Framework for a protein ontology.Darren A.Natale,Cecilia N. Arighi,Winona Barker,Judith Blake,Ti-Cheng Chang,Zhangzhi Hu,Hongfang Liu,Barry Smith &Cathy H. Wu -2007 -BMC Bioinformatics 8 (Suppl 9):S1.detailsBiomedical ontologies are emerging as critical tools in genomic and proteomic research where complex data in disparate resources need to be integrated. A number of ontologies exist that describe the properties that can be attributed to proteins; for example, protein functions are described by Gene Ontology, while human diseases are described by Disease Ontology. There is, however, a gap in the current set of ontologies—one that describes the protein entities themselves and their relationships. We have designed a PRotein Ontology (PRO) (...) to facilitate protein annotation and to guide new experiments. The components of PRO extend from the classification of proteins on the basis of evolutionary relationships to the representation of the multiple protein forms of a gene (products generated by genetic variation, alternative splicing, proteolytic cleavage, and other post-translational modification). PRO will allow the specification of relationships between PRO, GO and other OBO Foundry ontologies. Here we describe the initial development of PRO, illustrated using human proteins from the TGF-beta signaling pathway. (shrink)
The Protein Ontology: A structured representation of protein forms and complexes.DarrenNatale,Cecilia N. Arighi,Winona C. Barker,Judith A. Blake,Carol J. Bult,Michael Caudy,Harold J. Drabkin,Peter D’Eustachio,Alexei V. Evsikov,Hongzhan Huang,Jules Nchoutmboube,Natalia V. Roberts,Barry Smith,Jian Zhang &Cathy H. Wu -2011 -Nucleic Acids Research 39 (1):D539-D545.detailsThe Protein Ontology (PRO) provides a formal, logically-based classification of specific protein classes including structured representations of protein isoforms, variants and modified forms. Initially focused on proteins found in human, mouse and Escherichia coli, PRO now includes representations of protein complexes. The PRO Consortium works in concert with the developers of other biomedical ontologies and protein knowledge bases to provide the ability to formally organize and integrate representations of precise protein forms so as to enhance accessibility to results of protein (...) research. PRO (http://pir.georgetown.edu/pro) is part of the Open Biomedical Ontologies (OBO) Foundry. (shrink)
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Ethics and enterprise.Samuel M.Natale -1983 -Journal of Business Ethics 2 (1):43 - 49.detailsThis paper summarizes three major approaches to the problem of business ethics. Comparisons and contrasts are drawn between the moralistic approach of Berhman, the social contract theory of Nash, and a comprehensive systems approach as articulated by Elbing. In the final section, some attempt is made to indicate how these models may be implemented into managerial policy decision making process by the use of group work and ascending communication. Some consideration of using organizational structure to implement ethical concerns is indicated.
Exceeding Our Grasp: Curricular Change and the Challenge to the Assumptive World.Samuel M.Natale &Sebastian A. Sora -2010 -Journal of Business Ethics 92 (1):79-85.detailsThe recent global economic collapse brings new calls for reform and change as well as a re-examination of the ethical foundations underpining it. Most professors as well as students remain profoundly unhappy with the Business Curricula. The curricula appear to swing between technological training and academic theory. There is little genuine focus on the central issue of the problem: the students’ and faculty’s assumptive world which drives the selection of the materials chosen for presentation as well as the decision-making process. (...) In the pragmatic quest to achieve status within academe, business schools appear to have forgotten that their subject matter is not one cognate domain but a mixture of several areas including mathematics, economics, anthropology, sociology, psychology, logic and planning. Course structures must be redesigned as consilient. That is, each course contains in it the links to other courses and is not expected to be complete in themselves; the new structures proposed are no longer under the direct control of one instructor but each course is under the control of a committee. This creates a linkage between courses that together from a linked chain of knowledge where the strength of the curriculum is tied to the consilient strength of the courses. The result is an organic and developmental model for teaching and learning with a strong ethical foundation as well as developed moral links to effective decision making. (shrink)
Teoreticheskiĭ analiz filosofii mifa M. Ėliade: osnovnye idei i kognitivnyĭ potent︠s︡ial = Theoretical analysis of M. Eliade's philosophy of myth: basic ideas and cognitive potential.Natal ́â Anatol ́evna Nikonovič -2018 - Minsk: "Belaruskai︠a︡ navuka".detailsChastʹ 1. Analiz osnovnykh napravleniĭ issledovanii︠a︡ filosofii mifa i religii M. Ėliade -- Chastʹ 2. Kulʹturfilosofskiĭ proekt M. Ėliade -- Chastʹ 3. Kont︠s︡ept︠s︡ii︠a︡ filosofii istorii M. Ėliade -- Chastʹ 4. Teoretiko-metodologicheskoe znachenie vzgli︠a︡dov M. Ėliade dli︠a︡ issledovanii︠a︡ problem filosofii kulʹtury i religii.
Values, Work, Education: The Meanings of Work.SamuelNatale,Brian M. Rothschild,Joseph W. Sora &Tara M. Madden (eds.) -1995 - Brill | Rodopi.detailsThis book is a collection of reflections and empirical studies which examine the many facets of the meanings of work. The authors are significant scholars in fields of study ranging from ethics to sociology. The book is a text which aims at balancing the academic with the practical and so the chapters often reflect the tensions implicit in such a venture. The reader will find in these pages historical, philosophical, educational, religious, entrepreneurial and many other points of view which combine (...) to emerge as a text which is both encyclopedic in information yet engaging and lively in style. The reader will be able to understand how the meanings of work have changed over the centuries varying according to historical place and point of view. At the same time, the diligent reader will observe the centrality that work has in the lives of people both practically and in terms of life quests. Work has previously been defined as an activity that produces something of value for other people. This definition does not even begin to include the information about work that is presented in this book. The reader will feel a invigorating sense of worth from this book. (shrink)
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Higher Education and Wealth Equity: Calibrating the Moral Compass Empathy, Ethics, and the Trained Will.Samuel M.Natale &Anthony F. Libertella -2016 -Journal of Academic Ethics 14 (1):35-47.detailsThis paper will argue the importance of the creation of a moral compass, driven by empathy and a rigorously trained will in higher education leadership to develop a tighter relationship between higher education and wealth equity. We will explore the foundational documents that first discussed these issues within a global context. Further, We explore how these goals, enhanced by insights promulgated by the United Nations, can be achieved by teaching empathy, developing a moral compass and training the will.
Octavian and Orestes in Pausanias.Natale Cecioni -1993 -Classical Quarterly 43 (02):506-.detailsM. J. Dewar argues that in Georg. 1.511–4 Virgil may have been drawing a disquieting parallel between Orestes, evoked through an imitation of Aeschylus , and Octavian, present a few lines above . Pausanias probably supports this suggestion; he shows that the link Octavian-Orestes existed quite early and in a sense favourable to Octavian, even though it may soon have been used in a negative sense by anti-Caesarian propaganda on account of the dark side of the myth. In front of (...) the temple of Hera in Argos there was still visible in the second century a statue representing Orestes, but identified by the inscription as Augustus. Certainly this parallel Augustus-Orestes was not proposed-and preserved - with polemical purpose in a famous sanctuary and in the Augustan age. Given the resemblance between history and myth and the moral weight of the famous myth itself, it is unlikely that we have to do with the mere re-use of any old statue. (shrink)
University Quarter as a form of cultural interaction between the University and the city.Natal'ya Vladimirovna Baraboshina,Larisa Gennad'evna Ilivitskaya &Ivan Viktorovich Stepanov -forthcoming -Philosophy and Culture (Russian Journal).detailsThe object of the study is the university quarter as a socio-cultural phenomenon. The subject of the study is the forms of cultural interaction between the university quarter and the city. The use of comparative and typological methods made it possible to identify and describe four forms of university presence in the city space, grouped around two basic directions. The first direction assumes the priority of the university in relation to the city, which gives rise to such a form of (...) their interaction as a "university city". In this case, university activity, in fact, fulfills the role of the economic basis of urban life. The second direction, which is characterized by the leading role of the city, is represented by the student quarter, campus, university quarter. And in this case, we can talk about the "growing" of the university into the urban space, which has both its positive and negative sides. Special attention is paid to the university quarter, the need for which is associated with the expansion of the university's interaction with the urban community. Combining the project nature, openness, flexible targeting, it demonstrates greater potential compared to traditional options. In turn, the university quarter project can be represented by various complementary options. The analysis of the Samara experience of its design revealed two promising forms of its implementation: building a citywide university space and updating the historical past on the basis of available university resources. (shrink)
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Projeções da Revolução Mexicana na América Latina no pós 1917: o caso brasileiro.Natally Vieira Dias -2018 -Dialogos 22 (2):04.detailsEste artigo analisa a projeção continental do México revolucionário no pós 1917 a partir do caso brasileiro. Após a eclosão da Revolução Russa, o modelo bolchevique passou a rivalizar indiretamente com o protagonismo que o México revolucionário pretendia exercer no cenário latino-americano. Assim, a ideia de um “autoctonismo continental” passou a ser enfatizada na propaganda mexicana como elemento que faria da Revolução Mexicana um modelo mais apropriado de transformação social para os países latino-americanos. Discutimos neste artigo os aspectos tomados pela (...) propaganda mexicana e algumas apropriações da experiência revolucionária do México por parte dos brasileiros, com destaque para o caso dos socialistas. (shrink)
For-Profit Education: The Sleep of Ethical Reason.Samuel M.Natale,Anthony F. Libertella &Caroline J. Doran -2015 -Journal of Business Ethics 126 (3):415-421.detailsThis article argues the philosophical concerns and foundational challenges raised by a for-profit model of education. The for-profit model is governed by a business paradigm, without reference to the context in which it is found. The authors explore primary ethical questions and challenges presented by this model. As such, they present potential solutions to the growing problem in higher education as a corporate entity. The authors introduce a potential model for analysis of the issues and suggest an interventional technique with (...) concrete directions for change. Universities are on the threshold of a transformation which can no longer be isolated from wider society. This environment awakened the critical task of blending corporate success with educational integrity. (shrink)
Online Education: Values Dilemma in Business and the Search for Empathic Engagement.S. M.Natale &A. F. Libertella -2016 -Journal of Business Ethics 138 (1):175-184.detailsOnline education lacks the moral and ethical engagement as well as the empathic interactions that are essential and integral to true liberal education, including business. While the online venue can provide useful information and put libraries at the hands of the student or employee, there is an implicit lack of focus on the sacredness and centrality of the person, his or her values, attitudes, needs, and expectations. The focus of online education is on the delivery of data, not the student’s (...) engagement with the material or the process. Critically absent from online education is the ability to explore the transformation of data as it changes, first to information, then to knowledge, and finally to wisdom, within each person. Finally, absent is the ability to raise the level of abstraction. Since all needs to be measurable in concrete terms in online education, we are left with the language of metrics, such as deliverables, outcomes, inputs, and outputs. Where is the person in all of this? Where is the focus on the moral compass that is so necessary in any type of education? (shrink)
Platón y el problema de la política.Nicolás DiNatale -2024 -Tópicos 46:e0105.detailsEl presente artículo recorre la lectura arendtiana de Platón guiada a partir de las anotaciones y reflexiones de la autora alemana bosquejadas en el Denktagebuch, 1950 bis 1973. Si bien, la figura de Platón a sido recurrentemente evocada en diferentes trabajos de Arendt, aquí nos detendremos a hilvanar lo que denominó como el problema de la tradición del pensamiento político occidental, es decir, la hostilidad de la filosofía para con la política.
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La melancolía como konstruktion histórica.Nicolás DiNatale -2020 -Eikasia Revista de Filosofía 95:401-412.detailsEn su último trabajo el historiador Enzo Traverso afirma que las utopías del siglo XX han desaparecido dejando un presente cargado de memoria pero impotente a la hora de proyectarse en el futuro (Traverso, 2018: 34). La era actual del presentismo histórico, tal como lo denomina François Hartog, momifica toda experiencia pasada despojando el potencial revolucionario y, a su vez, anulando la posibilidad de un futuro emancipador ante la inmanencia de lo mismo. Esa fuerza histórica totalitaria se nos presenta como (...) un continuo inanimado carente de toda narración histórica. La historiografía dominante es producto de la adición de relatos inconexos, tanto que el principio de rekonstruktion actualiza el pasado en consonancia a la legitimación de los vencedores. Ante ello, la melancolía de izquierda es un ejercicio que busca “repensar un proyecto revolucionario en una era no revolucionaria” (Traverso, 2018: 55). En la melancolía, a diferencia del duelo, “el sujeto mantiene su fidelidad al objeto perdido, negándose a renunciar a su vínculo con él” (Žižek, 2019: 63). La cultura de la derrota recolectó las huellas del pasado sepultado y es ahora, en un presente uniforme, donde intenta recuperar del olvido aquel proyecto concluido de forma catastrófica. El objetivo del presente trabajo es repensar y construir el pasado a la luz de la recuperación de aquello que no ha acontecido. Recolectar los fragmentos inacabados por intermedio del principio de konstruktion es también dar un haz de luz a la potencia suspensiva del tiempo presente. (shrink)
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Protein Ontology: A controlled structured network of protein entities.A.Natale Darren,N. Arighi Cecilia,A. Blake Judith,J. Bult Carol,R. Christie Karen,Cowart Julie,D’Eustachio Peter,D. Diehl Alexander,J. Drabkin Harold,Helfer Olivia,Barry Smith & Others -2013 -Nucleic Acids Research 42 (1):D415-21..detailsThe Protein Ontology (PRO; http://proconsortium.org) formally defines protein entities and explicitly represents their major forms and interrelations. Protein entities represented in PRO corresponding to single amino acid chains are categorized by level of specificity into family, gene, sequence and modification metaclasses, and there is a separate metaclass for protein complexes. All metaclasses also have organism-specific derivatives. PRO complements established sequence databases such as UniProtKB, and interoperates with other biomedical and biological ontologies such as the Gene Ontology (GO). PRO relates to (...) UniProtKB in that PRO’s organism-specific classes of proteins encoded by a specific gene correspond to entities documented in UniProtKB entries. PRO relates to the GO in that PRO’s representations of organism-specific protein complexes are subclasses of the organism-agnostic protein complex terms in the GO Cellular Component Ontology. The past few years have seen growth and changes to the PRO, as well as new points of access to the data and new applications of PRO in immunology and proteomics. Here we describe some of these developments. (shrink)
The nature of water.Natale Gaspare De Santo,Carmela Bisaccia &Rosa Maria De Santo (eds.) -2013 - New York: Nova Publishers.detailsWater, the most represented substance in the human body, is a trace of the primordial sea where life originated. Its virtues may be represented by the Venus of Botticelli coming out from the sea, as well as by Velasquezs water seller and by Aristophanes chant of the clouds. Water has been connected with medicine from time immemorial and is a common good.