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The Drosophila position‐specific (PS) integrins are members of the integrin family of cell surface receptors and are thought to be receptors for extracellular matrix components. Each PS integrin consists of an α subunit, αPS1 or αPS2, and a βPS subunit. Mutations in the βPS subunit and the αPS2 subunit have been characterised and reveal that the PS integrins have an essential role in the adhesion of different cell layers to each other. The PS integrins are especially required for the function (...) of the cell‐matrix‐cell junctions, where the muscles attach to the epidermis and where one surface of the developing wing adheres to the other. These junctions are similar to vertebrate focal adhesions and hemidesmosomes, which also contain integrins. Integrin‐mediated cell to cell adhesion via the extracellular matrix provides a way for tissues to adhere to each other without intermingling of their cells. (shrink)

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1 Evidence-based policy requires researchers to provide the answers to ecological questions that are of interest to policy makers. To find out what those questions are in the UK, representatives from 28 organizations involved in policy, together with scientists from 10 academic institutions, were asked to generate a list of questions from their organizations. 2 During a 2-day workshop the initial list of 1003 questions generated from consulting at least 654 policy makers and academics was used as a basis for (...) generating a short list of 100 questions of significant policy relevance. Short-listing was decided on the basis of the preferences of the representatives from the policy-led organizations. 3 The areas covered included most major issues of environmental concern in the UK, including agriculture, marine fisheries, climate change, ecosystem function and land management. 4 The most striking outcome was the preference for general questions rather than narrow ones. The reason is that policy is driven by broad issues rather than specific ones. In contrast, scientists are frequently best equipped to answer specific questions. This means that it may be necessary to extract the underpinning specific question before researchers can proceed. 5 Synthesis and applications. Greater communication between policy makers and scientists is required in order to ensure that applied ecologists are dealing with issues in a way that can feed into policy. It is particularly important that applied ecologists emphasize the generic value of their work wherever possible. (shrink)

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The chapter contrasts views of Punk as a playlist and an attitude with one based on a kind of action: praxis! -/- Can be downloaded from my Website.

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A clearly written, authoritative introduction to Taylor's work.

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In this collection, philosophers, social psychologists, and social scientists approach contemporary social reality from the viewpoint of solidarity. They examine the nature of solidarity and explore its normative and explanatory potential.

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In 1985, after nearly a decade of inconclusive professional response to public concern about misconduct in research, Congress passed legislation requiring action. Subsequent to this legislation, federal agencies and research universities adopted policies for responding to allegations of misconduct in research. Conferences, sessions at professional meetings, and special publications were organized. New educational initiatives were begun, many in response to a 1989 National Institutes of Health/ Alcohol, Drug Abuse, and Mental Health Administration requirement to include ethics instruction in training grants. (...) Notwithstanding a few key unresolved issues, such as the lack of a uniform federal definition of misconduct in research, the years since 1985 have witnessed a marked change in the professional response to misconduct in research. This paper evaluates the change since 1985 from the perspective of three key goals: 1) confronting misconduct, 2) promoting integrity and 3) ensuring integrity. While significant progress has been made in achieving the first two goals, the third remains largely unaddressed. The latter is due to the fact that researchers have not been interested in studying the integrity of their own profession. It is therefore suggested that studies are needed of routine or normal research practices and their impact on integrity for use in making decisions about research conduct policy. (shrink)

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The article considers how Richard Rorty's writings on religion dovetail with his views on the philosophical significance of hope. It begins with a reconstruction of the central features of Rorty's philosophy of religion, including its critique of theism and its attempt to rehabilitate religion within a pragmatist philosophical framework. It then presents some criticisms of Rorty's proposal. It is argued first that Rorty's "redescription" of the fulfilment of the religious impulse is so radical that it is hard to see what (...) remains of its specifically religious content. This casts doubt on Rorty's claim to have made pragmatism and religion compatible. The article then offers an analysis of Rorty's key notion of "unjustifiable hope". Different senses of unjustifiable hope are distinguished, in the course of which a tension between the "romantic" and "utilitarian" aspects of Rorty's pragmatist philosophy of religion comes into view. (shrink)

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The paper argues that we should read Taylor’s philosophy as a philosophy of liberation and that it is as a philosopher of liberation that Taylor distinguishes himself as a critical theorist. It beg...

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During the 1980s, federal regulations transferred significant portions of the responsibility for monitoring the care and use of research animals from animal care programs to Institutional Animal Care and Use Committees (IACUCs). After a brief review of the history of the regulation of the use of animals in research preceding and during the 4 decades following World War 11, this article raises 4 problems associated with the role IACUCs currently play in monitoring the use of animals in research: (a) lack (...) of expertise, (b) diverted resources, (c) conflict of interest, and (d) restrictions of academic freedom. It is concluded that the care and treatment of animals used in research would be served better and organized more rationally if the day-to-day responsibilities for approving projects and caring for animals were separated more clearly from broader, oversight functions, with the former being assigned to animal care programs and the latter to IACUCs. (shrink)

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The ‘interpretive turn’ in twentieth-century hermeneutics rests on the general ontological claim that human reality is the reality of self-interpreting animals. But under the circumstances of advanced modernity, there are aspects of human life, or spheres of human thought and action, that appear to contradict this general thesis, in that they do not present themselves as the doings of self-interpreting animals at all. Of these, the predominant one is the sphere of work or 'productive' action. In face of historical circumstances (...) in which work presents itself as bereft of the meanings that concern self-interpreting animals, hermeneutic philosophy faces a choice: Does it exempt work from the realm of self-interpretive activity, making it an exception to the general ontological thesis; or does it seek to retrieve the hermeneutic provenance of productive action? With a focus on the writings of Gadamer and Ricoeur, the chapter shows that philosophical hermeneutics has vacillated on this issue and it suggests that retrieval of the self-interpretive dimension of productive action is a central task for hermeneutics today. (shrink)

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A short reflective piece on the occasion of Charles Taylor's 85th birthday.

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The chapter begins by contrasting two approaches to the analysis of hope, one which takes its departure from a view broadly shared by Hobbes, Locke and Hume, another which fits better with Aquinas's definition of hope. The former relies heavily on a sharp distinction between the cognitive and conative aspects of hope. It is argued that while this approach provides a valuable source of insights, its focus is too narrow and it rests on a problematic rationalist psychology. The chapter then (...) discusses the phenomenology of hope with particular reference to the contrast between the lived experience of expectation and anticipation. This leads to a discussion of the value of hope. My thesis here is that when philosophers reflect on hope, they bring along background, tacit assumptions regarding its worth, which I attempt to make explicit. Finally the chapter identifies a second kind of philosophical reflection on hope, which is concerned not so much with the logic or value of hope as with hope understood as a 'principle.'. (shrink)

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The paper is a critical analysis of Paul Ricoeur’s philosophy of work as it is formulated in a number of essays from the 1950s and 60s. It begins with a reconstruction of the central theses advanced in ‘Travail et parole’ (1953) and related texts, where Ricoeur sought to outline a philosophical anthropology in which work is given its due. To give work its due, from an anthropological standpoint, is to see it as limited by counter-concept of language, according to Ricoeur. (...) The paper then argues that this way of understanding the anthropological significance of work is not only internally problematic, but at odds with phenomenological insights to be found elsewhere in Ricoeur’s oeuvre, particularly Le Volontaire et l’involontaire (1950). The final section of the paper makes some suggestions for how the phenomenological and anthropological poles of a philosophy of work might be better integrated, and the ‘nexus between speech and work’ better described. (shrink)

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This article examines a neglected but crucial feature of Honneth's critical theory: its use of a concept of recognition to articulate the norms that are apposite for the contemporary world of work. The article shows that from his first writings on the structure of critical social theory in the early 1980s to the recent exchange with Nancy Fraser on recognition and redistribution, the problem of grounding a substantive critique of work under capitalism has been central to Honneth's enterprise. This answers (...) the routine objection that the recognition paradigm fails to take into account economic or material realities. At the same time, Honneth's approach to the critique of work has undergone significant shifts, and it is yet to be fully developed. The article traces these changes in direction, and it proposes an expressivist conception of work that builds upon the `normative content' of the concept of work described by Honneth in his 1980 essay `Work and Instrumental Action'. (shrink)

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The essay reflects on Gadamer’s ambiguous legacy for the philosophy of work. On the one hand, there are times when Gadamer reproduces the problematic distinction between language and labor which short-circuits the very idea of a hermeneutics of work. This is particularly evident in Gadamer’s reflections on technique and craftsmanship in the central sections of Truth and Method, as well as in his descriptions of the “art” of dialogue and the tasks of hermeneutics that separate them emphatically them from the (...) sphere of “making.” I raise some questions about the adequacy of the distinction Gadamer draws between techne and phronesis that structures this account. I argue here that Gadamer’s characterization of the learning process involved in the mastery of a technique, as well as his conception of the instrumentality and monologicality of technical knowledge, is difficult to sustain, especially in view of recent research in the psychology and anthropology of work. I then go on to point out that elsewhere in his oeuvre Gadamer himself is critical of the conception of work that emerges through the lens of the techne / phronesis distinction. Indeed, on these occasions he hints at a conception of work that points beyond the Arendt / Habermas conception towards a critical hermeneutics of working life. This alternative approach to work is particularly apparent in Gadamer’s appropriation of Hegel’s dialectic, in his understanding of play, and in some of his later diagnostic reflections on the spirit of the age. In section four, I offer some suggestions for explaining how the tensions evident in Gadamer’s approach to work came about. Here I am interested in what prevented Gadamer from embracing whole-heartedly the project of a hermeneutics of work that he himself helped to lay the foundations for. I conclude with some brief remarks on why we should seek to build upon these foundations and renew the project of a critical hermeneutics of work today. (shrink)

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I suggest that the post-Hegelian tradition presents us with three contrasting normative models of work. According to the first model, the core norms of work are those of means-ends rationality. In this model, the modern world of work is constitutively a matter of deploying the most effective means to bring about given ends. The rational kernel of modern work, the core norm that has shaped its development, is on this view instrumental reason, and this very same normative core, in the (...) shape of advanced technology and more efficient, time-saving production, can help to liberate it. The second model, by contrast, takes the core norms of work to be internal to working activity. Rather than work gaining its normativity from something external to it, from ends to which the work is a contingent means, on this second view the core norms of work are expressions of values or meanings that are immanent to working practices themselves. The expressive model of work regards the actual world of work to be constituted historically by work-specific norms, norms which working subjects themselves have invoked and mobilised around in the course of their struggles for emancipation. According to the third model, the core norms of work have to do neither with instrumental rationality nor authentic self-expression. Rather they concern norms that relate either to individual achievement or contribution through work (in the form of esteem) or to the conditions that must in place for individuals to participate in the exchange of services by which market societies reproduce themselves (in the form of mutual respect). (shrink)

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This paper examines the justice of unconditional basic income (UBI) through the lens of the Hegel-inspired recognition-theory of justice. As explained in the first part of the paper, this theory takes everyday social roles to be the primary subject-matter of the theory of justice, and it takes justice in these roles to be a matter of the kind of freedom that is available through their performance, namely ‘social’ freedom. The paper then identifies the key criteria of social freedom. The extent (...) to which the introduction of an UBI would meet these criteria is then examined, with a focus on the social role that stands to be most affected by an UBI, namely that of the worker-earner. It is argued that while an UBI is likely to be only partially effective as an instrument of specifically social freedom, its main justification lies not here, but in securing a basis for the subjective freedom that social freedom presupposes. (shrink)

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This article examines Levinas as if he were a participant in what Habermas has called `the philosophical discourse of modernity'. It begins by comparing Levinas' and Habermas' articulations of the philosophical problems of modernity. It then turns to how certain key motifs in Levinas' later work give philosophical expression to the needs of the times as Levinas diagnoses them. In particular it examines how Levinas interweaves a modern, post-ontological conception of `the religious' or `the sacred' into his account of subjectivity. (...) Finally, the article looks at some problems that arise for Levinas once his position in the philosophical discourse on modernity is made explicit. Key Words: Jürgen Habermas • Emmanuel Levinas • modernity • ontology • otherness • religion • social relation. (shrink)

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Introduction to themed papers on 'Work after Liberalism'.

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The medial prefrontal cortex (mPFC) has been the subject of intense interest as a locus of cognitive control. Several computational models have been proposed to account for a range of effects, including error detection, conflict monitoring, error likelihood prediction, and numerous other effects observed with single-unit neurophysiology, fMRI, and lesion studies. Here, we review the state of computational models of cognitive control and offer a new theoretical synthesis of the mPFC as signaling response–outcome predictions. This new synthesis has two interacting (...) components. The first component learns to predict the various possible outcomes of a planned action, and the second component detects discrepancies between the actual and intended responses; the detected discrepancies in turn update the outcome predictions. This single construct is consistent with a wide array of performance monitoring effects in mPFC and suggests a unifying account of the cognitive role of medial PFC in performance monitoring. (shrink)

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In this article we examine the idea of a politics of misrecognition of working activity. We begin by introducing a distinction between the kind of recognition and misrecognition that attaches to one’s identity, and the kind of recognition and misrecognition that attaches to one’s activity. We then consider the political significance of the latter kind of recognition and misrecognition in the context of work. Drawing first on empirical research undertaken by sociologists at the Institut für Sozialforschung in Frankfurt, we argue (...) for a differentiated concept of recognition that shows the politics of misrecognition at work to be as much a matter of conflict between modes of recognition as it is a struggle for recognition as opposed to non -recognition. The differentiated concept of recognition which allows for this empirical insight owes much to Axel Honneth’s theory. But as we argue in the section that follows, this theory is ambiguous about the normative content of the expectations of recognition that are bound up with the activity of working. This in turn makes it unclear how we should understand the normative basis of the politics of the misrecognition of what one does at work. In the final sections of the article, we suggest that the psychodynamic model of work elaborated by Christophe Dejours and others at the Conservatoire National des Arts et Métiers in Paris can shed light on this matter; that is to say, it can help to clarify the normative significance and political stakes of the misrecognition of working activity. (shrink)

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In the past two decades, reinforcement learning has become a popular framework for understanding brain function. A key component of RL models, prediction error, has been associated with neural signals throughout the brain, including subcortical nuclei, primary sensory cortices, and prefrontal cortex. Depending on the location in which activity is observed, the functional interpretation of prediction error may change: Prediction errors may reflect a discrepancy in the anticipated and actual value of reward, a signal indicating the salience or novelty of (...) a stimulus, and many other interpretations. Anterior cingulate cortex has long been recognized as a region involved in processing behavioral error, and recent computational models of the region have expanded this interpretation to include a more general role for the region in predicting likely events, broadly construed, and signaling deviations between expected and observed events. Ongoing modeling work investigating the interaction between ACC and additional regions involved in cognitive control suggests an even broader role for cingulate in computing a hierarchically structured surprise signal critical for learning models of the environment. The result is a predictive coding model of the frontal lobes, suggesting that predictive coding may be a unifying computational principle across the neocortex. (shrink)

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Motor training to improve walking and balance function is a common aspect of rehabilitation following motor-incomplete spinal cord injury. Evidence suggests that moderate- to high-intensity exercise facilitates neuroplastic mechanisms that support motor skill acquisition and learning. Furthermore, enhancing corticospinal drive via transcranial direct current stimulation may augment the effects of motor training. In this pilot study, we investigated whether a brief moderate-intensity locomotor-related motor skill training circuit, with and without tDCS, improved walking and balance outcomes in persons with MISCI. In (...) addition, we examined potential differences between within-day and between-day effects of MST. Twenty-six adults with chronic MISCI, who had some walking ability, were enrolled in a 5-day double-blind, randomized study with a 3-day intervention period. Participants were assigned to an intensive locomotor MST circuit and concurrent application of either sham tDCS or active tDCS. The primary outcome was overground walking speed measured during the 10-meter walk test. Secondary outcomes included spatiotemporal gait characteristics, peak trailing limb angle, intralimb coordination, the Berg Balance Scale, and the Falls Efficacy Scale-International questionnaire. Analyses revealed a significant effect of the MST circuit, with improvements in walking speed, cadence, bilateral stride length, stronger limb TLA, weaker limb ACC, BBS, and FES-I observed in both the MST+tDCSsham and MST+tDCS groups. No differences in outcomes were observed between groups. Between-day change accounted for a greater percentage of the overall change in walking outcomes. In persons with MISCI, brief intensive MST involving a circuit of ballistic, cyclic locomotor-related skill activities improved walking outcomes, and selected strength and balance outcomes; however, concurrent application of tDCS did not further enhance the effects of MST.Clinical Trial Registration[ClinicalTrials.gov], identifier [NCT03237234]. (shrink)

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After characterizing Taylor’s general approach to the problems of solidarity, we distinguish and reconstruct three contexts of solidarity in which this approach is developed: the civic, the socio-economic, and the moral. We argue that Taylor’s distinctive move in each of these contexts of solidarity is to claim that the relationship at stake poses normatively justified demands, which are motivationally demanding, but insufficiently motivating on their own. On Taylor’s conception, we need some understanding of extra motivational sources which explain why people (...) do (or would) live up to the exacting demands. Taylor accepts that our self-understanding as members of either particular communities or humanity at large has some motivational power, but he suspects that in many cases the memberships are too thin to resonate deeply and enduringly within us. In Taylor’s view, a realistic picture of what moves people to solidarity has to account for the extra motivation, when it happens. We propose an alternative view in which morality, democracy and socio-economic cooperation can be seen as separate spheres or relations which are normatively justified, motivationally demanding, but also sufficiently motivating on their own. (shrink)

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I begin by picking up on Brandom’s suggestion that expressivism follows American pragmatism in seeking to advance the cause of the Enlightenment. This provides us with a first point of contrast with Taylor’s understanding of expressivism, since Taylor takes expressivism to be inseparably bound up with the Romantic critique of the Enlightenment and as fundamentally opposed to Enlightenment naturalism. I then distinguish two features of what we ordinarily mean by the term ‘expression’, one of which provides an intuitive basis for (...) understanding Brandom’s expressivist program, the other of which provides an interpretive key for understanding Taylor’s version of expressivism. After looking briefly at the main tenets of Taylor’s expressivism, I conclude by considering its relation to Romanticism on the one hand, and to Brandom’s expressivist renewal of the Enlightenment project on the other. (shrink)

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An analysis of how the sphere of work can be considered to instantiate norms of recognition, even when those norms give rise to paradoxes and ideologies surrounding how work ought to be done and the goods at stake in it.

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What is the fundamental purpose that justifies the existence of the modern university? The answer proposed in this essay is the promotion of social freedom. The essay begins by distinguishing social freedom from negative freedom and reflective freedom along the lines proposed by other theorists of social freedom, such as Frederick Neuhouser and Axel Honneth. After noting the need for a more developed account of the university than has so far been provided by these other theorists, the essay analyses the (...) various dimensions in which universities have, at their best, promoted social freedom. The essay then explains why it is through the promotion of social, as distinct from negative or reflective freedom, that universities fulfil their purpose. It concludes with some reflections on how this understanding of the purpose of the university fits an “immanent” model of social criticism. (shrink)

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The aim of this article is to situate Arendt’s account of labour as a critical response to humanisms of labour, or put otherwise, to situate it as an anti-humanism of labour. It compares Arendt’s account of labour with that of the most prominent humanist theorist of labour at the time of the composition of The Human Condition: Georges Friedmann. Arendt’s and Friedmann’s accounts of labour are compared specifically with respect to the range of capacities, social relations, and possibilities of fulfilment (...) at stake in the activity of labour. The comparison provides a previously unexplored context for understanding Arendt’s account of labour and her distinction between labour and work. The relevance of Arendt’s and Friedmann’s theories of labour for the contemporary debate about the meaning of work in an age of automation is also briefly discussed. (shrink)

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