Reinforced reasoning in medicine.Daniel Auker-Howlett &Michael Wilde -unknowndetailsSome philosophers have argued that evidence of underlying mechanisms does not provide evidence for the effectiveness of a medical intervention. One such argument appeals to the unreliability of mechanistic reasoning. However, mechanistic reasoning is not the only way that evidence of mechanisms might provide evidence of effectiveness. A more reliable type of reasoning may be distinguished by appealing to recent work on evidential pluralism in the epistemology of medicine. A case study from virology provides an example of this so‐called reinforced (...) reasoning in medicine. It is argued that in this case study, the available evidence of underlying mechanisms did in fact play a role in providing evidence in favour of a medical intervention. This paper therefore adds a novel and recent case study to the literature in support of evidential pluralism in medicine. (shrink)
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The use of mechanistic reasoning in assessing coronavirus interventions.Jeffrey Aronson,Daniel Auker-Howlett,Virginia Ghiara,Michael P. Kelly &Jon Williamson -unknowndetailsEvidence-based medicine (EBM), the dominant approach to assessing the effectiveness of clinical and public health interventions, focuses on the results of association studies. EBM+ is a development of EBM that systematically considers mechanistic studies alongside association studies. In this paper we provide several examples of the importance of mechanistic evidence to coronavirus research. (i) Assessment of combination therapy for MERS highlights the need for systematic assessment of mechanistic evidence. (ii) That hypertension is a risk factor for severe disease in the (...) case of SARS-CoV-2 suggests that altering hypertension treatment might alleviate disease, but the mechanisms are complex, and it is essential to consider and evaluate multiple mechanistic hypotheses. (iii) To be confident that public health interventions will be effective requires a detailed assessment of social and psychological components of the mechanisms of their action, in addition to mechanisms of disease. (iv) In particular, if vaccination programmes are to be effective, they must be carefully tailored to the social context; again, mechanistic evidence is crucial. We conclude that coronavirus research is best situated within the EBM+ evaluation framework. (shrink)
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The clustering of galaxies in the SDSS-III baryon oscillation spectroscopic survey: Baryon acoustic oscillations in the data releases 10 and 11 galaxy samples. [REVIEW]Lauren Anderson,Éric Aubourg,Stephen Bailey,Florian Beutler,Vaishali Bhardwaj,Michael Blanton,Adam S. Bolton,J. Brinkmann,Joel R. Brownstein,Angela Burden,Chia-Hsun Chuang,Antonio J. Cuesta,Kyle S. Dawson,Daniel J. Eisenstein,Stephanie Escoffier,James E. Gunn,Hong Guo,Shirley Ho,Klaus Honscheid,CullanHowlett,David Kirkby,Robert H. Lupton,Marc Manera,Claudia Maraston,Cameron K. McBride,Olga Mena,Francesco Montesano,Robert C. Nichol,Sebastián E. Nuza,Matthew D. Olmstead,Nikhil Padmanabhan,Nathalie Palanque-Delabrouille,John Parejko,Will J. Percival,Patrick Petitjean,Francisco Prada,Adrian M. Price-Whelan,Beth Reid,Natalie A. Roe,Ashley J. Ross,Nicholas P. Ross,Cristiano G. Sabiu,Shun Saito,Lado Samushia,Ariel G. Sánchez,David J. Schlegel,Donald P. Schneider,Claudia G. Scoccola,Hee-Jong Seo,Ramin A. Skibba,Michael A. Strauss,Molly E. C. Swanson,Daniel Thomas,Jeremy L. Tinker,Rita Tojeiro,Mariana Vargas Magaña,Licia Verde &Dav Wake -unknowndetailsWe present a one per cent measurement of the cosmic distance scale from the detections of the baryon acoustic oscillations in the clustering of galaxies from the Baryon Oscillation Spectroscopic Survey, which is part of the Sloan Digital Sky Survey III. Our results come from the Data Release 11 sample, containing nearly one million galaxies and covering approximately 8500 square degrees and the redshift range 0.2< z< 0.7. We also compare these results with those from the publicly released (...) DR9 and DR10 samples. Assuming a concordance Λ cold dark matter cosmological model, the DR11 sample covers a volume of 13 Gpc3 and is the largest region of the Universe ever surveyed at this density. We measure the correlation function and power spectrum, including density-field reconstruction of the BAO feature. The acoustic features are detected at a significance of over 7σ in both the correlation function and power spectrum. Fitting for the position of the acoustic features measures the distance relative to the sound horizon at the drag epoch, rd, which has a value of rd,fid = 149.28 Mpc in our fiducial cosmology. We find DV = at z = 0.32 and DV = at z = 0.57. At 1.0 per cent, this latter measure is the most precise distance constraint ever obtained from a galaxy survey. Separating the clustering along and transverse to the line of sight yields measurements at z = 0.57 of DA = and H =. Our measurements of the distance scale are in good agreement with previous BAO measurements and with the predictions from cosmic microwave background data for a spatially flat CDM model with a cosmological constant. © 2014 The Author Published by Oxford University Press on behalf of the Royal Astronomical Society. (shrink)
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Injustice: political theory for the real world.Michael E. Goodhart -2018 - New York, NY: Oxford University Press.detailsThis book challenges the dominant approach to problems of justice in global normative theory and offers a radical alternative designed to transform our thinking about what kind of problem injustice is and how political theorists might do better in understanding and addressing it. It argues that the dominant approach, ideal moral theory (IMT), takes a fundamentally wrong-headed approach to the problem of justice. IMT seeks to work out what an ideally just society would look like, and only then outlines our (...) moral obligations in realizing that ideal. In other words, it ignores the realities of everyday politics. AsMichael Goodhart asserts, IMT postpones engagement with actually existing injustices and distorts our understanding of them, and it normalizes many problematic features of our world. On the other hand, the leading alternatives to IMT struggle to make sense of the role values play in politics. This book sees justice as an ideology and develops an innovative bifocal theoretical framework for making sense of it. This framework provides two complementary perspectives on justice: a theoretical perspective that situates competing ideological claims about justice in a broader political context and a partisan perspective that evaluates the structure and coherence of particular conceptions of justice. As opposed to IMT, it focuses on barriers to justice and advocates an activist political theory that takes sides in political struggles against injustice. Goodhart argues that theorists can help to generate the countervailing power necessary for social transformation through the work of articulation, translation, and mapping, work which contributes to a more comprehensive social science of injustice. (shrink)
Shadow, Self, Spirit: Essays in Transpersonal Psychology.Michael Daniels -2005 - Imprint Academic.detailsTranspersonal Psychology concerns the study of those states and processes in which people experience a deeper sense of who they are, or a greater sense of connectedness with others, with nature, or the spiritual dimension. Pioneered by respected researchers such as Jung, Maslow and Tart, it has nonetheless struggled to find recognition among mainstream scientists. Now that is starting to change. Dr.Michael Daniels teaches the subject as part of a broadly-based psychology curriculum, and this book brings together the (...) fruits of his studies over recent years. It will be of special value to students, and its accessible style will appeal also to all who are interested in the spiritual dimension of human experience. The book includes a detailed 38-page glossary of terms and detailed indexes. (shrink)
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Phenomenalism: A Metaphysics of Chance and Experience.Michael Pelczar -2022 - Oxford: Oxford University Press, Oxford.detailsJ.S. Mill famously equated physical things with "permanent possibilities of sensation." This view, known as phenomenalism, holds that a rock is a tendency for experiences to occur as they do when people perceive a rock, and similarly for all other physical things. In _Phenomenalism_,Michael Pelczar develops Mill's theory in detail, defends it against the objections responsible for its current unpopularity, and uses it to shed light on important questions in metaphysics, the philosophy of science, and the philosophy of (...) mind. Identifying physical things with possibilities of sensation establishes a transparent connection between the world of physics and the world of sense, provides an attractive alternative to currently fashionable structuralist and panpsychist metaphysics, offers a fresh perspective on the problem of consciousness, and yields a satisfying theory of perception, all by taking two things notoriously resistant to reduction, chance and experience, and constructing everything else out of them. (shrink)
Proof: Its Nature and Significance.Michael Detlefsen -2008 - In Bonnie Gold & Roger A. Simons,Proof and Other Dilemmas: Mathematics and Philosophy. Mathematical Association of America. pp. 3-32.detailsI focus on three preoccupations of recent writings on proof. -/- I. The role and possible effects of empirical reasoning in mathematics. Do recent developments (specifically, the computer-assisted proof of the 4CT) point to something essentially new as regards the need for and/or effects of using broadly empirical and inductive reasoning in mathematics? In particular, should we see such things as the computer-assisted proof of the 4CT as pointing to the existence of mathematical truths of which we cannot have a (...) priori knowledge? -/- 2. The role of formalization in proof. What are the patterns ofinference according to which mathematical reasoning naturally proceeds? Are they of 'local' character (i.e. sensitive to the subject-matter of the reasoning concerned) or 'global' character (i.e. invariant across all subject-matters)? Finally, what if any relationship is there (a) between the patterns of inference manifest in a proof and its explanatory capacity and (b) between explanatory capacity and rigor? -/- 3. Diagrams and their role in mathematical reasoning. What essentially is diagrammatic reasoning, and what is the nature and basis of its usefulness? Can it play a justificative role in the development of mathematical knowledge and, more particularly, in genuine proof? Finally, does the use of diagrammatic reasoning force an adjustment either in our conception of rigor or in our view of its importance? (shrink)
With All Your Mind: A Christian Philosophy of Education.Michael L. Peterson -2001 - Notre Dame University Press.detailsWith All Your Mind makes a compelling case for the value of thinking deeply about education in America from a historically orthodox and broadly ecumenical Christian point of view. Few people dispute that education in America is in a state of crisis. But not many have posed workable solutions to this serious problem.Michael Peterson contends that thinking philosophically about education is our only hope for meaningful progress. In this refreshing book, he invites all who are concerned about education (...) in America to "participate" in his study, which analyzes representative theories and practical strategies that reveal the power of Christian ideas in this vital area. Peterson addresses the most fundamental questions facing educators, and society in general, such as: What is the purpose of education? What goals do new techniques and methods serve? What kind of person is our educational system supposed to produce? He also explores questions of unique importance to Christians, such as: What is the relation between Christianity and the pursuit of intellectual excellence? How can Christians bring their faith to bear on all areas of knowledge? Can educated Christians significantly influence culture? With All Your Mind examines the key assumptions and implications of influential classical and contemporary philosophies with respect to education, including idealism, naturalism, Thomism, experimentalism, existentialism, linguistic analysis, and postmodernism. Based on this analysis, Peterson develops an unapologetically Christian philosophy of education in regard to curriculum design, instilling ethics and values, and the nature of teaching and learning. Peterson further advances the merits of an ecumenical Christian philosophy of education by showing how it can be used to analyze key issues in educational theory, such as the relation of general education to liberal learning, the integration of faith and learning, and the demand for professional and technical training. From a practical standpoint, Peterson's approach brings balance and common sense to issues such as the clash between public and private education, the rise of multiculturalism, the changing demographic and psychological profile of America's youth, and the impact of computer and Internet technology. With All Your Mind concludes with a stirring vision for education that is embedded in an all-encompassing Christian view of life. Using clear, jargon-free language, Peterson teaches a good deal of basic philosophy while developing a powerful argument for the value of liberal arts education iinteracting with Christian faith at all levels of schooling. (shrink)
Aristotle’s Direct Realism In De Anima.Michael Esfeld -2000 -Review of Metaphysics 54 (2):321 - 336.detailsARISTOTLE’S THEORY OF PERCEPTION AND THOUGHT in books 2 and 3 of de Anima is usually interpreted in terms of representationalism: in perception and thought, we receive sensible or intelligible forms. These forms are representations of qualities, things, or events in the world. We gain epistemic access to the world by means of these representations. In this paper I argue that contrary to received opinion, Aristotle’s text can also be read in terms of direct realism: we have epistemic access to (...) the world in perception and thought without representations intervening as epistemic intermediaries. (shrink)
Nicholas of Cusa and the kairos of modernity: Cassirer, Gadamer, Blumenberg.Michael Edward Moore -2013 - Brooklyn, New York: Punctum Books.detailsIn this far-reaching essay, historianMichael Edward Moore examines modernity as an historical epoch following the end of the medieval period -- and as a "messianic concept of time." In the early twentieth century, a debate over the meaning and origins of modernity unfolded among the philosophers Ernst Cassirer, Hans-Georg Gadamer and Hans Blumenberg. These thinkers tried to resolve the puzzle of the fifteenth-century master Nicholas of Cusa. Was Cusanus the last great medieval thinker, his ideas a summa of (...) medieval tradition? Or was he a mysterious epochal figure, seated at one end of the bridge leading to modern thought? Nicholas of Cusa lived during a time of historical and existential crisis, or kairos, when medieval governments and cherished sources of unity were shaken. Likewise, the debate over his significance took place during a later phase of crisis for Europe, in the decades before and after the Second World War, when the collapse of European civilization was witnessed. Moore argues that modernity, so intently examined as an historical and spiritual problem, has significance for our contemporary sense of crisis. (shrink)
Fusion, Comparative, "Constructive Engagement Comparative," Or What? Third Thoughts on Levine's Critique of Siderits.Michael Nylan &Martin Verhoeven -2016 -Journal of World Philosophies 1 (1):119-127.detailsWe have been invited to contribute a short assessment of Levine's response to Siderits’ position in the emerging debate between "fusion philosophy" and "comparative philosophy." Perhaps a brief word is in order regarding our backgrounds:Michael Nylan is a student of early China, with strong inter-disciplinary training and interests, who has attempted work in both philosophy and translation. Martin Verhoeven is a historian by training, a translator by avocation, and a Buddhist practitioner. Both of us have committed ourselves for (...) decades to past traditions that can only be accessed through classical Chinese language, and that surely colors our views. At the same time, those views are not identical, but stereophonic. (shrink)
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The Body of Faith: God and the People Israel.Michael Wyschogrod -1983 - San Francisco: Jason Aronson.detailsThe original edition of this book describes it as an attempt to 'develop a comprehensive understanding of traditional Judaism in conversation with contemporary philosophical and Christian thought.' This book has been praised by many as one of the most exciting and inspiring books of Jewish theology to be published in a long time.
Consciousness Studies: Research prospects in the ‘Cradle of Human Consciousness’.Michael Pitman -2003 -Alternation 10 (1):271-291.detailsThe paper introduces the field of consciousness studies to an audience outside of philosophy and the cognitive sciences, using the work of the late David Brooks as a starting point. Brooks' account of consciousness, and the cognitive and evolutionary significance of for-the-organism properties, are discussed. Brooks' account is evaluated in the light of the debate over conscious inessentialism; and alternative lines for developing Brooks' account are proposed, drawing on the work of Gerald Edelman.
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