Results for 'Matthew L. Blank'
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- Challenges to Building a Gene Variant Commons to Assess Hereditary Cancer Risk: Results of a Modified Policy Delphi Panel Deliberation.Mary A. Majumder,Matthew L.Blank,Janis Geary,Juli M. Bollinger,Christi J. Guerrini,Jill Oliver Robinson,Isabel Canfield,Robert Cook-Deegan &Amy McGuire -2021 -J. Pers. Med 7 (11):646.Understanding the clinical significance of variants associated with hereditary cancer risk requires access to a pooled data resource or network of resources—a “cancer gene variant commons”—incorporating representative, well-characterized genetic data, metadata, and, for some purposes, pathways to case-level data. Several initiatives have invested significant resources into collecting and sharing cancer gene variant data, but further progress hinges on identifying and addressing unresolved policy issues. This commentary provides insights from a modified policy Delphi process involving experts from a range of stakeholder (...) groups involved in the data-sharing ecosystem. In particular, we describe policy issues and options generated by Delphi participants in five domains critical to the development of an effective cancer gene variant commons: incentives, financial sustainability, privacy and security, equity, and data quality. Our intention is to stimulate wider discussion and lay a foundation for further work evaluating policy options more in-depth and mapping them to those who have the power to bring about change. Addressing issues in these five domains will contribute to a cancer gene variant commons that supports better care for at-risk and affected patients, empowers patient communities, and advances research on hereditary cancers. (shrink)No categories
- Counterfactuals.Matthew L. Ginsberg -1986 -Artificial Intelligence 30 (1):35-79.
- The Good Life in the Scientific Revolution: Descartes, Pascal, Leibniz, and the Cultivation of Virtue.Matthew L. Jones -2006 - University of Chicago Press.Amid the unrest, dislocation, and uncertainty of seventeenth-century Europe, readers seeking consolation and assurance turned to philosophical and scientific books that offered ways of conquering fears and training the mind—guidance for living a good life. _The Good Life in the Scientific Revolution_ presents a triptych showing how three key early modern scientists, René Descartes, Blaise Pascal, and Gottfried Leibniz, envisioned their new work as useful for cultivating virtue and for pursuing a good life. Their scientific and philosophical innovations stemmed in (...) part from their understanding of mathematics and science as cognitive and spiritual exercises that could create a truer mental and spiritual nobility. In portraying the rich contexts surrounding Descartes’ geometry, Pascal’s arithmetical triangle, and Leibniz’s calculus,Matthew L. Jones argues that this drive for moral therapeutics guided important developments of early modern philosophy and the Scientific Revolution. (shrink)
- Counterfactual Plausibility and Comparative Similarity.L. StanleyMatthew,W. Stewart Gregory &Brigard Felipe De -2017 -Cognitive Science 41 (S5):1216-1228.Counterfactual thinking involves imagining hypothetical alternatives to reality. Philosopher David Lewis argued that people estimate the subjective plausibility that a counterfactual event might have occurred by comparing an imagined possible world in which the counterfactual statement is true against the current, actual world in which the counterfactual statement is false. Accordingly, counterfactuals considered to be true in possible worlds comparatively more similar to ours are judged as more plausible than counterfactuals deemed true in possible worlds comparatively less similar. Although Lewis (...) did not originally develop his notion of comparative similarity to be investigated as a psychological construct, this study builds upon his idea to empirically investigate comparative similarity as a possible psychological strategy for evaluating the perceived plausibility of counterfactual events. More specifically, we evaluate judgments of comparative similarity between episodic memories and episodic counterfactual events as a factor influencing people's judgments of plausibility in counterfactual simulations, and we also compare it against other factors thought to influence judgments of counterfactual plausibility, such as ease of simulation and prior simulation. Our results suggest that the greater the perceived similarity between the original memory and the episodic counterfactual event, the greater the perceived plausibility that the counterfactual event might have occurred. While similarity between actual and counterfactual events, ease of imagining, and prior simulation of the counterfactual event were all significantly related to counterfactual plausibility, comparative similarity best captured the variance in ratings of counterfactual plausibility. Implications for existing theories on the determinants of counterfactual plausibility are discussed. (shrink)
- Hippocampal function and interference.Matthew L. Shapiro &David S. Olton -1994 - In D. Schacter & E. Tulving,Memory Systems. MIT Press. pp. 1994--87.
- Investigating Constituent Order Change With Elicited Pantomime: A Functional Account of SVO Emergence.Matthew L. Hall,Victor S. Ferreira &Rachel I. Mayberry -2014 -Cognitive Science 38 (5):943-972.One of the most basic functions of human language is to convey who did what to whom. In the world's languages, the order of these three constituents (subject [S], verb [V], and object [O]) is uneven, with SOV and SVO being most common. Recent experiments using experimentally elicited pantomime provide a possible explanation of the prevalence of SOV, but extant explanations for the prevalence of SVO could benefit from further empirical support. Here, we test whether SVO might emerge because (a) (...) SOV is not well suited for describing reversible events (a woman pushing a boy) and (b) pressures to be efficient and mention subjects before objects conspire to rule out many other alternatives. We tested this by asking participants to describe reversible and non‐reversible events in pantomime, and we instructed some participants to be consistent in the form of their gestures and to teach them to the experimenter. These manipulations led to the emergence of SVO in speakers of both English (SVO) and Turkish (SOV). (shrink)
- Analytic-thinking predicts hoax beliefs and helping behaviors in response to the COVID-19 pandemic.Matthew L. Stanley,Nathaniel Barr,Kelly Peters &Paul Seli -2021 -Thinking and Reasoning 27 (3):464-477.Confirmed COVID-19 cases in the United States increased exponentially, quickly leading to a pandemic in 2020, which created a serious public-health emergency. During the period in which the COVID-1...
- Network Modularity as a Foundation for Neural Reuse.Matthew L. Stanley,Bryce Gessell &Felipe De Brigard -2019 -Philosophy of Science 86 (1):23-46.The neural reuse framework developed primarily by Michael Anderson proposes that brain regions are involved in multiple and diverse cognitive tasks and that brain regions flexibly and dynamically interact in different combinations to carry out cognitive functioning. We argue that the evidence cited by Anderson and others falls short of supporting the fundamental principles of neural reuse. We map out this problem and provide solutions by drawing on recent advances in network neuroscience, and we argue that methods employed in network (...) neuroscience provide the means to fully engage in a research program operating under the principles of neural reuse. (shrink)
- Research Portfolio Analysis in Science Policy: Moving from Financial Returns to Societal Benefits.Matthew L. Wallace &Ismael Rafols -2015 -Minerva 53 (2):89-115.Funding agencies and large public scientific institutions are increasingly using the term “research portfolio” as a means of characterizing their research. While portfolios have long been used as a heuristic for managing corporate R&D, they remain ill-defined in a science policy context where research is aimed at achieving societal outcomes. In this article we analyze the discursive uses of the term “research portfolio” and propose some general considerations for their application in science policy. We explore the use of the term (...) in private R&D and related scholarly literature in existing science policy practices, and seek insight in relevant literature in science policy scholarship. While the financial analogy can in some instances be instructive, a simple transposition from the world of finance or of corporate R&D to public research is problematic. However, we do identify potentially fruitful uses of portfolio analysis in science policy. In particular, our review suggests that the concept of research portfolio can indeed be a useful analytical instrument for tackling complex societal challenges. Specifically, the strands of scholarship identified suggest that the use of research portfolio should: i) recognize the diversity of research lines relevant for a given societal challenge, given the uncertainty and ambiguity of research outcomes; ii) examine the relationships between research options of a portfolio and the expected societal outcomes; and iii) adopt a systemic perspective to research portfolios – i.e. examine a portfolio as a functional whole, rather than as the sum of its parts. We argue that with these considerations, portfolio-driven approaches may foster social inclusion in science policy decisions, help deliberation between “alternative” portfolios to tackle complex societal challenges, as well as promote cost-effectiveness and transparency. (shrink)
- A circumscriptive theorem prover.Matthew L. Ginsberg -1989 -Artificial Intelligence 39 (2):209-230.
- Reasoning about action I.Matthew L. Ginsberg &David E. Smith -1988 -Artificial Intelligence 35 (2):165-195.
- Short-term memory stages in sign vs. speech: The source of the serial span discrepancy.Matthew L. Hall &Daphne Bavelier -2011 -Cognition 120 (1):54-66.
- Matters of fact.Matthew L. Jones -2010 -Modern Intellectual History 7 (3):629-642.At the end of Matters of Exchange , Harold Cook's major revisionist account of the early modern scientific revolution, he locates the political and economic writings of Bernard Mandeville within the practices and values of contemporaneous Dutch observational medicine. Like Mandeville, Cook describes the potency of early modern capitalism and its attendant value system in generating industry and knowledge; like Mandeville, Cook finds coercive systems of moral regulation to be mistaken in their estimation of human capacities; and like Mandeville, Cook (...) does not shy away from the violence that often made the worldwide commerce in matters of fact possible. “Every Part was full of Vice,” famously rhymed Mandeville, “Yet the whole Mass a Paradise.” The practices and values of science, this book suggests, stemmed from the vices of the merchant and the consumer, not the sprezzatura of the baroque courtier, the asceticism of the Christian gentleman, the speculation of the university philosopher, or the dour appraisal of the theologian. Interest, not claims to disinterest, made modern science and its attendant values possible. Scrupulous attention to goods from around the world and right at home created the conditions for natural knowledge. (shrink)
- Iterative broadening.Matthew L. Ginsberg &William D. Harvey -1992 -Artificial Intelligence 55 (2-3):367-383.
- Utopia rising.Matthew L. Sexton -2011 - [United States?]: [Matthew L. Sexton].If you assume the progression of humanity points to a pattern, then nearly everything you encounter in life is a piece of data in the puzzle of mankind's fate. Does it paint a doom and gloom prospect or is it going somewhere amazing?Matthew Sexton's debut novel is a glimpse into the evolution of humanity and its inherent potential going forward. The goal to marginalize pessimism and negativity is critical to our efforts of progression. But it is not just (...) optimism or wishful thinking that Sexton professes; it's realism based on the wonders of the modern world. Knowledge and its results, such as technology and standardized practices which have proven their worth, are not the products of a single individual's efforts but a 'collective consciousness,' a concerted, connected effort that portends an extraordinary future of boundless possibility. There is no reason to assume this progress is reaching its boundaries or even that they are in sight. Thought provoking and sound in principle, Utopia rising probes without cynicism and with a desire for deeper understanding of the overall complexity, interrelatedness, and nature of our beings. It then goes on to offer suggestions on how to maximize the efforts toward the long range goals and thoughts on what will eventually prove to be the ideals of a future built by mankind's incredible ability to achieve"--Back cover. (shrink)
- The Internet "A tissue of nothingness", says one of its Pioneers - in a book.Matthew L. Wald -1995 -Logos. Anales Del Seminario de Metafísica [Universidad Complutense de Madrid, España] 6 (2):84-85.No categories
- Decision trees, random forests, and the genealogy of the black box.Matthew L. Jones -2022 - In Morgan G. Ames & Massimo Mazzotti,Algorithmic modernity: mechanizing thought and action, 1500-2000. New York, NY: Oxford University Press.
- History, Method, and Theology: A Dialectical Comparison of Wilhelm Dilthey's Critique of Historical Reason and Bernard Lonergan's Meta-methodology.Matthew L. Lamb -1974
- Modularity in network neuroscience and neural reuse.Matthew L. Stanley &Felipe De Brigard -2016 -Behavioral and Brain Sciences 39.No categories
- The Trial Narratives: Conflict, Power, and Identity in the New Testament.Matthew L. Skinner -2010No categoriesExport citation
Bookmark - Genetic control of fungal differentiation: The three sporulation pathways of Neurospora crassa.Matthew L. Springer -1993 -Bioessays 15 (6):365-374.Sporulation in the mold Neurospora crussa can proceed along three very different pathways, leading to the production of three types of spores. Two asexual sporulation pathways that lead to the formation of macroconidia and microconidia involve budding from hyphae by two different mechanisms. A much more complex sexual reproductive pathway involves the formation of a fruiting body called a perithecium, in which meiosis takes place and ascospores are formed in sac‐like cells called asci. Numerous mutations exist that affect these developmental (...) pathways, and genes have been isolated that are expressed preferentially during sporulation. The Neurospora sporulation pathways offer a simple system with which to study mechanisms and regulation of development that are usually obscured by complex cell‐cell interactions involved in animal and plant development. (shrink)
- Introducing Islamic Critical Realism: A Philosophy for Underlabouring Contemporary Islam.Matthew L. N. Wilkinson -2013 -Journal of Critical Realism 12 (4):419-442.This article makes the case for a contemporary philosophy of Islam to help Muslims surmount the challenges of postmodernity and to transcend the hiatuses and obstacles that Muslims face in their interaction and relationships with non-Muslims. It argues that the philosophy of critical realism so fittingly underlabours for the contemporary interpretation, clarification and conceptual deepening of Islamic doctrine and practice as to suggest and necessitate the development of a distinctive Islamic critical realist philosophy, social and educational theory and world-view, specifically (...) suited for this purpose. This approach is called Islamic critical realism. (shrink)No categories
- Memory and Counterfactual Simulations for Past Wrongdoings Foster Moral Learning and Improvement.Matthew L. Stanley,Roberto Cabeza,Rachel Smallman &Felipe De Brigard -2021 -Cognitive Science 45 (6):e13007.In four studies, we investigated the role of remembering, reflecting on, and mutating personal past moral transgressions to learn from those moral mistakes and to form intentions for moral improvement. Participants reported having ruminated on their past wrongdoings, particularly their more severe transgressions, and they reported having frequently thought about morally better ways in which they could have acted instead (i.e., morally upward counterfactuals; Studies 1–3). The more that participants reported having mentally simulated morally better ways in which they could (...) have acted, the stronger their intentions were to improve in the future (Studies 2 and 3). Implementing an experimental manipulation, we then found that making accessible a morally upward counterfactual after committing a moral transgression strengthened reported intentions for moral improvement—relative to resimulating the remembered event and considering morally worse ways in which they could have acted instead (Study 4). We discuss the implications of these results for competing theoretical views on the relationship between memory and morality and for functional theories of counterfactual thinking. (shrink)
- Cognitive constraints on constituent order: Evidence from elicited pantomime.Matthew L. Hall,Rachel I. Mayberry &Victor S. Ferreira -2013 -Cognition 129 (1):1-17.
- Acceptability judgments still matter: Deafness and documentation.Matthew L. Hall,Rachel I. Mayberry &Victor S. Ferreira -2017 -Behavioral and Brain Sciences 40.
- The Input Matters: Assessing Cumulative Language Access in Deaf and Hard of Hearing Individuals and Populations.Matthew L. Hall -2020 -Frontiers in Psychology 11.
- Approximate planning.Matthew L. Ginsberg -1995 -Artificial Intelligence 76 (1-2):89-123.
- From Heisenberg's cat to Eichenbaum's rat: Uncertainty in predicting the neural requirements for animal behavior.Matthew L. Shapiro -1994 -Behavioral and Brain Sciences 17 (3):493-494.
- The Millennial Challenges Facing Catholic Intellectual Life.Matthew L. Lamb -2013 -Nova et Vetera 11 (4).No categoriesExport citation Bookmark
- Pros and cons of blurring gesture-language lines: An evolutionary linguistic perspective.Matthew L. Hall -2017 -Behavioral and Brain Sciences 40.
- Liberation Theology and Social Justice.Matthew L. Lamb -1985 -Process Studies 14 (2):102-123.
- Methodology, Metascience, and Political Theology.Matthew L. Lamb -1981 -Lonergan Workshop 2:281-403.No categories
- Mother Teresa's Mysticism: A Christo-Ecclesio-Humano-Centric Mysticism by Robert M. Garrity.Matthew L. Lamb -2019 -Nova et Vetera 17 (1):284-287.No categories
- The Metaphysics of a Contemporary Islamic Shari'a: A MetaRealist Perspective.Matthew L. N. Wilkinson -2015 -Journal of Critical Realism 14 (4):350-365.The philosophy of metaReality and, in particular, ideas of transcendence can ‘underlabour’ for the re-enchantment of Islamic praxis, ethics and law by helping to uncover in a systematic, non-arbitrary way the spiritual objectives inherent in the basic beliefs, practices and obligations of Islam. The commonly accepted elements of the Islamic legal pathway, such as the obligation of marriage, far from being inhibiting, can help humans access the dialectical pulse of freedom and the emancipatory meaning inherent tendentially in human relationships. Thus, (...) the Islamic Shari'a, underlaboured by the philosophy of metaReality, rather than a symbol of legal backwardness and inflexibility, can be conducive once again to greater personal ontological wholeness and collective human flourishing. (shrink)
- Historicity and Eternity.Matthew L. Lamb -1994 -Lonergan Workshop 10:179-227.No categories
- Counterfactual state explanations for reinforcement learning agents via generative deep learning.Matthew L. Olson,Roli Khanna,Lawrence Neal,Fuxin Li &Weng-Keen Wong -2021 -Artificial Intelligence 295 (C):103455.
- I’m not the person I used to be: The self and autobiographical memories of immoral actions.Matthew L. Stanley,Paul Henne,Vijeth Iyengar,Walter Sinnott-Armstrong &Felipe De Brigard -2017 -Journal of Experimental Psychology. General 146 (6):884-895.People maintain a positive identity in at least two ways: They evaluate themselves more favorably than other people, and they judge themselves to be better now than they were in the past. Both strategies rely on autobiographical memories. The authors investigate the role of autobiographical memories of lying and emotional harm in maintaining a positive identity. For memories of lying to or emotionally harming others, participants judge their own actions as less morally wrong and less negative than those in which (...) other people lied to or emotionally harmed them. Furthermore, people judge those actions that happened further in the past to be more morally wrong than those that happened more recently. Finally, for periods of the past when they believed that they were very different people than they are now, participants judge their actions to be more morally wrong and more negative than those actions from periods of their pasts when they believed that they were very similar to who they are now. The authors discuss these findings in relation to theories about the function of autobiographical memory and moral cognition in constructing and perceiving the self over time. (shrink)
- Descartes's Geometry as Spiritual Exercise.Matthew L. Jones -2001 -Critical Inquiry 28 (1):40-71.
- Plato on false pains and modern cognitive science.Matthew L. Usher &Spyridon George Couvalis -unknownExport citation Bookmark
- Resistance to Position Change, Motivated Reasoning, and Polarization.Matthew L. Stanley,Paul Henne,Brenda Yang &Felipe De Brigard -forthcoming -Political Behavior.People seem more divided than ever before over social and political issues, entrenched in their existing beliefs and unwilling to change them. Empirical research on mechanisms driving this resistance to belief change has focused on a limited set of well-known, charged, contentious issues and has not accounted for deliberation over reasons and arguments in belief formation prior to experimental sessions. With a large, heterogeneous sample (N = 3,001), we attempt to overcome these existing problems, and we investigate the causes and (...) consequences of resistance to belief change for five diverse and less contentious socio-political issues. After participants chose initially to support or oppose a given socio-political position, they were provided with reasons favoring their chosen position (affirming reasons), reasons favoring the other, unchosen position (conflicting reasons), or all reasons for both positions (reasons for both sides). Our results indicate that participants are more likely to stick with their initial decisions than to change them no matter which reasons are considered, and that this resistance to belief change is likely due to a motivated, biased evaluation of the reasons to support their initial beliefs (prior-belief bias). More specifically, they rated affirming reasons more favorably than conflicting reasons—even after accounting for reported prior knowledge about the issue, the novelty of the reasons presented, and the reported strategy used to make the initial decision. In many cases, participants who did not change their positions tended to become more confident in the superiority of their positions after considering many reasons for both sides. (shrink)
- Reasoning about action II.Matthew L. Ginsberg &David E. Smith -1988 -Artificial Intelligence 35 (3):311-342.
- Fr. Giovanni Sala, S.J., Philosopher and Theologian.Matthew L. Lamb -2017 -Nova et Vetera 15 (1).No categoriesExport citation Bookmark
- The Production Process and Exponential Growth.Matthew L. Lamb -1978 -Lonergan Workshop 1:257-307.No categories
- Is social interaction based on guile or honesty?Matthew L. Brooks &William B. Swann -2011 -Behavioral and Brain Sciences 34 (1):17-18.Von Hippel & Trivers suggest that people enhance their own self-views as a means of persuading others to adopt similarly inflated perceptions of them. We question the existence of a pervasive desire for self-enhancement, noting that the evidence the authors cite could reflect self-verification strivings or no motive whatsoever. An identity negotiation framework provides a more tenable approach to social interaction.
- Changes in global and regional modularity associated with increasing working memory load.Matthew L. Stanley,Dale Dagenbach,Robert G. Lyday,Jonathan H. Burdette &Paul J. Laurienti -2014 -Frontiers in Human Neuroscience 8.
- Justice and the Slaughter Bench.Matthew L. N. Wilkinson -2019 -Journal of Critical Realism 18 (1):91-94.In his book, ‘Justice and the Slaughter Bench’, Alan Norrie poses the Big Legal Questions with insight and erudition. Specifically, he challenges all those who care about the nature of justice to m...No categories
- Emotional intensity in episodic autobiographical memory and counterfactual thinking.Matthew L. Stanley,Natasha Parikh,Gregory W. Stewart &Felipe De Brigard -2017 -Consciousness and Cognition 48:283-291.
- The Monoamine Oxidase A (MAOA) Genetic Predisposition to Impulsive Violence: Is It Relevant to Criminal Trials?Matthew L. Baum -2011 -Neuroethics 6 (2):287-306.In Italy, a judge reduced the sentence of a defendant by 1 year in response to evidence for a genetic predisposition to violence. The best characterized of these genetic differences, those in the monoamine oxidase A (MAOA), were cited as especially relevant. Several months previously in the USA, MAOA data contributed to a jury reducing charges from 1st degree murder (a capital offence) to voluntary manslaughter. Is there a rational basis for this type of use of MAOA evidence in criminal (...) court? This paper will review in context recent work on the MAOA gene–environment interaction in predisposing individuals to violence and address the relevance of such findings to murder trials. Interestingly, the MAOA genetic variants impact future violence and aggression only when combined with the adverse environmental stimuli of childhood maltreatment. Thus nature and nurture interact to determine the individual’s risk. Based on current evidence, I argue there is a weak case for mitigation. But should future experiments confirm the hypothesis that individual differences in impulse control and response to provocation found in MAOA-L men (without abuse) are significantly magnified when combined with childhood maltreatment, the case could turn into a stronger one. (shrink)
- Viktor Mayer-Schönberger, Delete: the virtue of forgetting in the digital age. [REVIEW]Matthew L. Smith -2009 -Identity in the Information Society 2 (3):369-373.Viktor Mayer-Schönberger, Delete: the virtue of forgetting in the digital age Content Type Journal Article DOI 10.1007/s12394-010-0039-x AuthorsMatthew L. Smith /, International Development Research Centre Ottawa Canada Journal Identity in the Information Society Online ISSN 1876-0678 Journal Volume Volume 2 Journal Issue Volume 2, Number 3.
- Remembering moral and immoral actions in constructing the self.Matthew L. Stanley,Paul Henne &Felipe De Brigard -forthcoming -Memory and Cognition.Having positive moral traits is central to one’s sense of self, and people generally are motivated to maintain a positive view of the self in the present. But it remains unclear how people foster a positive, morally good view of the self in the present. We suggest that recollecting and reflecting on moral and immoral actions from the personal past jointly help to construct a morally good view of the current self in complementary ways. More specifically, across four studies we (...) investigated the extent to which people believe they have changed over time after recollecting their own moral or immoral behaviors from the personal past. Our results indicate that recollecting past immoral actions is associated with stronger impressions of dissimilarity and change in the sense of self over time than recollecting past moral actions. These effects held for diverse domains of morality (i.e., honesty/dishonesty, helping/harming, fairness/unfairness, and loyalty/disloyalty), and they remained even after accounting for objective, calendar time. Further supporting a motivational explanation, these effects held when people recollected their own past actions but not when they recollected the actions of other people. (shrink)
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David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Area Editors:
David Bourget
Gwen Bradford
Berit Brogaard
Margaret Cameron
David Chalmers
James Chase
Rafael De Clercq
Ezio Di Nucci
Esa Diaz-Leon
Barry Hallen
Hans Halvorson
Jonathan Ichikawa
Monte Johnson
Michelle Kosch
Øystein Linnebo
Paul Livingston
Brandon Look
Manolo Martínez
Matthew McGrath
Michiru Nagatsu
Susana Nuccetelli
Giuseppe Primiero
Jack Alan Reynolds
Darrell P. Rowbottom
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Thomas Senor
Daniel Star
Jussi Suikkanen
Aness Kim Webster
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