Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis.David C. Whitcomb,Jessica LaRusch,Alyssa M. Krasinskas,Lambertus Klei,Jill P. Smith,Randall E. Brand,John P. Neoptolemos,Markus M. Lerch,Matt Tector,Bimaljit S. Sandhu,Nalini M. Guda,Lidiya Orlichenko,Samer Alkaade,Stephen T. Amann,Michelle A. Anderson,John Baillie,Peter A. Banks,Darwin Conwell,Gregory A. Coté,Peter B. Cotton,James DiSario,Lindsay A. Farrer,Chris E. Forsmark,Marianne Johnstone,Timothy B. Gardner,Andres Gelrud,William Greenhalf,Jonathan L. Haines,Douglas J. Hartman,Robert A. Hawes,Christopher Lawrence,Michele Lewis,Julia Mayerle,Richard Mayeux,Nadine M. Melhem,Mary E.Money,Thiruvengadam Muniraj,Georgios I. Papachristou,Margaret A. Pericak-Vance,Joseph Romagnuolo,Gerard D. Schellenberg,Stuart Sherman,Peter Simon,Vijay P. Singh,Adam Slivka,Donna Stolz,Robert Sutton,Frank Ulrich Weiss,C. Mel Wilcox,Narcis Octavian Zarnescu,Stephen R. Wisniewski,Michael R. O'Connell,Michelle L. Kienholz,Kathryn Roeder &M. Micha Barmada -unknowndetailsPancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)
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Governance and Incentives: Is It Really All about theMoney?Mary Beth Yount &Robert E. Till -2019 -Journal of Business Ethics 159 (3):605-618.detailsGovernance theories impact how corporations are run, which in turn impacts societal well-being. This dynamic is commonly accepted, as evidenced by the flood of articles exploring the links between corporate governance and corporate social responsibility (e.g., Hong et al. in J Bus Ethics 136:199–213, 2016). This article supplements current corporate governance theories with Catholic social thought (CST) to address burgeoning societal issues such as the increasing trust gap, income inequality (the compensation gap), and an overemphasis on financial compensation as the (...) primary way to motivate senior managers. The authors propose a shift away from agency theory and stakeholder theory, both of which, with their limited depictions of the motivations of managers, have contributed to excessive executive compensation. Instead, the authors develop an alternative—justice stewardship theory—which integrates organizational justice theory, the principles of stewardship theory, and the insights of 150 years of CST. (shrink)
Ethical challenges experienced by clinical research nurses:: A qualitative study.Mary E. Larkin,Brian Beardslee,Enrico Cagliero,Catherine A. Griffith,Kerry Milaszewski,Marielle T. Mugford,Joanna M. Myerson,Wen Ni,Donna J. Perry,Sabune Winkler &Elizabeth R. Witte -2019 -Nursing Ethics 26 (1):172-184.detailsBackground: Clinical investigation is a growing field employing increasing numbers of nurses. This has created a new specialty practice defined by aspects unique to nursing in a clinical research context: the objectives (to implement research protocols and advance science), setting (research facilities), and nature of the nurse–participant relationship. The clinical research nurse role may give rise to feelings of ethical conflict between aspects of protocol implementation and the duty of patient advocacy, a primary nursing responsibility. Little is known about whether (...) research nurses experience unique ethical challenges distinct from those experienced by nurses in traditional patient-care settings. Research objectives: The purpose of the study was to describe the nature of ethical challenges experienced by clinical research nurses within the context of their practice. Research design: The study utilized a qualitative descriptive design with individual interviews. Participants and research context: Participating nurses (N = 12) self-identified as having experienced ethical challenges during screening. The majority were Caucasian (90%), female (83%), and worked in outpatient settings (67%). Approximately 50% had > 10 years of research experience. Ethical considerations: The human subjects review board approved the study. Written informed consent was obtained. Findings: Predominant themes were revealed: (1) the inability to provide a probable good, or/do no harm, and (2) dual obligations (identity as a nurse vs a research nurse). The following patterns and subthemes emerged: conflicted allegiances between protocol implementation, needs of the participant, desire to advance science, and tension between the nurse–patient therapeutic relationship versus the research relationship. Discussion: Participants described ethical challenges specific to the research role. The issues are central to the nurse–participant relationship, patient advocacy, the nurse’s role in implementing protocols, and/or advancing science. Conclusion: Ethical challenges related to the specialized role of clinical research nurses were identified. More research is warranted to fully understand their nature and frequency and to identify support systems for resolution. (shrink)
Giant leap for p53, small step for drug design.Mary E. Anderson &Peter Tegtmeyer -1995 -Bioessays 17 (1):3-7.detailsWe review the findings of Cho et al.(1) on the crystal structure of a p53 tumor suppressor‐DNA complex. The core DNA binding domain of p53 folds into a structure termed a β‐sandwich, which organizes two loops and a loop‐sheet‐helix structure on one surface of p53 to interact with the consensus DNA recognition sequence of p53. These structures help to explain the functions of wild‐type p53 and the effects of tumor‐associated mutations on p53 DNA binding, transactivation and suppression of cellular proliferation.
Response II to Rosemary Radford Ruether: ‘Should Women Want Women Priests or Women-Church?’.Mary E. Hunt -2011 -Feminist Theology 20 (1):85-91.detailsMary E. Hunt agrees with Rosemary Radford Ruether’s conclusion that women-church and women priests ‘both have their place in a vision of renewed church and renewed priestly ministry.’ She observes that the ‘either/or’ frame plays into what many feminists have tried to avoid with integrity, namely, setting progressive Catholic women against one another in the public arena. The writer explores the evolving relationship between and among the various feminist individuals and groups that are engaged in this work. She describes (...) how they co-operate to transform kyriarchal Roman Catholicism and meet the needs of the world. (shrink)
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Educational Assessment, Evaluation and Research: The Selected Works ofMary E. James.Mary E. James -2016 - Routledge.detailsIn the _World Library of Educationalists_, international experts themselves compile career-long collections of what they judge to be their finest pieces – extracts from books, key articles, salient research findings, major theoretical and practical contributions – so the world can read them in a single manageable volume, allowing readers to follow the themes of their work and see how it contributes to the development of the field.Mary James has researched and written on a range of educational subjects which (...) encompass curriculum, pedagogy and assessment in schools, and implications for teachers´ professional development, school leadership and policy frameworks. She has written many books and journals on assessment, particularly assessment for learning and is an expert on teacher learning, curriculum, leadership for learning and educational policy. Starting with a specially written introduction in whichMary gives an overview of her career and contextualises her selection, the chapters are divided into three parts: Educational Assessment and Learning Educational Evaluation and Curriculum Development Educational Research and the Improvement of Practice Through this book, readers can follow the different strands thatMary James has researched and written about over the last three decades, and clearly see her important contribution to the field of education. (shrink)
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Spirituality, shifting identities and social change: Cases from the Kalahari landscape.Mary E. Lange &Lauren Dyll-Myklebust -2015 -HTS Theological Studies 71 (1).detailsStorytelling, art and craft can be considered aesthetic expressions of identities. Kalahari identities are not fixed, but fluid. Research with present-day Kalahari People regarding their artistic expression and places where it has been, and is still, practised highlights that these expressions are informed by spirituality. This article explores this idea via two Kalahari case studies: Water Stories recorded in the Upington, Kakamas area, as well as research on a specific rock engraving site at Biesje Poort near Kakamas. The importance of (...) the Kalahari People’s spiritual beliefs as reflected in these case studies and its significance regarding their identities and influence on social change and/or community development projects is discussed. The article thus highlights ways in which spirituality can be considered in relation to social change projects that are characterised by partnerships between local community, non-government and tertiary education representatives and researchers and that highlight storytelling as an integral part of people’s spirituality. (shrink)
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Why bother with hebrews?Marie E. Isaacs -2002 -Heythrop Journal 43 (1):60–72.detailsFew, if any, present‐day undergraduate degree courses in Theology include in their syllabus a study of the Epistle to the Hebrews or other New Testament writings other than the Gospels and the Pauline epistles. The result is in effect that we create a canon within a canon.This paper, originally read at a postgraduate seminar, gives reasons why Hebrews in particular should not be neglected.Hebrews provides evidence of the diversity of early Christian tradition, for example, with its teaching that it is (...) impossible to be re‐admitted to the community of faith, having once abandoned it, and with its unique use of Israel’s day of Atonement rites in its presentation of Christ. Moreover, the very genre of Hebrews merits particular interest.Hebrews also evidences a Christian community which has yet to break with Judaism. Its thoroughly Jewish background illustrates for students of the New Testament the necessity of knowing the Jewish Scriptures as well as the writings of the New Testament. Moreover, a study of the Epistle could make a constructive contribution to present‐day Jewish–Christian dialogue, even if in the past it has been enlisted on the side of a thinly‐disguised anti‐Semitism.Finally, Hebrews brings the student face to face with the metaphorical character of much of the language of the New Testament – a form of language which is not to be taken less seriously than other kinds of language; and in this case, Hebrews’ Day of Atonement metaphors issue in new insights – in an innovative theology of access to God.For this and other reasons, the study of Hebrews has an important contribution to make to theology degree syllabuses. (shrink)
Factors Associated with the Timing and Patient Outcomes of Clinical Ethics Consultation in a Catholic Health Care System.Mary E. Homan -2018 -The National Catholic Bioethics Quarterly 18 (1):71-92.detailsLittle is known about how certain patient characteristics can affect the timing of an ethics consultation, which has been hypothesized to affect patient length of stay. This study assessed how specific patient characteristics affect the timing of an ethics consultation, namely, age (over 65 years), race, Medicaid status, the presence of a living will, the presence of a health care proxy, and the absence of decisional capacity. Moving beyond the typical case-series evaluation of an ethics consultation service, this study used (...) an innovative approach to model how predisposing, enabling, and need factors affect health behavior and subsequently affect health outcomes for patients who received an ethics consultation at a Catholic health care system in Oklahoma. (shrink)
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Inherent Conflict of Interest in Clinical Research: A Call for Effective Guidance.Marie E. Nicolini &Dave Wendler -2020 -American Journal of Bioethics 20 (10):94-96.detailsVolume 20, Issue 10, October 2020, Page 94-96.
The orphan child: humanities in modern medical education.Mary E. Kollmer Horton -2019 -Philosophy, Ethics, and Humanities in Medicine 14 (1):1-6.detailsUse of humanities content in American medical education has been debated for well over 60 years. While many respected scholars and medical educators have purported the value of humanities content in medical training, its inclusion remains unstandardized, and the undergraduate medical curriculum continues to be focused on scientific and technical content. Cited barriers to the integration of humanities include time and space in an already overburdened curriculum, and a lack of consensus on the exact content, pedagogy and instruction. Edmund Pellegrino, (...) physician and scholar of the latter twentieth century, spent much of his professional life promoting the value and importance of the humanities in medical education, seeking the best way to incorporate and teach this content in clinically relevant ways. His efforts included the founding of multiple enterprises starting in the 1960s and 1970s to promote human values in medical education, including the Society for Health and Human Values and its Institute on Human Values in Medicine. Regardless of his efforts and those of many others into the current century, the medical humanities remains a curricular orphan, unable to find a lasting home in medical education and training. (shrink)
Pure Complexity:Mary Daly’s Catholic Legacy.Mary E. Hunt -2014 -Feminist Theology 22 (3):219-228.detailsMary Daly had a complicated relationship to the Catholic tradition. While it is commonly assumed that she rejected it thoroughly, this article offers a more nuanced look at the various ways in which it shaped her thinking. What is clear is that she had a decisive impact on the Catholic tradition, indeed on religion in general. Language about the divine, images of deities, human participation in things spiritual will never be the same after her thorough-going feminist critique. Her legacy (...) is multi-faceted like the woman herself. (shrink)
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The Seamless Web and Communications Equity: The Shaping of a Community Network.Mary E. Virnoche -1998 -Science, Technology and Human Values 23 (2):199-220.detailsDrawing on field data gathered from 1994 to 1996, this article considers tensions in the development of community networks and highlights the decisions that shape particular types of networks. Four key decision points include interface choice, content, interaction, and outreach. Discourse about decision making is often dichotomized around civic and consumer social currents. Civic currents demand text-only interfaces, exclusively non- profit content, full electronic interaction capabilities for everyone, and deep outreach efforts. In contrast, consumer currents push graphical interfaces, the inclusion (...) of profit-making content, limited interaction options, and meso to shallow outreach. While considering the influences of these currents, the article problematizes the dichotomy and considers more specific social influences on decision making. It also suggests specific network decisions that may contribute to greater communications equity. (shrink)
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Violence and the Politics of Explanation: Kampuchea revisited[1].Mary E. Hawkesworth -1985 -Journal of Applied Philosophy 2 (1):69-83.detailsABSTRACT The criteria for adequate explanation have been the subject of intense debate in the philosophy of social science. This paper examines a variety of explanations of a decade of violence in Kampuchea in order to clarify the dimensions of the Kampuchean tragedy and to challenge both the hypothetico‐deductive and the Verstehen models of explanation central to contemporary debates in the philosophy of social science. Using the Kampuchean case as an example, I suggest that the analyst's propensity to assimilate new (...) information into a tacit, pre‐supposition‐laden conceptual framework contributes to an oversimplification or caricature of the event to be explained. For this reason, no individual explanation of an event can be definitive. An adequate explanation can emerge only from the juxtaposition of and extrapolation from multiple, non‐privileged interpretations representing different methodological and ideological perspectives on the socio‐political event to be explained. (shrink)
In Search of Human Nature.Mary E. Clark -2002 - Routledge.detailsHuman Nature offers a wide-ranging and holistic view of human nature from all perspectives: scientific, historical, and sociological.Mary Clark takes the most recent data from a dozen or more fields, and works it together with clarifying anecdotes and thought-provoking images to challenge conventional Western beliefs with hopeful new insights. Balancing the theories of cutting-edge neuroscience with the insights of primitive mythologies,Mary Clark provides down-to-earth suggestions for peacefully resolving global problems. Human Nature builds up a coherent, and (...) above all positive, picture of who we really are. (shrink)
Priesthood and the epistle to the hebrews.Marie E. Isaacs -1997 -Heythrop Journal 38 (1):51–62.detailsCurrent controversies about the ordination of women have shown the need for a re‐examination of what the Christian Church means by priesthood. This article looks at the Epistle to the Hebrews’ contribution to our understanding. To that end it focuses on the institution of priesthood in its first‐century Jewish context and shows the use made of it by the author of Hebrews in his presentation of Christian faith.Section 1 emphasizes some all‐important differences between the NT’s use of the language of (...) priesthood and ours. Not least, it nowhere uses “priest” to designate Christian ministers. All the more striking, therefore, is Hebrews’ depiction of Jesus as “high priest”.Section 2 discusses Judaism’ Day of Atonement ceremonies – Hebrews’ dominant cultic model. In the comparison drawn between Christ’s death and exaltation with these rites, he becomes not only the high priest but also the expiatory victim.As far as Judaism’ cultic institutions are concerned, however, Jesus was not and never could be a priest, since he was of the tribe of Judah rather than Levi. Hence Hebrews appeals to Melchizedek. How this non‐Israelite model is used by Hebrews to subvert the whole notion of priesthood as caste is discussed in section 3.Finally, in section 4 Isaacs concludes that for Hebrews there is no longer a role for an ongoing priesthood, since Jesus has definitively achieved access to God, which was its raison d’être. Melchizedekian high priesthood is unique to Christ; neither inherited nor transmitted. Hence, unlike other NT authors, for Hebrews even the church as a corporate body is not a priesthood. As its closing chapters show, in this Epistle the cultic model gives way to the more inclusive one of pilgrimage. (shrink)
Reading Object Lessons in India today.Mary E. John -2023 -Feminist Theory 24 (2):323-329.detailsThis essay situates Object Lessons in the contemporary academic spaces of women’s studies in India. A decade ago, Object Lessons offered an extensive critique of identity knowledges in the US academy with a special focus on women’s studies. What might its relevance be in the contemporary Indian context? The institutionalisation of women’s studies in India has been shaped by the resources of the social sciences, with their empirical bent and especially their connection to state and development policy. This makes for (...) specific differences with the US context while many concerns are shared. The essay also looks at how gender as a category has been deployed in specific contexts in contrast to that of “women”, in the light of Wiegman’s cautions over seeking resolutions to particular problems through a preferential treatment of categories. By way of concluding thoughts on the Indian situation, women’s studies in India is hypervisible compared to other identity knowledges. In spite of its marginal and precarious location in the academy, it carries a disproportionate political burden, one that a heterogeneous student body is shouldering in their struggles for a sustainable future. (shrink)
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