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© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)

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There is the world of ideas and the world of practice; the French are often for sup pressing the one and the English the other; but neither is to be suppressed. -Matthew Arnold The Function of Criticism at the Present Time From its inception, bioethics has confronted the need to reconcile theory and practice. At first the confrontation was purely intellectual, as writers on ethical theory (within phi losophy, theology, or other humanistic disciplines) turned their attention to topics from (...) the world of medical practice. Recently the confrontation has grown more intense. The ap pointment of clinical ethicists in hospitals and other health care settings is an accelerating trend in North America. Concomitantly, those institutions involved in training peo ple in clinical ethics have added organized exposure to the world of practice, in the form of placement requirements, to the normal academic course load. In common with other dis ciplines, bioethics has begun to see clinical training as a con dition of didactic theory and apprenticeship. (shrink)

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There is at this point no shortage of testimonials regarding the practice of philosophy for children. In addition, there have been a number of studies which give further support to the claim that philosophy for children is a valuable classroom practice. The idea that pre-college instruction in philosophy is beneficial is no longer in doubt, nor is there a significant lack of materials for use in philosophy for children programs. From Lewis Carroll toMatthew Lipman authors constructed texts that (...) go far in engaging children's philosophical inclinations. If there is any weakness in the practice of philosophy for children it is usually found in the individual classroom. (shrink)

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In recent years an increasing number of moral theorists have come to embrace the term "moral pluralism" to describe a particular kind of moral theory. Unfortunately, there has been little consensus regarding what exactly constitutes a pluralistic theory, and what specific commitments such theories involve. My dissertation takes on the task of articulating the underlying schema of pluralist moral theory, and of analyzing the plausibility and implications of pluralism's fundamental commitments. I argue that the most thoroughgoing pluralist theories are shaped (...) by two defining theses; the plurality of the good , and the plurality of the right , and that these are conceptually linked by two additional meta-ethical commitments. My analysis of the plausibility of these commitments is at times friendly to moral pluralism and at times critical of it. For instance, I develop an account of "value incommensurability," an idea upon which pluralism depends, that resists some of more the important attacks within the literature. Yet I also criticize the commitment to the plurality of the right, as held by Susan Wolf and several other pluralists. I argue that this view is less plausible than "limited pluralism"---a view that is pluralistic about the good but monistic about the right. In the final chapter I explore the relationship between moral pluralism and political liberalism, focusing on the role that overriding values play within each type of theory. (shrink)

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Ultimate reality is often characterized in terms of a variety of what are thought to be incompatible concepts, like God, Dao, Brahman, etc. This book examines the plausibility of a genuine religious pluralism, arguing against relativism but in favor of the authenticity of a plurality of the world's major religious traditions.

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We are experiencing a historical moment characterized by unprecedented conditions of virality: a viral pandemic, the viral diffusion of misinformation and conspiracy theories, the viral momentum of ongoing Hong Kong protests, and the viral spread of #BlackLivesMatter demonstrations and related efforts to defund policing. These co-articulations of crises, traumas, and virality both implicate and are implicated by big data practices occurring in a present that is pervasively mediated by data materialities, deeply rooted dataist ideologies that entrench processes of datafication as (...) granting objective access to truth and attendant practices of tracking, data analytics, algorithmic prediction, and data-driven targeting of individuals and communities. This collection of papers explores how data is figuring in the making of the discourses, lived realities, and systemic inequalities of the uneven impacts of the coronavirus pandemic. (shrink)

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The primary aim of this paper is to analyze the concept of degrees of causal contribution for actual events and examine the way in which it can be formally defined. This should go some way to filling out a gap in the legal and philosophical literature on causation. By adopting the conception of a cause as a necessary element of a sufficient set (the so-called NESS test) we show that the concept of degrees of causation can be given clear and (...) even empirical meaning. We then apply a game theoretical framework to derive a measure of causal contribution. Our favoured measure turns out to be a generalised version of the normalized Penrose–Banzhaf index of voting power. (shrink)

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There are three broad ethical issues related to handling public health emergencies. They are the three R's - rationing, restrictions and responsibilities. Recently, a severe shortage of annual influenza vaccine in the US, combined with the threat of pandemic flu, has provided an opportunity for policy makers to think about rationing in very concrete terms. Some lessons from annual flu vaccination likely will apply to pandemic vaccine distribution, but many preparatory decisions must be based on very rough estimates. What ethical (...) principles should guide rationing decisions, what data should inform these decisions, how to revise decisions as new data emerge, and how to implement rationing decisions on the ground are all important considerations. In addition, ethicists might be able to help policy makers think through the importance of international cooperation in surmounting global rationing dilemmas and to accept the inevitable responsibilities of government in making and implementing rationing decisions. (shrink)

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Abstract I provide an account of the nature of seemings that explains why they are necessary for justification. The account grows out of a picture of cognition that explains what is required for epistemic agency. According to this account, epistemic agency requires (1) possessing the epistemic aims of forming true beliefs and avoiding errors, and (2) having some means of forming beliefs in order to satisfy those aims. I then argue that seeming are motives for belief characterized by their role (...) of providing us with doxastic instructions guided by our epistemic aims. Understanding the nature of seemings allows us to underwrite recent epistemological work by Michael Huemer, and shows why he was right to claim that seemings are the source of all justification. I then look at some objections both to my arguments regarding the connection between seemings and justification, and to Huemer’s related “Principle of Phenomenal Conservatism”. Content Type Journal Article Pages 1-21 DOI 10.1007/s11098-011-9830-2 AuthorsMatthew Skene, Syracuse University, 8330 E. Quincy Ave., I-307, Denver, CO 80237, USA Journal Philosophical Studies Online ISSN 1573-0883 Print ISSN 0031-8116. (shrink)

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This book undertakes a critical survey of art history across Europe, examining the recent conceptual and methodological concerns informing the discipline as well as the political, social and ideological factors that have shaped its development in specific national contexts.

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This thesis examines the function of art in Nietzsche's philosophy. Its primary concern is with Nietzsche's turn to art as the means to counter what he terms metaphysics. Metaphysics is a metonym for the system of beliefs sustaining our culture whereby human judgements about the world are perceived as uncovering an objective truth antecedent to those judgements, with an implicit faith in the possibility of exhausting the totality of these antecedent truths. This thesis consequently has two principal strands. The first (...) is to analyse Nietzsche's criticism of metaphysics. The second is to explore the way in which, using a specific understanding of art, Nietzsche attempts to reconcile extreme scepticism towards all forms of human knowledge with a continued belief in their necessity. The thesis argues that Nietzsche lays an importance on art as providing an aesthetic education to replace the misguided theoretical orientation of metaphysics. Nietzsche criticises metaphysics for its inability to recognise that its interpretations are mere interpretations, that logic and the rational serve as means to make the world meaningful from the human perspective. My thesis explores how he sees art, and in particular the tragic, as constituting a mode of world interpretation which declares its status as such. I argue that for Nietzsche this is crucial inasmuch as a failure to recognise the contingency of our interpretations results in a refusal to give value in any interpretations. For Nietzsche the advent of the Modern age heralds the danger of such refusal, and hence I argue that his turn to art is a response to the specifically Modern temptation to descend into mere cynical Nihilism. (shrink)

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I defend the acceptance principle for testimony (APT), that hearers are justified in accepting testimony unless they have positive evidence against its reliability, against Elizabeth Fricker's local reductionist view. Local reductionism, the doctrine that hearers need evidence that a particular piece of testimony is reliable if they are to be justified in believing it, must on pain of scepticism be complemented by a principle that grants default justification to some testimony; I argue that (APT) is the principle required. I consider (...) two alternative weaker principles as complements to local reductionism; one yields counter-intuitive results unless we accept (APT) as well, while the other is too weak to enable local reductionism to avoid scepticism. (shrink)

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Despite the ongoing need for managers to fire employees and the wide prevalence of downsizing and layoffs, little research has examined how the conduct of termination interviews affects employee reactions. The current research was designed to explore reactions to several commonly used termination interview practices. Two scenario-based experiments examined the effectiveness of having a third party (an HR manager or a security guard) present, mentioning the employee's positive characteristics and contributions, and using alone, discrete escort, or public escort modes of (...) exit from the interview. Perceptions of being treated with respect and empathy, levels of anger, and the likelihood of complaining to others and taking legal action were assessed. Support for the effectiveness of specific termination interview practices was mixed. Specifically, in Experiment 1, third party presence was viewed as demonstrating a lack of respect, whereas mentioning positive characteristics was generally viewed favorably. Experiment 2 showed the favorable effects of mentioning positive characteristics were eroded by a security guard escort from the interview, and actually reversed and became negative when that escort was public in nature. A public escort also produced the highest levels of anger. These results suggest that multiple aspects of the termination interview process should be considered carefully when developing managerial policies. (shrink)

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A new culture of care -- Maximising capacity -- Assessing capacity -- Advocacy and empowerment -- Advance care planning -- Best interests -- Liberty and choice.

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*The views represented are the author's alone and should not be construed as representing policies of the American Medical Association.

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In part I of this paper, I argue that #MeToo testimony increases epistemic value for the survivor qua hearer when experiences like hers are represented by others; for society at large when false but dominant narratives about sexual violence and sexual harassment against women are challenged and replaced with true stories; and for the survivor qua teller when her true story is believed. In part II, I argue that the epistemic significance of #MeToo testimony compels us to consider the tremendous (...) and often unappreciated costs to the individual tellers, and the increased credibility they are owed in virtue thereof. (shrink)

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In 1823, F.W. Bessel published a startling conclusion: ‘involuntary constant differences’ mark out the recorded astronomical transit times of distinct observers. Bessel’s discovery eventually led to the institutionalization of the ‘personal equation’ for astrometry and spurred psychological investigations into the processes of visual perception. Bessel’s discovery revealed that the epistemic terrain of astrometry was more unpredictable than had been previously thought. Yet the solution to these worries was not a rigorous theory of the observer, but rather a set of cautionary (...) practices in data recording. This paper investigates the reasoning process Bessel used to discover involuntary constant differences and asks whether the apparent perceptual relativity he had discovered constituted a threat to data integrity. Bessel’s solution was epistemically responsible because it treated individual observational differences as a type of potential error that was avoided by preventing mixed observations. Additionally, error was not primarily viewed as a mismatch with reality, but rather as endemic to observational data, which kept the focus on practical matters rather than ontological ones. (shrink)

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In this dissertation I critically engage and draw insights from classical Indian, Anglo-American, phenomenological, and cognitive scientific approaches to the topic of self-awareness. In particular, I argue that in both the Western and the Indian tradition a common and influential view of self-awareness---that self-awareness is the product of an act of introspection in which consciousness takes itself as an object---distorts our understanding of both self-awareness and consciousness as such. In contrast, I argue for the existence and primacy of pre-reflective self-awareness (...) ---a form of self-awareness that is an effect of both our embodiment and the basic structure of consciousness. In arguing for this account of self-awareness, I take up, among other things, the following: the semantics of the first-person and of indexicals in general, qualia and phenomenal consciousness; the possibility of non-conceptual self-awareness, the nature of introspection; the importance of embodiment and agency for our understanding of self-awareness, and the consequences of my account for the metaphysics of personal identity. (shrink)

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To what risks may children participating in research be subjected? Institutional review boards can stand surrogate for parents by filtering out studies whose risk is unacceptably high.

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Books reviewed in this article: The Anchor Bible Dictionary. Edited by David NoelFreedman with Gary A. Herion, David F. Graf, John David Pleins. The Gospel ofMatthew. By Daniel J. Harrington. Paul: An Introduction to his Thought. By C. K. Barrett. A Radical Jew: Paul and the Politics of Identiy. By Daniel Boyarin. New Testament Theology. By G. B. Caird, completed and edited by L. D. Hurst. The Fatherhood of God from Origen to Athanasius. By Peter Widdicombe. (...) Dieu et le Christ selon Grégoire de Nysse. By Bernard Pottier. Eucharistic Presence: A Study in the Theology of Disclosure. By Robert Sokolowski. Theological Hermeneutics: Development and Significance. By Werner Jeanrond. Theologie aus Efahrung der Gnade. Annäherungen an Karl Rahner: Edited by Mariano Delgado and Mathias‐Lutz Bachmann. Bernhard Welte's Fundamental Theological Approach to Christology.. By Anthony J. Godzieba. Sacred Identity: Exploring a Theology of the Person. By Jane Kopas. A Salvation Audit. By Colin Grant. Medical Ezhics: Sources Of Catholic Teachings, Second Edition. Edited by Kevin O'Rourke and Philip Boyle. Mission and Conversion: Proselytizing in the Religious History of the Roman Empire. By Martin Goodman. Literacy and Power in the Ancient World. Edited by Alan K. Bowman and Greg Woolf. St Cyril of Alexandria: The Christological Controversy. Its History, Theology and Texts. By John A. McGuckin. Ambrose of Milan: Church and Court in a Christian Capital. By Neil B. McLynn. Basil of Cuesareu. By Philip Rousseau. Augustine. By Mary T. Clark. Irenaeus. By Dennis Minns. Divine Heiress: The Virgin Mary and the Creation of Christian Constantinople. By Vasiliki Limberis. The Irish Tradition in Old English Literature. By Charles D. Wright. Relics, Apocalypse and the Deceils of History: Ademar of Chabannes, 989–1034. By Richard Landes. Huguccio: The Life, Works, and Thought of a Twelfth‐Centuy Jurist. By Wolfgang P. Müller. The Presence of God: A History of Western Christian Mysticism, Volume II: The Growth of Mysticism. By Bernard McGinn. Preaching the Crusades: Mendicant Friars and the Cross in the Thirteenth Century. By Christoph T. Maier. Mary Ward: A World in Contemplation. By Henriette Peters. The Letters of Teilhard de Chardin and Lucile Swan. Edited by Thomas M. King and Mary Wood Gilbert. Pseudo‐Marry: By John Donne. Edited, with an Introduction and Commentary, by Anthony Raspa. Donne and the Politics of Conscience in Early Modern England. By M. L. Brown. The Caroline Captivity of the Church: Charles 1 and the Remoulding of Anglicanism. By Julian Davies. Érudition et religion aux XVIIe et XVIIIe siécles. By Bruno Neveu. Cardinal Lavigerie: Churchman, Prophet and Missionary. By François Renault. Dom Columba Marmion: A Biography By Mark Tierney. Christian Mission in the Twentieth Century. By Timothy Yates. Religion in Africa: Experience and Expression. Edited by Thomas D. Blakely, Walter E. A. van Beek and Dennis Thomson. (shrink)

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We present evidence for the existence of `responsibility voids' in committee decision-making, that is, the existence of situations where no member of a committee can individually be held morally responsible for the outcome. We analyse three types of reasons (causal, normative and epistemic) for the emergence of responsibility voids, and show that each of them can occur in committees. But the conditions for these voids are so restrictive as to reduce the philosophical or institutional significance they might be thought to (...) possess. (shrink)

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In _Camus, Philosophe: To Return to our Beginnings_Matthew Sharpe reads Camus as a _philosophe_ in the classical and enlightenment lineages, arguing that his defense of _mesure_ singles him out amidst 20th century French thought and makes him of renewed relevance today.

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In Zizek and Politics, Geoff Boucher andMatthew Sharpe go beyond standard introductions to spell out a new approach to reading Zizek, one that can be highly critical as well as deeply appreciative. They show that Zizek has a raft of fundamental positions that enable his theoretical positions to be put to work on practical problems. Explaining these positions with clear examples, they outline why Zizek's confrontation with thinkers such as Derrida, Foucault and Deleuze has so radically changed how (...) we think about society. They then go on to track Zizek's own intellectual development during the last twenty years, as he has grappled with theoretical problems and the political climate of the War on Terror. This book is a major addition to the literature on Zizek and a crucial critical introduction to his thought. (shrink)

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Emotional clarity and attention to emotions represent the extent to which people understand and attend to their own emotions, respectively, and are broad facets of emotional awareness, alexithymia, and emotional intelligence. To examine the extent to which these two constructs are associated, we conducted a meta-analysis of studies including well-validated self-report measures of trait clarity and attention to emotion. Clarity and attention were moderately, positively associated. Assessment instrument, but not sample gender or age, moderated the association between clarity and attention. (...) Analyses of between-study heterogeneity and publication bias suggested that results were valid and generalizable. We discuss potential causes of the association between clarity and attention, and elaborate on the implications of our results for emotion regulation, well-being, and psychopathology. (shrink)

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The aim of this volume is to critically assess the philosophical importance of phenomenology as a method for studying the normativity of meaning and its transcendental conditions. Using the pioneering work of Steven Crowell as a springboard, phenomenologists from all over the world examine the promise of phenomenology for illuminating long-standing problems in epistemology, the philosophy of mind, action theory, the philosophy of religion, and moral psychology. The essays are unique in that they engage with the phenomenological tradition not as (...) a collection of authorities to whom we must defer, or a set of historical artifacts we must preserve, but rather as a community of interlocutors with views that bear on important issues in contemporary philosophy. The book is divided into three thematic sections, each examining different clusters of issues aimed at moving the phenomenological project forward. The first section explores the connection between normativity and meaning, and asks us to rethink the relation between the factual realm and the categories of validity in terms of which things can show up as what they are. The second section examines the nature of the self that is capable of experiencing meaning. It includes essays on intentionality, agency, consciousness, naturalism, and moral normativity. The third section addresses questions of philosophical methodology, examining if and why phenomenology should have priority in the analysis of meaning. Finally, the book concludes with an afterword written by Steven Crowell. Normativity, Meaning, and the Promise of Phenomenology will be a key resource for students and scholars interested in the phenomenological tradition, the transcendental tradition from Kant to Davidson, and existentialism. Additionally, its forward-looking focus yields crucial insights into pressing philosophical problems that will appeal to scholars working across all areas of the discipline. ks us to rethink the relation between the factual realm and the categories of validity in terms of which things can show up as what they are. The second section examines the nature of the self that is capable of experiencing meaning. It includes essays on intentionality, agency, consciousness, naturalism, and moral normativity. The third section addresses questions of philosophical methodology, examining if and why phenomenology should have priority in the analysis of meaning. Finally, the book concludes with an afterword written by Steven Crowell. Normativity, Meaning, and the Promise of Phenomenology will be a key resource for students and scholars interested in the phenomenological tradition, the transcendental tradition from Kant to Davidson, and existentialism. Additionally, its forward-looking focus yields crucial insights into pressing philosophical problems that will appeal to scholars working across all areas of the discipline. (shrink)

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