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In many animal species, the early development of the embryo follows a stereotypic pattern of cell cleavage, lineage allocation and generation of tissue asymmetry leading to delineation of the body plan with three primary embryonic axes. The mammalian embryo has been regarded as an exception and primary body axes of the mouse embryo were thought to develop after implantation. However, recent findings have challenged this view. Asymmetry in the fertilised oocyte, as defined by the position of the second polar body (...) and the sperm entry point, can be correlated with the orientation of the animal–vegetal and the embryonic–abembryonic axes in the preimplantation blastocyst. Studies of the pattern of morphogenetic movement of cells and genetic activity in the peri‐implantation embryo suggest that the animal–vegetal axis of the blastocyst might presage the orientation of the anterior–posterior axis of the gastrula. This suggests that the asymmetry of the zygote that is established at fertilisation and early cleavage has a lasting impact on the delineation of body axes during embryogenesis. BioEssays 23:508–517, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

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In lieu of an abstract, here is a brief excerpt of the content:EXISTENTIAL PROPOSITIONS IN THE THOUGHT OF ST. THOMAS AQUINAS A REVALENT VIEW of St. Thomas Aquinas's position on the logic of propositions has been that according to him propositions of the :form, x is, hold a privileged place, that they are in a special sense " existential," and that such propositions straight.forwardly attribute the act of exi,stence to an individual or to a class of individuals.1 Some texts seem (...) to support such an interpretation. For example, in his commentary on Aristotle's Perihermeneias, Aquinas says: " To clarify this we must note that the verb 'is ' itself is sometimes predicated in an enunciation, as in ' Socrates is.' By this we intend to signify that Socrates really is." 2 This passage seems to treat the predicate " exists " or " is " as unproblematical, as though it had a straightforward meaning needing little clarification, at least in the context of a logical treatise. On the basis of such a text, one may be tempted to infer that for Aquinas " Socrates exists " has the same logical form as " Socrates sits," and that " Men exist " is of the same form as " Men are mortal.'' Peter Geach has shown, however, that Aquinas's doctrine here is not as simple as it may first appear. For Aquin,as some of the propositions which have the grammatical form of x is have 'a different logical form.3 Geach points out that for Aquinas the sentence, "Blindness exists," for example, actual1 E.g., Etienne Gilson, Being and Some Philosophers, 2nd ed. (Toronto: Pontifical Institute of Mediaeval Studies, 1952), 190-215. 2 Super Peri, Bk. II, lect. 2, # 212. Cf. Summa Contra Gentiles, Bk. II, ch. 37 at "FJ11J hoc..•." a Peter Geach, in P. T. Geach and G. E. M. Anscombe, Three Philosophers (New York: Cornell University, 1961), 88 ff; Peter Geach, "Form and Existence," in Aquinas: A Collection of Critical Essays, ed. A. Kenny (New York: Notre Dame U., 1969), pp. 41-47. 605 606PATRICK LEE ly means, Something or other is blind. That is, blind is the real predicate rather than exists. Mo11eover, Geach argues, the logical peculiarity of this sentence is equally found in any sentence of the form, "an F exists." Such a proposition, " does not,attribute actuality (existence) to an F, but F-ness to something or other..." 4 And yet Geach will not apply rthis interpretation to all sentences of the form, " x is." He al'lgues that sentences in which " is " or " exists " is. joined to a logically pl'oper name are in a different category. Unlike in general propositions such as "an F exists," in such singular propositions, those using logically proper names, Geach,argues, actual existence is attributed to or predicated of an individual. "We have here a sense of 'is ' or 'exists ' that seems to me to be certainly a genuine predicate of individuals: the sense of ' exists ' in which one says that an individual came to exist, still exists, no longer exists, etc...."5 I believe that, while Geach's position is more accurate than the first interpretation, mentioned above, it is nevertheless still inaccurate on certain key points. While it is misleading to say that for Aquinas exists is never a genuine predicate; nevertheless, I will argue that it is his position that exists or existence is not a genuine predicate in any proposition which does not refer back to a previous proposition (or to what is known in or by previous propositional knowledge). Let us crull a proposition which refers to something known in a previous proposition a " second-order p11oposition," and one that does not thus refer a " first-order proposition." Then, I shall argue that for Aquinas exists is not a genuine predicate in any first-order proposition. Moreover, I believe that these points are crucial to understanding Aquinas's position on existence as well as his position on how knowledge is related,to reality, i.e., his realism. In this article I would like to examine Aquinas's thought on the logic of existential propositions and discuss its significance for epistemology. 4 Geach, " Form and Existence," Zoo. int., p. 45. 5 Ibid., p. 46. EXISTENTIAL PROPOSITIONS IN AQUINAS 607 In sections... (shrink)

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The plane was going to crash, but it didn't. Johnny was going to bleed to death, but he didn't. Geach sees here a changing future. In this paper, I develop Geach's primary argument for the (almost universally rejected) thesis that the future is mutable (an argument from the nature of prevention), respond to the most serious objections such a view faces, and consider how Geach's view bears on traditional debates concerning divine foreknowledge and human freedom. As I hope to show, (...) Geach's view constitutes a radically new view on the logic of future contingents, and deserves the status of a theoretical contender in these debates. (shrink)

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The focus of this study was to assess the mediating effect of green innovation, in the relationship between green human resources management (GHRM) and organizational competitiveness of manufacturing multinational enterprises (MNEs). The study further looked at the moderating effect of organizational learning in the relationship between GHRM on organizational competitiveness of manufacturing MNEs. The population comprises manufacturing MNEs in Ghana. Through purposive and simple random sampling techniques, 231 manufacturing MNEs were selected for the study. Data was analyzed using frequencies, percentages, (...) mean scores, and Structural Equation Modeling (SEM), using SPSS and SMART‐PLS (Partial Least Square) software. The study concludes that green innovation partially mediates the relationship between GHRM and organizational competitiveness. It was further concluded that organizational learning positively moderates the positive relationship between GHRM and organizational competitiveness. The study recommends that manufacturing MNEs should invest and improve the level of their organizational learning as it not only strengthens the effects of GHRM on organizational competitiveness, but it also directly improves competitiveness. Further, particular attention should also pay to green innovation, as it intervenes the relationship between GHRM and organizational competitiveness. (shrink)

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Primary progressive multiple sclerosis (PPMS) shows a highly variable disease progression with poor prognosis and a characteristic accumulation of disabilities in patients. These hallmarks of PPMS make it difficult to diagnose and currently impossible to efficiently treat. This study aimed to identify plasma metabolite profiles that allow diagnosis of PPMS and its differentiation from the relapsing-remitting subtype (RRMS), primary neurodegenerative disease (Parkinson’s disease, PD), and healthy controls (HCs) and that significantly change during the disease course and could serve as surrogate (...) markers of multiple sclerosis (MS)-associated neurodegeneration over time. We applied untargeted high-resolution metabolomics to plasma samples to identify PPMS-specific signatures, validated our findings in independent sex- and age-matched PPMS and HC cohorts and built discriminatory models by partial least square discriminant analysis (PLS-DA). This signature was compared to sex- and age-matched RRMS patients, to patients with PD and HC. Finally, we investigated these metabolites in a longitudinal cohort of PPMS patients over a 24-month period. PLS-DA yielded predictive models for classification along with a set of 20 PPMS-specific informative metabolite markers. These metabolites suggest disease-specific alterations in glycerophospholipid and linoleic acid pathways. Notably, the glycerophospholipid LysoPC(20:0) significantly decreased during the observation period. These findings show potential for diagnosis and disease course monitoring, and might serve as biomarkers to assess treatment efficacy in future clinical trials for neuroprotective MS therapies. (shrink)

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Streszczenie: Idea sacrum w lirycznej twórczości Dariusza Dekańskiego to konglomerat wielu składowych. Zarówno rzeczywistości konsystencjalnej, jak i tej sensytywnej – wyobrażonej, percypowanej na drodze synestezji. W prezentowanym artykule, pełniącym rolę asumptu do dalszych badań nad poetycką aktywnością autora Saudade, zwrócono szczególną uwagę na więź człowieka z Bogiem, kontakt z sacrum, przejawiającymi się w wewnętrznych przeżyciach podmiotu lirycznego, bezustannie szukającego swojego miejsca w świecie. Aby zbliżyć się do zrozumienia działań bohatera tej poezji wykorzystano przede wszystkim instrumentarium oferowane przez metodologie badań sacrum.

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At present, there are almost 700 million rural population in China, and the farm and farmers in China are highly associated with the steadiness and development of the country and even the world. Farmers are the main subjects in rural development and play a vital role in the reception, management, and benefit distribution in rural tourism activities during the development of rural tourism. Farmers’ perception and participation intention in rural tourism development are directly related to the sustainable development of rural (...) tourism and the realization of rural revitalization goals. The decision-making process of participation in the rural tourism development fits the application conditions of the technology acceptance model. Therefore, in order to explore the influencing factors of farmers’ decision-making process in participating in the rural tourism, this study employs the technology acceptance model to predict and judge individual farmers’ willingness and behavior to participate in the rural tourism. The government trust and perceived risk in the real problem of low participation of farmers in the rural tourism development are considered. Then, an extended technology acceptance model was established by taking 409 farm households as research samples. The influence of government trust on farmers’ participation intention in the rural tourism was empirically analyzed based on the PLS-SEM model. The results show that farmers’ perceived usefulness and perceived ease of use in rural tourism affect their participation intention. Farmers’ judgments on whether governments can assume public responsibilities and achieve public interests through rural tourism development affects their trust in government, while the government trust can positively affect farmers’ participation intention via perceived usefulness and perceived ease of use. This indicates that government trust is an important antecedent variable influencing farmers’ participation in the rural tourism. The perceived risk affects farmers’ perceived usefulness and participation intention in the rural tourism, and plays a moderating role in the relationship between government trust and perceived usefulness. Finally, this study recommends to highlight the utility and convenience of rural tourism participation during the promotion of farmers’ participation in rural tourism development, enhance the ability of farmers to participate in rural tourism development, and choose multiple channels to increase government trust to reduce farmers’ risk concerns. (shrink)

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W tekście poddano analizie wywiady przeprowadzone z czterema uchodźczyniami wojennymi z Ukrainy, które przyjechały do Polski po 24 lutego 2022 r. (z dwoma z nich przeprowadzono wywiad ponownie po roku ich pobytu w Polsce).Autorki tekstu interesował samoopis sytuacji kryzysowej, w jakiej badane się znalazły i jak przedstawiają one radzenie sobie w tej sytuacji, dlatego główną kategorią interpretacyjną uczyniły „radzenie sobie w kryzysie”. Celem badań było dotarcie do obrazu, jakie uchodźczynie mają na swój temat, oraz uchwycenie zachodzących zmian w roku 2022 (...) i 2023 (m.in. jak postrzegają siebie, kontekst wojenny oraz życie w warunkach, do jakich dostosowywały się po ucieczce). Podejście teoretyczne było wielodyscyplinarne, ponieważ oprócz koncepcji psychologicznych związanych z główną kategorią interpretacyjną namysł został dodatkowo oparty na antropologii kulturowej emocji, antropologii doświadczenia, a także etyce troski oraz autoetnografii. (shrink)

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Cryptocurrency could redefine the interplay of Internet-connected world markets by eliminating constraints set by traditional local currencies and exchange rates. It has the potential to revolutionise digital markets through the use of duty-free trading. This study investigates the factors which influence the behavioural intention to use cryptocurrency based on the Technology Acceptance Model 3 (TAM 3) during the COVID-19 (SARS-COV-2) pandemic. Data were collected through a cross-sectional questionnaire from 357 Pakistani business-educated adults, including investors who had a rudimentary understanding of (...) the technology and financial instruments. Partial least square (PLS)-based structural equation modeling (SEM) was used to test the developed theoretical framework based on the Technology acceptance model 3. The PLS model has explained 72.1% of what constitutes the behavioural intention to use cryptocurrency. Surprisingly, risk was not a major consideration. This might be due to the fact that the majority of respondents thought working with cryptocurrency was hazardous. Willingness to handle cryptocurrency risk, on the other hand, might be a stumbling block to acceptance. The most essential aspect of a cryptocurrency's success was the perceived usefulness. Moreover, the moderating role of experience was not substantiated in this study. However, perceived usefulness was identified as a partial mediator of subjective norm and the perceived ease to use. This study contributed to the literature through the application of TAM 3 (an extension of the technology acceptance models) to investigate the fundamental qualities a cryptocurrency should have in order to influence investor's behavioural intention to use it. These findings provide revolutionary insights for the present and future market players for investment planning and for improved cryptocurrencies development. (shrink)

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Conspiracy theories are rather a popular topic these days, and a lot has been written on things like the meaning of _conspiracy theory_, whether it’s ever rational to believe conspiracy theories, and on the psychology and demographics of people who believe conspiracy theories. But very little has been said about why people might be led to posit conspiracy theories in the first place. This paper aims to fill this lacuna. In particular, I shall argue that, in open democratic societies, citizens (...) justifiably presuppose that the epistemic authorities—journalists, academics, scientists, and so on—are engaged in a good faith pursuit of the truth. This presupposition generates certain normative expectations on the behaviors of the epistemic authorities—they ought to be open to new evidence, possess a healthy degree of skepticism, be willing to engage with opponents, and so on. So, when an epistemic authority is presented with some putatively anomalous data or an alternative hypothesis for some event or phenomena, people expect the epistemic authority to respond in a way that is consonant with these norms. In some instances, however, the epistemic authorities do not respond in this way and instead are dogmatic, dismissive, and engage in _ad hominem_. From the point of view of the citizen, there’s a tension here between how the epistemic authorities ought to behave and how they have, in fact, behaved which is best resolved either by taking the epistemic authorities less seriously or by positing a conspiracy theory. Put another way, the failure of the epistemic authorities to adhere to the norms by which we take them to be governed when presented with apparent anomalies or alternative hypotheses is one reason for which one might initially posit a conspiracy theory. (shrink)

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Joe Horton argues that partial aggregation yields unacceptable verdicts in cases with risk and multiple decisions. I begin by showing that Horton’s challenge does not depend on risk, since exactly similar arguments apply to riskless cases. The underlying conflict Horton exposes is between partial aggregation and certain principles of diachronic choice. I then provide two arguments against these diachronic principles: they conflict with intuitions about parity, prerogatives, and cyclical preferences, and they rely on an odd assumption about diachronic choice. Finally, (...) I offer an explanation, on behalf of partial aggregation, for why these diachronic principles fail. (shrink)

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One important task of metaphysics is to answer the question of what it is for an object to exist. The first part of this book offers a systematic reconstruction and critique of contemporary views on existence. The upshot of this part is that the contemporary debate has reached an impasse because none of the considered views is able to formulate a satisfactory answer to this fundamental metaphysical question. The second part reconstructs Thomas Aquinas’s view on existence (esse) and argues that (...) it contributes a new perspective which allows us to see why the contemporary debate has reached this impasse. It has come to this point because it has taken a premise for granted which Aquinas’s view rejects, namely, that the existence of an object consists in something’s having a property. A decisive contribution of Aquinas’s theory of esse is that it makes use of the ideas of metaphysical participation and composition. In this way, it can be explained how an object can have esse without being the case that esse is a property of it. This book brings together a reconstruction from the history of philosophy with a systematic study on existence and is therefore relevant for scholars interested in contemporary or medieval theories of existence. (shrink)

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Die Studie handelt von Nietzsches ursprünglicher Fragestellung, Sie geht von Nietzsches Satz in der vorrede zur Genealogie der Moral "Was habe ich mit Widerlegungen zu schaffen!" aus und zeigt, wie er zu verstehen ist. Nietzsche verschiebt sowohl die Fragestellung wie die Methode des Philosophierens: von der traditionellen Frage nach der Wahrheit über die Frage nach den Werten , nach der décadence, der Moral und der Rangordnung zur Frage nach der Kultur und zur Aufgabe der "Züchtung" im Sinne einer "Erhöhung der (...) Kultur". Diese Aufgabe ist das zweite Strukturmoment von Nietzches Denken neben der Genealogie.Diese bereitet die "Erhöhung der Kultur" nur vor.The purpose of this study is to identify the original problem which organizes the whole of Nietzsche's reflection. Starting from the statement, "what have I to do with refutations!" and the analysis of its meaning, it shows that Nietzsche imposes a mutation on both the problem of philosophy and its method; he dismisses the traditional question of truth and replaces it with the problem of culture, of which the questions of values , of morals, of décadence or hierarchy are particular aspects. Consequently, the task he assigns to the philosopher is that of Züchtung, which is to be understood as "the enhancement of culture". This task appears therefore as the second dimension of Nietzsche's reflection, in addition to geneology, which merely prepares the "enhancement of culture". (shrink)

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Cet article étudie le renouvellement de sens que Nietzsche fait subir à la notion de scepticisme. Il part de la double appréciation déroutante du scepticisme grec, loué pour la probité intellectuelle de son ephexis et critiqué simultanément comme une forme de nihilisme de type bouddhiste préservant les valeurs ascétiques, pour montrer que le scepticisme évoqué par la formule « les grands esprits sont des sceptiques. Zarathoustra est un sceptique » renvoie au « frédéricisme » ( Par-delà bien et mal ), (...) c ’ est-à-dire à une expérimentation pratique – audacieuse et dangereuse – menée sur les valeurs. (shrink)

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L’analyse menée par Nietzsche dans le second traité des Éléments pour la généalogie de la morale ne se heurte-t-elle pas à une sourde contradiction? Bien qu’il rejette l’idée de contrat comme modèle pour comprendre la genèse de l’État, c’est en effet sur cette notion que semble reposer toute la logique argumentative du traité. C’est sur cette tension interne que se penche le présent article, qui s’efforce de la résoudre en réexaminant le statut exact que Nietzsche prête au schéma contractuel.

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In chapters 9 and 10 of their book Roman but Not Catholic, Kenneth Collins and Jerry Walls criticize the Roman Catholic positions on the Eucharist as a sacrifice and on the ministerial priesthood. I reply to their historical and theological objections, and defend the belief that the Eucharistic sacrifice, the Mass, is a re-presentation, or making present, of Jesus’s redemptive sacrifice on Calvary, and a key component in God’s incarnational strategy for redeeming us.

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This paper investigates the meaning of Nietzsche’s puzzling use of the first person, which seems both to depart from philosophical discussion by introducing biographical remarks and to contradict his rejection of the reality of the self. On closer scrutiny however, it appears that these texts are not to be understood as referring to an empirical unity, but as the sign of a problem that philosophy has, of course, to face: namely the challenge presented by the ability to evaluate values. In (...) that respect, first person writing is not aimed at displaying a model to be imitated by thinkers, but, on the contrary, is intended to reveal the atypical position which gives Nietzsche a privilege regarding the philosophical task, namely the characteristic extent of his instinctual spectrum enabling him to experience and assess a huge number of life conditions, ranging from illness to good health. (shrink)

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Sur quelles raisons Nietzsche fonde-t-il sa critique de la vérité et quelles en sont les retombées pour la caractérisation de la pratique philosophique? La découverte d'un antagonisme entre pensée et verité établit que l'irréfutable n'est pas assimilable au vrai, et en quoi la vérité est interprétation. Se révèle alors son statut de valeur, ainsi que la logique d'incorporation dont elle relève, qui en fait un genre d'erreur devenu pour nous indispensable. À titre de conséquence, la philosophie ne peut plus se (...) comprendre comme recherche de la vérité, mais bien plutôt comme interrogation sur la valeur de cette valeur et création de « vérités » nouvelles. Le philosophe authentique, esprit libre, est alors à penser comme amateur d' énigmes, sur un modèle épicurien et non plus platonicien. What are Nietzsche's reasons for criticizing truth, and how does he understand the consequences of his position for the philosophical praxis? The discovery of the opposition of truth and thought shows that being irrefutable cannot be assimilated to being true, and that truth is interpretation. It appears therefore to be a value, a type of error which has become essential for us, linked to a process of physical-psychological absorption. As a consequence, philosophy cannot be equated with the pursuit of truth any longer ; its aim is to investigate the value of this particular value, and to create new « truths ». Being a free spirit, the genuine philosopher is to be thought of as a lover of riddles, shaped on Epicure's pattern rather than on Plato's. (shrink)

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Originally presented as the author's thesis (doctoral - Bonn) under the title: Perfektionistischer Liberalismus - Analyse, Kritik und Verteidigung einer Alternative zu einem Politischen Liberalismus.

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C. A. W. Manning was an important figure in the early days of what became known as the English School, and was one of the most philosophically explicit articulators of the interpretivist approach t...

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We show that Kubota and Levine’s characterization of the HPSG-based theory of non-constituent coordination proposed in Yatabe Proceedings of the 7th International Conference on Head-Driven Phrase Structure Grammar, CSLI, Stanford, pp 325–344, 2001) and later works is inaccurate, and that the theory in question does not require any ad hoc mechanisms to account for the long-known fact that right-node raising and left-node raising can affect semantic interpretation. In the course of demonstrating this, we fill in some details of this HPSG-based (...) theory that were left unspecified in the previous literature, and we also present novel accounts of split-antecedent relative clauses and of respectively interpretation that are consistent with the theory. Furthermore, we argue that the phenomenon of summative agreement may provide a reason to prefer this theory over CG-based theories like Kubota and Levine’s. (shrink)

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Examines the perennial issues that keep science and religion at arm's length, clarifies those issues, and fits them into an historical framework—from Plato, to Aquinas, to today's thinkers.

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The field of mindfulness and the emerging science of heroism have a common interest in the causes and conditions of selfless altruism though up to this point there has been little cross-pollination. However, there is increasing evidence that mindfulness training delivers heroically relevant qualities such as increased attentional functioning, enhanced primary sensory awareness, greater conflict monitoring, increased cognitive control, reduced fear response, and an increase in loving kindness and self-sacrificing behaviors. Predicated on the notion of a “no self,” traditional mindfulness (...) and its focus on enlightenment and selfless service may in fact be ideally suited to the development of the elusive “trait” (predictable) versus “state” (intermittent) heroic character. Interweaving observations and questions drawn from the science of heroism, the article explores the relevant theory, practices, and scientific outcomes of mindfulness. It finds that there is evidence that heroically relevant qualities are trainable with the suite of mindfulness techniques and that an enduring experience of selflessness and service of others (the enlightened hero) may well be within the grasp of the serious practitioner. (shrink)

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This chapter explores some of the major developments in the philosophical understanding of suicide in 19th Century Western thought. Two developments in particular are considered. The first is a widespread shift towards thinking about suicide in medical terms rather than moral terms. Deploying methods initiated by a number of French and German thinkers in the preceding century who worked at the then emerging interface between the social and biological sciences, a number of 19th century thinkers ejected what they took to (...) be old metaphysical superstitions about ‘good’ and ‘evil’, and replaced them with (allegedly) hard-nosed scientific diagnoses of ‘health’ and ‘sickness’. Dismissing traditional moral arguments against the permissibility of suicide, the phenomenon came to be viewed as a symptom of decline or degeneration. How variations of this view, in biological and social contexts, reorientated practical responses to suicide in terms of treatment rather than moral condemnation is explored. The second 19th century development in philosophical thought with respect to suicide the chapter considers concerns its place in one of the most significant controversies in Germany from 1860 to the turn of the century: the Pessimismusstreit or ‘pessimism dispute’. While philosophical pessimism might be thought to vindicate or even entail suicide, many of the most prominent pessimists—including Arthur Schopenhauer and Eduard von Hartmann—denied that this was the case, and perhaps surprisingly took suicide to involve a special kind of moral and/or epistemic failing. The chapter aims to elucidate the different arguments which pessimists appealed to in order to ground this position. (shrink)

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