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It may be possible, one day, to use gene therapy to treat diseases whose genetic defects have been discerned. Because many genes responsible for inherited eye disorders within the retina have been identified, diseases of the eye are prime candidates for this form of therapy. The eye also has the advantage of being highly accessible with altered immunological properties, important considerations for easy delivery of virus and avoidance of systemic immune responses. Currently, adenovirus, adeno‐associated virus and lentivirus have been used (...) to successfully transfer genetic material to retinal pigment epithelium and photoreceptor cells. By harnessing therapeutic genes to these viruses, researchers have been able to demonstrate rescue in rodent models of retinitis pigmentosa, providing evidence that this form of therapy can be effective in delaying photoreceptor cell death. Future challenges include confirming therapeutic effects in animal models with eyes more anatomically similar to those of humans and demonstrating long‐term rescue with minimal toxicity. BioEssays 23:662–668, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

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Warning research participants and patients about potential risks associated with participation/treatment is a fundamental part of consent. However, such risk warnings might cause negative expectations and subsequent nocebo effects (i.e., negative expectations cause negative outcomes) in participants. Because no existing review documents how past research has quantitatively examined nocebo effects – and negative expectations – arising from consent risk warnings, we conducted a pre-registered scoping review (N = 9). We identified several methodological issues across these studies, which in addition to (...) mixed findings, limit conclusions about whether risk warnings cause nocebo effects. (shrink)

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ABSTRACT Despite Institutional Review Board concerns about psychological harm arising from research participation, evidence from trauma-questionnaire research suggests that participation is typically well-tolerated by participants. Yet, it is unclear how participant experiences of in-lab trauma simulations align with IRB ethical guidelines. Thus, we compared reactions to a trauma film paradigm with reactions to a positive film task or cognitive tasks. Overall, relative to other conditions, the trauma film was well-tolerated by participants: they generally reported low-to-moderate negative emotions, moderate benefits, and (...) that participation was not worse than everyday stressors. Our results have implications for the research community in designing trauma-based research. (shrink)

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The informed consent process presents challenges for psychological trauma research (e.g. Institutional Review Board [IRB] apprehension). While previous research documents researcher and IRB-member perspectives on these challenges, participant views remain absent. Thus, using a mixed-methods approach, we investigated participant views on consent guidelines in two convenience samples: crowdsourced (N = 268) and undergraduate (N = 265) participants. We also examined whether trauma-exposure influenced participant views. Overall, participants were satisfied with current guidelines, providing minor feedback and ethical reminders for researchers. Moreover, (...) participant views for consent were similar irrespective of trauma-exposure. Our study has implications for IRBs and psychological researchers. (shrink)

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Pereboom has formulated a Frankfurt-style counterexample in which an agent is alleged to be responsible despite the fact that there are only non-robust alternatives present (Pereboom, Moral responsibility and alternative possibilities: essays on the importance of alternative possibilities, 2003; Phil Explor 12(2):109–118, 2009). I support Widerker’s objection to Pereboom’s Tax Evasion 2 example (Widerker, J Phil 103(4):163–187, 2006) (which rests on the worry that the agent in this example is derivatively culpable as opposed to directly responsible) against Pereboom’s recent counterarguments (...) to this objection (Pereboom 2009). Building on work by Moya (J Phil 104:475–486, 2007; Critica 43(128):3–26, 2011) and Widerker (Widerker 2006), I argue that there is good reason to measure the robustness of alternatives in terms of comparative, rather than non-comparative likelihood of exemption, where the important factor for blame is whether the agent is “doing her reasonable best” to avoid blameworthy behaviour. I maintain that an agent only ever appears responsible when alternatives are robust in this sense. In Pereboom’s examples, both Tax Evasion 2, and his more recent version, Tax Evasion 3 (Pereboom 2009), I maintain the robustness of the alternatives, so understood, is unclear. We can clear up any ambiguity by sharpening the examples, and the result is that the agent appears responsible when the alternatives are made clearly robust, and does not appear responsible when alternatives appear clearly non-robust. The comparative nature of our judgements about blame, I maintain helps to explain the continuing appeal of the “leeway-incompatibilist” viewpoint. (shrink)

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Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

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Cécile Wick's work, oscillating among photography, painting, and drawing, is one of the most important oeuvres in contemporary Swiss art. Solo exhibitions in various galleries and a large retrospective at the Museum of Fine Art in Berne have recently showcased her prints and etchings to great acclaim. Cécile Wick. Colored Waters offers readers the first glimpse of the artist's more recent photographs and, in particular, drawings. Watercolors, ink drawings, inkjet prints and photographs are presented in series, putting media and motifs (...) in a dialogue and revealing new aspects of Wick's work. Around 160 color reproductions of artworks are complemented with essays by Martin Jaeggi andNadine Olonetzky on subjects such as light, traces, signs, buildings, nature, and rhythm in Wick's oeuvre. (shrink)

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This article argues that Simone de Beauvoir's The Second Sex continues to teach academic feminism why difference feminism holds productive and generative potential for feminists and why equality feminism has been consistently subject to criticism since the second wave of feminism. Using Hegel's master—slave dialectic as a lens to interpret subjectivity in The Second Sex, this text reveals an aspect of equality feminism that relies upon masculine subjectivity, a subjectivity that inherently constitutes otherness. This reliance on masculine subjectivity is anathema (...) to difference feminism because the otherness inherently constituted by such subjectivity simultaneously and paradoxically constitutes women's ongoing subordination. In assuming equality with men by adopting masculine subjectivity, women are not immune to constituting women as other. Difference feminisms, on the other hand, start from where women are as they choose to see themselves socially, economically, racially, sexually. The Second Sex reveals that difference feminisms imagine freedom in order to identify the difference that would empower women, not strictly towards sex equality with a stable referent, but towards emancipatory projects that make a difference for women themselves. The Second Sex portends that such imagined freedom has not been actualized, thus the present remains circumscribed by power that subordinates the difference in question. When read alongside The Second Sex, the tension between equality and difference feminisms can still be read as feminisms that coexist with one another, each with their limitations, each with productive potential and cautionary rejoinders. (shrink)

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For more than twenty years, Swiss photographer Tobias Madörin has been working on his photo series Topos. Creating staged tableaux in the manner of nineteenth-century painters, Madörin investigates the interaction between the inhabitants and their surrounding environments in countries as diverse as Spain, Uganda, Indonesia, and Japan. His large-scale images examine communal spaces, the outskirts of metropolises, waste disposals sites, and landscapes marked by agriculture and mining. Madörin's work reveals that these locations are the products of human visions and ideals, (...) yet they are also places of environmental exploitation. This tension, as well as Madörin's intelligent and empathetic approach to his subjects, makes his photographs evocative and complex. This book includes lavish, full-page photographs, many of which have never been published, and an introductory essay byNadine Olonetzky that explains and contextualizes the photographer's oeuvre. (shrink)

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Controversies in food and agriculture abound, with many portrayed as conflicts between polarized viewpoints. Framing such controversies as dichotomies, however, can at times obscure what might be a plurality of views and potential common ground on the subject. We used Q methodology to explore stakeholders’ views about pesticide safety, agricultural worker exposure, and human health concerns in the tree fruit industry of central Washington State. Using a purposive sample of English and Spanish-speaking agricultural workers, industry representatives, state agencies, educators, and (...) advocates, participants sorted 45 statements on pesticide use and perceived human safety risks in the tree fruit industry in 2011. We used PQMethod 2.33 statistical software program to identify viewpoints, based on differences between how participants sorted the statements. The results revealed three distinct viewpoints among 38 sorters that explained 52 percent of the variance. The viewpoints included the: skeptics who expressed concern over the environmental and human health impacts of pesticide use; acceptors who acknowledged inherent risks for using pesticides but saw the risks as known, small and manageable; and incrementalists who prioritized opportunities to introduce human capital and technological improvements to increase agricultural worker safety. We then brought representatives with these different viewpoints together to analyze the results of the Q study, and to brainstorm mutually acceptable improvements to health and safety in tree fruit orchards. In describing and analyzing this case study, we argue that Q methodology can serve as one potentially effective tool for collaborative work, in this case facilitating a process of orchard safety improvements despite perceived stakeholder polarization. (shrink)

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A partir de l’étude de corpus de textes, manuelle et informatique, nous présentons une réflexion sur l’analyse de texte ou de discours à travers l’exemple de l’exposition didactique. Celle-ci peut s’envisager à différents grains. Nous posons la question de la taille du texte, de son style collectif à travers sa disposition et ses marques. Nous interrogeons la pertinence du modèle choisi en relation avec la notion d’échelle. Enfin, nous posons la question de la résolution adéquate pour des logiciels d’analyse, à (...) l’aide d’une dizaine d’exemples. (shrink)

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Recent feminist criticism suggests that Hegel’s account of Antigone in the Phenomenology of Spirit is antithetical to feminism on two key counts: first, Hegel does not develop an authentic political representation of women’s agency and participation in the community, and second, he does not provide a model for a genuinely ethical order especially where relations between men and women are concerned. Patricia Jagentowicz Mills and Luce Irigaray are two feminist thinkers who have expressed these positions. They both take issue with (...) Hegel’s interpretation of Antigone’s actions, although each for different reasons. Mills argues that Hegel misrepresents the experience of women in the Greek community, symbolized by Antigone, as not self-conscious, unreflective, and incapable of enduring ethical conflict. The main reason for this mistaken identity, according to Mills, stems from Hegel’s beliefs that human law and man are ethically superior to divine law and woman, and that the former can legitimately rule over, indeed dominate, the latter. Irigaray asserts that the phallogocentric power of the masculine in Hegel’s text almost completely eliminates the possibility of an authentic feminine individual and action. According to this view, an autonomous feminine understanding of purpose and action is rendered impossible by the feminine’s very masculinization at the outset. At issue here is whether Antigone can indeed be understood as an ethical actor when she acts on behalf of the family and/or whether she can be understood as an ethical actor who represents the community. The conclusions drawn from these interpretations have been that, for Hegel, women are not genuine political actors, on the one hand, because their association with the family disqualifies them as such, and on the other hand, because their actions are constituted by consciousness which is masculine, and also instrumentalized for the masculine. (shrink)

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John Lemos argues persuasively that libertarian free will is required for moral desert, that we may have free will, and that even if we have doubts, we should retain the assumption of desert, given its importance to essential values, such as justice, dignity, love, and pride. While sharing his optimism about the possibility of free will, I challenge two claims: The claim that we can confidently attribute responsibility for actions to agents across the board on the basis that each agent (...) has some opportunity to shape their own characters, and the claim that if we cannot appeal to desert, we would have reason to lower evidentiary standards, as a way of keeping the most vulnerable safe from crime. (shrink)

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The artistic work of photographer Gudio Baselgia focuses on landscapes formed by nature s forces and, more recently, on the sky with the stellar and solar movements and phenomena as we see them from earth. Celestial mechanics have fascinated mankind in all known cultures, the Babylonians and ancient Egyptians as well as the Greek and Celts, the Maya, or the ancient Indians and Chinese. Until the present day we look at the sky and keep being amazed, and try to read (...) what it tells us. Many artists throughout history have been captivated by the spectacle we observe above us day and night. The modern term astrodynamics describes all movements of celestial bodies, in particular the solar system including the moon and other satellites, asteroids and comets, but also movements of stars within a stellar system or galaxy, or of galaxies towards each other. They are well understood today and depicted in coordinate systems and elaborate visualizations. Guido Baselgia s artistic project on astrodynamics and celestial phenomena has no scientific or didactic ambition. His analogue camera is used as a recorder inscribing the movement of stars on the light-sensitive surface of photographic paper. Thus Baselgia s images make traceable the trajectory of celestial bodies invisible to the human eye and show us astounding occurrences of light and shadow. Baselgia has been captivated in particular also by the phenomenon of the umbra, planet earth s shadow thrown into space. It becomes visible occasionally on a clear evening at sunset when a slight mist lies at the horizon: looking in opposite direction to the sun, a dark and sharply marked band of shadow can be seen rising while sun sets behind the observer. But also by recording sunrise and sunset at the polar circle or the tropic, Baselgia visualizes the geometry of celestial mechanics and the concurrence of forces, as well as the miracle of light as such that leaves us awestruck today as much as it did our ancestors. The new book "Guido Baselgia Light Fall" presents 80 outstanding black-and-white images from the artist s Light Fall project taken in Norway, the Tierra del Fuego archipelago in Argentina, in Ecuador, and the Swiss Alps. The brilliant tritone plates are complemented with essays by the German scholar Andrea Gnam and Swiss photography criticNadine Olonetzky. ". (shrink)

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Living in modern biopolitical risk culture might be seen as synonymous with living in prognosis time, in the sense that risk of illness is endlessly forecast (prognosticated) in the broad social arena. ‘Safety,’ in this context, is framed as the anticipatory guarding against risk or disease in order to ‘make live.’ Thinking of risk and safety in these ways is limited, however, in that the prognosis cannot account for the individual’s life or death drama. This paper asks: how are we (...) to understand the constellation of risk, prognosis, and safety in relation to ‘the subject in breast cancer prognosis’? (shrink)

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A large number of feminist philosophers and social critics accept that Simone de Beauvoir's conception of transcendence in The Second Sex relies on masculinist ontology. In contrast with feminist interpretations that see Beauvoir claiming the success of masculinist ontology, this article argues that transcendence as masculinist ontology does not succeed in The Second Sex because it requires a relation of domination, something contrary to its own definition of freedom-producing relations. The Second Sex obliquely reveals this failure, but Beauvoir does not (...) ruminate upon it. Instead, Beauvoir turns to imagine freedom-producing gender relations in the future where the body and consciousness are already emancipated from constitutive domination. This is a future that resonates with G. W. F. Hegel's `Stoic Consciousness'. The significance of this finding is that the location of freedom neither resides in the intertwinement of the male body and consciousness previously argued to be the case, for Beauvoir, nor does it reside in the intertwinement of the female body and consciousness. Rather, freedom resides in the intertwinement of male and female bodies and consciousness where domination is already absent, that is, a place outside of history. Thus, the conclusion of The Second Sex can be read as a consolation and an escape from the inescapable limits of the present. (shrink)

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In his article “Issues of Pragmaticism” published in 1905, in The Monist, Charles S. Peirce complains that “Logicians have been at fault in giving Vagueness the go-by, so far as not even to analyze it.” That same year, occupying himself with the consequences of “Critical commonsensism,” he affirmed, “I have worked out the logic of vagueness with something like completeness,” a statement that causes the majority of the commentators on his work, including the editors of the Collected Papers to ask (...) where this logic is to be found. The fever for finding Peirce's manuscripts is fed by the hope of some researchers of discovering the logic of vagueness, a hope that has grown since Carolyn Eisele's publication of his mathematical works. Others - and I count myself among them - believe that in reality this is a matter of something already known. That is, they interpret the affirmation ending the paragraph of reproach addressed to logicians, “The present writer has done his best to work out the Stechiology, Critic, and Methodeutik of the subject,” as a tripartite semiotic of the vague, still limited, according to Peirce's older works, to symbols, that is, to the signs of natural language examined from the perspective of logic. (shrink)

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A so-called revision of the history of World War 11, which began shortly after the war, was popularized in France in the 1980s through the progressively combined action of extreme-right and former ultra-left militants. This "revision," actually a negation of the genocide perpetrated by the Nazis against the Jews, has focused on what were precisely the means of this mass murder, that is, the gas chambers. Using traditional patterns of antiSemitism, this peculiar rewriting of history claims that the genocide never (...) took place and was in fact a hoax, built up by an international Jewish plot, to extort gigantic amounts of money from the Germans as reparations. In today's France, where racism and exclusion are strongly encouraged by a growing extreme right, and where anti-Semitism progressively comes out of the silence it has been forced to keep since 1945, such a "revisionist" view could gain a certain popularity. (shrink)

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Despite the burgeoning literature on professionalism in other health professions, psychology lags behind in the level of attention given to this core competency. In this article, we review definitions from other health professions and how they address professionalism. Next, we review how this competency evolved within health service psychology (HSP), and we propose a definition. We offer an approach for assessing professionalism within HSP. Consideration is given to strategies and methods for providing effective education and training in this multifaceted competency. (...) Finally, recommendations are made for creating a culture of professionalism within HSP and honoring psychology’s social contract with multiple publics. (shrink)

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In this paper I explore a neglected discussion of vagueness put forward by Wittgenstein in his Philosophical Grammar (1932–34). In this work, unlike Philosophical Investigations (1953), Wittgenstein not only discusses the venerable Sorites paradox but provides a novel conception of vagueness using an analogy with coin tossing and converging intervals. As he sees it, the problematic picture of vagueness arises because we conflate aspects of the functioning of vague concepts with those of non-vague ones. Thus, while we accept that vague (...) concepts have no sharp cut-off points (are boundaryless), we nevertheless retain the idea that we can progress towards the penumbra the way we progress towards the cut-off points of non-vague concepts. As a potential remedy, Wittgenstein's analogy with coin tossing and converging intervals replaces this picture and provides an understanding of the functioning of vague concepts in which no notion of a progression arises. (shrink)

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Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

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Leading and Managing Early Childhood Settings: Inspiring People, Places and Practices examines what it means to be a leader, manager and administrator across the early childhood education field. The first section of the book introduces readers to core concepts, including self-understanding through professional reflection and consideration of people's beliefs and values. These chapters explore the challenges of working within various early childhood settings and the importance of connecting and communicating with families and the broader community. The second section considers four (...) key roles that early childhood professionals undertake – team stakeholder, policy designer, pedagogy creator and rights advocate. This book challenges readers to make links across research, theories and everyday practices by thinking, reflecting, sharing with others and writing stories. The storytelling approach guides readers through the chapters and explores the themes of embodiment and sustainability. Leading and Managing Early Childhood Settings is an invaluable resource for pre- and in-service educators alike. (shrink)

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It is widely accepted that Russell wrongly took Wittgenstein to be concerned with the conditions required for an ideal language in his _Tractatus Logico-Philosophicus_. Given Russell’s relatively extensive communications with Wittgenstein, this misunderstanding is puzzling. I argue that Russell’s mistake rests on two prior assumptions for which he had some justification. First, communications with Wittgenstein were plausibly interpreted by Russell as confirming, rather than refuting, the belief that Wittgenstein shared with him the view that psychology, epistemology, and logic are interdependent. (...) Second, results from these areas in turn led Russell to the view that ordinary language is irredeemably vague and, as such, in need of replacement with an ideal language. In truth, however, Wittgenstein severed psychology and epistemology from his work and saw vagueness as a surface phenomenon only. (shrink)

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The aim of this paper is to contribute to debate on Hegel's conception of the relationship between religion and philosophy by proposing that it can be a read as a division of labour between Christian religion and speculative philosophy. This reading allows us to understand better Hegel's idea that religion and philosophy have the same content in two different forms. I distinguish between the institutional and the intrapersonal dimensions of Hegel's claim of a division of labour between religion and philosophy. (...) I then turn to a critique of Hegel's philosophy of religion by showing how David Friedrich Strauss's concluding dissertation from The Life of Jesus, Critically Examined can call our attention to some internal tensions within Hegel's conception. Although Strauss's interpretation does not present an insurmountable objection against Hegel's conception of a division of labour, it can help to illuminate to what extent Hegel oversimplified the practical implications that his conception might have for the priest's attempt to continue his instruction to the members of his community. (shrink)

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The claim that theoretical foundations are historically contingent does not draw the same intensity of fire as it did one or especially two decades ago. The aftermath of debates on the political boundaries created by foundations allows for a deeper exploration of the foundations of feminist theory. This article re-examines the (anti)-Hegelian foundations of the feminist standpoint put forward by Nancy Hartsock and argues that the Hegelian subject of the early Phenomenology of Spirit resists gender codification in its experience of (...) ongoing rediscovery and fallibility in knowing. The subject against which the feminist self was constituted does not fit the masculinity thought to be natural. Hegel’s master-slave dialectic and phenomenological subject reveal contradictions that cannot be resolved by an opposing feminist standpoint, and may provide resources that resist the rigid gender categories upon which the standpoint depends. Key Words: abstract masculinity • feminist standpoint • feminist theory • foundations • Nancy Hartsock • Hegel • master-slave dialectic • subjectivity. (shrink)

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Theories of decision-making and its neural substrates have long assumed the existence of two distinct and competing valuation systems, variously described as goal-directed vs. habitual, or, more recently and based on statistical arguments, as model-free vs. model-based reinforcement-learning. Though both have been shown to control choices, the cognitive abilities associated with these systems are under ongoing investigation. Here we examine the link to cognitive abilities, and find that individual differences in processing speed covary with a shift from model-free to model-based (...) choice control in the presence of above-average working memory function. This suggests shared cognitive and neural processes; provides a bridge between literatures on intelligence and valuation; and may guide the development of process models of different valuation components. Furthermore, it provides a rationale for individual differences in the tendency to deploy valuation systems, which may be important for understanding the manifold neuropsychiatric diseases associated with malfunctions of valuation. (shrink)

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With robots being introduced into caregiving, particularly for older persons, various ethical concerns are raised. Among them is the fear of replacing human caregiving. While ethical concepts like well-being, autonomy, and capabilities are often used to discuss these concerns, this paper brings forth the concept of social dignity to further develop guidelines concerning the use of robots in caregiving. By social dignity, we mean that a person’s perceived dignity changes in response to certain interactions and experiences with other persons. In (...) this paper, we will first present the concept of social dignity, and then identify a niche where robots can be used in caregiving in an ethical manner. Specifically, we will argue that, because some activities of daily living are performed in solitude to maintain dignity, a care recipient will usually prefer robotic assistance instead of human assistance for these activities. Secondly, we will describe how other philosophical concepts, which have been commonly used to judge robotic assistance in caregiving for the elderly so far, such as well-being, autonomy, and capabilities, are less useful in determining whether robotic assistance in caregiving is ethically problematic or not. To conclude, we will argue that social dignity offers an advantage to the other concepts, as it allows to ask the most pressing questions in caregiving. (shrink)

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I examine Manuel Vargas's revisionist justification for continuing with our responsibility-characteristic practices in the absence of basic desert. I query his claim that this justification need not depend on how we settle questions about the content of morality, arguing that it requires us to reject the Kantian principle that prohibits treating anyone merely as a means. I maintain that any convincing argument against this principle would have to be driven by concerns that arise within the sphere of moral theory itself, (...) whereas Vargas's argument draws solely on concerns about the expensive metaphysics involved in a libertarian conception of freedom. I argue that this amounts not just to changing the concept of free will by stipulation, but also (more problematically) to changing our moral principles by stipulation. (shrink)

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Measures aimed at general deterrence are often thought to be problematic on the basis that they violate the Kantian prohibition against sacrificing the interests of some as a means of securing a greater good. But even if this looks like a weak objection because deterrence can be justified as a form of societal self-defence, such measures may be regarded as problematic for another reason: Harming in self-defence is only justified when it’s necessary, i.e., when there are no relatively harmless alternatives. (...) While there are few harmless ways to remove the threat posed by dangerous individuals, there are many relatively harmless methods for preventing crime. We can bracket off our preventative failings when we think of present threats, but we cannot do so when contemplating alternative preventative measures. (shrink)

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Incompatibilism is often accused of incoherence because it introduces randomness in support of freedom. I argue that the sort of randomness that's thought to be detrimental to freedom results not from denying causal determinism, so much as denying what we might call ‘rational determinism’: denying that agents' actions are determined by their reasons for acting. Compatibilists argue that introducing the ability to decide differently allows agents to make choices that are irrational, and this undermines rather than furthering freedom. I maintain (...) that this argument neglects scenarios in which reasons are in conflict with one another. In such scenarios, we can preserve rationality without claiming that the agent's choices are rationally determined. (shrink)

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This book project intends to serve as a course adoption book unpacking theories of biopolitical life-making and death-making, with chapters dedicated to specific objects that ostensibly affirm life (and argue for life's inextricable links to capital), but that ultimately reify a politics of death and erasure. Specific objects, such as the pink Kommen Foundation-branded handgun, the 'super user' of health care resources, and fat cells allow the authors to discuss the political junctures at which determinations of healthy and unhealthy, life (...) and death, are made. (shrink)

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ArgumentTextual and material evidence suggests that early Byzantine architects, known asmechanikoi, were comprehensively educated in the mathematical sciences according to contemporary standards. This paper explores the significance of the astronomical and optical sciences for the working methods of the twomechanikoiof Hagia Sophia in Constantinople, Anthemios of Tralles and Isidoros of Miletus. It argues that one major concern in the sixth-century architectural design of the Great Church was the visual effect of its sacred interior, particularly the luminosity within. Anthemios and Isidoros (...) seem to have been thoroughly conversant with the ancient corpus of astronomical and optical writings and, as will be shown, implemented their theoretical knowledge in the design of Hagia Sophia. Specifically, the paper demonstrates that the orientation of the building's longitudinal axis coincides with the sunrise on the winter solstice according to ancient computations, implying that the orientation was intentionally calculated in order to secure an advantageous natural illumination of the interior. Light and visual effects served to reinforce the symbolic significance of the sacred space that furthermore provides evidence for optical considerations with respect to late antique concepts of light and vision. (shrink)

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Over the last decade, our appreciation of the importance of the nucleolus for cellular function has progressed from the ordinary to the extraordinary. We no longer think of the nucleolus as simply the site of ribosome production, or a dynamic subnuclear body noted by pathologists for its changes in size and shape with malignancy. Instead, the nucleolus has emerged as a key controller of many cellular processes that are fundamental to normal cell homeostasis and the target for dysregulation in many (...) human diseases; in some cases, independent of its functions in ribosome biogenesis. These extra‐nucleolar or new functions, which we term “non‐canonical” to distinguish them from the more traditional role of the nucleolus in ribosome synthesis, are the focus of this review. In particular, we explore how these non‐canonical functions may provide novel insights into human disease and in some cases new targets for therapeutic development. (shrink)

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This paper argues that Chris Marker's 1982 film Sans Soleil derives its affective force from doublings and ‘faces’ of horror and beauty that reveal a twofold synthesis of actual and virtual. While a focus upon the material, ever in relation to transient yet lingering sensations, cannot discharge the power and force of the film, this paper endeavours nevertheless to assess and evoke Marker and Deleuze's own interrogative methods that thoroughly explore, in the manner of a revelatory ‘schizoanalysis’ or empiricism, molecular (...) and variable operations beneath our ‘molar’ structures and organisations. As Sans Soleil's voiceover states, ‘If they don't see happiness in the picture, at least they'll see the black’, a provocative remark that invokes indefinable singularities and the darkness of a wound, cracking of time and splitting of self in film, life and death. Considerations of death, consciousness and subjectivity extend this paper's examinations. (shrink)

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In this paper I present the philosophical backdrop to Russell's 1923 "Vagueness" paper. I argue that his view of vagueness in 1923 is the result of a rise in the importance of symbolism in his thinking coupled with a new interest in psychology. I show how these new interests are related to concerns he had with his theory of judgment as well as his logicist project. I attend to the two major complaints against his view of vagueness: that all language (...) is vague and his purported conflation of vagueness with generality. I lastly show how Russell's view is distinct from modern approaches to vagueness in so far as he is not concerned with truth-value gaps but instead sees vagueness as applying primarily to what is cognitive and as a transitory position between ignorance and knowledge. (shrink)

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How do the practices of philosophy and film converge in ethical and political theory? Untimely Affects is an ethical and aesthetic interweaving of Deleuzian philosophy and close film analysis to discern how thought persists productively after the horrors of World War II. In the first extensive analysis of Chris Marker and Alain Resnais' films,Nadine Boljkovac draws on concepts and images that interrogate 'what we are now living through', in the words of Klossowski's Nietzsche. Mindful of the seen and (...) unseen 'that quicken the heart', this book of film-philosophy discerns new and deeply ethical life-affirming possibilities through its weave of cine-philosophy. As such, this book speaks directly to essences of cinema, thought and life through creative untimeliness and the idea of the 'ever new'. (shrink)

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In her recently published monography Transformative Experience L.A. Paul has defended a concept of ‘lived experience’ that is meant to account for the transformative effects of major life decisions. According to Paul, “humans vary so much and so deeply, that even small differences (contextually speaking) in experiences between people can prevent us from knowing what it is like to be a different type of person” (Paul 2014, 7). In this article I will argue that Paul's account results from a problematic (...) conception of lived experience that cannot account for the intersubjective dimensions of personal experience, i.e. for the fact that our lived experience is intrinsically tied to our relationships with others. These, however, are of central import to our ethical practice, e. g. in raising awareness for the particular experiences and needs of others. After providing some introductory remarks concerning the concept of ‘lived experience’ in section I, the aim of section II is to critically investigate Paul's conception of ‘lived experience’ and to show that her approach not only rests on highly contestable assumptions but yields several unplausible consequences. Given these problems, I will suggest an alternative account of lived experience in section III. I will argue that mental phenomena like pain, sadness or desperation have characteristic manifestations in linguistic and non-linguistic behaviour which are part of the concept of a particular mental phenomenon. It is due to this that we possess intersubjective criteria that enable us to ascribe mental properties to ourselves as well as to others. The alternative account can thereby avoid the problems that are concomitant with Paul's approach. It can nevertheless take into account the distinct perspective of first person ‘lived experiences’. (shrink)

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If indeterminism is to be necessary for moral responsibility, we must show that it doesn’t preclude responsibility (the Luck Problem) and that it might enhance it (the Enhancement Problem). A ‘strong luck claim’ motivates the Luck Problem: if an agent’s choice is undetermined, then her mental life will be causally irrelevant to her choice, whichever way she decides. A ‘weak luck claim’ motivates the Enhancement Problem: if an agent’s choice is undetermined, then even if her mental life is causally relevant (...) to her choice, whichever way she decides, we cannot explain how she _settles_ her choice. Only the weak luck claim is plausible. However, its plausibility depends on our accepting that we could only settle our choices if they are settled by additional exercises of agency. If we instead understand the process of settling decisions in procedural terms, we can begin to sketch a solution to the Enhancement Problem. (shrink)

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Abstract‘Relativists' and ‘absolutists' about truth often see their own camp as promoting virtues, such as open-mindedness and intellectual humility, and see the opposing camp as fostering vices, like closed-mindedness and arrogance. Relativism is accused of fostering these vices because it entails that each person’s beliefs are automatically right for the person who holds them. How can we be humble or open-minded if we cannot concede that we might be wrong? Absolutism is accused of fostering these vices because the view is (...) seen as entailing certainty. This also seems to preclude us from conceding that we could be wrong. However, no relativist defends the Protagorean version of relativism that entails infallibilism. And no absolutist posits infallible certainty. Fallibilism really is a precondition of various virtues, but both camps take themselves to be defending fallibilist positions against opponents who they take to be committed to infallibilism. Philosophers may inadvertently end up promoting precisely the sort of infallibilism they oppose by creating a false dichotomy and caricaturing the opposing camp. This underscores the importance of interpretive charity in both academic and public debate. (shrink)

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This brief introduction explains the historical background of the Hoffman Report, the 2015 independent counsel's investigation into the American Psychological Association's role in aiding ‘enhanced interrogations’ of detainees in the Bush Administration's Global War on Terror. It also outlines the articles in this special section of History of the Human Sciences on the Hoffman Report in Historical Context.

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