Giant leap for p53, small step for drug design.Mary E. Anderson &PeterTegtmeyer -1995 -Bioessays 17 (1):3-7.detailsWe review the findings of Cho et al.(1) on the crystal structure of a p53 tumor suppressor‐DNA complex. The core DNA binding domain of p53 folds into a structure termed a β‐sandwich, which organizes two loops and a loop‐sheet‐helix structure on one surface of p53 to interact with the consensus DNA recognition sequence of p53. These structures help to explain the functions of wild‐type p53 and the effects of tumor‐associated mutations on p53 DNA binding, transactivation and suppression of cellular proliferation.
The Idea of Principles in Early Modern Thought: Interdisciplinary Perspectives.Peter R. Anstey (ed.) -2017 - New York: Routledge.detailsThis collection presents the first sustained examination of the nature and status of the idea of principles in early modern thought. Principles are almost ubiquitous in the seventeenth and eighteenth centuries: the term appears in famous book titles, such as Newton’s _Principia_; the notion plays a central role in the thought of many leading philosophers, such as Leibniz’s Principle of Sufficient Reason; and many of the great discoveries of the period, such as the Law of Gravitational Attraction, were described as (...) principles. Ranging from mathematics and law to chemistry, from natural and moral philosophy to natural theology, and covering some of the leading thinkers of the period, this volume presents ten compelling new essays that illustrate the centrality and importance of the idea of principles in early modern thought. It contains chapters by leading scholars in the field, including the Leibniz scholar Daniel Garber and the historian of chemistry William R. Newman, as well as exciting, emerging scholars, such as the Newton scholar Kirsten Walsh and a leading expert on experimental philosophy, Alberto Vanzo. _The Idea of Principles in Early Modern Thought_ charts the terrain of one of the period’s central concepts for the first time, and opens up new lines for further research. (shrink)
Revolution and Continuity.Peter Barker &Roger Ariew -2018 - CUA Press.detailsThis volume presents new work in history and historiography to the increasingly broad audience for studies of the history and philosophy of science. These essays are linked by a concern to understand the context of early modern science in its own context.
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Pragmatism in Transition: Contemporary Perspectives on C.I. Lewis.Peter Olen &Carl Sachs (eds.) -2017 - Palgrave Macmillan.detailsThis collection is an attempt by a diverse range of authors to reignite interest in C.I. Lewis’s work within the pragmatist and analytic traditions. Although pragmatism has enjoyed a renewed popularity in the past thirty years, some influential pragmatists have been overlooked. C. I. Lewis is arguably the most important of overlooked pragmatists and was highly influential within his own time period. The volume assembles a wide range of perspectives on the strengths and weaknesses of Lewis’s contributions to metaphysics, epistemology, (...) semantics, philosophy of science, and ethics. (shrink)
The a B C of Armageddon: Bertrand Russell on Science, Religion, and the Next War, 1919-1938.Peter H. Denton -2001 - State University of New York Press.detailsAn exploration of Bertrand Russell's writings during the interwar years, a period when he advocated "the scientific outlook" to insure the survival of humanity in an age of potential self-destruction.
Grundlagen der anwendungsbezogenen Sozialwissenschaft.Peter Derschka -1978 - Opladen: Westdeutscher Verlag. Edited by Adolf Maria Stöber.detailsAnlaB, dieses Bueh niederzusehreiben, ist ein empiriseh-analytisehes Unbehagen. Besehaftigt mit einer Untersuehung zur Anwendung sozialwissensehaftlieher Erkenntnisse in Wirtsehaftsbetrieben und in der politisehen Administration, muBten wir feststellen, daB die Grundlagen der Befragung einer theoretisehen Klarung besonders bedurftig waren. Dieser die Untersuehung begleitende ProzeB der theoretisehen Se1bstverstandigung begann mit der Einsieht, daB der empiriseh-analytisehe Erfahrungsbegriff der Sozialwissensehaft die Wirkliehkeit dieser Wissensehaft nur unvollkommen erreieht. Es war daher naheliegend, zunaehst einige methodologisehe Grundfragen zu diskutieren, die fur die sozialwissensehaftliehe Theorie und Empirie konstitutiv sind. (...) Das Ergebnis dieser Diskussion laBt sieh dahingehend zusammenfassen, daB die Grunddisziplin der Sozialwissenschaft dann die Philosophie sein muB, wenn die Inter pretation empiriseher Befunde nieht beliebig sein solI. Und zwar eine Philosophie, die sieh nieht aussehlieBlieh mit einer wissensehafts theoretisehen Naehzeiehnung wissensehaftlieher Methoden begnugt, sondern deren inhaltsbezogene Kategorien Bestandteil der sozial wissensehaftliehen Theorien se1bst sein mussen. Sozialwissensehaft wird vor diesem Hintergrund eine Form mog lieher Erkenntnis, einer Erkenntnis, die beispielsweise im Gegensatz zur Physik, ihren Erkenntnisgegenstand im wesentliehen mit dem AlI tagswissen teilt. Sozialwissensehaftlieh zu ersehlieBende Erfahrungen konnen also nieht von den Erfahrungen des alltagliehen BewuBtseins vollig abstrahieren; aber sie mussen diese Form des BewuBtseins der art konkretisieren, daB seine Erfahrungen in ihrer Komplexitat und vie1fliltigen gesellsehaftliehen Bezogenheit verstehbar werden. (shrink)
The Importance of Gilson.Peter A. Redpath -2012 -Studia Gilsoniana 1:45–52.detailsThe author aims at answering why preserving, reading, and understanding the work of Étienne Gilson is crucial for the Western civilization if one wishes to be able to understand precisely the problems that are besetting the West and how one can best resolve them. He claims that among all the leading intellectuals of the past or present generation, no one has better diagnosed the philosophical ills of Western culture and better understood the remedy for those ills than has Étienne Gilson.
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Why the Romantics Matter.Peter Gay -2015 - Yale University Press.details_A renowned scholar’s reflections on the romantic period, its disparate participants, and our unacknowledged debt to them_ With his usual wit and élan, esteemed historianPeter Gay enters the contentious, long-standing debates over the romantic period. Here, in this concise and inviting volume, he reformulates the definition of romanticism and provides a fresh account of the immense achievements of romantic writers and artists in all media. Gay’s scope is wide, his insights sharp. He takes on the recurring questions about (...) how to interpret romantic figures and their works. Who qualifies to be a romantic? What ties together romantic figures who practice in different countries, employ different media, even live in different centuries? How is modernism indebted to romanticism, if at all? Guiding readers through the history of the romantic movement across Britain, France, Germany, and Switzerland, Gay argues that the best way to conceptualize romanticism is to accept its complicated nature and acknowledge that there is no “single basket” to contain it. Gay conceives of romantics in “families,” whose individual members share fundamental values but retain unique qualities. He concludes by demonstrating that romanticism extends well into the twentieth century, where its deep and lasting impact may be measured in the work of writers such as T. S. Eliot and Virginia Woolf. (shrink)
The “ old hume”.Peter Millican -manuscriptdetailsSince all inductive inference is equally The main aim of the two definitions of Since all inductive inference is equally The main aim of the two definitions of irrational, there is no consistent basis for irrational, there is no consistent basis for causation is to clarify the meaning of the causation is to clarify the meaning of the drawing any demarcation between drawing any demarcation between concept of concept of “ “necessity necessity” ”, in accordance with , in accordance with (...) scientific prediction and superstition. scientific prediction and superstition. (shrink)
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The Problem of the First Enquiry: Concluding the 1998 Stirling Conference.Peter Millican -unknowndetailsI’d like to start by thanking all those who’ve played a part in making this conference such a success, including all the readers who helped us decide which papers to include, Jane (McIntyre) who chaired the Reading Committee, and especially Tony (Pitson), who organized the splendid local arrangements here in Stirling. Compared to Jane and Tony, I’ve had it relatively easy. Though I proposed, back at Lancaster in 1989, that this year’s conference should be mainly focused on the first Enquiry (...) on its 250th anniversary, and originally planned to host it in Leeds, the last few years have been so horrendously busy and stressful for me that I would have found it very hard to cope as local organizer. Even without these strains, I would not have succeeded in doing things in Tony’s calm, efficient manner. (shrink)
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Social humanism: A new metaphysics [Book Review].Peter G. Woolcock -2013 -The Australian Humanist 109 (109):21.detailsWoolcock,Peter G Review of: Social humanism: A new metaphysics, by Brian Ellis, Routledge, New York, 2012. $120.
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Kant und die Französische Revolution.Peter Burg -1974 - Berlin: Duncker und Humblot.detailsA revision of the author's thesis, Universitèat des Saarlandes, Saarbrèucken, 1973.
Chapter four: Truncated story-listening.Peter Alward -manuscriptdetailsIn this chapter, a positive account of reader engagement with fiction will developed. According to this picture, the basic reader attitude towards fictional works is imaginative. But, in my view, engagement with fiction does not require any de se imagining on the part of readers; it requires only de dicto and de re imagining. The account of reader engagement is modelled on the attitudes of story-listeners to the stories to which they listen and the performers who tell them. In engaged (...) reading, however, the activity of story-listening is, in an important sense, truncated: reader engagement with the text occurs without the mediation of a storyteller. As a result, readers have to imaginatively supply a substitute – a fictionalized version of the author. (shrink)
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Commentary on “A Meinongian View of Definite Descriptions”.Peter Alward -unknowndetailsMy original reaction to Yosh’s paper was to grumble. It seemed to me to contain a number of terminological infelicities, unpersuasive arguments, and counterintuitive implications. And while I think that some of my superficial complaints are worth pointing out (and I can’t help myself), a commentary consisting only of grumbling would be neither interesting nor helpful. Paul Viminitz would describe such a commentary as “unseemly”. And so I revisited Yosh’s paper with a more sympathetic eye. My second reaction was to (...) suppose that what Yosh had actually done was to provide a Russellian analysis of sentences containing descriptions but in a 2nd order logical system – a system in which quantification over properties is permitted and in which 1st order quantifiers are reinterpreted as 2nd order properties. This would be an interesting albeit modest contribution to the description literature. But as I reread Yosh’s paper in preparation for writing this commentary, I realized that given the account of individual kinds that was being developed this wasn’t right. Individual kinds are not properties at all, they are a new sort of individual – teams of one. Yosh’s proposal is hardly modest at all. So, in these comments, I am going to focus on the notion of an individual kind and whether or not we ought to endorse such entities in our semantic theorizing. But first, some preliminary grumbling – I really can’t help myself. (shrink)
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Scito te ipsum (Ethica) =.Peter Abaelard -2006 - Hamburg: Meiner. Edited by Philipp Steger.detailsIn dieser zwischen 1135 und 1139 verfaßten Schrift, der er zwei Titel gab: Ethica oder Scito te ipsum, erörtert Abaelard die Frage nach dem Guten und dem Bösen, vor allem aber erstmals die Bedeutung des Gewissens für die Selbstbestimmung des Menschen. Er unterscheidet zwischen der Schwäche des Menschen, die durch Selbstbeherrschung überwunden werden kann, und der Sünde, die darin besteht, sich den eigenen Schwächen zu unterwerfen. Seine These, das Gewissen sei die oberste Instanz der Moral und die Moralität oder Verwerflichkeit (...) einer Handlung bestimme sich daher aus der Gesinnung des Handelnden, führte ihn zu der Folgerung, daß derjenige, der böse handelt, ohne es doch selbst zu wissen, dadurch noch nicht schuldig wird - sondern erst dann, wenn er entgegen besserer Einsicht, die ihm aufgegeben und möglich ist, das Böse wählt. Diese Behauptung stieß bei den Zeitgenossen und der Kirche auf Kritik und führte zur Verurteilung Abaelards auf dem Konzil von Sens ; wirkungsgeschichtlich gewann sie gleichwohl große Kraft und Bedeutung, da durch diesen Gedanken die überkommene Doxa, allein der Verstoß gegen moralisch geltende Regeln gebe den Maßstab dafür ab, ein Individuum der Sünde zu bezichtigen, dahingehend zu relativieren, daß nur der sich schuldig macht, der auch wußte, daß er eine Verfehlung begeht. Aus diesem Grund zählt die Schrift zu den bedeutendsten Werken der Weltliteratur. Die Ausgabe präsentiert sie erstmalig in einer vollständigen deutschen Übersetzung. Beigegeben sind der lateinische Text und eine kompetente Einleitung, die die besondere Stellung dieser Schrift im Gesamtwerk Abaelards prägnant vor Augen führt. (shrink)