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Reciprocal interactions between the host circadian clock and the microbiota are evidenced by recent literature. Interestingly, dysregulation of either the circadian clock or microbiota is associated with common human pathologies such as obesity, type 2 diabetes, or neurological disorders. However, it is unclear to what extent a perturbation of pathways regulated by both the circadian clock and microbiota is involved in the development of these disorders. It is speculated that these perturbations are associated with impaired growth hormone (GH) secretion and (...) sexual development. The GH axis is a broadly neglected pathway and could be the main converging point for the interaction of both circadian clock and microbiota. Here, the links between the circadian clock and microbiota are reviewed. Finally, the effects of chronodisruption and dysbiosis on physiology and pathology are discussed and it is speculated whether a common deregulation of the GH pathway could mediates those effects. (shrink)

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Challenging the fundamental tenet of the multicultural movement -- that social struggles turning upon race, gender, and sexuality are struggles for recognition -- this work offers a powerful critique of current conceptions of identity and ...

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In his paper ``What is Structural Realism?'' James Ladyman drew a distinction between epistemological structural realism and metaphysical (or ontic) structural realism. He also drew a suggestive analogy between the perennial debate between substantivalist and relationalist interpretations of spacetime on the one hand, and the debate about whether quantum mechanics treats identical particles as individuals or as `non-individuals' on the other. In both cases, Ladyman's suggestion is that an ontic structural realist interpretation of the physics might be just what is (...) needed to overcome the stalemate. The main thesis of this paper is that, whatever the interpretative difficulties of generally covariant spacetime physics are, they do not support or suggest structural realism. In particular, I hope to show that there is in fact no analogy that supports a similar interpretation of the metaphysics of spacetime points and of quantum particles. (shrink)

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Diffeomorphism invariance is sometimes taken to be a criterion of background independence. This claim is commonly accompanied by a second, that the genuine physical magnitudes (the ``observables'') of background-independent theories and those of background-dependent (non-diffeomorphism-invariant) theories are essentially different in nature. I argue against both claims. Background-dependent theories can be formulated in a diffeomorphism-invariant manner. This suggests that the nature of the physical magnitudes of relevantly analogous theories (one background free, the other background dependent) is essentially the same. The temptation (...) to think otherwise stems from a misunderstanding of the meaning of spacetime coordinates in background-dependent theories. (shrink)

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Over the last 60 years the idea of human dignity has become increasingly prominent in the political discourse on human rights. In United Nations documents, for instance, human dignity is currently presented as the justification for human rights. In this paper I shall argue that the contemporary way in which human dignity is thought to ground human rights is very different from the way human dignity has been understood traditionally. My aim is to contrast the contemporary paradigm of dignity to (...) a different one that has been prominent historically from Cicero onwards. My conclusion is that if one wants to use the contemporary conception of dignity, one cannot refer to the history of philosophy for support of this conception, and if one wants to use this history in support, one would have to employ a different conception of dignity that uses a different pattern of thought. (shrink)

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We present a plural logic that is as expressively strong as it can be without sacrificing axiomatisability, axiomatise it, and use it to chart the expressive limits set by axiomatisability. To the standard apparatus of quantification using singular variables our object-language adds plural variables, a predicate expressing inclusion (is/are/is one of/are among), and a plural definite description operator. Axiomatisability demands that plural variables only occur free, but they have a surprisingly important role. Plural description is not eliminable in favour of (...) quantification; on the contrary, quantification is definable in terms of it. Predicates and functors (function signs) can take plural as well as singular terms as arguments, and both many-valued and single-valued functions are expressible. The system accommodates collective as well as distributive predicates, and the condition for a predicate to be distributive is definable within it; similarly for functors. An essential part of the project is to demonstrate the soundness and completeness of the calculus with respect to a semantics that does without set-theoretic domains and in which the use of settheoretic extensions of predicates and functors is replaced by the sui generis relations and functions for which the extensions were at best artificial surrogates. Our metalanguage is designed to solve the difficulties involved in talking plurally about individuals and about the semantic values of plural items. (shrink)

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In the first part of this paper a relational account of incongruent counterparts is defended against an argument due to Kant. I then consider a more recent attack on such an account, due to John Earman, which alleges that the relationalist cannot account for the lawlike left--right asymmetry manifested in parity-violating phenomena. I review Hoefer's, Huggett's and Saunders' responses to Earman's argument and argue that, while a relationalist account of parity-violating laws is possible, it comes at the cost of non-locality.

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For at least the last twenty years, philosophers have attempted various strategies for reviving the Hegelian notion of recognition and redeploying it in discourses centered around social justice, including multiculturalism, feminism, race theory, and queer theory. Hegel’s master-slave dialectic may seem like an obvious place to start to analyze the oppression of one group by another. Given that Hegel is not literally talking about slaves, however, but a stage of consciousness, indeed the onset of self-consciousness, we might wonder why his (...) notion of recognition has become so important to these contemporary discourses on oppression. One reason is that the Hegelian model of recognition proposes that.. (shrink)

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Name der Zeitschrift: Kant-Studien Jahrgang: 106 Heft: 1 Seiten: 107-129.

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Methods of machine learning (ML) are gradually complementing and sometimes even replacing methods of classical statistics in science. This raises the question whether ML faces the same methodological problems as classical statistics. This paper sheds light on this question by investigating a long-standing challenge to classical statistics: the reference class problem (RCP). It arises whenever statistical evidence is applied to an individual object, since the individual belongs to several reference classes and evidence might vary across them. Thus, the problem consists (...) in choosing a suitable reference class for the individual. I argue that deep neural networks (DNNs) are able to overcome specific instantiations of the RCP. Whereas the criteria of narrowness, reliability, and homogeneity, that have been proposed to determine a suitable reference class, pose an inextricable tradeoff to classical statistics, DNNs are able to satisfy them in some situations. On the one hand, they can exploit the high dimensionality in big-data settings. I argue that this corresponds to the criteria of narrowness and reliability. On the other hand, ML research indicates that DNNs are generally not susceptible to overfitting. I argue that this property is related to a particular form of homogeneity. Taking both aspects together reveals that there are specific settings in which DNNs can overcome the RCP. (shrink)

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Sethi and Schepers have identified an important issue for the global economy: Providing some mechanism for requiring assurance that environmental, social, and corporate governance information provided by a business is accurate and objective. Where they have gone wrong is in trying to change the mission of the United Nations Global Compact. From its inception, the UNGC has been clear that its mission is not to provide such assurance. This article first outlines the background for the historic announcement of the UNGC (...) by the then Secretary-General of the UN, Kofi Annan. Then a summary of the major criticisms of the initiative is provided with a focus on the Sethi–Schepers article. Finally, I argue that the mission of the UNGC, to gain consensus in the global community on the shared values and moral norms that will guide the global economy, is being accomplished, although it is a work in progress. (shrink)

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Doubts are raised concerning Rickles' claim that ``an exact analog of the hole argument can be constructed in the loop representation of quantum gravity'' (Rickles, `A new spin on the hole argument', Studies in History and Philosophy of Modern Physics 36 (2005) 415–434).

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Formal learning theory is the mathematical embodiment of a normative epistemology. It deals with the question of how an agent should use observations about her environment to arrive at correct and informative conclusions. Philosophers such as Putnam, Glymour and Kelly have developed learning theory as a normative framework for scientific reasoning and inductive inference.

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Why and under what conditions are individuals altruistic to family and friends in their social networks? Evolutionary psychology suggests that such behaviour is primarily the product of adaptations for kin- and reciprocal altruism, dependent on the degree of genetic relatedness and exchange of benefits, respectively. For this reason, individuals are expected to be more altruistic to family members than to friends: whereas family members can be the recipients of kin and reciprocal altruism, friends can be the recipients of reciprocal altruism (...) only. However, there is a question about how the effect of kinship is implemented at the proximate psychological level. One possibility is that kinship contributes to some general measure of relationship quality (such as ‘emotional closeness’), which in turn explains altruism. Another possibility is that the effect of kinship is independent of relationship quality. The present study tests between these two possibilities. Participants (N= 111) completed a self-report questionnaire about their willingness to be altruistic, and their emotional closeness, to 12 family members and friends at different positions in their extended social networks. As expected, altruism was greater for family than friends, and greater for more central layers of the network. Crucially, the results showed that kinship made a significant unique contribution to altruism, even when controlling for the effects of emotional closeness. Thus, participants were more altruistic towards kin than would be expected if altruism was dependent on emotional closeness alone – a phenomenon we label a ‘kinship premium’. These results have implications for the ongoing debate about the extent to which kin relations and friendships are distinct kinds of social relationships, and how to measure the ‘strength of ties’ in social networks. (shrink)

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In a companion paper (Pooley & Brown 2001) it is argued that Julian Barbour's Machian approach to dynamics provides a genuinely relational interpretation of Newtonian dynamics and that it is more explanatory than the conventional, substantival interpretation. In this paper the extension of the approach to relativistic physics is considered. General relativity, it turns out, can be reinterpreted as a perfectly Machian theory. However, there are difficulties with viewing the Machian interpretation as more fundamental than the conventional, spacetime interpretation. Moreover, (...) this state of affairs provides little solace for the relationist for, even when interpreted along Machian lines, general relativity is a substantival theory although the basic entity is space, not spacetime. (shrink)

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Se explora el desarrollo del campo de la Alfabetización Mediática y Digital en México, entre 2000 y 2021, mediante el análisis bibliométrico de publicaciones en Scopus y Web of Science, a partir del uso de frases sinónimas. Se observa una incipiente y dispersa producción científica en dicha área del conocimiento para el periodo de estudio.

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The notion of common morality plays a prominent role in some of the most influential theories of biomedical ethics. Here, I focus on Beauchamp and Childress’s models in the fourth and fifth edition of Principles of Biomedical Ethics as well as on a revision that Beauchamp proposed in a recent article. Although there are significant differences in these works that require separate analysis, all include a role for common morality as starting point and normative framework for theory construction in combination (...) with a coherence theory of moral justification. I defend to some extent the existence and empirical significance of common morality, as delineated by Beauchamp and Childress in different versions, but criticize its normative role. It is neither convincing as a moral foundation nor well compatible with a standard coherentist justification. I suggest that the authors should give up the foundational account for a more modest account of common morality as resource of well-established moral insights and experiences, which have proved generally valid but neither sufficient nor infallible. Beauchamp’s latest proposal appears as a step in this direction; indeed, it may be the beginning of the end of his common-morality theory. (shrink)

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Routledge is now re-issuing this prestigious series of 204 volumes originally published between 1910 and 1965. The titles include works by key figures such asC.G. Jung, Sigmund Freud, Jean Piaget, Otto Rank, James Hillman, Erich Fromm, Karen Horney and Susan Isaacs. Each volume is available on its own, as part of a themed mini-set, or as part of a specially-priced 204-volume set. A brochure listing each title in the "International Library of Psychology" series is available upon request.

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Islamic philosophy has often been treated as being largely of historical interest, belonging to the history of ideas rather than to philosophical study. This volume successfully overturns that view. Emphasizing the living nature and rich diversity of the subject, it examines the main thinkers and schools of thought, discusses the key concepts of Islamic philosophy and covers a vast geographical area. This indispensable reference tool includes a comprehensive bibliography and an extensive index.

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Mein Beitrag behandelt zentrale Probleme der Methodologie der Textinterpretation im Lichte der neueren Erkenntnis- und Wissenschaftstheorie. Nach Vorbemerkungen zum Begriff der Interpretation wende ich mich den Methoden der Bildung und kritischen Prüfung von Interpretationshypothesen zu. Wie ist das Verhältnis von Daten und Hypothesen im Falle der Textinterpretation? Wie können Interpretationshypothesen epistemisch gerechtfertigt bzw. gestützt werden? Zur Beantwortung dieser Fragen untersuche ich die Anwendung der Hypothetisch-Deduktiven Methode und der Methode des Schlusses auf die beste Erklärung auf die Textinterpretation. Der Vergleich zeigt, (...) dass die Methode des Schlusses auf die beste Erklärung vorzuziehen ist. (shrink)

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This paper explores the possibility for a means of bringing about novelty which does not rely on kairological philosophies based on an event. In contrast to both common sense and contemporary philosophical understandings of the term where for novelty to arise there must be some break in the repetition of the structure, this paper argues that it is possible for novelty to come about through small-scale experimentation. This is done by relying on the philosophical notion of ‘economy’ in order to (...) understand how we think about the world. In this regard, our thinking about the world depends upon acknowledging certain possibilities at the expense of others. History can then be seen as the distribution of emphasis which allows for these past possibilities and the future potentiality they may hold. Novelty, defined here as a rereading of history, is precisely the disruption of these possibilities and a challenge to the memory of the system. The conclusion to this paper argues that experimentation is an important means by which we can bring novelty into the world. (shrink)

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A key factor for the acceptance of robots as regular partners in human-centered environments is the appropriateness and predictability of their behaviors, which depend partially on the robot behavior’s conformity to social norms. Previous experimental studies have shown that robots that follow social norms and the corresponding interactions are perceived more positively by humans than robots or interactions that do not adhere to social norms. However, the conducted studies only focused on the effects of social norm compliance in specific scenarios. (...) Therefore, this paper aims to guide further research studies by compiling how researchers in relevant research fields think the perception of robots and the corresponding interactions are influenced independently of a specific scenario if a robot’s behavior conforms to social norms. Additionally, this study investigates what characteristics and metrics constitute a good general benchmark to objectively evaluate the behavior of social robots regarding its conformity to social norms according to researchers in relevant research communities. Finally, the paper summarizes how the obtained results can guide future research toward socially aware robot behavior. (shrink)

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According to a common reading of Kant, autonomy refers to the idea that pure reason gives the moral law to itself. Pauline Kleingeld and Marcus Willaschek reject this standard view both on textual as well as philosophical grounds. Instead, they argue that autonomy only selects mid-level principles, such as ‘help others,’ and that the moral law is a priori and not given. – In this paper, I first analyze on textual grounds what Kant means when he says that a principle (...) is a priori. I argue that Kant does not conceive of a priori laws as permanently existing entities. Rather they are the product of how reason necessarily functions if it is prompted by sensibility. Kant also uses the word ‘autonomy’ in this context. I then argue that this non-standard view of autonomy as an activity can meet the philosophical objections that Kleingeld and Willaschek raise against autonomy as a giving of the moral law. (shrink)

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Despite the popularity of many of Kant’s ethical notions, such as autonomy, dignity and respect for persons, there is a perception, even among Kant scholars themselves, that one cannot reliably derive concrete duties from Kant’s moral philosophy. Against this, I shall argue that — properly understood — Kant’s ethics is of prime importance even today. I shall argue that Kant’s preferred procedure is actually the way we develop new ethical rules during the recent Coronavirus pandemic. In order to demonstrate this, (...) I shall first reflect on how we came up with ethical rules such as keeping six feet of distance, wearing a mask, or restricting the number of people who can occupy a room at the same time. I shall then give the reasons why I do not follow the standard interpretations of how one derives concrete duties from Kant’s main formulation of the Categorical Imperative or the Formula of Humanity. Finally, I shall present the textual evidence that Kant proposes a method like the one we use today during a pandemic, and argue that this alternative interpretation can deal much better with the main objections that are commonly levelled against the standard interpretation of Kant’s procedure to derive concrete duties from the Categorical Imperative. (shrink)

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A provocative and wide-ranging analysis of the cultural mood of anxiety and pessimism in the early 21st century.

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The function and legitimacy of values in decision making is a critically important issue in the contemporary analysis of science. It is particularly relevant for some of the more application-oriented areas of science, specifically decision-oriented science in the field of regulation of technological risks. Our main objective in this paper is to assess the diversity of roles that non-cognitive values related to decision making can adopt in the kinds of scientific activity that underlie risk regulation. We start out, first, by (...) analyzing the issue of values with the help of a framework taken from the wider philosophical debate on science and values. Second, we study the principal conceptualizations used by scholars who have applied them to numerous case studies. Third, we appraise the links between those conceptualizations and learning processes in decision-oriented science. In this, we recur to the concept of methodological learning, i.e., learning about the best methodologies for generating knowledge that is useful for science-based regulatory decisions. The main result of our analysis is that non-cognitive values can contribute to methodological improvements in science in three principal ways: as basis for critical analysis, for contextualizing methodologies, and for establishing the burden of proof. (shrink)

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The character of the scholarly patronage community of Jixia in the Warring States polity of Qi has been hotly debated. Was it indeed an “academy,” as it has been retrospectively dubbed? What kind of activities did resident scholars engage in? What teachings did they propound, what writings did they compose? Following the lead of research by Nathan Sivin and Andrew S. Meyer, the present article does not treat Jixia as an academy proper, but assumes that it was a patronage community (...) sponsored by the Tian/Chen clan. Rather than indulge in more speculations about institutional arrangements and the activities of specific scholars, however, it is argued that intertextual relationships are more likely to shed light on the intellectual concerns of scholars at Jixia. To demonstrate the viability of such an approach, this article analyzes dialogues between King Xuan of Qi and Master Meng in the book Mengzi, demonstrating that they can be divided into hostile and supportive ones, the latter propounding the principle of “sharing pleasures.” Dialogues included in other compilations that advocate the same principle are then shown to be almost invariably associated with Jixia scholars. The notion of sharing pleasures, it is finally argued, was part of a wider political debate on princely wastefulness that was characteristic of Qi and is likewise reflected in such compilations as Guanzi, Yanzi chunqiu, and Liu tao. (shrink)

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Islamic philosophy represents one of the most important philosophical traditions in the world.

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Learning to argue in a computer-mediated and structured fashion is investigated in this research. A study was conducted to compare dyads that were scripted in their computer-mediated collaboration with dyads that were not scripted. A process analysis of the chats of the dyads showed that the scripted experimental group used significantly more words, engaged in significantly more broadening and deepening of the discussion, and appeared to engage in more critical and objective argumentation than the non-scripted control group.

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This interdisciplinary book examines the work of several female artists since 1960 in the areas of dance, music, installation, photography, architecture, poetry, literature, theater, film, and performance art. Each chapter is primarily devoted to an important work by a single artist, seen within its historical context, and with particular attention to how each artist incorporated gender issues or feminist thought into her respective art form. Laurie Anderson, Gwendolyn Brooks, Jane Campion, Judy Chicago, Zaha Hadid, Pauline Oliveros, Yvonne Rainer, Cindy Sherman, (...) Amy Tan, and Paula Vogel have each made groundbreaking contributions to their fields. As a group, they represent a tremendous diversity of approaches to art making: from accessible to opaque, from overtly feminist to apolitical, from emotive to cool, from controversial to mainstream. (shrink)

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The development of new theory is often spurred by novel techniques that provide better answers to existing questions, or that allow asking new ones. In the field of strategy and organization science, models of complex adaptive systems have renewed theoretical work on a fundamental question: how organizations can adapt effectively to their environments. This article has three objectives: to highlight some areas where models of organizations as complex adaptive systems have made substantial contributions: the search for solutions to sets of (...) interdependent choices, the challenge of balancing processes of exploration and exploitation, and the organization of imperfect decision makers; to point to several challenges and tradeoffs which can limit the explanatory power and eventual impact of the modeling enterprise; and to sketch out possible future directions of research that would do further justice to the notion of organizations as complex adaptive systems. (shrink)

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Sensen analyzes Kant’s justification of duties to oneself. Why does Kant say that duties to oneself have priority over other duties? Sensen concludes that there is a common idea behind the different formulas of the categorical imperative: the idea that our human capacities have a high importance. Kant’s ethics needs anthropology to derive concrete duties from this general idea.

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In this article I examine the dispute between F. H. Bradley and Bertrand Russell concerning the reality of relations. I show that Bradley’s objections to Russell’s view, that there are such things as relations which serve to effect the unity of complex items, were rooted in a methodological approach which Russell did not share. On Bradley’s view, one must be able to offer reductive analyses of the items one postulates in order that commitment to those items be justified. I argue (...) that Russell expressly rejected this methodological principle of Bradley’s, and instead adopted the view that one may justifiably postulate entities if doing so aids in the illumination of mathematical truths. I show that the postulation of relations does, on Russell’s view, serve to provide that illumination. Russell held that the truths of mathematics constitute fixed data, and that philosophical positions may be judged as successful according to the extent that they possess explanatory power with respect to this data. I argue that Bradley’s and Russell’s exchanges in print, as well as in private correspondence, reflect Russell’s awareness of a fundamental difference in methodological approach. I conclude that Russell elected not to answer Bradley’s objections on their own terms, but rather rejected the methodological assumptions from which those objections emerged. (shrink)

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We present a French translation of Paul Ehrenfest’s review of Louis Couturat’s The Algebra of Logic, written in 1910 for a Russian scientific journal. In this review, the Austrian physicist Ehrenfest suggests to use symbolic logic in the analysis of switching circuits. In a short introduction, we explain the historical context of this review and its philosophical importance.

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