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When stripped to the bare bone, there are only 11 foundational paradigms in social sciences. These foundational paradigms are like flashlights that can be utilized to shed light on different aspects of human society, but each of them can only shed light on a limited area of human society. Different schools in social science result from different but often incomplete combinations of these foundational paradigms. To adequately understand human society and its history, we need to deploy all 11 foundational paradigms, (...) although more limited combinations of them may be adequate for understanding more specific social facts. (shrink)

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Niche construction theory (NCT) has become a prominent strain within the “Extended Synthesis” literature in evolutionary biology. Moreover, because human beings are indisputably “the most creative niche constructor”, “the ultimate ecosystem engineers”, and “the world’s greatest evolutionary force”, niche construction has been imported to social sciences as social niche construction (SNC) or human niche construction. Yet, NCT has also encountered quite a bit of criticism. If so, what is the value of importing NCT to social sciences as SNC? This article (...) takes the criticisms against NCT and SNC seriously and advances a set of ontological and epistemological principles for applying SNC in social sciences. In particular, I highlight the potential explanatory power of SNC, contending SNC can help us transcend the agent-structure/system debate in social theory, illustrating with Norbert Elias’s [1939] 1994a. The Civilizing Process. I also stress that SNC allows us to synthesize micro, meso, and macro for understanding social changes in different niches or domains through time and space, by firmly bringing time and space into theorization in social sciences inquires. (shrink)

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If the coming of the last universal cellular ancestor marks the crossing of the “Darwinian Threshold”, pre-LUCA evolution must have been pre-Darwinian. But how did pre-Darwinian evolution actually operate? Bringing together and extending insights from both earlier and more recent contributions, this essay advances three principal arguments regarding the pre-Darwinian evolution. First, in the pre-Darwinian epoch, survival essentially meant persistence within the prebiotic system, and it depended mostly on chemical variation and interaction. Second, selection operated upon four different properties: chemical; (...) chemical-physical; vesicles’ capacities in absorbing, engulfing, and merging; and protocells’ coupling of metabolism, replication, and division. Third, division evolved from a state without tight coupling of replication with division to a state of tight coupling. Eventually, protocells with a tight coupling of replication with division became the First Universal Cellular Ancestors and then LUCA. (shrink)

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There are hundreds, if not thousands, of pathways in a unicellular prokaryotic organism, and all these pathways will have to be controlled, regulated, and coordinated to ensure their proper functioning. As organisms evolve from unicellular eukaryotic organisms to multicellular organisms such as the metazoans, more pathways have evolved to support more diverse biological functions. As a result, fine-tuned control, regulation, and coordination of these pathways becomes an immensely complex and demanding task. Yet, consistent with Darwin’s insight that “nature is prodigal (...) in variety, though niggard in innovation,” nature has produced only a few master coordination hubs for these pathways. Moreover, multicellular organisms such as metazoans have evolved two broader means for coordinating various pathways: crosstalk and communication. Crosstalk operates via having shared components and links between intracellular pathways whereas communication operates via transmitting intercellular signals such as hormones and other ligands with membrane receptors and downstream intracellular signal transductions pathways. Our framework points to a more complex network-based approach for understanding biological pathways and the consequences of their disruption, escape, and malfunction such as cancer, aging, and other diseases. (shrink)

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In this essay I survey the key themes within China's discourse on international order, especially how China views its position and role in shaping the existing and future order. I go on to explore the possible implications of China's thinking and actions toward the existing international order. I conclude that overall, China sees no need for and hence does not seek fundamental transformation, but rather piecemeal modification of the existing order. In fact, China has been quite content with the existing (...) order that supports globalization, despite occasional rhetoric indicating otherwise. In the near future, China will likely invest heavily in two key issue areas: (1) regionalism in East Asia and Central Asia; and (2) interregional cooperation and coordination. Perhaps unsurprisingly, China's ambitious “One Belt and One Road” initiative seeks to integrate these two issue areas. (shrink)

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