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Today, nearly two years after Wexler and Sullivan’s (2023) article was first published, the crucial questions discussed therein are all the more pertinent and troubling. The advent of novel interve...

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This special issue examines the diverse realities created by the intersection of emerging technologies, new scientific knowledge, and the human being. It engages with two key questions: how is the human being shaped and constructed in new ways through advances in science and technology? and how might these new ways of imagining the subject shape present and future human rights law and practice? The papers examine a variety of scientific technologies—personalized medicine and organ transplant, mitochondrial DNA replacement, and scaffolds and (...) regenerative medicine—and their implications for our conceptualization of the human subject. Each is then followed by a commentary that both brings to light new dimensions of the original paper and presents a new theoretical take on the topic. Together these papers offer a serious challenge to the vision of the human subject at the root of human rights law. Instead of the autonomous, rational, unique, and physically discrete individual who owns herself and her body, the subject that emerges from the human technology assemblage has physically porous boundaries and a relational self. This depiction of the human being as a relational subject enmeshed in her technoscientific environment requires that we reconceptualize human rights law and practice. (shrink)

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Early Buddhist Metaphysics provides a philosophical account of the major doctrinal shift in the history of early Theravada tradition in India: the transition from the earliest stratum of Buddhist thought to the systematic and allegedly scholastic philosophy of the Pali Abhidhamma movement. Entwining comparative philosophy and Buddhology, the author probes the Abhidhamma's metaphysical transition in terms of the Aristotelian tradition and vis-à-vis modern philosophy, exploits Western philosophical literature from Plato to contemporary texts in the fields of philosophy of mind and (...) cultural criticism. (shrink)

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Depression is associated with increased maintenance of negative affect (NA) and reduced – blunted and short-lived – maintenance of positive affect (PA). Studies have focused on factors associated with the maintenance of NA, specifically, the emotion regulation strategy of brooding and the capacity to hold negative affective experiences in working memory (WM). Despite its theoretical importance, less attention has been given to factors associated with the maintenance of PA in depression. This study aims to synthesise factors playing a role in (...) the maintenance of both NA and PA. Specifically, we used self-reported assessment of PA and NA regulation and performance-based measures of NA and PA processing in WM to predict depressive symptoms severity. Participants (N = 219) completed the Affective Maintenance Task (AMT, Mikels et al., Citation2008), which provided performance-based measures of PA and NA maintenance, and filled out questionnaires assessing brooding, positive rumination and depressive severity. Brooding, positive rumination and AMT-based measures of positive (but not negative) affective information processing were independently associated with depressive symptoms. We highlight the unique contributions of PA processing, as well as of self-reported emotion regulation strategies in understanding depression maintenance. (shrink)

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Plurality of beliefs and theories in different knowledge domains calls for modelling multi-viewpoint ontologies and knowledge organization systems. A generic theoretical approach recently proposed for heterogeneity representation in KOS was linking each ontological statement to a specific validity scope to determine a set of conditions under which the statement is valid. However, the practical applicability of this approach has yet to be empirically assessed. In addition, there is still a need to investigate the types of inconsistencies that might arise in (...) multi-viewpoint ontologies as well as their possible causes. This study proposes a new framework for systematic analysis and classification of inconsistencies in multi-viewpoint ontologies. The framework is based on eight generic logical structures of ontological statements. To test the validity of the proposed framework, two ontologies from different knowledge domains were examined. We found that only three of the eight structures led to inconsistencies in both ontologies, while the other two structures were always present in logically consistent statements. The study has practical implications for building diversified and personalized knowledge systems. (shrink)

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It was questions about points on the real line that initiated the study of set theory. Points paved the way to point sets and these to ever more abstract sets. And there was more: Reflection on structural properties of point sets not only initiated the study of ordinary sets; it also supplied blueprints for defining extra-ordinary, “large” sets, transcending those provided by standard set theory. In return, the existence of such large sets turned out critical to settling open conjectures about (...) point sets.How to explain such action at a distance between the very large and the rather small? Rather than having an air of magic, could these results rest on deep structural similarities between the two superficially distant species of sets?In this essay I dissect one group of such two-way results. Their linchpin is the notion of measure.§1. Vitali's impossibility result. Our starting point is a problem in measure theory regarding the notion of “Lebesgue measure.” Before presenting the problem, I would like to review the notion of Lebesgue measure. Rather than listing its main properties, I would like to show how Lebesgue measure is born out of an attempt to generalize the notion of the length of an interval to arbitrary sets of reals. One tries to approximate arbitrary sets of reals by intervals, in the hope that the lengths of the intervals will induce a measure on these sets. (shrink)

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ArgumentThis article describes how science and law were called upon (and failed) to resolve a controversy that created a painful rift between the Israeli State and some of its elite soldiers. The controversy, which came to be known as “the Kishon affair,” erupted in 2000, when veterans of an elite and secretive unit in the Israeli navy claimed that pollution in the Kishon River where they had trained and dived during their military service had been the cause of a rash (...) of cancers. The veterans demanded that the Ministry of Defense take responsibility for their illnesses, finance their medical treatment, and support their families if they die. The military denied the causal connection between the polluted river and the veterans’ cancers and rejected their demands. The dispute quickly escalated into a bitter public controversy, and a high-rank commission comprised of one of Israel's top jurists and two prominent scientists was called upon to study the disputed causal relation and reveal its true nature. However, after nearly three years of intense inquiry the jurist and the scientists reached opposing conclusions: the jurist found a causal connection while the scientists rejected it. (shrink)

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This second installment in a chronologically arranged, three-part sequence continues the author's examination of Anglo-American literati who, in the later nineteenth and twentieth centuries, turned — in acts of combined xenophilia and xenophobia — to Russian literature and literary theory in order to escape the dominant influence of avant-garde movements in France. These Anglophone writers found in Russian exemplars a responsible, morally rigorous, and pragmatic, yet philosophically sophisticated, alternative to what they described as the amoral, superficial, and pretentious aestheticism of (...) French literary culture. Part 2 treats the poetry and criticism of the English “Movement” poet Donald Davie in light of his turn, in 1958, toward the example of Boris Pasternak as a way of escaping the influence of French Symbolist poetics and the post-Symbolist poetics of anglophone modernism. Although Davie understood that Pasternak was as much a modernist as T. S. Eliot or Ezra Pound, he also argued that the Russian's poetry, unlike theirs, sought, on explicitly moral grounds, to maintain conventional syntax and purity of diction, with the result that Pasternak's verse communicates with the reader more as prose than as music does. (shrink)

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Immanuel Kant has long been considered one of the leading exponents of the theory of knowledge with his philosophical writings inspiring generations of political theorists, underpinning many notions and ideas on the concept of progress. Based on and innovative reading of Kant's theory of knowledge, this book challenges contemporary critiques of the concept of progress from post-Marxist, post-Modern and or existentialist approaches which dismiss progress as an anachronistic and deceptive concept that has formed the basis of many of modernity's abominations. (...) Instead this book reveals Kant's unique synthetic theory of knowledge, arguing that the idea of progress should be thought of as a crucial political idea in matters of political management at the outset of the 21st century. (shrink)

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The current international asylum regime recognizes only persecuted persons as rightful asylum applicants. The Geneva Convention and Protocol enumerate specific grounds upon which persecution is recognized. Claimants who cannot demonstrate a real risk of persecution based on one of the recognized grounds are unlikely to be granted asylum. This paper aims to relate real-world practices to normative theories, asking whether the Convention’s restricted preference towards persecuted persons is normatively justified. I intend to show that the justifications of the persecution criterion (...) also apply to grounds currently lacking recognition. My main concern will be persecution on the grounds of gender.The first section introduces the dominant standpoints in theories of asylum, which give different answers to the question of who should be granted asylum, based on different normative considerations. Humanitarian theories base their claims on the factual neediness of asylum-seekers, holding that whoever is in grave danger of harm or deprivation should be granted asylum. Political theories base their justifications on conceptions of legitimacy and membership, holding that whoever has been denied membership in their original state should be granted asylum. Under political theories, Matthew Price’s theory will be discussed, which provides a normative justification of the currently recognized persecution criterion. The second section provides a descriptive definition of persecution based on Kuosmanen, and evaluates the normative relevance of the different elements of this definition based on the theories presented previously. The third section is devoted to the examination of the normative justifiability of the nexus clause’s exclusive list of the bases upon which persons might be persecuted. The section argues that while the clause does not recognize that persecution might be based on gender, in fact many women experience harms based on gender that fulfil all the normatively relevant definitive conditions constituting persecution. The conclusion shows that although the current law’s preferences towards the persecuted are justifiable, the nexus clause’s limiting enumeration of grounds is not. This applies especially to the exclusion of gender as grounds for granting asylum.Article first published online: 21 DEC 2015. (shrink)

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The following is an account of an early Socialist approach to American historiography, including a biographical note on Fedor Kapelusz (1876–1945).

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In contrast to the fruitful relationship between psychoanalysis/psychoanalysts and the humanities, institutionalized psychoanalysis has been largely resistant to the integration of psychoanalysis with other empirical branches of knowledge, as well as clinical ones [primarily cognitive-behavioral therapy ]. Drawing from two decades of theoretical and empirical work on psychopathology, psychotherapy, and psychoanalysis, the author aims to show how a reformulation of object relations theory using psychological science may enhance a clinical-psychoanalytic understanding and treatment of suicidal depression, which constitutes one of the (...) most formidable health challenges of our time. Specifically, he rewrote the notion of Melanie Klein positions—primarily the depressive position—using extant knowledge of structure of emotions, the centrality of mental representations of the future and the toxic nature of criticism-based emotions. This reformulation enables a dialog between clinical psychoanalysis and other therapeutic schools of thought and sheds light on the understanding and treatment of suicidal depression. (shrink)

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The term “Cartesianism” is commonly applied to a wide range of philosophical and scientific doctrines. The question of what constitutes the spirit or essence of Cartesianism – providing a common core for the works of Descartes, Arnauld, Rohault, La Forge, Régis, Spinoza, Le Grand or Malebranche, among others – has elicited a great variety of answers. Without attempting a comprehensive response to the question, I begin by presenting some main presuppositions and goals commonly attributed to Descartes and other Cartesian doctrines (...) – both by their proponents and opponents. A fundamental Cartesian postulate concerns the metaphysical dualism of body and mind. Thoughts (e.g., ideas, volitions and judgments) are regarded by Descartes as modifications of the mind, whereas extension, size, shape, motion or rest are modifications of matter. According to the Cartesian “way of ideas,” the mind is directly acquainted only with its own modifications, and the objects external to the mind are known only through the mediation of ideas. External reality is viewed as given independently of any individual subjective consciousness. Although Descartes was not the first to posit this view, he invested it with a new meaning in his novel conception of the human mind. Within this framework, the Cartesian subject has been viewed mainly as an observer – one who can only represent independent reality rather than constitute it. Some indication of this view may be found in the third part of the.. (shrink)

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Fertility treatments, which are part of "assisted reproductive technologies" (ART), mainly undertaken through in vitro fertilization (IVF), offer the opportunity to infertile couples to conceive. IVF treatments are undertaken in Israel in significantly higher numbers than in the rest of the world. As such, Israel provides an important case-in-point for examining the validity of the actual claims used to justify the more generous public funding of IVF treatments at the policy level. In this article, we utilize an analytical philosophy approach (...) to conduct this examination. First, we highlight two fundamental concepts that were used at the Israeli public policy level in order to justify the generous public funding of IVF treatments. These concepts are “emotional vulnerability” and the “worthlessness of the childless,” where the latter emphasizes the infinite value of children. Then, by applying the perspective of the European model of Bioethical Principlism, and focusing the attention to these two concepts we show that these justifications are invalid. Specifically, it is suggested that these concepts are on the one hand both relying on and expressing the principles of vulnerability, dignity, and integrity; yet on the other hand, these concepts are also undermining the very principles of bioethics they are supposed to express and rely on. Based on this suggested criticism, we offer two “take home” messages informed by our analysis of the Israeli case, but reaching beyond it. (shrink)

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This article explores attempts at legalization of the practice of euthanasia and assisted suicide. Although in many countries there have been high levels of public support for euthanasia and assisted suicide, in most of them, no legislative activity has taken place concerning these practices, and there is a lack of clarity about what is permitted and what is not. I argue that accurate definition of the relevant concepts and a clear delineation of the territory of the debate would help draw (...) a coherent roadmap for legalization. To this end, I analyze five legal approaches to the legalization euthanasia: maintenance of the status quo, legal defenses, de-prioritization, de-criminalization, and legislation. I conclude with a discussion of the moral and legal implications of the foregoing analysis. (shrink)

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Spinoza’s bold claim that there exists only a single infinite substance entails that finite things pose a deep challenge: How can Spinoza account for their finitude and their plurality? Taking finite bodies as a test case for finite modes in general I articulate the necessary conditions for the existence of finite things. The key to my argument is the recognition that Spinoza’s account of finite bodies reflects both Cartesian and Hobbesian influences. This recognition leads to the surprising realization there must (...) be more to finite bodies than their finitude, a claim that goes well beyond the basic substance-monism claim, namely, that anything that is, is in God. This leads to the conclusion, which may seem paradoxical, that finite bodies have both an infinite as well as a finite aspect to them. Finite bodies, I argue, both actively partially determine all the other finite bodies, thereby partially causing their existence insofar as they are finite, as well as are determined by the totality of other bodies. I articulate precisely what this infinite aspect is and how it is distinct from the general substance-monism dictum. (shrink)

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ABSTRACTIn this study, we developed a cognitive bias modification procedure that targets inferential style, and tested its effect on hope, mood, and self-esteem. Participants were randomly assigned to training conditions intended to encourage either a negative or a positive inferential style. Participants’ inferences for their failure on a cognitive challenge were congruent with their training condition. Moreover, compared to participants in the positive training condition, those in the negative condition reported less hope and exhibited lower mood and self-esteem following the (...) failure. Finally, the training affected mood and self-esteem indirectly via its effect on participants’ inferences for their failure. These findings provide support for the causal role of inferential style in depressed affect. (shrink)

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I explore, from a proof-theoretic perspective, the hierarchy of classical and paraconsistent logics introduced by Barrio, Pailos and Szmuc in (Journal o f Philosophical Logic,49, 93-120, 2021). First, I provide sequent rules and axioms for all the logics in the hierarchy, for all inferential levels, and establish soundness and completeness results. Second, I show how to extend those systems with a corresponding hierarchy of validity predicates, each one of which is meant to capture “validity” at a different inferential level. Then, (...) I point out two potential philosophical implications of these results. (i) Since the logics in the hierarchy differ from one another on the rules, I argue that each such logic maintains its own distinct identity (contrary to arguments like the one given by Dicher and Paoli in 2019). (ii) Each validity predicate need not capture “validity” at more than one metainferential level. Hence, there are reasons to deny the thesis (put forward in Barrio, E., Rosenblatt, L. & Tajer, D. (Synthese, 2016)) that the validity predicate introduced in by Beall and Murzi in (Journal o f Philosophy,110(3), 143–165, 2013) has to express facts not only about what follows from what, but also about the metarules, etc. (shrink)

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Ignorance, or the lack of knowledge, appears to be steadily spreading, despite the increasing availability of information. The notion of informed ignorance herein proposed to describe the widespread position of being exposed to an abundance of information yet lacking relevant knowledge, which is tied to the exponential growth in misinformation driven by technological developments and social media. Linked to many of societies’ most looming catastrophes, from political polarization to the climate crisis, practices related to knowledge and information are deemed some (...) of the most imminent and daunting modern threats, evidenced by the latest report of the World Economic Forum, which has named misinformation the most severe short-term global risk. This paper’s epistemic perspective links the properties of today’s information culture and the ways in which it interacts with individual capacities and limitations in current technological and socio-political contexts. Such a position is analyzed through the lens of epistemic principles as a contemporary epistemic phenotype that emerges from an environment of ill-adapted and excessive information inputs and leads to a distinctive type of social injustice that is primarily epistemic in nature. While equity and accessibility are widely discussed as important contributing factors to epistemic discrepancies, other overlooked but fundamental issues underlying epistemic injustices are considered, such as information manipulation, cognitive limitations, and epistemic degradation. To effectively face this elusive threat, we propose an inclusive viewpoint that harnesses knowledge from cognitive science, science and technology studies, and social epistemology to inform a unifying theory of its main impacts and driving forces. By adjusting a modern epistemic framework to the described phenomena, we intend to contextually outline its trajectory and possible means of containment based on a shared responsibility to maintain ethical epistemic standards. In a time of international unrest and mounting civil acts of violence, it is pertinent to emphasize the ethical principles of knowledge systems and authorities and suggest policy adaptations to maintain a social contract based on the shared values of truth and freedom. (shrink)

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This chapter focuses on the dispute between necessitarians and contingentists, mainly addressing the issue as to whether laws of nature are metaphysically necessary or metaphysically contingent with a weaker kind of necessity, commonly referred to as natural, nomological, or nomic necessity. It is assumed here that all fundamental properties are dispositional or role properties, making the dispute a strictly verbal one. The existence of categorical intrinsic properties as well as dispositional properties is also assumed and the relationship between them examined. (...) Finally, the chapter concludes by returning to the debate between necessitarians and contingentists under the assumption that both dispositional and categorical fundamental properties exist. It is argued here that necessitarian positions can be recast as contingentist, but that there are unequivocally contingentist positions preferred because they are less mysterious despite being ontologically more complex. (shrink)

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There is a long tradition of reading Spinoza as committed, perhaps unwillingly, to the non-reality of finite modes. While acknowledging that Spinoza does seem to rely on the reality of modes in certain places, Michael Della Rocca has called attention to what he labels an “idealist strand.” As a concluding remark in “Steps Toward Eleaticism in Spinoza's Philosophy of Action,” he claims that faced with these two conflicting strands, which are genuinely to be found in the text, it is better (...) to note both rather than artificially imposing a unity on the text. In this paper, I suggest that one need not admit two conflicting strands in Spinoza, on the one hand, nor arbitrarily disregard one strand, on the other. Rather, I argue for a unified view that diagnoses what gives rise to both seemingly conflicting strands. The key to this enterprise is recognizing that finite modes, paradoxically seeming perhaps at first, are not wholly finite. That is, a finite mode is determined by the totality of finite modes—wherein lies its finite aspect, but at the same time, and equally, partially actively determines this totality—wherein lies its infinite aspect. (shrink)

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The increasing awareness of personal health responsibility had led to the claim that patients with ‘self-inflicted’ conditions have less of a right to treatment at the public's expense than patients whose conditions arose from ‘uncontrollable’ causes. This paper suggests that regardless of any social decision as to the limits and scope of individual responsibility for health, the moral framework for discussing this issue is equality. In order to reach a consensus, discourse should be according to the common basis of all (...) theories of justice, Aristotle's formal principle of justice: ‘equals must be treated equally and unequals must be treated unequally, in proportion to the relevant inequality’. This paper deals with the question of whether and under what circumstances risk-taking behaviour could be regarded as a ‘relevant inequality’ with respect to the right to health care. Following a discussion of the relevant inequalities in health care, the conclusion is reached that the fact that the condition was avoidably caused by the patient and is therefore his or her fault can not be regarded necessarily as a relevant inequality. Therefore, the issue is one of societal support for health care; after defining relevant inequalities in this respect, the paper attempts to apply them to self-inflicted conditions. This analysis reveals that, in theory, it may be just to restrict societal support in such cases. However, the application of this conclusion requires proof of many factual claims—for which there is often very limited evidence. (shrink)

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Volume 25, Issue 3, March 2025, Page 146-148.

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Ferritins (FTs) are iron storage proteins that are involved in managing iron‐oxygen balance. In our work, we present a hypothesis on the putative effect of geological changes that have affected the evolution and radiation of ferritin proteins. Based on sequence analysis and phylogeny reconstruction, we hypothesize that two significant factors have been involved in the evolution of ferritin proteins: fluctuations of atmospheric oxygen concentrations, altering redox potential, and changing availability of water rich in bioavailable ferric ions.Fish, ancient amphibians, reptiles, and (...) placental mammals developed the broadest repertoire of singular FTs, attributable to embryonic growth in aquatic environments containing low oxygen levels and abundant forms of soluble iron. In contrast, oviparous land vertebrates, like reptiles and birds, that have developed in high oxygen levels and limited levels of environmental Fe2+ exhibit a lower diversity of singular FTs, but display a broad repertoire of subfamilies, particularly notable in early reptiles. (shrink)

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Models of set theory are constructed where the non-stationary ideal on PΩ1λ is presaturated. The initial model has a Woodin cardinal. Using the Lévy collapse the Woodin cardinal becomes λ+ in the final model. These models provide new information about the consistency strength of a presaturated ideal onPΩ1λ for λ greater than Ω1.

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Minimally inconsistent LP (MiLP) is a nonmonotonic paraconsistent logic based on Graham Priest's logic of paradox (LP). Unlike LP, MiLP purports to recover, in consistent situations, all of classical reasoning. The present paper conducts a proof-theoretic analysis of MiLP. I highlight certain properties of this logic, introduce a simple sequent system for it, and establish soundness and completeness results. In addition, I show how to use my proof system in response to a criticism of this logic put forward by JC (...) Beall. (shrink)

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Though we have access to a wealth of information, the main issue is always how to process the available information. How to make sense of all we observe and know. Just like the English alphabet: we know there are 26 letters but unless we put these letters together in a meaningful way, they convey no information. There are infinitely many ways of putting these letters together. Only a small number of those make sense. Only some of those convey exactly what (...) we wish to convey though the message may be interpreted differently by different individuals. That same issue comes up with information: how can we process the information we have? How can we infer and reason under conditions of incomplete observed information? In his seminal book on the philosophy of information, Floridi (2011a) raises a number of open questions. I discuss here one of these questions. That question is how to process information. To do so, I take the more realistic view that information is always limited, incomplete and possibly noisy. I define types of information, relate it to Floridi’s definitions and discuss a basic formulation for processing information under a unified framework. I relate it to some of the basic concepts discussed in the book. (shrink)

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The use of models to assign truth values to sentences and to counterexemplify invalid inferences is a basic feature of model theory. Yet sentences and inferences are not the only phenomena that model theory has to take care of. In particular, the development of sequent calculi raises the question of how metainferences are to be accounted for from a model-theoretic perspective. Unfortunately there is no agreement on this matter. Rather, one can find in the literature two competing model-theoretic notions of (...) metainferential validity, known as the ‘global’ notion and the ‘local’ notion. In this article, I argue that, given certain plausible considerations about metainferential validity, the global notion collapses into the local notion. (shrink)

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To assess whether and how environmental values and sense of place relate to sustainable farming practices, we conducted a study in South Kona, Hawaii, addressing environmental values, sense of place, and farm sustainability in five categories: environmental health, community engagement and food security, culture and history, education and research, and economics. We found that the sense of place and environmental values indexes showed significant correlation to each category of sustainability in both independent linear regressions and multivariate regression. In total, sense (...) of place explained a larger share of the overall farm performance. However, each indicator showed relative strengths; environmental values showed significantly higher correlation to environmental and educational practices. Furthermore the scales were complimentary, and the use of both scales greatly improved prediction of good farming practices from a multiple-impact perspective. With implications for community and environmental impacts, results suggest that a more comprehensive view of farmers’ environmental values and place connections may help illuminate individual farmers’ decisions and sustainability-related practices. (shrink)

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