Do wild carnivores forage for prey or for nutrients?Kevin D. Kohl,Sean C. P.Coogan &David Raubenheimer -2015 -Bioessays 37 (6):701-709.detailsA widespread perception is that carnivores are limited by the amount of prey that can be captured rather than their nutritional quality, and thus have no need to regulate macronutrient balance. Contrary to this view, recent laboratory studies show macronutrient‐specific food selection by both invertebrate and vertebrate predators, and in some cases also associated performance benefits. The question thus arises of whether wild predators might likewise feed selectively according to the macronutrient content of prey. Here we review laboratory studies demonstrating (...) the regulation of macronutrient intake by invertebrate and vertebrate predators, and address the question of whether this is likely to also occur in the wild. We conclude that it is highly likely that wild predators select prey or selectively feed on body parts according to their macronutrient composition, a possibility that could have significant implications for ecological and foraging theory, as well as applied wildlife conservation and management. (shrink)
Agent-based modeling: a systematic assessment of use cases and requirements for enhancing pharmaceutical research and development productivity.C. Anthony Hunt,Ryan C. Kennedy,Sean H. J. Kim &Glen E. P. Ropella -2013 -Wiley Interdisciplinary Reviews 5 (4):461-480.detailsA crisis continues to brew within the pharmaceutical research and development (R&D) enterprise: productivity continues declining as costs rise, despite ongoing, often dramatic scientific and technical advances. To reverse this trend, we offer various suggestions for both the expansion and broader adoption of modeling and simulation (M&S) methods. We suggest strategies and scenarios intended to enable new M&S use cases that directly engage R&D knowledge generation and build actionable mechanistic insight, thereby opening the door to enhanced productivity. What M&S requirements (...) must be satisfied to access and open the door, and begin reversing the productivity decline? Can current methods and tools fulfill the requirements, or are new methods necessary? We draw on the relevant, recent literature to provide and explore answers. In so doing, we identify essential, key roles for agent-based and other methods. We assemble a list of requirements necessary for M&S to meet the diverse needs distilled from a collection of research, review, and opinion articles. We argue that to realize its full potential, M&S should be actualized within a larger information technology framework—a dynamic knowledge repository—wherein models of various types execute, evolve, and increase in accuracy over time. We offer some details of the issues that must be addressed for such a repository to accrue the capabilities needed to reverse the productivity decline. (shrink)
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Commentaries on David Hodgson's "a plain person's free will".Graham Cairns-Smith,Thomas W. Clark,Ravi Gomatam,Robert H. Kane,Nicholas Maxwell,J. J. C. Smart,Sean A. Spence &Henry P. Stapp -2005 -Journal of Consciousness Studies 12 (1):20-75.detailsREMARKS ON EVOLUTION AND TIME-SCALES, Graham Cairns-Smith; HODGSON'S BLACK BOX, Thomas Clark; DO HODGSON'S PROPOSITIONS UNIQUELY CHARACTERIZE FREE WILL?, Ravi Gomatam; WHAT SHOULD WE RETAIN FROM A PLAIN PERSON'S CONCEPT OF FREE WILL?, Gilberto Gomes; ISOLATING DISPARATE CHALLENGES TO HODGSON'S ACCOUNT OF FREE WILL, Liberty Jaswal; FREE AGENCY AND LAWS OF NATURE, Robert Kane; SCIENCE VERSUS REALIZATION OF VALUE, NOT DETERMINISM VERSUS CHOICE, Nicholas Maxwell; COMMENTS ON HODGSON, J.J.C. Smart; THE VIEW FROM WITHIN,Sean Spence; COMMENTARY ON HODGSON, Henry (...) Stapp. (shrink)
The Two Cultures.C. P. Snow &Stefan Collini -2012 - Cambridge University Press.detailsThe notion that our society, its education system and its intellectual life, is characterised by a split between two cultures – the arts or humanities on one hand and the sciences on the other – has a long history. But it was C. P. Snow's Rede lecture of 1959 that brought it to prominence and began a public debate that is still raging in the media today. This fiftieth anniversary printing of The Two Cultures and its successor piece, A Second (...) Look features an introduction by Stefan Collini, charting the history and context of the debate, its implications and its afterlife. The importance of science and technology in policy run largely by non-scientists, the future for education and research, and the problem of fragmentation threatening hopes for a common culture are just some of the subjects discussed. (shrink)
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The Ethical Implications of Organism-Environment Interdependency.Sean C. Lema -2014 -Environmental Ethics 36 (2):151-169.detailsModern ethical perspectives toward the environment often emphasize the connection of humans to a broader biotic community. The full intimacy of this connectedness, however, is only now being revealed as scientific findings in developmental biology and genetics provide new insights into the importance of environmental interaction for the development of organisms. These insights are reshaping our understanding of how organism-environment interaction contributes to both consistency and variation in organism development, and leading to a new perspective whereby an “organism” is not (...) solely viewed as the adaptive product of evolutionary selection to an external environment over generations, but as continuously being constructed through systems of interactions that link an organism’s characteristics developmentally to the physical and social influences it experiences during life. This newfound emphasis on “interaction” leads to an interdependency whereby any change to an “environment” impacts the interacting “organism,” and an alteration to the “organism” eventually affects its “environment.” The causal reciprocity embedded within this organism-environment interdependency holds implications for our moral obligations to environments, given their compulsory role in shaping all organisms including ourselves. (shrink)
Modeling unconscious gender bias in fame judgments.Sean C. Draine,Anthony G. Greenwald &Mahzarin R. Banaji -1995 -Consciousness and Cognition 5 (1-2):221-225.detailsIn the preceding article, Buchner and Wippich used a guessing-corrected, multinomial process-dissociation analysis to test whether a gender bias in fame judgments reported by Banaji and Greenwald was unconscious. In their two experiments, Buchner and Wippich found no evidence for unconscious mediation of this gender bias. Their conclusion can be questioned by noting that the gender difference in familiarity of previously seen names that Buchner and Wippich modeled was different from the gender difference in criterion for fame judgments reported by (...) Banaji and Greenwald, the assumptions of Buchner and Wippich's multinomial model excluded processes that are plausibly involved in the fame judgment task, and the constructs of Buchner and Wippich's model that corresponded most closely to Banaji and Greenwald's gender-bias interpretation were formulated so as to preclude the possibility of modeling that interpretation. Perhaps a more complex multinomial model can model the Banaji and Greenwald interpretation. (shrink)
Reexamining the categorical exclusion of pediatric participants from controlled human infection trials.Sean C. Murphy,Devan M. Duenas,Thomas L. Richie &Seema K. Shah -2020 -Bioethics 34 (8):785-796.detailsABSTRACT Controlled human infection (CHI) models have been developed for numerous pathogens in order to better understand disease processes and accelerate drug and vaccine testing. In the past, some researchers conducted highly controversial CHIs with vulnerable populations, including children. Ethical frameworks for CHIs now recommend vulnerable populations be excluded because they cannot consent to high risk research. In this paper we argue that CHI studies span a wide spectrum of benefit and risk, and that some CHI studies may involve minimal (...) risk. The categorical exclusion of children from CHIs therefore departs from the standard approach to evaluating research risks, as international regulations and ethical guidance for pediatric research generally permit non‐beneficial research with low risks. The paradigm in research ethics has also shifted from focusing on protecting vulnerable participants to recognizing that inclusion can be important as a matter of justice, providing new reasons to question this default exclusion of children from CHIs. Recognizing that pediatric CHIs can raise complex ethical issues and are easy to sensationalize in ways that may threaten the public’s trust in research and sponsor institutions, we conclude by describing additional complexities that must be addressed before pediatric CHIs beyond licensed vaccine studies might be ethically acceptable. (shrink)
Beyond Consent: Seeking Justice in Research.Jeffrey P. Kahn,Anna C. Mastroianni &Jeremy Sugarman (eds.) -1998 - Oup Usa.detailsBeyond Consent examines the concept of justice, and its application to human subject research, through the different lenses of various research populations: children, the vulnerable sick, captive and convenient populations, women, people of colour, and subjects in international settings. Separate chapters address the evolution of research policies, implications of the concept of justice for the future of human subject research, and the ramifications of this concept throughout the research enterprise.
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Thought Experiment Analyses of René Descartes' Cogito.C. P. Hertogh -2016 -Trans/Form/Ação 39 (3):9-22.detailsABSTRACT: René Descartes' Cogito is an example of a paradigmatic thought experiment, herald of both subjectivism and new science in Europe's Modern Age, that seems to have escaped the attention of thought experiment philosophers. On deep analysis, the Cogito appears as universal instantiation. The Cogito has strong rhetorical effects for it narratively generalizes from I to all human kind, and its historical and philosophical success can be explained from its concise enthymematic structure that rings true in many possible senses. We (...) consider it a preeminent example of a thought experiment as it states the power of thinking as its very contents. From Descartes' methodology of doubt we can conclude that, e.g., on a Wittgensteinian interpretation, the Cogito is a logical thought experiment rather than a psychological one. RESUMO: O Cogito de René Descartes é um exemplo de experimento mental paradigmático, precursor tanto do subjetivismo quanto da nova ciência, na Idade Moderna europeia, o qual parece ter escapado à atenção dos filósofos que estudaram o experimento mental. Na análise profunda, o Cogito aparece como uma instanciação universal. O Cogito tem fortes efeitos retóricos por si mesmo, generalizando narrativamente desde o eu para toda a espécie humana, e seu sucesso histórico e filosófico pode ser explicado por sua estrutura entimemática concisa, que soa através de muitos sentidos possíveis. Consideramos que é um exemplo proeminente de um experimento mental, na medida em que afirma o poder de pensar como seus próprios conteúdos. A partir da metodologia da dúvida de Descartes, podemos concluir que, em uma interpretação wittgensteiniana, o Cogito é um experimento mental mais lógico que psicológico. (shrink)
The Nuisance Principle in Infinite Settings.Sean C. Ebels-Duggan -2015 -Thought: A Journal of Philosophy 4 (4):263-268.detailsNeo-Fregeans have been troubled by the Nuisance Principle, an abstraction principle that is consistent but not jointly satisfiable with the favored abstraction principle HP. We show that logically this situation persists if one looks at joint consistency rather than satisfiability: under a modest assumption about infinite concepts, NP is also inconsistent with HP.
A Preface to Logic. [REVIEW]C. P. A. -1957 -Review of Metaphysics 10 (3):537-537.detailsAn attractive paperback reprint of Cohen's illuminating studies in the philosophy of logic.--A. C. P.
Abstraction Principles and the Classification of Second-Order Equivalence Relations.Sean C. Ebels-Duggan -2019 -Notre Dame Journal of Formal Logic 60 (1):77-117.detailsThis article improves two existing theorems of interest to neologicist philosophers of mathematics. The first is a classification theorem due to Fine for equivalence relations between concepts definable in a well-behaved second-order logic. The improved theorem states that if an equivalence relation E is defined without nonlogical vocabulary, then the bicardinal slice of any equivalence class—those equinumerous elements of the equivalence class with equinumerous complements—can have one of only three profiles. The improvements to Fine’s theorem allow for an analysis of (...) the well-behaved models had by an abstraction principle, and this in turn leads to an improvement of Walsh and Ebels-Duggan’s relative categoricity theorem. (shrink)