Lighting up gap junction channels in a flash.W. HowardEvans &Patricia E. M. Martin -2002 -Bioessays 24 (10):876-880.detailsGap junction intercellular communication channels permit the exchange of small regulatory molecules and ions between neighbouring cells and coordinate cellular activity in diverse tissue and organ systems. These channels have short half‐lives and complex assembly and degradation pathways. Much of the recent work elucidating gap junction biogenesis has featured the use of connexins (Cx), the constituent proteins of gap junctions, tagged with reporter proteins such as Green Fluorescent Protein (GFP) and has illuminated the dynamics of channel assembly in live cells (...) by high‐resolution time‐lapse microscopy. With some studies, however, there are potential short‐comings associated with the GFP chimeric protein technologies. A recent report by Gaietta et al., has highlighted the use of recombinant proteins with tetracysteine tags attached to the carboxyl terminus of Cx43, which differentially labels ‘old’ and ‘new’ connexins thus opening up new avenues for studying temporal and spatial localisation of proteins and in situ trafficking events.1 BioEssays 24:876–880, 2002. © 2002 Wiley Periodicals, Inc. (shrink)
Introduction: Sharing Data in a Medical Information Commons.Amy L. McGuire,Mary A. Majumder,Angela G. Villanueva,Jessica Bardill,Juli M. Bollinger,Eric Boerwinkle,Tania Bubela,Patricia A. Deverka,Barbara J.Evans,Nanibaa' A. Garrison,David Glazer,Melissa M. Goldstein,Henry T. Greely,Scott D. Kahn,Bartha M. Knoppers,Barbara A. Koenig,J. Mark Lambright,John E. Mattison,Christopher O'Donnell,Arti K. Rai,Laura L. Rodriguez,Tania Simoncelli,Sharon F. Terry,Adrian M. Thorogood,Michael S. Watson,John T. Wilbanks &Robert Cook-Deegan -2019 -Journal of Law, Medicine and Ethics 47 (1):12-20.detailsDrawing on a landscape analysis of existing data-sharing initiatives, in-depth interviews with expert stakeholders, and public deliberations with community advisory panels across the U.S., we describe features of the evolving medical information commons. We identify participant-centricity and trustworthiness as the most important features of an MIC and discuss the implications for those seeking to create a sustainable, useful, and widely available collection of linked resources for research and other purposes.
Word and world: practice and the foundations of language.Patricia Hanna -2004 - New York: Cambridge University Press. Edited by Bernard Harrison.detailsThis important book proposes a new account of the nature of language, founded upon an original interpretation of Wittgenstein. The authors deny the existence of a direct referential relationship between words and things. Rather, the link between language and world is a two-stage one, in which meaning is used and in which a natural language should be understood as fundamentally a collection of socially devised and maintained practices. Arguing against the philosophical mainstream descending from Frege and Russell to Quine, Davidson, (...) Dummett, McDowell,Evans, Putnam, Kripke and others, the authors demonstrate that discarding the notion of reference does not entail relativism or semantic nihilism. A provocative re-examination of the interrelations of language and social practice, this book will interest not only philosophers of language but also linguists, psycholinguists, students of communication and all those concerned with the nature and acquisition of human linguistic capacities. (shrink)
Natural signs and knowledge of God: a new look at theistic arguments.C. StephenEvans -2012 - Oxford: Oxford University Press.detailsIs there such a thing as natural knowledge of God? C. StephenEvans presents the case for understanding theistic arguments as expressions of natural signs in order to gain a new perspective both on their strengths and weaknesses. Three classical, much-discussed theistic arguments - cosmological, teleological, and moral - are examined for the natural signs they embody. At the heart of this book lie several relatively simple ideas. One is that if there is a God of the kind accepted (...) by Christians, Jews, and Muslims, then it is likely that a 'natural' knowledge of God is possible. Another is that this knowledge will have two characteristics: it will be both widely available to humans and yet easy to resist. If these principles are right, a new perspective on many of the classical arguments for God's existence becomes possible. We understand why these arguments have for many people a continued appeal but also why they do not constitute conclusive 'proofs' that settle the debate once and for all. Touching on the interplay between these ideas and contemporary scientific theories about the origins of religious belief, particularly the role of natural selection in predisposing humans to form beliefs in God or gods,Evans concludes that these scientific accounts of religious belief are fully consistent, even supportive, of the truth of religious convictions. (shrink)
The myth of language universals: Language diversity and its importance for cognitive science.NicholasEvans &Stephen C. Levinson -2009 -Behavioral and Brain Sciences 32 (5):429-448.detailsTalk of linguistic universals has given cognitive scientists the impression that languages are all built to a common pattern. In fact, there are vanishingly few universals of language in the direct sense that all languages exhibit them. Instead, diversity can be found at almost every level of linguistic organization. This fundamentally changes the object of enquiry from a cognitive science perspective. This target article summarizes decades of cross-linguistic work by typologists and descriptive linguists, showing just how few and unprofound the (...) universal characteristics of language are, once we honestly confront the diversity offered to us by the world's 6,000 to 8,000 languages. After surveying the various uses of “universal,” we illustrate the ways languages vary radically in sound, meaning, and syntactic organization, and then we examine in more detail the core grammatical machinery of recursion, constituency, and grammatical relations. Although there are significant recurrent patterns in organization, these are better explained as stable engineering solutions satisfying multiple design constraints, reflecting both cultural-historical factors and the constraints of human cognition.Linguistic diversity then becomes the crucial datum for cognitive science: we are the only species with a communication system that is fundamentally variable at all levels. Recognizing the true extent of structural diversity in human language opens up exciting new research directions for cognitive scientists, offering thousands of different natural experiments given by different languages, with new opportunities for dialogue with biological paradigms concerned with change and diversity, and confronting us with the extraordinary plasticity of the highest human skills. (shrink)
God and Moral Obligation.C. StephenEvans -2013 - Oxford: Oxford University Press.detailsGod and moral obligations -- What is a divine command theory of moral obligation? -- The relation of divine command theory to natural law and virtue ethics -- Objections to divine command theory -- Alternatives to a divine command theory -- Conclusions: The inescapability of moral obligations.
Ethical issues in disability and rehabil[i]tation: report of a 1989 international conference.Barbara Duncan &Diane E. Woods (eds.) -1989 - New York, N.Y., USA: World Rehabilitation Fund.detailsThis monograph consists of five parts: (1) introductory material including a conference overview; (2) papers presented at an international symposium on the topic of ethical issues in disability and rehabilitation as a section of the Annual Conference of the Society for Disability Studies; (3) responses to the symposium, prepared by four of the participants; (4) selected additional papers which offer views from perspectives or cultures not represented at the Denver conference; and (5) an annotated international bibliography. Representatives from 10 countries (...) discussed ethical issues and decision making in disability and rehabilitation. Conference papers include: "Genetic Engineering--The New Eugenics? Evolving Medical Attitudes towards the Quality of Life" (Hugh Gallagher);"Description of the Decision-Making Project" (DarylEvans); "Treatment and Nontreatment Decisions with Respect to Extremely Premature, Very Low Birthweight Infants (500-750g)" (Ernle Young); "Allocation of Resources and Distributive Justice" (John Mather); "Quality Assurance as an Aid to Ethical Decision Making in Disability Management: Lessons from Recent Ethical Issues Involving Disadvantaged Groups in New Zealand" (Peter Gow); "Disability and Ethical Issues: A Point of View from the Netherlands" (Yolan Koster-Dreese); "Who Shall Live or How Shall They Live? Consumer and Professional Perspectives on Treatment/Non-Treatment Decisions" (Joseph Kaufert andPatricia Kaufert); and "Debates across Social Movements on Reproductive Technologies, Genetic Engineering, and Eugenics" (Theresia Degener). Conference commentaries include: "The Meeting of Disability and Bioethics: A Beginning Rapprochement" (Adrienne Asch); "A Plea for More Dialogue: Commentary on Ethics Conference" (Robert Slater); "Healing Our Wounds" (Martha Lentz Walker); "Theories and Values: Ethics and Contrasting Perspectives on Disability" (Harlan Hahn); and "Current Example of Ethical Dilemma" (Susan Lacetti). Selected additional papers include: "High-tech Medicine Is Basic Care" (Frederick Abrams); "Prevention of Disabilities as a Medical Question" (G. Schioler); "The Ethics of Disability Prevention: A Parent's Point of View" (Mrs. J. Baker); "A Reference Matrix for Issues of Life and Personhood" (Mike Miles); "Nazi Scientists and Ethics of Today" (Isabel Wilkerson); "Ethical and Policy Issues in Rehabilitation Medicine (Hastings Center Report)" (Arthur Caplan et al.); and "Differing Approaches to Prevention of Disability and Treatment of Impaired Infants Creates Controversies Worldwide" (Barbara Duncan). (JDD). (shrink)
Heidegger's Philosophy of Science.Patricia Glazebrook -1994 - Dissertation, University of Toronto (Canada)detailsIn this dissertation, I argue that Heidegger offers a philosophy of science by explicating that philosophy of science. The following chapter presents Heidegger's early analysis of modern science, from 1916 to the mid-1930s. During these years Heidegger maintains two theses: that the essence of science is the mathematical projection of nature; and that metaphysics is the science of being. As the latter thesis becomes more problematic, Heidegger turns from metaphysics as a science, to the sciences. ;The pivot for this turn (...) is the experiment. Chapter 3 is an analysis of three specific issues surrounding the experiment. I raise the question of whether a single experimental result is enough to overturn a theory, the problem of the theory-loadedness of observation, and the question of representation. ;These issues serve to explicate Heidegger's claim that the essence of science is research, and to show that Heidegger's philosophy of science shares issues with contemporary analytic philosophy of science. Further, I take Heidegger's claim that the essence of science is the ground from out of which the essence of the modern epoch can be shown, as proof that his consideration of science is not secondary in his thinking but rather is the basis from which his critique of the modern epoch is made. ;Chapter 4 is an account of Heidegger's view of the role of science in the university. Heidegger's vision is that the German university can serve to guide historical destiny. His complete disillusionment with that vision comes with his realization that, whereas he calls for a renewal of science for the sake of the sciences in their service of the people, the Nazi call for a renewal of the sciences is toward their own political ends. What little I have to say about Heidegger's involvement with the Nazis is found in this chapter. ;Chapter 5 considers Heidegger's view of ancient science. It lays out Aristotle's distinction between physis and techne under Heidegger's reading. In Chapter 6, I argue that the ancient distinction between physis and techne is not sustained in the modern epoch under Heidegger's account. ;I close with a brief account of Heidegger on quantum theory. (shrink)
Towards a descriptivist psychology of reasoning and decision making.Jonathan St BtEvans &Shira Elqayam -2011 -Behavioral and Brain Sciences 34 (5):275-290.detailsOur target article identified normativism as the view that rationality should be evaluated against unconditional normative standards. We believe this to be entrenched in the psychological study of reasoning and decision making and argued that it is damaging to this empirical area of study, calling instead for a descriptivist psychology of reasoning and decision making. The views of 29 commentators (from philosophy and cognitive science as well as psychology) were mixed, including some staunch defences of normativism, but also a number (...) that were broadly supportive of our position, although critical of various details. In particular, many defended a position that we call which sees a role for normative evaluation within boundaries alongside more descriptive research goals. In this response, we clarify our use of the term and add discussion of defining both as descriptive and non-normative concepts. We consider the debate with reference to dual-process theory, the psychology of reasoning, and empirical research strategy in these fields. We also discuss cognitive variation by age, intelligence, and culture, and the issue of relative versus absolute definitions of norms. In conclusion, we hope at least to have raised consciousness about the important boundaries between norm and description in the psychology of thinking. (shrink)
Wonder and the clinical encounter.H. M.Evans -2012 -Theoretical Medicine and Bioethics 33 (2):123-136.detailsIn terms of intervening in embodied experience, medical treatment is wonder-full in its ambition and its metaphysical presumption; yet, wonder’s role in clinical medicine has received little philosophical attention. In this paper, I propose, to doctors and others in routine clinical life, the value of an openness to wonder and to the sense of wonder. Key to this is the identity of the central ethical challenges facing most clinicians, which is not the high-tech drama of the popular conceptions of medical (...) ethics but, rather, the routine of patients’ undramatic but unremitting demands for the clinician’s time and respectful attention. Wonder (conceived as an intense and transfiguring attentiveness) is a ubiquitous ethical source, an alternative to the more familiar respect for rational autonomy, a source of renewal galvanizing diagnostic imagination, and a timely recalling of the embodied agency of both patient and clinician. (shrink)
Labour relations and working conditions of workers on smallholder cocoa farms in Ghana.Evans Appiah Kissi &Christian Herzig -2023 -Agriculture and Human Values 41 (1):109-120.detailsThe millions of farm workers in the Global South are an important resource for smallholder producers. However, research on their labour organisation is limited. This article focuses on smallholder farm workers in Ghana’s cocoa sector, drawing on insights from qualitative interviews and the concept of bargaining power. We review the labour relations and working conditions of two historical and informally identified labour supply setups (LSSs) in Ghana’s cocoa sector, namely, hired labour and Abusa, a form of landowner–caretaker relations, and identify (...) an imbalance of horizontal power. Further, we analyse the labour relations and working conditions of an emerging and formal LSS in Ghana’s cocoa sector: private labour providers (PLPs). We argue that PLPs are likely to address the imbalance of horizontal power between farm workers and smallholders and bring about significant improvements in the working conditions of farm workers. We also assess the sustainability potential and limitations of PLPs and argue that tensions exist. We contribute to the growing horizontal power perspective by providing avenues for research and policy related to promoting sustained labour rights for farm workers in smallholder agriculture in the Global South. (shrink)
Frege on identity statements.Robert May -2001 - In C. Cecchetto, G. Chierchia & M. T. Guasti,Semantic Interfaces: Reference, Anaphora, and Aspect. CSLI Publications. pp. 1-51.details*I am very pleased to be able to contribute this paper to a festschrift for Andrea Bonomi. This is not however, the paper I really wanted to write; I would have much rather have contributed a paper comparing the pianistic styles of Lennie Tristano and BillEvans, which I think Andrea would have found much more fascinating than an essay devoted to an understanding of Frege’s thinking. But I do not totally despair. Andrea’s first paper published in English was (...) entitled “On the Concept of Logical Form in Frege,” so perhaps I can maintain some hope that this paper will appeal to lingering interests that Andrea wrote of in the past. I would like to thank Johannes Brandl, Ben Caplan, Bill Demopoulos, Bob Fiengo, Mark Kalderon,Patricia Marino, Gila Sher, Michael Thau, Dan Vest and especially Aldo Antonelli for very helpful discussion. (shrink)
Moral Perception.CameronEvans -unknowndetailsAs Jonathan Dancy points out, if we are tempted to think morality is a rational enterprise, we would expect moral judgments to be constrained by requirements of consistency. If our judgments and choices use general moral principles as guides or standards -- like the laws that feature in the explicit calculations of Immanuel Kant’s moral agent – we can be somewhat confident we respond to moral salience with consistency and, perhaps, rationally. For Kant, explicit reason ensures consistency because the explicit (...) application of maxims is autonomous from volatile external factors. Contemporary empirical studies in moral psychology show that when we respond morally we seemingly do so from emotion or intuition, not reason. For Kant, emotions and intuitions fluctuate with respect to volatile external factors. They are not the sort of things upon which we ought to base judgment and decision. If we hold the Kantian model true, we must assume that we fail to participate rationally in the moral enterprise. I argue against the Kantian model of moral cognition and turn to Aristotle to develop an account of moral cognition that allows us to retain our standing as rational moral agents. First, I argue for a particularist conception of moral reasons: I deny that the consistency required of a picture of morality as a rational enterprise requires our thought utilizes general moral rules. Next, I develop a particularist account of moral knowledge – a demand from their generalist opponents – by providing an account of moral perception. I subsequently argue that the deliverances of moral perception can constitute knowledge by providing a McDowellian account of perceptual justification. Lastly, I return to examine how the empirical work motivating the idea that we don’t participate in morality rationally. I show how none of these studies threatens the Aristotelian model as a viable alternative to the Kantian model. (shrink)
Integrating ethical dimensions into a model of budgetary Slack creation.Patricia Casey Douglas &Benson Wier -2000 -Journal of Business Ethics 28 (3):267 - 277.detailsThe "Ibercorp affair" was front-page news in Spain at various times between 1992 and 1995. In itself, there was nothing particularly new about it: a newly formed financial group engaged in legally and ethically reprehensible behaviour that eventually came to light in the media, ruining the company (and the careers of those involved). What aroused public interest at the time was the fact that it involved individuals connected with Spanish public and political life, the media and certain business circles. Above (...) all, it demonstrated the personal, economic, social and political consequences of a business culture based on the pursuit of easy profits at any price (what came to be known as the cultura del pelotazo or "culture of the fast buck"). Again, this is all too familiar in business ethics. But it served to goad Spanish society into a rejection of such behaviour. This article describes the facts and their ethical implications. (shrink)
Reasoning is for thinking, not just for arguing.Jonathan St BtEvans -2011 -Behavioral and Brain Sciences 34 (2):77-78.detailsThere is indeed extensive evidence that people perform fairly poorly in reasoning tasks and that they often construct arguments for intuitively cued responses. Mercier & Sperber (M&S) may also be right to claim that reasoning evolved primarily as argumentation. However, if it did, the facility became exapted to the function of supporting uniquely human abilities for reflective thinking and consequential decision making.
Environment, Cognition, and Action: An Integrated Approach.Tommy Garling &Gary W.Evans (eds.) -1991 - Oxford University Press USA.detailsHere, a distinguished group of international contributors examines what we know about, feel, and hope to accomplish in real-world environments.
Make Them Rare or Make Them Care: Artificial Intelligence and Moral Cost-Sharing.Blake Hereth &NicholasEvans -2023 - In Daniel Schoeni, Tobias Vestner & Kevin Govern,Ethical Dilemmas in the Global Defense Industry. Oxford University Press.detailsThe use of autonomous weaponry in warfare has increased substantially over the last twenty years and shows no sign of slowing. Our chapter raises a novel objection to the implementation of autonomous weapons, namely, that they eliminate moral cost-sharing. To grasp the basics of our argument, consider the case of uninhabited aerial vehicles that act autonomously (i.e., LAWS). Imagine that a LAWS terminates a military target and that five civilians die as a side effect of the LAWS bombing. Because LAWS (...) lacks moral agency, and in particular the capacity for moral emotions, moral cost-sharing is limited to dead civilians and their loved ones. We argue that's unjust insofar as those responsible for unjust harm to others ought to share in those costs. Our worry expands to other strategic uses of AI, e.g., cyber warfare. This presents a dilemma: Either we design autonomous weaponry capable of moral emotions, or we limit the use of autonomous weaponry. The former undermines the risk-mitigation purpose of creating autonomous weaponry and expands the number of sentient individuals whose welfare is risked in war. The latter risks worsening combatant casualties and achieving strategic aims. (shrink)
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The Toll From Coal: Power Plants, Emissions, Wildlife, and Human Health.Patricia Glick -2001 -Bulletin of Science, Technology and Society 21 (6):482-500.detailsThe article describes how emissions from the nation’s coal-fired power plants create far-reaching problems for people and wildlife, including acid rain; ozone pollution; the deposition of mercury and nitrogen in lakes, streams, and coastal waters; and global climate change. These environmental problems cut across all regions and endanger the entire range of wildlife, from the tiniest invertebrates to top predator mammals, in addition to threatening our health and economy. Moreover, current efforts to address these problems are not sufficient. In this (...) article, the National Wildlife Federation makes a series of recommendations for reducing the toll from coal, including: closing the loophole in the Clean Air Act that allows older power plants to emit significantly more pollution than newer, more efficient ones; toughening restrictions on sulfur dioxide and nitrogen oxides and creating meaningful mercury and carbon dioxide emissions caps; and promoting energy efficiency and renewable energy sources. (shrink)
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The geometry of Hrushovski constructions, I: The uncollapsed case.David M.Evans &Marco S. Ferreira -2011 -Annals of Pure and Applied Logic 162 (6):474-488.detailsAn intermediate stage in Hrushovski’s construction of flat strongly minimal structures in a relational language L produces ω-stable structures of rank ω. We analyze the pregeometries given by forking on the regular type of rank ω in these structures. We show that varying L can affect the isomorphism type of the pregeometry, but not its finite subpregeometries. A sequel will compare these to the pregeometries of the strongly minimal structures.
Philosophy of Communication Ethics: Alterity and the Other.Ronald C. Arnett &Patricia Arneson (eds.) -2014 - Madison: Fairleigh Dickinson University Press.detailsPhilosophy of Communication Ethics is a unique and timely volume that creatively examines communication ethics, philosophy of communication, and the 'Other.'.
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Enfrentando los desafíos en la evaluación de la participación política: aportes a la discusión sobre indicadores y escalas.Silvina A. Brussino,Patricia M. Sorribas,Hugo H. Rabbia &Débora Imhoff -2013 -Polis: Revista Latinoamericana 35.detailsEn los estudios sobre participación política se observan diferencias tanto conceptuales como metodológicas relativas a su evaluación que afectan la producción del conocimiento en este campo. Tales diferencias configuran un nivel de complejidad mayor cuando refieren a estudios hechos sobre una misma población. Con el fin de evaluar la participación política de la población cordobesa se desarrollaron 7 estudios en un período de 14 años utilizando diferentes innovaciones metodológicas tendientes a mejorar la calidad de los datos y con el propósito (...) de contribuir a la discusión en torno a la evaluación de este constructo de marcada relevancia social y complejidad. Los resultados reportados son consistentes con la tendencia observada en el campo de estudios que sugiere la complejización de la evaluación de este constructo abarcando su intensidad, amplitud y orientación para conocer de modo más preciso su multidimensionalidad. (shrink)
Victorian Critics of Democracy: Carlyle, Ruskin, Arnold, Stephen, Maine, Lecky.BenjaminEvans Lippincott -1938 - University of Minnesota Press.detailsVictorian Critics of Democracy was first published in 1938. Minnesota Archive Editions uses digital technology to make long-unavailable books once again accessible, and are published unaltered from the original University of Minnesota Press editions.
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A global health model integrating psychological variables involved in cancer through a longitudinal study.Patricia Macía,Susana Gorbeña,Mercedes Barranco,Nerea Iglesias &Ioseba Iraurgi -2022 -Frontiers in Psychology 13.detailsObjectiveThe literature has shown the relevance of certain psychological variables in adjustment to cancer. However, there is a great variability, and these features could be modified through the disease process. The aim of this study is to provide an integrated and global perspective of the importance of variables such as coping, resilience, emotional control, social support, affect, and others in cancer patients through a longitudinal study, with the objective of exploring their associations and underlying interactions.MethodsThe sample was composed of 71 (...) people diagnosed with cancer who were attending psychological support at the Spanish Association Against Cancer. We assessed the following variables in two periods of 6 months: perceived stress, emotional control, resilience, coping strategies, personality, social support, affect, emotional distress, quality of life and visual-analogic scales.ResultsResults showed predictive effects of perceived stress on physical health perception. Mental health perception was influenced by almost all the psychological variables. Consciousness at baseline, change in Extraversion and Resilience had significant effects on perceived mental health.ConclusionThis study provides a global health model that integrates and explores associations between psychological variables related to cancer disease. This information could be useful for guiding personalized psychotherapeutic interventions, with the aim of increasing adjustment to disease. (shrink)