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The predominant view is that a study using health data is observational research and should require individual consent unless it can be shown that gaining consent is impractical. But recent arguments have been made that citizens have an ethical obligation to share their health information for research purposes. In our view, this obligation is sufficient ground to expand the circumstances where secondary use research with identifiable health information is permitted without explicit subject consent. As such, for some studies the Institutional (...) Review Board/Research Ethics Committee review process should not assess the practicality of gaining consent for data use. Instead the review process should focus on assessing the public good of the research, public engagement and transparency. (shrink)

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The future of health research will be characterised by three continuing trends: rising demand for health data; increasing impracticability of obtaining specific consent for secondary research; and decreasing capacity to effectively anonymise data. In this context, governments, clinicians and the research community must demonstrate that they can be responsible stewards of health data. IRBs and RECs sit at heart of this process because in many jurisdictions they have the capacity to grant consent waivers when research is judged to be of (...) particular value. However, several different terms are used to refer to this value, indicating a lack of conceptual clarity regarding the appropriate test for access to health data for research without consent. In this paper we do three things. First we describe the current confusion and instability in terminology relating to public interest in the context of consent waivers. Second we argue for harmonisation of terminology on the grounds of clarity, transparency and consistency. Third we argue that the term ‘public interest’ best reflects the normative work required to justify consent waivers because it is the broadest of the competing terms. ‘Public interest’ contains within its scope positive and negative implications of a study, as well as welfare, justice and rights considerations. In making this argument, we explain the normative basis for consent waivers, and provide a starting place for further discussion about the precise conditions in which a given study can be said to advance the public interest. Ipsos MORI study found that: … the public would be broadly happy with administrative data linking for research projects provided Those projects have social value, broadly defined. Data are de-identified. Data are kept secure. Businesses are not able to access the data for profit. (shrink)

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A précis of Sergio Tenenbaum's Rational Powers in Action (Oxford 2021).

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In this article we scrutinize what can be called an "experimentalist dogma" presupposed in Pablo Melogno's analysis of empirical incommensurability in the chemical revolution. According to Melogno, the fact that experimental methods were preserved throughout the chemical revolution was an indication that there were no relevant perceptual differences between Joseph Priestley and Antoine Lavoisier. In order to refine Melogno's general analysis, we will present a taxonomy of varieties of empirical incommensurability and discuss their relationships. To exemplify this categorization, and to (...) show its metatheoretical adequacy, we will apply it to the neuronist revolution, that is, to the process of discovery of the neuron in the late 19th and early 20th centuries within neuroanatomy, taking as our main case study the controversy between Camillo Golgi and Santiago Ramón y Cajal. From the analysis of the controversies regarding dendritic spines and stellate cells of the cerebellum, in particular, we question the experimentalist dogma, highlighting how, in these controversies, the conservation of experimental practices does not guarantee the similarity of perceptual contents. Moreover, we will argue that, all other experimental conditions being equal, differences in experiential content between Golgi and Cajal are best explained by differences in their commitments to incompatible conceptual schemes. (shrink)

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Resumen Las interfaces cerebro-computadora (ICCs) son tecnologías que proveen herramientas para la comunicación entre el ser humano y las computadoras. Dado que las nuevas técnicas asociadas a ICCs podrían influir en la autorregulación emocional, la memoria autobiográfica, el sentido del yo, la identidad, la autonomía, la autenticidad y las atribuciones de responsabilidad presentan importantes objeciones éticas. Entender las consecuencias a largo plazo de estas nuevas tecnologías puede ser difícil. Por lo tanto, los aspectos éticos vinculados a las ICCs necesitan ser (...) continuamente revisados a la par de los avances técnicos en el área. El personalismo ontológicamente fundado se ha formalizado como un camino de reflexión que tiene como referencia una antropología que defiende el valor de la vida física corpórea, la relación libertad-responsabilidad y la adecuada interacción individuo y sociedad y brinda pautas éticas que permitan formular normas de conducta acordes con la dignidad de la persona humana. Por lo tanto, en este artículo se aplican los principios de la bioética personalista al ámbito de las ICCs, de modo tal de dar directrices generales para la acción que puedan contribuir a elaborar un juicio ético acerca del desarrollo y uso de estas neurotecnologías. Abstract Brain-computer interfaces (BCIs) are technologies that provide tools for communication between humans and computers. Since the new techniques associated with BCIs could influence emotional self-regulation, autobiographical memory, sense of self, identity, autonomy, authenticity, and attributions of responsibility present important ethical objections. Understanding the long-term consequences of these innovative technologies can be difficult. Therefore, the ethical aspects linked to BCIs need to be continuously reviewed in line with technical advances in the area. Ontologically grounded personalism has been formalized as a path of reflection that has as its reference an anthropology that defends the value of corporeal physical life, the relationship between freedom and responsibility, and the appropriate interaction between the individual and society. This approach provides ethical guidelines for the formulation of norms of conduct in accordance with the dignity of the human person. Therefore, in this article, the principles of personalist bioethics are applied to the field of BCIs, in order to provide general guidelines for action that can contribute to the elaboration of an ethical judgment about the development and use of these neurotechnologies. (shrink)

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In their response to ‘Public interest in health data research: laying out the conceptual groundwork’, Grewal and Newson critique us for inattention to the law and putting forward an impracticably broad conceptual understanding of public interest. While we agree more work is needed to generate a workable framework for Institutional Review Boards/Research Ethics Committees, we would contend that this should be grounded on a broad conception of public interest. This broadness facilitates regulatory agility, and is already reflected by some current (...) frameworks such as that found in the guidelines approved under Australia’s Privacy Act. It remains unclear which elements of our broad account Grewal and Newson would reject, or indeed where the substantive disagreement with our position lies. (shrink)

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Though it is held that some models in science have explanatory value, there is no conclusive agreement on what provides them with this value. One common view is that models have explanatory value vis-à-vis some target systems because they are developed using an abstraction process. Though I think this is correct, I believe it is not the whole picture. In this paper, I argue that, in addition to the well-known process of abstraction understood as an omission of features or information, (...) there is also a family of abstraction processes that involve aggregation of features or information and that these processes play an important role in endowing the models they are used to build with explanatory value. After offering a taxonomy of abstraction processes involving aggregation, I show by considering in detail several models drawn from different sciences that the abstraction processes involving aggregation that are used to build these models are responsible for their having explanatory value. (shrink)

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Italian translation by Sergio Cremaschi of ROBERTO MANGABEIRA UNGER, Knowledge and Politics, , Free Press, New York 1975.

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Recently, Piccinini and Craver have stated three theses concerning the relations between functional analysis and mechanistic explanation in cognitive sciences: No Distinctness: functional analysis and mechanistic explanation are explanations of the same kind; Integration: functional analysis is a kind of mechanistic explanation; and Subordination: functional analyses are unsatisfactory sketches of mechanisms. In this paper, I argue, first, that functional analysis and mechanistic explanations are sub-kinds of explanation by scientific (idealized) models. From that point of view, we must take into account (...) the tradeoff between the representational/explanatory goals of generality and precision that govern the practice of model-building. In some modeling scenarios, it is rational to maximize explanatory generality at the expense of mechanistic precision. This tradeoff allows me to put forward a problem for the mechanist position. If mechanistic modeling endorses generality as a valuable goal, then Subordination should be rejected. If mechanists reject generality as a goal, then Integration is false. I suggest that mechanists should accept that functional analysis can offer acceptable explanations of cognitive phenomena. (shrink)

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Andrew Dickson White played a pivotal role in constructing the image of a necessary, and even violent, confrontation between religion and science that persists to this day. Though scholars have long acknowledged that his position is more complex, given that White claimed to be saving religion from theology, there has been no attempt to explore what this means in light of his overwhelming attack on existing religions. This essay draws attention to how White's role as a historian was decisive in (...) allowing him to posit a future for religion purified of dogma by science. It argues, furthermore, that this effort is better understood as religious innovation, rather than a plea for strictly secular science. In so doing it hopes to lay the foundation for a more fruitful historical treatment of White, and a range of other figures whose devotion to science has otherwise been difficult to grasp. (shrink)

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O artigo apresenta uma reflexão sobre a guerra a partir de Carl Schmitt e Hannah Arendt. Para tanto, realiza-se um recorte na obra de cada autor. De Carl Schmitt, discute-se o livro O conceito do político (2009) que contém ainda A teoria do Partisan. De Hannah Arendt, restringe-se a Sobre a violência (2001), A promessa da política (2020), e alguns ensaios contidos em Entre o passado e o futuro (2009). Neste sentido, Carl Schmitt permite discutir o papel da inimizade para (...) a decisão acerca da guerra e como essa situação-limite, ao mesmo tempo, constitui e afeta a dimensão do político. Já Hannah Arendt permite delinear certos traços constitutivos das guerras modernas que escapam à preocupação central Schmittiana, sobretudo o perigo intrínseco da inimizade produzir não a intensificação do político, mas a eliminação da vida humana sobre à Terra. Trata-se, enfim, de pensar o efeito do avanço tecnológico no campo dos assuntos humanos e como essa tópica transforma o estatuto da guerra. (shrink)

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The important roles of prediction and prior experience are well established in music research and fit well with Clark's concept of unified perception, cognition, and action arising from hierarchical, bidirectional predictive processing. However, in order to fully account for human musical intelligence, Clark needs to further consider the powerful and variable role of affect in relation to prediction error.

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This paper focuses on the framework for the compositional relations of properties in the sciences, or "realization relations", offered by Ken Aizawa and Carl Gillett (A&G) in a series of papers, and in particular on the analysis of "multiple realizations" they build upon it. I argue that A&G's analysis of multiple realization requires an account of levels and I try to show, then, that the A&G framework is not successful under any of the extant accounts of levels. There is consequently (...) a real concern tha thte A&G framework for realization may not be viable. (shrink)

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This paper argues that the Encomium of Helen must be seen as a speech about the value and importance of wisdom in human life and not as much as one as about logos. Gorgias sustains his vision based on a certain intellectualism which reduces moral faults to intellectual errors. This intellectualist program comprises a rationalization of emotions and a commitment with a certain tradition that discriminates between a minority with knowledge and a majority with only opinion. The consequence for Helen (...) is that she can be excused from her action at the expense of being reproached for her lack of wisdom and is thus relegated to the ignorant majority. Therefore, what is initially praise and an apology turns into severe blame. For this, I argue, the encomium can be qualified as an amusement (paignion). For the Encomium’s listeners the amusement becomes a challenge that demands they decipher the speech’s paradoxical character and appeal to their own wisdom to not be reproached like Helen. Thus the Encomium cannot be seen as a treaty nor as mere joke but rather as an intellectual agôn between the speech and the listener, which serves them “to arm the soul for contests of excellence”, as the epigram dedicated to Gorgias in Delfos says. (shrink)

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RésuméLa présente étude aborde la question de savoir comment l’œuvre du Marquis de Sade reste sur les développements des jeux du langage wittgensteniens, c’est-à-dire des pratiques langagières associées à la communication dans un contexte donné. Tout d’abord, une identification de la règle (en tant qu’élément organique d’une pratique langagière), et du rôle de l’abduction peircienne pour son application, montre que pour Sade « faire la même chose » (c’est-à-dire suivre la règle) lui permet de créer un système sémiotique pour justifier (...) une idéologie du privilège bourgeois. Ainsi conçue, la règle d’auteur devient expérience iconique d’hypervisibilité (fondée sur la frontalité de la sexualité) lorsqu’elle est appliquée par le lecteur (participant potentiel) à des nouveaux jeux du langage. En ce sens, les jeux du langage proposés par Sade visent à franchir les rets du livre pour justifier les illusions (im)morales de l’auteur, clés de voûte de toute son œuvre. (shrink)

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This introduction a) presents organized religion as a source of "spiritual goods" and briefly summarizes each of the seventeen tradition-centeredarticles; b) explains why organized religion merits the attention of business ethics; c) categorizes the articles according to rubrics useful for teaching and research; d) further explains the value of these essays to academic researchers, business practitioners, and spiritual seekers.

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Action theorists and formal epistemologists often pursue parallel inquiries regarding rationality, with the former focused on practical rationality, and the latter focused on theoretical rationality. In both fields, there is currently a strong interest in exploring rationality in relation to time. This exploration raises questions about the rationality of certain patterns over time. For example, it raises questions about the rational permissibility of certain patterns of intention; similarly, it raises questions about the rational permissibility of certain patterns of belief. While (...) the action-theoretic and epistemic questions raised are closely related, advances in one field are not always processed by the other. This volume brings together contributions by scholars in action theory and formal epistemology working on questions regarding rationality and time so that researchers in these overlapping fields can profit from each other’s insights. This book was originally published as a special issue of the _Canadian Journal of Philosophy. _. (shrink)

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Santiago Ramón y Cajal, the primary architect of the neuron doctrine and the law of dynamic polarization, is considered to be the founder of modern neuroscience. At the same time, many philosophers, historians, and neuroscientists agree that modern neuroscience embodies a mechanistic perspective on the explanation of the nervous system. In this paper, I review the extant mechanistic interpretation of Cajal’s contribution to modern neuroscience. Then, I argue that the extant mechanistic interpretation fails to capture the explanatory import of Cajal’s (...) law of dynamic polarization. My claim is that the definitive formulation of Cajal’s law of dynamic polarization, despite its mechanistic inaccuracies, embodies a non-mechanistic pattern of reasoning (i.e., design explanation) that is an integral component of modern neuroscience. (shrink)

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En este trabajo sostengo que la concepción mecanicista no captura la relevancia explicativa de la ley de polarización dinámica de Cajal. La relevancia explicativa de la ley se fundamenta en su rol como principio de diseño neuronal. Como tal, la ley nos brinda acceso epistémico a intervenciones ideales, conceptualmente posibles, sobre la localización de los diversos componentes de los centros nerviosos, y nos permiten evaluar el impacto de esas intervenciones sobre las condiciones de viabilidad del organismo.

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This chapter provides a brief overview of the history of behavioral neurology, dividing it roughly into six eras. In the ancient and classical eras, emphasis is placed on two transitions: firstly, from descriptions of head trauma and attempted neurosurgical treatments to the exploratory dissections during the Hellenistic period and the replacement of cardiocentrism; and secondly, to the more systematic investigations of Galenus and the rise of pneumatic ventricular theory. In the medieval through post-Renaissance eras, the scholastic consolidation of knowledge and (...) the role of compendia are emphasized, along with the use of new methods from within a mechanistic framework. With the discovery of electrical conductance and the rise of experimentalism, we frame the modern era as period of intense debate over localization, decomposition, and other mechanistic principles, and marked by rapid discovery about the brain. The chapter ends with a discussion of the contemporary era, focusing on the establishment of behavioral neurology research on aphasia, apraxia, and neuropsychiatric conditions. (shrink)

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Geometric statements are expressions of natural language with descriptive meaning, since they refer to things such as triangles, and to their characteristics. It is shown, following statements by authors such as Carnap (Philosophical foundations of physics) that geometric meanings are not factual, but mathematical, so that it is not geometric theories that apply, but geometrically interpreted factual theories. Under the Euclidean paradigm, the object of study of geometry was space, but the theoretical pluralism that replaced it resulted in the creation (...) in the discipline of a new plural ontology according to which there are different spaces: Euclidean, hyperbolic and elliptic. Thus, geometrical knowledge no longer seems to be a knowledge of the universal (of universal characteristics of space), but of the particular: of individual spaces. If geometrical theories are mathematical, these questions constitute obstacles both to the thesis that mathematical knowledge is universal, and to the thesis that it is universally applicable. (shrink)

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The present work has as objective to analyse the embodied dimension of language, reviewing the conceptual issues of cognition, mind and language. Starting from the emerging of new data and knowledge that come from different disciplinary areas and taking Merlau-Ponty’s phenomenology as epistemologica..

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El objetivo del presente artículo consiste en analizar la relación Dewey-Honneth con el propósito de profundizar en la comprensión de la idea de > y evidenciar algunos puntos de encuentro que, en el ámbito de la filosofía social, se dan entre la tradición pragmatista y la teoría crítica de la sociedad representadas por John Dewey y Axel Honneth. Se considera la existencia de cierto aire de familia en el entendimiento de Honneth sobre la idea > con relación a las consideraciones (...) del pragmatismo, especialmente las elaboradas por C. S. Peirce y Dewey, en lo que respecta al análisis de la relación entre teoría y praxis. La tesis que se defiende afirma que para Dewey y Honneth, existe una prioridad metodológica de la experiencia para la comprensión de la moralidad en el contexto de la reconstrucción normativa de la misma; dicha prioridad entiende que la fuente de normatividad se constituye en el análisis de las prácticas sociales individuales y colectivas, de cómo se relacionan los individuos y los grupos con las instituciones vigentes, y de la incidencia recíproca de las mismas en su interacción con el ambiente social, económico, político y cultural. (shrink)

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A response to review essays by Chrisoula Andreou, John Brunero, Matthias Haase, Erasmus Mayr, and Sarah Paul on Sergio Tenenbaum's _Rational Powers in Action_.

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ABSTRACT: Brandom argues that functionalism must ultimately fail because it will not be able to explain how we can holistically update our beliefs solely in terms of abilities possessed by non-linguistic things. In this paper I respond to this argument by arguing that non-linguistic animals encounter and overcome an analogous sort of holistic updating problem. I will also try to demystify holism and de-intellectualize language use/reasoning.

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Este trabajo presenta y analiza dos posturas acerca de las representaciones y clasificaciones científicas que Ian Hacking en ¿La construcción social de qué? denomina realismo o estructurismo inherente y nominalismo. La primera sostiene que las divisiones del conocimiento científico expresan o reflejan divisiones estructurales de la realidad a la que se refieren, en tanto que la segunda considera que toda división o estructura atribuida por la ciencia a la realidad se encuentra sólo en las representaciones mismas. Se sostiene que tal (...) criterio clasificatorio resulta pertinente y fructífero para las discusiones actuales acerca de la naturaleza del conocimiento científico, que pone de relieve diversas cuestiones profundas e intensamente debatidas a lo largo de la historia de la filosofía, y que el empleo del término “nominalismo” –a pesar de su polisemia y de ser poco utilizado actualmente en la filosofía de la cienciaes acertado por cuanto la discusión es en gran medida semántica, ya que se basa en dos concepciones contrapuestas acerca de la naturaleza del lenguaje humano. (shrink)

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Nos proponemos exponer, analizar y contrastar dos de las principales reflexiones sobre los fundamentos de la técnica en la filosofía contemporánea: Bergson y Heidegger. Para esto, en primer lugar, revisaremos el planteamiento bergsoniano del homo faber, destacando su comprensión instrumental y antropológica de la técnica. Con esto, en segundo lugar, contrastaremos la reflexión del filósofo francés con la descripción heideggeriana de la técnica. Es fundamental realizar este contraste, dado que, si para Bergson la técnica se resuelve en la fabricación instrumental, (...) para Heidegger responderá a un modo de apertura fundamental del Dasein. Finalmente, expondremos algunos puntos de cercanía entre ambas propuestas en el marco de sendas críticas a la ciencia y técnica moderna, destacando su operatividad provocante e irreflexiva. (shrink)

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This article starts from two books by Santiago Alba Rico and Peter Sloterdijk to address the problem of nihilism, leading to Nietzsche and Heidegger to theoretically center the discussion and to conclude that the very idea of Salvation is nihilistic and belongs to its own logic. The fundamental problem can be approached as the conflict between the escape to some metaphysical or transcendent instance — the State or the Revolution, material forms of the Kingdom —or the immersion— which implies the (...) whole assumption of suffering and enjoyment —in immanence. (shrink)

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Estableciendo las bases de su primera síntesis precrítica, Kant presenta en la Nova dilucidatio los principios de sucesión y de coexistencia, que, además de hacer posible un conocimiento metafísico de la naturaleza, pretendían ser útiles para la ciencia natural. Ambos son derivados del principio de razón determinante, formulado en el marco de una crítica a Wolff. Estos principios establecen que el mundo está constituido por la totalidad de las substancias conformada por una red dinámica de interconexiones causales, cuyo fundamento último (...) es el esquema relacional con el que el intelecto divino concibe al mundo. (shrink)

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This paper describes the admissible classes of parametric distribution functions of return portfolios and analyzes their consistency with the maximization of the expected utility. In particular, we present a general theory and a unifying framework with the following aims: (1) studying the implications of the classical market restrictions on the portfolio distributions; (2) establishing general rules of ordering, when the uncertain prospect depends by a finite number of parameters; (3) understanding how a dispersion measure has to be used, in order (...) to obtain the investors' optimal portfolios. (shrink)

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La lectura de _El Príncipe_ de Maquiavelo por parte de Althusser, parece revelar en el seno de la tensión virtud-fortuna, una falta de consecuencias sistemáticas del despliegue teórico sobre lo político. Así, lo políticamente posible se redefine incesantemente, lo cual es diametralmente opuesto a una Posibilidad Política construida sobre la semántica de Mundos Posibles. En este contexto, el artículo se centrará en dicha contraposición para intentar dilucidar la propia Posibilidad Política.

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En este artículo sostenemos que, en aquellos casos en los cuales la capacidad _ explanandum _ de un análisis sistémico o mecanicista constituye una función biológica, globalmente, la función explica la estructura y no a la inversa, a pesar de que en algunos casos particulares, el orden en que se determinan los conceptos participantes en la explicación no coincide con el orden de la explicación. Para defender esta tesis, adoptaremos una concepción mínima de explicación basada en la idea de subsunción (...) ampliativa del estructuralismo e ilustraremos las diferencias entre el orden de la explicación y el orden de determinación de los conceptos mediante un estudio de caso tomado de la afasiología moderna. (shrink)

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This article contains the Spanish translation of the entry “Staat”, of Hermann Heller, with an introduction to his political and juridical thought.

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An incomplete degree is cuppable if it can be joined by an incomplete degree to a complete degree. For sets fulfilling some type of simplicity property one can now ask whether these sets are cuppable with respect to a certain type of reducibilities. Several such results are known. In this paper we settle all the remaining cases for the standard notions of simplicity and all the main strong reducibilities.

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Chromosomes are not randomly packed and positioned into the nucleus but folded in higher‐order chromatin structures with defined functions. However, the genome of a fertilized embryo undergoes a dramatic epigenetic reprogramming characterized by extensive chromatin relaxation and the lack of a defined three‐dimensional structure. This reprogramming is followed by a slow genome refolding that gradually strengthens the chromatin architecture during preimplantation development. Interestingly, genome refolding during early development coincides with a progressive loss of developmental potential suggesting a link between chromatin (...) organization and cell plasticity. In agreement, loss of chromatin architecture upon depletion of the insulator transcription factor CTCF in embryonic stem cells led to the upregulation of the transcriptional program found in totipotent cells of the embryo, those with the highest developmental potential. This essay will discuss the impact of genome folding in controlling the expression of transcriptional programs involved in early development and their plastic‐associated features. (shrink)

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