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Transfer RNA (tRNA) modifications play an important role in regulating mRNA translation at the codon level. tRNA modifications can influence codon selection and optimality, thus shifting translation toward specific sets of mRNAs in a dynamic manner. Queuosine (Q) is a tRNA modification occurring at the wobble position. In eukaryotes, queuosine is synthesized by the tRNA‐guanine trans‐glycosylase (TGT) complex, which incorporates the nucleobase queuine (or Qbase) into guanine of the GUN anticodons. Queuine is sourced from gut bacteria and dietary intake. Q (...) was recently shown to be critical for cellular responses to oxidative and mitochondrial stresses, as well as its potential role in neurodegenerative diseases and brain health. These unique features of Q provide an interesting insight into the regulation of mRNA translation by gut bacteria, and the potential health implications. In this review, Q biology is examined in the light of recent literature and nearly 4 decades of research. Q's role in neuropsychiatric diseases and cancer is highlighted and discussed. Given the recent interest in Q, and the new findings, more research is needed to fully comprehend its biological function and disease relevance, especially in neurobiology. (shrink)

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Rashad Rehman and Darius J. Bägli draw on the example of congenital adrenal hyperplasia in order to outline appropriate uses of the term “disorder” versus “difference” of sexual development.

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This article explores the concept of internationally acceptable codes of ethics within the context of an Egyptian nurse’s PhD studies. Theoretical work, including gaining ethical approval for the project, took place in the UK, while the data collection phase of the study was done in Egypt. This highlighted areas where the Arab Muslim interpretation of some ethical principles, especially around the issue of gaining informed consent, differed from that currently accepted in British research ethics. The authors argue that it may (...) not be possible, or even desirable, to standardize codes of ethics globally in areas such as academic research. Ethical principles develop from a unique mix of culture and religion. It may be more important to develop cultural competence that includes the ability to understand and respect the way in which ethical principles are interpreted by various societies. (shrink)

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Rashad Rehman, Nipa Chauhan and Rebecca Greenberg argue that beneficent paternalism should be integrated into shared decision-making in the NICU to maximize the patient’s best interests.

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Rashad Rehman calls for the bioethical community to help contribute conceptual clarity to the debate about the ethics of intersex pediatric surgery.

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Digital art examines the transformation of traditional art forms into new modes of expression through digital technologies. The article analyzes the impact of the digital environment on contemporary art, how creators benefit from this medium, and how art evolves into new forms in conjunction with technology. Unlike traditional art forms, digital art provides artists with the opportunity to create visual expressions through “zeros and ones.” In this environment, they can realize their ideas more conveniently, and the resulting artworks become more (...) accessible to people. The digital environment offers not just a technological tool but a new intellectual and spiritual platform for artists and viewers. Emerging in the 1950s-60s with the development of computer technologies, digital art has expanded over time through its interactive forms, transforming aesthetic perceptions. The digital realm broadens the boundaries of human creativity, establishing new harmonies between art and technology. The article covers the historical development of digital art, its impact on contemporary practices, and its future prospects. This new form of creativity reflects how technology influences aesthetics and supports human intellect. (shrink)

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This chapter asks the following question: What are the conditions, within and fostered by contemporary educational institutions, for social justice to be grounded philosophically and put into concrete action? In answer- ing this question, I argue that a defense of the liberal arts is a plausible candidate for grounding the possibility of “social justice,” understood as fulfilling an obligation to another in virtue of their intrinsically being owed that obligation. The liberal arts are not merely mechanical, special- ized disciplines; instead, (...) they embody a philosophical anthropology in which human beings are responsible, reflective and contemplative indi- viduals capable of intrinsically meaningful actions. It is to this end that I argue that Josef Pieper’s defense of the Geisteswissenschaften (liberal arts), and the philosophical anthropology which underlies it, is a plausi- ble way to ground social justice. I begin this chapter by outlining what the liberal arts are and how they have been challenged implicitly and explic- itly. I then outline a specific consequence of this explicated in Bryan Met- calfe’s dissertation Pedagogy of Mythos (2013). Having done this, I outline Pieper’s defense of the liberal arts, offer objections to his defense and respond to them. In the end, I conclude that while Pieper’s defense grounds a requisite philosophical anthropology for social justice, a contemporary defense of the liberal arts will always be needed, especially given contem- porary “sophistry.” I finish this chapter in the hope that this always- contemporary defense can be done with an aim to change, while main- taining peaceful, civil discourse. (shrink)

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This book explores emerging conflicts about religious liberty and discrimination. In point-counterpoint format, it brings together longtime LGBT rights advocate John Corvino and rising conservative thinkers Ryan T. Anderson andSherif Girgis to debate Religious Freedom Restoration Acts, anti-discrimination law, and age-old questions about identity, morality, and society.

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In this paper, we present a dialectical argument for a priori skepticism (i.e. the thesis that we can be skeptical about a priori knowledge). Then, we propose a framework that combines elements from inferential contextualism and logical conventionalism to offer a weak transcendental argument against a priori skepticism.

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It is a relatively uncontroversial proposition that without “ethics,” an “ethics of homelessness” is impossible. What is less uncontroversial, though, is that philosophy—or at least philosophical analysis—is a necessary condition of ethical discourse. The distrust—or skepticism regarding the utility of— philosophical analysis is predicated on rendering philosophy as useless. This, though, should create a sense of cognitive dissonance, since we universally acknowledge that ethics informs how we interact with ourselves and others, while we also accept, and rightly so, the uselessness (...) of philosophy. While pop- ular parlance has it that uselessness is logically and semantically equivalent to not needed or conceptually irrelevant, this, I will argue, is mistaken. This mis- take, as I see it, is a result of the failure to recognize that liberal arts are intrinsi- cally useless—and ought to be treated as such. To mend this mistake, I will outline the liberal arts in contrast to the servile arts and explain how Aristotle, and his later defender Josef Pieper, correctly understood the distinction. I will then move onto suggest that while philosophy—as a liberal art—is useless, and rightfully so, it is a conceptually relevant, necessary condition for dealing with conceptual problems which arise in ethics—and therefore in the ethics of homelessness. To explicate and defend this thesis, I argue that Plato’s three- fold division of goods, originating in Book ii of his Republic, helps to amalgamate our reservations in accepting philosophy as useless—strictly speaking—and simultaneously useful. From this, I move on to provide various ways in which philosophy is relevant to questions of home and homelessness generally, and display how philosophers themselves have, historically, taken seriously the question of home and homelessness as serious philosophical concepts. Finally, I outline how philosophers can work on the ethics of home- lessness by taking seriously the necessary presuppositions which make work- ing on the alleviation of homelessness not merely possible, but morally obligatory. Having sketched a broad picture of how philosophy interacts with the practical problems of homelessness, I conclude that progress in the field of the ethics of homelessness—as a conceptual endeavor—will ultimately arise from overcoming our prima facie interpretation of the liberal/servile arts distinction and thereby preserve its original meaning. (shrink)

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This chapter has two aims.* First, it exegetes Aquinas’ notion of peace (pax) in his Commentary on the Gospel of St. John (14:7), which is centred around the definition, kinds and possibility of a perfected peace, as well as how love (amor) is the cause of peace. Second, rather than defending Aquinas’ position at length, I take the more humble task to defend one attractive, plausible feature of Aquinas’ position, showing how it reveals Medieval wisdom for the establishment of modern (...) peace. The position is two-fold: First, Aquinas’ position – at least how Josef Pieper (1904–97) reads him – that love is essentially the affirmation of the goodness of the existence of the other person. I read this as an empirically-supported, plausible source of peace. This thesis also reiterates Aquinas’ rejection of monadic theories of peace which hold that peace need only be outward (exterius) e.g., establishing socio-political peace by fighting for human rights, and not inward (interius) e.g., peace with oneself by cultivating the inner life (14, 7, 1962). Second, Aquinas’ position that love, and not other candidates e.g., tolerance, as the cause of peace, is an alternative, plausible position that merits critical attention. (shrink)

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Intersex pediatric surgery is a family of surgical practices performed by pediatric urologists which aim to clarify the sex of an individual with differences/disorders of sexual development, specifically those with ‘intersex’ conditions. It aims to functionally and aesthetically disambiguate an individuals’ binary sex that is obscured by intersex conditions. I ethically reassess intersex pediatric surgery in light of contemporary biotechnology, formal specialization in pediatric urology and long-term data on the efficacy of intersex pediatric surgery, finding that there are only select (...) contexts in which intersex pediatric surgery is morally justifiable. I develop novel, operationalizable and testimonially-informed moral criteria to regulate intersex pediatric surgery, working out the details for how medical professionals in pediatric healthcare facilities are best able to facilitate and augment the decision-making of parents as they decide whether intersex pediatric surgery is in the best interests of their child with intersex conditions. (shrink)

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Self-medication of antibiotics is an irrational use of drugs, contributing to microbial resistance, increasing healthcare costs and higher mortality and morbidity. This study aimed to assess self-medication with antibiotics without a medical prescription in the community of Libya. This is a cross-sectional study conducted from June to December 2022 and the total number of participants was 200. The design of the study and sample size were modified according to the proficiency of pharmacists and the medical and non-medical population of Libya. (...) The questionnaire was developed in English and Arabic language and was distributed through social media platforms. The questions were used after a thorough literature search and assessing the validity and reliability. The significant signs regarding reasons for the treatment by self-medication drugs of antibiotics, because of its various drugs of antibiotic by pharmacist (n=80, 40.0%) and family (n=90, 45.0%) compared with experience and physicians by used prescription was 13 (6.50%) and significant sings regarding by nasal congestion self-medication of various antibiotics (n=100, 50.0%). This sign must be practiced based on a previous physician’s prescription. The antibiotics are often self-administered as patients feel that they will save money and time but this can lead to substantial adverse drug reactions, antibiotic resistance, treatment failure and drug-related toxicity. This study respondent's medical and non-medical public of Libya who should be relatively informed and educated about the risk of treatment by self-medication of antibiotics with the development of resistance. (shrink)

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One must accept the complexity of modern society as a multifaceted influence that will direct the future of all social organizations. Technology has brought the people of the world into almost instant communication. Biomedical science has conquered most infectious, acute diseases and has provided several medicines for the successful maintenance therapy of chronic diseases. The lifestyle of some people as smoking and drug addiction remains a strong factor in their achievement of the health goals of the good life. Universally, economic (...) inflation and international business have created an economic interdependence among nations and dealing with the economic problems of one country must take into account this interdependence. When one views the future within this technologic-social-economic framework, he has difficulty sorting out certain directing influences that may shape the future of pharmacy practice in Libya. (shrink)

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Germain Grisez’s philosophical argument for respecting human life has been developed by fellow new natural law theorists and applied to a range of lethal actions, for its conclusion is vast: intending the death of any human being as a means or an end is wrong in itself. For some Thomists, the NNL view on killing is both lax and rigorist: They consider it lax because its narrow criterion for what is “intended” leaves out some acts, especially ones related to abortion, (...) that the critics consider murder. And they consider the NNL view rigorist insofar as it apparently rules out the death penalty, contrary to the Thomistic tradition and perhaps even heretically. However, the most salient philosophical arguments for exceptions to the principle against intending anyone’s death are weaker than the case for any given premise of the contrary NNL argument. Nevertheless, some NNL theorists’ arguments on life are unsound, some can be defended better than they have been, and some nonphilosophical objections based on theological authority require more exploration. (shrink)

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We show in this paper how three continental philosophers (Husserl, Heidegger, and Derrida respectively) respond negatively to the analytic correspondence theory of truth using different notions developed by them (i.e. the notion of Intentionality by Husserl, the notion of Dasein by Heidegger, and the notion of Trace by Derrida). We show that despite the fact that the three philosophers are united against the analytic correspondence theory of truth, there are still deep differences between them which stem from the different tools (...) they use to articulate the concept of truth. Also, we argue that Husserlian truth has an advantageous position over the other concepts of truth presented. (shrink)

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This paper argues that Canada is not ready to place a moratorium against intersex pediatric surgery.

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This article supplements Julio Tuleda, Enrique Burguete, and Justo Aznar's “The Vatican opinion on gender theory” (Linacre). It supplements their article by providing a stronger argument for the thesis that “intersex” does not violate binary sex in human beings. In their response to Timothy F. Murphy's criticism of “the Vatican's” (rightfully corrected as the Magisterium of the Catholic Church's) position on the sex binary, they argue subsidiarily that “intersex” does not violate the sex binary. However, their argument against Murphy as (...) stated is implausible; however, I provide a much stronger argument for their conclusion that intersex does not violate the sex binary. I intend to perform this supplementation in two stages, assuming the reader's familiarity with “The Vatican opinion on gender theory.” First, I provide a broader background than Murphy's to the challenge that “intersex” conditions violate the sex binary, showing both how Murphy's criticism is unoriginal and how “intersex” both has been, and continues to be, misunderstood. Second, I problematize Tuleda’s argument, and offer the strongest argument for the conclusion that “intersex” does not violate the sex binary on purely secular/nonreligious grounds (addressing Murphy's complaint). I conclude that the Magisterium of the Catholic Church remains correct that sex is binary. (shrink)

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Many people, communities and countries are in favour of abortion as a healthcare right, arguing that women have a right to receive an abortion upon request. Some contexts place ethical constraints on this right, typically based on the age of the preborn child, the mother’s safety, or the circumstances of the mother (and her conceiving of her child) more generally. At the same time, intersex pediatric surgery (IPS) is being increasingly ethically challenged with many countries banning healthcare facilities from performing (...) IPS. At first, there appears to be no relation between these two ethical issues. However, modern biotechnology such as the assistive reproductive technology (ART), preimplantation genetic diagnosis (PGD), makes it possible to screen for intersex conditions in utero, opening the possibility of intersex-selective abortion (ISA), a sub-set or instance of sex-selective abortion (SSA). What emerges is the realization that if IPS is wrong because, as its critics have argued, it wrongfully discriminates against and harms intersex lives, then ISA is much more wrong because instead of misvaluing intersex lives, it devalues intersex lives altogether. In other words, IPS might, as some have argued, discriminate by implying that an intersex child is better off being male or female but not intersex, but ISA discriminates by implying that an intersex child is better off not existing at all. Some have recognized this connection and have vainly tried to maintain both their pro-abortion commitments and their anti-IPS commitments. This has proved at best duplicitous, and at worst conceptually impossible. While it is known that a strong stance against IPS results in an inability to morally condemn ISA, with one notable exception in moral theology, this connection has not been generally appreciated. (shrink)

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Lifelong learning is becoming part of the philosophy of professional education. Continuing medical education is the responsibility of all personnel who are responsible for the delivery of components of the healthcare delivery system. Continuing education is becoming increasingly obvious for medical universities, hospitals, and health care providers. Pharmacists who practice in a community pharmacy and hospital, and who are participating in residency recognize that the traditional role of the pharmacist is changing. Over the last decades, a host of new services (...) have been identified as a function of the pharmacist [1]. A review of these services revealed a personal commitment to continuing education. It is the absolute need to develop a level of competence that will improve patient care. In Libya, pharmacists working in the community practice setting are pharmacists with a diploma of pharmacy or with a Bachelor of Pharmaceutical Science, Master of Science, and Doctor of Pharmacy (Pharm D). The main objective is that the graduates possess the knowledge and skills needed to optimally mange the pharmaceutical services [1, 2]. Patient's expectations from pharmacists are that the medicine should be effective, safe and affordable. (shrink)

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Disintegration is the most important step for drug bioavailability because after, the disintegration process, the ingredients of solid dosage forms dissolve and become bioavailable. Generally, the tablets and capsules should be taken with a glass of water otherwise the manufacturer gives instructions to use the proper beverage. Several drugs are taken with different forms of beverages to ensure easy swallowing of the tablet, masking the bad taste of the drug and overcoming the drug aftertaste, these beverages can influence the disintegration (...) of the solid dosage form. The most common cold beverages consumed by the Libyan population are juice, milk, and Coca-Cola. These beverages are consumed without awareness of the possible effect of these beverages on drugs, especially over-the-counter drugs such as analgesic, antipyretic, and anti-inflammatory drugs that are taken without a prescription. This study aimed to evaluate the influence of three beverages, namely: orange juice, milk, and Coca-Cola on the disintegration time of four over-the-counter-drugs: Panadol, Congestal, Brufen, and Reality Extra using disintegration test of drugs in 0.1 N HCL and in hybrid medium prepared by combination of 150 ml 0.1 N HCL and 550 ml of beverage to simulate in vivo condition. The findings show that the orange juice significantly increases the disintegration time of all the investigated drugs. Coca-Cola significantly increases the disintegration time of Reality Extra, and slightly increases the disintegration time of Brufen, Congestal, and Panadol and the full-fat milk significantly increases the disintegration time of Reality Extra and Panadol while slightly increasing the disintegration time for Brufen and Congestal. It is concluded that commonly used beverages affect the disintegration time of the examined over-the-counter drugs. Patients should be advised to take these medications without beverages which may delay the disintegration and the onset of action of the drug. (shrink)

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Diabetic ketoacidosis is a serious, medical emergency that can be fatal but treatable, we aimed to evaluate the clinical profile of patients admitted with diabetic ketoacidosis. This case series study enrolled 213 non-pregnant adult and adolescent patients admitted with diabetic ketoacidosis at Tripoli Diabetes Hospital from January to September 2023. Demographic data, clinical characteristics, laboratory findings, precipitating factors, and patient outcomes were extracted from medical records and analyzed. Type 1 diabetes mellitus was present in 187 (87.8%) of patients, the age (...) range 11-84 years, (30.26±13.28), with 130 patients ≤30 years old (61.0%), females accounting for 110 of the patients (51.6%), 109 had a diabetes duration of less than 10 years (51.2%). The most common precipitating factor was insulin omission 92 (43.2%) in patients with known diabetes mellitus, whereas, diabetic ketoacidosis as the first presentation of diabetes mellitus in 24 patients (11.7%), systolic blood pressure ranged 50-160 mmHg (112.82±16.19), diastolic blood pressure varied 30-100 mmHg (70.24±11.32). Plasma glucose at presentation ranged 183-1494 mg/dl (462.92±169.85), with Eu-glycemic diabetic ketoacidosis 100-249 mg/dl were in nine patients (4.2%), whereas most of cases (135 patients, 63.4%) present with plasma glucose 250-500 mg/dl, while hyperosmolar status (≥701 mg/dl) were present in 13 patients (6.1%). Venous pH varied from 6.7-7.42 (7.13±0.14), 132 (62.0%) patients presented with pH <7.24, while severe acidosis was pH < 7 in 32 of patients (14.6%), serum bicarbonate with 10.93±4.95, severe (<5 mmol) in 91 patients (42.7%) and moderate (5-10 mmol) were in 79 patients (37.08%). The mean length of hospital stay was 3.33 days, with an average of 2.11 days spent in the high-dependent unit. Serum potassium varied from 2.4-6.7 meq/L with 3.66± 0.63, most common complications of diabetic ketoacidosis treatment were hypokalemia observed in 82 (35.7%) of cases, and hypoglycemia was detected in 41 patients (19.2%). 170 patients were discharged in good condition (79.8%), and 17.8% of patients were transferred to another hospital to receive further management for co-morbid diseases with diabetes after controlling their hyperglycemic crises. The majority of patients presented with the critical status of diabetic ketoacidosis. The findings emphasize the importance of patient education about prevention measures prompt presentation to the hospital, and clinicians' awareness for early and aggressive treatment of hyperglycemic crises. (shrink)

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Inflammation is said to be a healthy component of the body's immune system's reaction. Inflammation is characterised by four key symptoms: pain, redness, heat or warmth and swelling. As secondary metabolites, plants may produce a wide range of phytochemical compounds, which possess anti-inflammatory characteristics. Herbal remedies are important therapies for a wide range of ailments all over the world. There are around 7,500 species of medicinal plants, including representatives from over 17,000 flowering plant species. Even though synthetic chemistry has developed (...) its expectations, the use of natural ingredients in the manufacture of drugs used in contemporary medicine is unparalleled. By interfering with the biology of inflammation, anti-inflammatory medications may assist to minimising tissue damage and increase patient comfort. Because of the bulky figure of species reachable for study, the effective development of novel naturally taking place anti-inflammatory drugs is mostly dependent on a multidisciplinary approach to discovering new chemicals. Despite the statistic that many review papers have been produced in this field, the conventional of them simply examined the issue from an area perspective. Several non-steroidal anti-inflammatory drugs have been shown to reduce inflammation and pain by decreasing the isoform of the cyclooxygenase enzyme's digestion of arachidonic acid, hence lowering prostaglandin production. Non-steroidal anti-inflammatory drugs have a host of harmful effects. There are, however, medicinal herbs with anti-inflammatory pharmacological properties that have few or no negative effects. (shrink)

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Postpartum depression is a major maternal health problem after childbirth. It can start at any time within the first year after delivery and continue for several years. It is characterized by an inability to experience pleasure, anxiety symptoms, panic attacks, spontaneous crying and depressed mood. Some women with postpartum depression even have thoughts of harming their child and self-harm. This study aims to find out the status of postpartum depression and the associated factors among postnatal mothers at the first, fourth (...) and sixth month. This study is a prospective descriptive study, carried out in three major health facilities in Misurata. This study consists of a three-part questionnaire. Part 1 covers the demographic characteristics of the participants, while Part 2 explores the associated risk factors according to the variables used. Part 3 consists of the psychological evaluation of the participants. A hundred mothers (ages between 15 and 43 years) were enrolled in this study. The findings revealed that the prevalence of depression is 60.0% and 22.0% are suffering from borderline depression. Development of depression was strongly correlated with sleeping disturbances, the state of the neonate after birth, excess consumption of stimulants, less weight acceptance by mothers during pregnancy and infant illness. There was a weak relation between depression and delivery state, maternal admission to the hospital during the current pregnancy, and infant gender dissatisfaction. No correlation was found with the development of depression regarding miscarriage, maternal medical problems after delivery, previous child sex, maternal age, education, parity or neonate weight. Thus, this study shows that the chance of having a miscarriage and an unhealthy neonate increases with advanced maternal age. It also shows that caesarean section is associated with bad neonatal outcomes, more weight gain and having gestational diabetes or preeclampsia during pregnancy. Maternal sleeping problems are more pronounced in the first month, attributed to the baby's care, compared with the fourth and sixth months. The study indicates that depression is a common state of psychiatric disorders among Libyan women and should have appropriate attention by physicians and gynecologists. (shrink)

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Postpartum depression is a major maternal health problem after childbirth. It can start at any time within the first year after delivery and continue for several years. It is characterized by an inability to experience pleasure, anxiety symptoms, panic attacks, spontaneous crying and depressed mood. Some women with postpartum depression even have thoughts of harming their child and self-harm. This study aims to find out the status of postpartum depression and the associated factors among postnatal mothers at the first, fourth (...) and sixth month. This study is a prospective descriptive study, carried out in three major health facilities in Misurata. This study consists of a three-part questionnaire. Part 1 covers the demographic characteristics of the participants, while Part 2 explores the associated risk factors according to the variables used. Part 3 consists of the psychological evaluation of the participants. A hundred mothers (ages between 15 and 43 years) were enrolled in this study. The findings revealed that the prevalence of depression is 60.0% and 22.0% are suffering from borderline depression. Development of depression was strongly correlated with sleeping disturbances, the state of the neonate after birth, excess consumption of stimulants, less weight acceptance by mothers during pregnancy and infant illness. There was a weak relation between depression and delivery state, maternal admission to the hospital during the current pregnancy, and infant gender dissatisfaction. No correlation was found with the development of depression regarding miscarriage, maternal medical problems after delivery, previous child sex, maternal age, education, parity or neonate weight. Thus, this study shows that the chance of having a miscarriage and an unhealthy neonate increases with advanced maternal age. It also shows that caesarean section is associated with bad neonatal outcomes, more weight gain and having gestational diabetes or preeclampsia during pregnancy. Maternal sleeping problems are more pronounced in the first month, attributed to the baby's care, compared with the fourth and sixth months. The study indicates that depression is a common state of psychiatric disorders among Libyan women and should have appropriate attention by physicians and gynecologists. (shrink)

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Prescribing drugs for elderly patients is not an easy task since elderly patients frequently have comorbid conditions. In Libya, there are no guidelines for the management of medications used in elderly patients and no specialized geriatric health institutions. This study aims to assess the pattern of medication use among hospitalized elderly patients in Sebha Medical Centre and the drug-related problems associated with these patterns. This report is a descriptive and retrospective cross-sectional study conducted at Sebha Medical Center in 2021. Potential (...) drug-related problems were assessed based on the classification of Hepler and Strand. In this study, out of 195 participants, most patients have been given antibiotics (92.0%). The majority of patients have been prescribed anti-gastric agents, vitamins and anti-thrombotic agents which accounted for 75.0%, 62.0% and 55.0%, respectively. To a lesser extent, anti-hypertensive agents, analgesics and antihyperlipidemic were reported by 45.0%, 43.0% and 38.0%, respectively. Almost all the patients have at least one event of drug-related problem and more than three-quarters of the patients had more than one event of drug-related problems. The highest rate was untreated indications which were reported for 77.0% then followed by drug use without indication in nearly half of the events 48.0%. To fewer extent rates were reported: “in improper drug selection”, “drug interaction” and “adverse effects” which were reported for 25.0%, 23.0% and 18.0% of the total events, respectively. Almost all elderly patients have been prescribed antibiotics, analgesics and vitamins. Drug-related problems are predominantly prevalent in the clinical practice at the center. This study highlights the importance of activation of clinical pharmacist interventions at hospitals which can contribute to reducing the chance of risk of drug-related problems events among hospitalized elderly patients and ensuring rational drug prescribing in the geriatric clinical settings. (shrink)

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Vitamin D deficiency and its effect have attracted considerable research interest due to its relation to glucose homeostasis, insulin secretion, sensitivity and synthesis. This study aimed to evaluate vitamin D levels in patients with type II diabetes mellitus aged between 35-65 years and investigate their relations with glycemic control and obesity. The study included 74 Libyan patients with a known history of type II diabetes mellitus (33 males and 41 females). Serum glucose, glycosylated hemoglobin (HbA1c) and vitamin D levels were (...) biochemically estimated in these patients. Further, body mass index (BMI) was calculated for all diabetic patients (weight in kilogram per height in meter square). The mean level of plasma glucose level was 150.58±63.82 mg/dl (mean±SD). The mean of HbA1c level was 7.90±8.48% (mean±SD). The mean level of vitamin D was 22.75±14.97 ng/ml. The mean of BMI was 26.55±4.10 Kg per m2. The findings showed that 58.10% of the cases had vitamin D deficiency (Out of which 24.24% were males and 85.36% were females). This study showed significant differences in glucose, HbA1c, vitamin D and BMI between male and female patients. Moreover, elderly ages for both sexes had adverse effects on vitamin D status. Vitamin D levels have negatively been correlated with levels of glucose, HbA1c and BMI. It is concluded that vitamin D deficiency has an adverse effect on glucose homeostasis in patients with type II diabetes mellitus and this can be a contributing risk factor in complications of type II diabetes mellitus development in Libyan patients. (shrink)

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This article comprehensively explores the application of sustainable development principles to project management in Azerbaijan. The primary objective of the study is to propose strategic approaches and recommendations for sustainable project management in Azerbaijan based on an in-depth analysis of global experiences. Global practices, including initiatives aimed at addressing climate change and environmental issues, have been reviewed and compared with Azerbaijan's current situation. The research highlighted the steps taken by Azerbaijan toward sustainable development. In particular, the Smart Villages project implemented (...) within the framework of the "Azerbaijan 2030" National Priorities and the assessment of renewable energy potential were emphasized as significant factors for ensuring sustainable development. Furthermore, existing ecological issues such as industrial waste and air pollution were analyzed, and general approaches to addressing these challenges were proposed. The article concludes with strategic approaches and recommendations aimed at achieving the country's sustainable development goals. These suggestions are focused on ensuring ecological and economic balance in Azerbaijan and implementing more efficient and sustainable project management practices. (shrink)

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In this article, we consider estimation of the parameters of a generalized Pareto distribution and some lifetime indices such as those relating to reliability and hazard rate functions when the failure data are progressive first-failure censored. Both classical and Bayesian techniques are obtained. In the Bayesian framework, the point estimations of unknown parameters under both symmetric and asymmetric loss functions are discussed, after having been estimated using the conjugate gamma and discrete priors for the shape and scale parameters, respectively. In (...) addition, both exact and approximate confidence intervals as well as the exact confidence region for the estimators are constructed. A practical example using a simulated data set is analyzed. Finally, the performance of Bayes estimates is compared with that of maximum likelihood estimates through a Monte Carlo simulation study. (shrink)

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The number of comments/reviews for movies is enormous and cannot be processed manually. Therefore, machine learning techniques are used to efficiently process the user’s opinion. This research work proposes a deep neural network with seven layers for movie reviews’ sentiment analysis. The model consists of an input layer called the embedding layer, which represents the dataset as a sequence of numbers called vectors, and two consecutive layers of 1D-CNN for extracting features. A global max-pooling layer is used to reduce dimensions. (...) A dense layer for classification and a dropout layer are also used to reduce overfitting and improve generalization error in the neural network. A fully connected layer is the last layer to predict between two classes. Two movie review datasets are used and widely accepted by the research community. The first dataset contains 25,000 samples, half positive and half negative, whereas the second dataset contains 50,000 specimens of movie reviews. Our neural network model performs sentiment classification among positive and negative movie reviews called binary classification. The model achieves 92% accuracy on both datasets, which is more efficient than traditional machine learning models. (shrink)

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One reading of the resurgence of popular philosophy in the secular world is a counter-cultural movement toward the recultivation of philosophical questions. With the advent of Mike Schur’s Netflix series A Man on the Inside (2024), there has again been renewed interest at the cultural level in philosophical themes pertaining to the nature of the good life and the role interpersonal relationships play within it. Although a first approximation of A Man on the Inside accentuates various unattractive and repellent secular (...) tropes, under critical analysis the series offers a powerful and compelling illustration of three enduring truths codified within—and spearheaded by—Catholicism, which are now gaining wider secular interest and attention. While these truths are grounded in and enriched by Catholicism, they are nonetheless grounds for optimism that secular culture, when led by truth and beauty, inches toward Christianity. (shrink)

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This study aims to use geographic information systems to analyze the spatial distribution of ATMs in Abha city. This is based on the most important applied aspects of geographic information systems, namely spatial analysis, to reveal the characteristics of the spatial distribution of ATMs and their distribution pattern, and to evaluate the efficiency of their distribution according to spatial variables. The study came out with a number of results and recommendations, the most important of which is increasing the number of (...) ATMs in high-density neighborhoods that are deprived of service, which reduces the pressure on them, in a way that ensures their sustainability, and in a manner that is proportional to both the area and the number of residents in the city's neighborhoods. (shrink)

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Service geography is one of the branches of applied geography that has emerged as an applied intellectual interest to engage with the immediate direct needs of both urban and rural communities. The importance of studying services is due to their connection to economic planning, so geographical interest in them increases, as applied geography is based on a specific approach and philosophy of relevance or social benefit that focuses on the application of geographical knowledge and skills. To come up with solutions (...) to real-world social, economic and environmental problems. The study focused on the use of geographic information systems in analyzing the geographic calendar of rental offices in the city of Abha, relying on the most important applied aspects of geographic information systems represented in spatial analysis. To reveal the characteristics of the spatial distribution of rental offices and their distribution pattern, and to evaluate the efficiency of their distribution according to the local standard. The study came out with a number of results and recommendations, and also verified the hypotheses assumed by the researchers. (shrink)

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Purpose Advances in electronic performance monitoring have raised employees’ concerns regarding the invasion of privacy and erosion of trust. On the other hand, EPM promises to improve performance and processes. This paper aims to focus on how the alignment of EPM design and organizational culture through effective organizational mechanisms can address privacy concerns, and, hence, positively affect employees’ perception toward technology. Design/methodology/approach Based on a theoretical lens extending two conceptual frameworks, a qualitative approach was used to analyze interview data collected (...) from a comparative case study of two organizations in the USA and Qatar within the oil and gas sector. These two contexts were selected to emphasize the cross-cultural and organizational differences in employees’ acceptance of EPM. Findings The study revealed that national and corporate cultures affected employees’ perception and acceptance of monitoring in both countries. Because of diversity, though EPM was better accepted in Qatar, as they are an easy way to enforce standardization and to push employees to adapt to a dominating corporate culture. Conversely, in the USA where culture is more innovation-oriented, organizational mechanisms shifted the perceptions of EPM to being mean to obtain feedback rather than to impose standards. Research limitations/implications This qualitative study is based on a descriptive comparative case study of two organizations with two cultural contexts. The limited sample size and cross-sectional nature of data may need to be extended to a larger cultural scope that is observed over a longer period to safely generalize the findings. Practical implications Decision-makers in multinational corporations with different cultural backgrounds may benefit of this study’s outcomes, as it emphasizes the importance of the fit between EPM designs and the cultural settings. Furthermore, organizations aiming to conduct analytics on EPM data have to justify and prove its benefits to employees to facilitate acceptance. Social implications The study shows that employees in Qatar have a different cultural frame of reference in their perception of fairness and ethics than their counterparts in the USA because of changes in the meaning of social relations, personal goals and behavioral norms. Originality/value The originality of this study lays in its empirical validation of a composite framework examining both national and corporate cultures on employees’ reactions to EPM systems. It also proves the critical importance of organizational mechanisms to align the EPM design with the organization cultural settings. (shrink)

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The single most influential and widely accepted objection against any form of dualism, the belief that human beings are both body and soul, is the objection that dualism violates conservation laws in physics. The conservation laws objection against dualism posits that body and soul interaction is at best mysterious, and at worst impossible. While this objection has been both influential from the time of its initial formulation until present, this paper occupies itself with arguing that this objection is a fleeting (...) one, and has successful answers from both scientific and philosophical perspectives. It is to this end that I provide three groups of responses to the conservation laws objection. First, I outline responses which take the ‘laws of nature’ as the proper entry point into the discussion. Secondly, I provide an analysis of those who argue that contemporary quantum physical data requires that the objection itself involves scientifically unjustified premises. Finally, I layout a philosophically oriented answer which argues that the objection is linguistically problematic since its demands on the dualist are categorically fallacious. From these groups of answers, I conclude that while the conservation laws objection has been arguably the most widely accepted objection against dualism, the objection is without philosophical justification. (shrink)

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Is intersexuality a mere difference or disorder? Since the 2006 Chicago consensus statement's disorder of sexual development (DSD) nomenclature, intersex scholars have criticized and repudiated the use of “disorder” by arguing that it is medically inaccurate, yields unwarranted surgical implications, unnecessarily pathologizes intersex individuals, and that, most importantly, intersex individuals do not prefer it. They argue for linguistic alternatives such as “difference” and other similar alternatives, for example, “variation,” “divergence,” and so forth. These criticisms of “disorder” have had significant uptake (...) by scholars writing on intersexuality. While the motivation(s) for using “mere difference” is doubtless rooted in beneficence for intersex persons, medically inaccurate intersex terminology compromises optimal clinical care and should consequently be either abandoned or revised. This focus paper argues (moderately) for the thesis that some cases of intersex are disorders, and some mere differences. The upshot of my proposal is not only that it conceptually disambiguates disorder and mere difference, but by failing to generalize unique intersex individuals their care is prioritized. (shrink)

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This paper investigates the prospects of a distinctively Plotinian argument for God’s existence. Specifically, this paper assesses Plotinus’ argument for the One/Good (Enneads; V.1,V.4), a principle rooted in Plato’s Republic (509b6-9), as a philosophical motivation for an argument for God’s existence. While the appropriative task of using Plotinus’ argument for natural theological purposes is not original to this work, this project remains in its philosophical infancy. It is to this end that the Plotinian background from which the argument proceeds is (...) articulated, and thereafter contextualised in Edward Feser’s Plotinian argument. This work defends Feser against two objections he does not consider, concluding that the appropriative strategy is successful and is a significant contribution to natural theology. (shrink)

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Josef Pieper’s critique of Martin Heidegger’s Wahrheitsbegriff has been virtually ignored in both Pieper and Heidegger scholarship; however, Pieper’s critique of Heidegger is both lethal and affirmative. On the one hand, Pieper makes a strong case against Heidegger’s Wahrheitsbegriff in “Vom Wesen der Wahrheit” and yet on the other he affirms his thesis that “the essence of truth is freedom.” This paper attempts to mend this gap in the literature by first presenting Heidegger’s “Vom Wesen der Wahrheit,” the essay in (...) which Heidegger explicates his concept of truth. Second, I exegete the critique of Josef Pieper found in his “Heideggers Wahrheitsbegriff.” Third, I conclude the paper by contextualizing Pieper’s critique within Pieper’s Werke, and make a note of the philosophical insights derivative from Pieper’s less than simple relationship to Heidegger. (shrink)

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