Genomics spawns novel approaches to mosquito control.Robin W. Justice,Harald Biessmann,Marika F.Walter,Spiros D. Dimitratos &Daniel F. Woods -2003 -Bioessays 25 (10):1011-1020.detailsIn spite of advances in medicine and public health, malaria and other mosquito‐borne diseases are on the rise worldwide. Although vaccines, genetically modified mosquitoes and safer insecticides are under development, herein we examine a promising new approach to malaria control through better repellents. Current repellents, usually based on DEET, inhibit host finding by impeding insect olfaction, but have significant drawbacks. We discuss how comparative genomics, using data from the Anopheles genome project, allows the rapid identification of members of three protein (...) classes critical to insect olfaction: odorant‐binding proteins, G‐protein‐coupled receptors, and odorant‐degrading enzymes. A rational design approach similar to that used by the pharmaceutical industry for drug development can then be applied to the development of products that interfere with mosquito olfaction. Such products have the potential to provide more complete, safer and longer lasting protection than conventional repellents, preventing disease transmission by interrupting the parasite life cycle. BioEssays 25:1011–1020, 2003. © 2003 Wiley Periodicals, Inc. (shrink)
Inventing the Universe: Plato's Timaeus, the Big Bang, and the Problem of Scientific Knowledge.Luc Brisson &F.Walter Meyerstein -1995 - State University of New York Press.detailsThese are inventions of the human mind. The scientific knowledge of the universe is entirely composed in a series of axioms and rules of inference underlying a formalized system.
Human genetics: The molecular challenge.Walter F. Bodmer -1987 -Bioessays 7 (1):41-45.detailsThe 1986 Cold Spring Harbor Symposium was on the subject of human genetics; it was the first symposium at Cold Spring Harbor on this topic since 1964. In the opening remarks for the conference,Walter F. Bodmer first summarized the progress in this field since 1964. He then described what is presently known about the functional complexity of the human genome and discussed the case for a definitive characterization and sequencing of the human genome. The following is an abridged (...) and slightly adapted version of this talk; it is reproduced courtesy of the Cold Spring Harbor Laboratory © 1987. (shrink)
Task Force Report: Ethics and American Population Policy.Walter F. Mondale -1971 -Hastings Center Report 1 (1):6-7.detailsThis is the first of a series of reports on the research groups of the institute: Death and Dying, Behavior Control, Genetic Engineering/Genetic Counseling, the Teaching of Medical Ethics, and the subject of this report, Population Control.