Hippocampal morphological atrophy and distinct patterns of structural covariance network in Alzheimer’s disease and mild cognitive impairment.Dawei Miao,Xiaoguang Zhou &Xiaoyuan Wu -2022 -Frontiers in Psychology 13:980954.detailsElucidating distinct morphological atrophy patterns of Alzheimer’s disease and its prodromal stage, namely, mild cognitive impairment helps to improve early diagnosis and medical intervention of AD. On that account, we aimed to obtain distinct patterns of voxel-wise morphological atrophy and its further perturbation on structural covariance network in AD and MCI compared with healthy controls. T1-weighted anatomical images of matched AD, MCI, and HCs were included in this study. Gray matter volume was obtained using voxel-based morphometry and compared among three (...) groups. In addition, structural covariance network of identified brain regions exhibiting morphological difference was constructed and compared between pairs of three groups. Thus, patients with AD have a reduced hippocampal volume and an increased rate of atrophy compared with MCI and HCs. MCI exhibited a decreased trend in bilateral hippocampal volume compared with HCs and the accelerated right hippocampal atrophy rate than HCs. In AD, the hippocampus further exhibited increased structural covariance connected to reward related brain regions, including the anterior cingulate cortex, the putamen, the caudate, and the insula compared with HCs. In addition, the patients with AD exhibited increased structural covariance of left hippocampus with the bilateral insula, the inferior frontal gyrus, the superior temporal gyrus, and the cerebellum than MCI. These results reveal distinct patterns of morphological atrophy in AD and MCI, providing new insights into pathology of AD. (shrink)
The colexification of vision and cognition in Mandarin: controlled activity surpasses uncontrolled experience.Ying Dai &Yicheng Wu -forthcoming -Cognitive Linguistics.detailsGiven the colexification of perception and cognition, Georgakopoulos et al. (2022. Universal and macro-areal patterns in the lexicon: A case-study in the perception-cognition domain. Linguistic Typology 26(2). 439–487) claim that uncontrolled experience rather than controlled activity has a direct linkage to cognition. To test whether this is a universal tendency, this study conducts a contrastive behavioral profile analysis of two basic vision verbs in Mandarin: kàn, a controlled activity verb, and jiàn, an uncontrolled experience verb. The results show that (i) (...) both kàn and jiàn colexify visual activity and cognitive senses; (ii) kàn is able to express a wider range of cognitive meanings, i.e., know, understand, and think, whereas jiàn only extends into know; and (iii) visual and cognitive meanings have more proximal relationships in the colexification pattern of kàn than that of jiàn. The study confirms the universality of the colexification between vision and cognition while providing counterexamples to the above-mentioned large data-based findings. Accordingly, a dichotomy of controlled activity versus uncontrolled experience is proposed for the colexification of vision and cognition in cognitive typology. (shrink)
Mechanistic insights and implications of FOXO‐SNAI interplay.Xiaowei Guo,Chenxi Wu,Yu Pan,Xiaojie Zhu,Kai Peng,Xianjue Ma &Lei Xue -2022 -Bioessays 44 (9):2200070.detailsAutophagy promotes both health and disease, depending on tissue types and genetic contexts, yet the regulatory mechanism remain incompletely understood. Our recent publication has uncovered a coherent FOXO‐SNAI feed‐forward loop in autophagy, which is evolutionarily conserved from Drosophila to human. In addition, it's revealed that DNA binding plays a critical role in intracellular localization of nucleocytoplasmic shuttling proteins. Based on these findings, herein we further integrate mechanistic insights of FOXO‐SNAI regulatory interplay in autophagy and unravel the potential link of FOXO‐induced (...) autophagy with SNAI in diseases. Besides, the generality of DNA‐retention mechanism on transcription factor nuclear localization is illustrated with wide‐ranging discussion, and more functions potentially regulated by FOXO‐SNAI feedforward loop are provided. Elucidation of these unsolved paradigms will expand the understanding of FOXO‐SNAI interplay and facilitate the development of new therapeutics targeting FOXO‐SNAI axis in diseases. (shrink)
Highness, locally noncappability and nonboundings.Frank Stephan &Guohua Wu -2013 -Annals of Pure and Applied Logic 164 (5):511-522.detailsIn this paper, we improve a result of Seetapun and prove that above any nonzero, incomplete recursively enumerable degree a, there is a high2 r.e. degree c>ac>a witnessing that a is locally noncappable . Theorem 1.1 provides a scheme of obtaining high2 nonboundings , as all known high2 nonboundings, such as high2 degrees bounding no minimal pairs, high2 plus-cuppings, etc.
The psychology of the internet fraud victimization of older adults: A systematic review.Yuxi Shang,Zhongxian Wu,Xiaoyu Du,Yanbin Jiang,Beibei Ma &Meihong Chi -2022 -Frontiers in Psychology 13.detailsCriminals targeting and exploiting older adults in online environments are of great concern. This study systematically retrieved and analyzed articles on the psychological characteristics of older adult victims of online fraud. First, we found that there was no evidence that older adults were more prevalent than other individuals of other ages among online fraud victims, and current researchers have focused more on why older adults are easy targets for fraud. Second, research on psychological factors of older adults' susceptibility to online (...) fraud has mainly focused on cognitive function, trust traits, and other personality traits, such as social loneliness, the Big Five personality traits, and self-control. Among them, most researchers claim that the cyber-cheating of older adults may be due to a decline in their cognitive function. However, there has not been a consensus on how cognitive function and physical and mental conditions affect older people who are cheated. Third, techniques and experience may be related to the susceptibility of older adults to fraud, and these studies have also not yet generated a consensus supported by reliable data. Based on the above research uncertainties, we propose that fraud prevention and control strategies for older adults should be applied with caution. (shrink)
Understanding the Impact of Competitive Advantage and Core Competency on Regional Tourism Revitalization: Empirical Evidence in Taiwan.Chaohsien Lee,Chihkang Wu &Din Jong -2022 -Frontiers in Psychology 13.detailsCompetitive advantage and core competency are the unique capabilities and assets of an organization to provide valuable products or services to customers, thus giving the organization a better competitive position in the market than its competitors. In addition, how to create a competitive advantage is also one of the main objectives of business strategy. Therefore, this study focuses on understanding the decisive factors in regional revitalization and the relationship between business strategy, strategic alliance, and alliance performance through small and medium (...) enterprises in Taiwan. This study selected a sample of 220 SMEs in Taiwan that had participated in the SME regional revitalization counseling program. The results showed that competitive advantage, core competency and strategic alliance partner selection had significant effects on alliance performance. In addition, core competency had an indirect effect on alliance performance through strategic alliance partner selection. However, competitive advantage did not have a significant effect on strategic alliance partner selection. Finally, this study proposes management implications and practical suggestions for SMEs’ competitive advantage, core competency, and alliance performance. (shrink)
Between Deontology and Justice: Chinese and Western Perspectives.Genyou Wu &Yong Li -2019 - New York: Routledge.detailsIn China, political philosophy is still a comparatively new academic discipline. While there is no such phrase as "political philosophy" in ancient Chinese texts, there are elements within them that could be considered part of that field. Central questions of Chinese ancient political philosophy include the legitimacy of the source of political power, the foundation of moral rationality for the use of political power, and the purpose of political activities. This book explores the ideas of rights, the foundations of law, (...) transference of power, democracy and other topic as debated in ancient times. Focusing on important political thinkers in Chinese history, such as Kongzi, Laozi, Xu Fuguan, Liang Qichao and Li Dazhao, the book explains characteristics that are particular to China, such as the system of abdication, the general will of the people, and the society of Great Harmony. While making comparisons between Chinese and Western political philosophy, the book also discusses how to establish a Chinese modern state and how to promote Chinese culture today so that it can influence more and more people around the world. The book will be a valuable reference for scholars of Chinese philosophy, political philosophy and Chinese culture. (shrink)
Bolatu de lun shan: "Feilibu pian" fang fa lun, kuai le lun yan jiu = Plato's Theory of the Good: an Academic Research of Philebus' Methodology and Hedonism.Guangrui Wu -2014 - Beijing: Zhongguo she hui ke xue chu ban she.details本书在如何发挥古典著作的教化作用以及如何把古典经典著作和今人的伦理识见结合在一起这两个问题意识的指导之下,在详细参阅多种希腊原本和译本的基础上,对菲利布篇进行了重新翻译,并对菲利布篇的哲学方法论问题和 快乐论问题进行了深入的研究.
Can science fiction engagement predict identification with all humanity? Testing a moderated mediation model.Fuzhong Wu,Mingjie Zhou &Zheng Zhang -2022 -Frontiers in Psychology 13.detailsIdentification with all humanity is viewed as a critical construct that facilitates global solidarity. However, its origins have rarely been explored in previous literature, and no study has yet investigated the role of pop-culture in cultivating IWAH. To address this gap, this study initially focuses on science fiction, a specific pop-culture genre with worldwide audiences, and examines its effect on IWAH. It hypothesized a direct association between sci-fi engagement and IWAH from the narrative persuasion approach, and an indirect association via (...) abstract construal based on the cognitive-literary approach. Moreover, the moderating role of actively open-minded thinking in the direct and indirect association was also assessed. Results were obtained through a cross-sectional survey conducted in China and showed that sci-fi engagement was positively associated with IWAH; this association was also partially mediated by abstract construal. Interestingly, and inconsistent with our hypotheses, AOT positively moderated the indirect effect but negatively moderated the direct effect. Theoretical and practical implications for cultivating IWAH from the media and pop-cultural perspective were discussed. (shrink)
Coping with Crisis in the Wake of the Cultural Revolution: Rehistoricising Chinese Postsocialism.Yiching Wu -2013 -Historical Materialism 21 (4):145-176.detailsOver three decades after China ventured onto the market path, the Chinese state’s reform programme, which was intended to invigorate socialism, has instead led the country down a capitalist path. This paper situates China’s post-Mao transition in the context of the crisis of the party-state during the Cultural Revolution. Using Gramsci’s idea of ‘passive revolution’, it examines the state’s tactics of crisis management aiming to contain and neutralise emergent opposition and pressure from below. As the combined result of state repression, (...) ideological appropriation and socioeconomic incorporation, a new reform paradigm emerged to rearticulate popular demands and initiatives to an official socialism centring on economic modernisation and market liberalisation. (shrink)
No categories
Establish a Digital Real-Time Learning System With Push Notifications.Hsin-Te Wu -2022 -Frontiers in Psychology 13.detailsThis study proposes a push notification system that combines digital real-time learning, roll-call, and feedback collection functions. With the gradually flourishing online real-time learning systems, this research further builds roll-call and feedback functions for students to enhance concentration and provide opinions. Additionally, the lecturers can do a roll call irregularly and randomly through the push notification function, avoiding students logging in but away from the keyboard. Lecturers can also send questions to a specific student or invite all students to answer; (...) the replies can show students' learning performance. The system will store each notification in a database and analyse messages automatically to record roll calls. Moreover, the system can record the time and intervals of student feedback, enabling lecturers to check students' attention and learning conditions. Currently, most online digital systems depend on the lecturer to be responsible for the entire system; taking a roll call and asking questions will consume the lecturer's teaching time and strength. The system developed in this article can do roll calls and feedback by push notifications, reducing lecturers' workload. Furthermore, the roll-call and automatic record functions can save the time of paperwork after a course. (shrink)
Huang Zongxi yu Qing dai Zhe dong xue pai =.Guang Wu -2009 - Beijing: Zhongguo ren min da xue chu ban she.details本书共分为黄宗羲的生平与著作、黄宗羲的思想与学术、黄宗羲与清代浙东经史学派3篇,主要内容包括从复社名士到抗清御史、以讲学著述为经世之务、振聋发聩的民主启蒙政治思想等.
Song Ming li xue.Naigong Wu -1994 - Changchun Shi: Jilin sheng xin hua shu dian fa xing.details本书分别论述了理学开创者周敦颐的濂溪学、邵雍的象数学、张载的关学、程颢、程颐的洛学、朱熹的闽学、陆九渊的心学、王守仁的阳明学及王夫之对中国理学和各种虚妄邪说的批判等。.