Biopolitics). Foucault’s initial analysis of biopolitics was couched in surprisingly epochal and totalizing claims about the characteristic forms of power in modernity. The later lectures, by contrast, suggest what I propose to call a ‘topological’ analysis that examines the ‘patterns of correlation’ in which heterogeneous elements — techniques, material forms, institutional structures and technologies of power — are configured, as well as the redeployments through which these patterns are transformed. I also indicate how attention to the topological dimension of Foucault’s analysis might change our understanding of key themes in his late work: biopolitics, the analysis of thinking, and the concept of governmentality. (shrink)
- Representational constraints on the development of memory and metamemory: A developmental–representational theory.Stephen J. Ceci,Stanka A. Fitneva &Wendy M. Williams -2010 -Psychological Review 117 (2):464-495.
- (1 other version)Coordination in language.Stephen J. Cowley &Sune Vork Steffensen -2015 -Interaction Studies. Social Behaviour and Communication in Biological and Artificial Systemsinteraction Studies / Social Behaviour and Communication in Biological and Artificial Systemsinteraction Studies 16 (3):474-494.Temporality underpins how living systems coordinate and function. Unlike measures that use mathematical conventions, lived temporalities grant functional cohesion to organisms-in-the-world. In foxtail grasses, for example, self-maintenance meshes endogenous processes with exogenous rhythms. In embrained animals, temporalities can contribute to learning. And cowbirds coordinate in a soundscape that includes conspecifics: social learning allows them to connect copulating with past events such that females exert ‘long-distance’ control over male singing. Using Howard Pattee’s work, we compare the foxtail’s self-maintenance, gender-based cowbird learning (...) and how humans manage multi-scalar activity. We argue that, while all living things coordinate, temporal ranging is typical of vertebrates. As primates, humans too use temporal ranging – they can draw on social learning, anticipate winter and manage coordinated action. However language behaviour grants new control over the scales of time. People connect the impersonal to lived experience in narratives, as they draw on autobiography and enact cultural practices. Humans become singular individuals who use temporal experience to manage affect, relationships, beliefs, fictions, and knowledge. Individual subjectivity permits collaborative and competitive activity based on linking events with quite different histories. As a result, alone of the vertebrates, we claim that humans become time-rangers. (shrink)No categories
- Belief, Truth and Knowledge.Stephen J. Noren -1974 -Philosophy and Phenomenological Research 34 (3):446-447.
- Curried Lakatos or, How Not to Spice up the Norm-Ladenness Thesis.Stephen J. Wykstra -1982 -PSA: Proceedings of the Biennial Meeting of the Philosophy of Science Association 1982:29 - 39.Using Currie's critique as a foil, this paper reconstructs Lakatos's thesis that historiography of science is laden with normative assumptions about scientific rationality. It is argued that this thesis comprises both a heuristic claim and a constitutive claim. The Received Critique of Lakatos fails to see that "internal history" and "rational reconstruction" receive a special meaning (by which they designate "rational preconstructions") when used in the context of the heuristic claim. Currie avoids this mistake, but attributes to Lakatos an "investigation-surrogate (...) claim" which misrepresents the heuristic claim, oversimplifying the relation Lakatos envisions between hard cores and the solutions they generate. (shrink)
- Conscious identification: Where do you draw the line?Stephen J. Lupker -1986 -Behavioral and Brain Sciences 9 (1):37-38.
- Business ethics and religion: Religiosity as a predictor of ethical awareness among students. [REVIEW]Stephen J. Conroy &Tisha L. N. Emerson -2004 -Journal of Business Ethics 50 (4):383-396.We survey students at two Southern United States universities (one public and one private, religiously affiliated). Using a survey instrument that includes 25 vignettes, we test two important hypotheses: whether ethical attitudes are affected by religiosity (H1) and whether ethical attitudes are affected by courses in ethics, religion or theology (H2). Using a definition of religiosity based on behavior (church attendance), our results indicate that religiosity is a statistically significant predictor of responses in a number of ethical scenarios. In seven (...) of the eight vignettes for which religiosity is significant, the effect is negative, implying that it reduces the acceptability of ethically-charged scenarios. Completion of ethics or religion classes, however, was a significant predictor of ethical attitudes in only two of the 25 vignettes (and in the expected direction). We also find that males and younger respondents appear to be more accepting of the ethically-questionable vignettes. We conclude that factors outside of the educational system may be more influential in shaping responses to ethical vignettes than are ethics and religion courses. (shrink)
- Against Voluntarism about Doxastic Responsibility.Stephen J. White -2019 -Journal of Philosophical Research 44:33-51.According to the view Rik Peels defends in Responsible Belief, one is responsible for believing something only if that belief was the result of choices one made voluntarily, and for which one may be held responsible. Here, I argue against this voluntarist account of doxastic responsibility and in favor of the rationalist position that a person is responsible for her beliefs insofar as they are under the influence of her reason. In particular, I argue that the latter yields a more (...) plausible account of the conditions under which ignorance may serve as an excuse for wrongdoing. (shrink)No categories
- Playing to win vs. playing for meaningful victories.Stephen J. Laumakis,Peter A. Laumakis &Paul J. Laumakis -2017 -Journal of the Philosophy of Sport 44 (2):174-182.John Laumakis has offered a thought-provoking, but ultimately unpersuasive argument in favor of playing to your opponent’s strength instead of playing to their weakness. In the course of this reply, we hope to show that the idea of PTS not only undermines the real goal of athletic competition, but it also rests upon a confusion between matters of morality and the aims of sports, as well as equivocations on the kind of ‘excellence’ one pursues, and the nature of the ‘challenge’ (...) involved in sport. We also plan to raise a serious objection against the logical consistency of PTS and note its incompatibility with real-world game smarts and tactics. Finally, we offer our own explanation for why ‘it is improbable that many coaches and athletes will shift their strategy from PTW to PTS.’. (shrink)
- Can Evolutionary Biology do Without Aristotelian Essentialism?Stephen J. Boulter -2012 -Royal Institute of Philosophy Supplement 70:83-103.It is usually maintained by biologists and philosophers alike that essentialism is incompatible with evolutionary biology, and that abandoning essentialism was a precondition of progress being made in the biological sciences. These claims pose a problem for anyone familiar with both evolutionary biology and current metaphysics. Very few current scientific theories enjoy the prestige of evolutionary biology. But essentialism – long in the bad books amongst both biologists and philosophers – has been enjoying a strong resurgence of late amongst analytical (...) philosophers with a taste for metaphysics. Indeed, to impartial observers it is likely to appear that both evolutionary biology and essentialism are as well supported in their respective domains as could reasonably be expected. There is thus at least a prima facie tension here between evolutionary biology, metaphysics and, as we shall see, pre-theoretical common sense. (shrink)
- Expression patterns of mouse hox genes: Clues to an understanding of developmental and evolutionary strategies.Stephen J. Gaunt -1991 -Bioessays 13 (10):505-513.Expression patterns of Antennapedia‐like homeogenes in the mouse embryo show many similarities to those of their homologues in Drosophila. It is argued here that homeogenes may regulate development of the body plan in mouse by mechanisms similar to those used in Drosophila. In particular, they may differentially specify positional address of cell groups within lineage compartments along the body axes. In vertebrates, a single ancestral homeogene cluster has become duplicated to give four separate clusters. Comparisons of homeogene expression patterns between (...) different clusters of the mouse suggest ways in which duplication has permitted development of a more complex body plan. Cluster duplication may therefore have provided a selective advantage during vertebrate evolution. (shrink)
- Arbitrariness, divine commands, and morality.Stephen J. Sullivan -1993 -International Journal for Philosophy of Religion 33 (1):33 - 45.
- Advanced introduction to substantive criminal law.Stephen J. Morse -2023 - Northampton, MA, USA: Edward Elgar Publishing.Elgar Advanced Introductions are stimulating and thoughtful introductions to major fields in the social sciences, business and law, expertly written by the world's leading scholars. Designed to be accessible yet rigorous, they offer concise and lucid surveys of the substantive and policy issues associated with discrete subject areas. This Advanced Introduction to Substantive Criminal Law explores the doctrines, issues and controversies in the substantive field of criminal law. Chapters cover important theoretical and doctrinal topics, including the justifications for state blame (...) and punishment, the foundations for criminalization, the prima facie case, affirmative defences of justification and excuse, and sentencing.Stephen J. Morse uses copious concrete examples drawn from cases, statutes and extended case studies, including the intricate grading of homicide, to enliven the discussion. Key Features: - Concise and accessible format - Theoretical explication of doctrinal intricacies - Informative coverage and real world examples of criminal law - Discussion of the challenges and responsibilities surrounding legal concepts of the person. Providing a compact and succinct introduction to the rich scholarship of the field, this Advanced Introduction will be an ideal read for lawyers and law students interested in criminal law and justice. It will also be a valuable resource for law enforcement personnel and anyone looking to understand the role of criminal law as a means to achieve justice and social safety. (shrink)
- Could Aquinas accept semantic anti-realism?Stephen J. Boulter -1998 -Philosophical Quarterly 48 (193):504-513.
- Agape.Stephen J. Pope -2013 - In Hugh LaFollette,The International Encyclopedia of Ethics. Hoboken, NJ: Blackwell.No categoriesExport citation Bookmark
- Chapter 3. Gildas.Stephen J. Joyce -2023 - In Marnie Hughes-Warrington & Daniel Woolf,History from loss: a global introduction to histories written from defeat, colonization, exile and imprisonment. New York: Routledge.Export citation Bookmark
- Causation, Facts and Coherence.Stephen J. Barker -1994 -Analysis 54 (3):179 - 182.
- The cradle of language : making sense of bodily connexions.Stephen J. Cowley -2007 - In Danièle Moyal-Sharrock,Perspicuous presentations: essays on Wittgenstein's philosophy of psychology. New York: Palgrave-Macmillan.
- The Works of Jonathan Edwards.Stephen J. Stein &Jonathan Edwards -1979 -Religious Studies 15 (1):127-130.
- Information management support for international negotiations.Stephen J. Andriole -1993 -Theory and Decision 34 (3):313-328.
- The Authority of Gower in Shakespeare's Pericles.Stephen J. Lynch -1990 -Mediaevalia 16:361-378.No categories
- Agent mobility and the evolution of cooperative communities.Stephen J. Majeski,Greg Linden,Corina Linden &Aaron Spitzer -1999 -Complexity 5 (1):16-24.
- The God of Jesus: The Historical Jesus and the Search for Meaning.Stephen J. Patterson -1998No categories
- A theory of patriotism for global journalism.Stephen J. A. Ward -2008 - In Stephen John Anthony Ward & Herman Wasserman,Media ethics beyond borders: a global perspective. Johannesburg: Heinemann.
- Conversation, coordination, and vertebrate communication.Stephen J. Cowley -1997 -Semiotica 115 (1-2):27-52.
- Prospective memory skill.Stephen J. Andrzejewski,Cathleen M. Moore,Maria Corvette &Douglas Herrmann -1991 -Bulletin of the Psychonomic Society 29 (4):304-306.
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David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Area Editors:
David Bourget
Gwen Bradford
Berit Brogaard
Margaret Cameron
David Chalmers
James Chase
Rafael De Clercq
Ezio Di Nucci
Esa Diaz-Leon
Barry Hallen
Hans Halvorson
Jonathan Ichikawa
Monte Johnson
Michelle Kosch
Øystein Linnebo
Paul Livingston
Brandon Look
Manolo Martínez
Matthew McGrath
Michiru Nagatsu
Susana Nuccetelli
Giuseppe Primiero
Jack Alan Reynolds
Darrell P. Rowbottom
Aleksandra Samonek
Constantine Sandis
Howard Sankey
Jonathan Schaffer
Thomas Senor
Daniel Star
Jussi Suikkanen
Aness Kim Webster
Other editors
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